Mutagenetix > Incidental Mutation

Incidental Mutation 'R2117:Otogl'

231097

Institutional Source

Beutler Lab

Gene Symbol

Otogl

Ensembl Gene

ENSMUSG00000091455

Gene Name

otogelin-like

Synonyms

Gm6924

MMRRC Submission

040121-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2117 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

107760531-107912134 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 107858918 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 823 (D823G)

Ref Sequence

ENSEMBL: ENSMUSP00000129467 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165341]

AlphaFold

F7A4A7

Predicted Effect

probably benign
Transcript: ENSMUST00000165341
AA Change: D823G

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000129467
Gene: ENSMUSG00000091455
AA Change: D823G

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
EGF_like	71	101	3.36e1	SMART
VWD	104	264	4.74e-29	SMART
C8	305	378	6.13e-6	SMART
VWD	463	625	7e-41	SMART
C8	668	733	3.6e-3	SMART
Pfam:TIL	736	791	2.3e-11	PFAM
SCOP:d1coua_	833	911	1e-6	SMART
VWD	928	1085	1.29e-30	SMART
C8	1120	1194	1.81e-26	SMART
Pfam:AbfB	1230	1350	1.2e-10	PFAM
Pfam:TIL	1364	1418	6.1e-8	PFAM
VWD	1497	1671	2.34e-10	SMART
C8	1705	1775	9.56e-17	SMART
Pfam:TIL	1778	1836	1.6e-8	PFAM
low complexity region	1870	1886	N/A	INTRINSIC
CT	2242	2325	6.9e-14	SMART

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.2%
20x: 95.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the otogelin family. This gene is expressed in the inner ear of vertebrates with the highest level of expression seen at the embryonic stage and lowest in adult. Knockdown studies in zebrafish suggest that this gene is essential for normal inner ear function. Mutations in this gene are associated with autosomal recessive deafness. [provided by RefSeq, Dec 2012]

Allele List at MGI

Other mutations in this stock

Total: 101 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	T	13: 81,492,537 (GRCm38)	C3357S	probably benign	Het
Ago1	T	A	4: 126,463,857 (GRCm38)		probably null	Het
Akap10	A	T	11: 61,890,303 (GRCm38)	D562E	possibly damaging	Het
Akr1b7	G	A	6: 34,418,994 (GRCm38)	A144T	possibly damaging	Het
Ankle1	A	G	8: 71,407,918 (GRCm38)	T340A	probably benign	Het
Arf5	C	T	6: 28,424,784 (GRCm38)	Q71*	probably null	Het
Arl15	C	T	13: 113,967,660 (GRCm38)	S111F	probably damaging	Het
Asph	G	A	4: 9,517,671 (GRCm38)	Q468*	probably null	Het
Bcam	G	T	7: 19,758,427 (GRCm38)	A581E	possibly damaging	Het
Blvra	G	T	2: 127,086,069 (GRCm38)	E80*	probably null	Het
Casc1	C	T	6: 145,205,241 (GRCm38)		probably null	Het
Ccr6	T	C	17: 8,256,082 (GRCm38)	F40L	possibly damaging	Het
Cfap161	A	T	7: 83,775,976 (GRCm38)	N302K	possibly damaging	Het
Ckmt2	T	A	13: 91,855,845 (GRCm38)	I345F	probably benign	Het
Cpsf6	A	G	10: 117,366,120 (GRCm38)		probably benign	Het
Ctnna1	A	G	18: 35,152,625 (GRCm38)	N8S	possibly damaging	Het
Cyp2d11	A	G	15: 82,391,753 (GRCm38)	L209P	probably damaging	Het
Dab2	T	C	15: 6,435,615 (GRCm38)	V628A	probably damaging	Het
Dcstamp	C	T	15: 39,755,175 (GRCm38)	Q327*	probably null	Het
Defb38	A	T	8: 19,023,467 (GRCm38)	Y63*	probably null	Het
Dlg5	A	T	14: 24,177,758 (GRCm38)	L365*	probably null	Het
Dnmt3l	C	A	10: 78,063,296 (GRCm38)	L110I	probably damaging	Het
Exoc3l2	G	T	7: 19,494,982 (GRCm38)	L108F	possibly damaging	Het
Exoc4	T	A	6: 33,347,825 (GRCm38)	N351K	possibly damaging	Het
Fam83h	C	A	15: 76,004,733 (GRCm38)	E252*	probably null	Het
Fancm	A	G	12: 65,077,174 (GRCm38)	D202G	probably damaging	Het
Fat1	T	A	8: 45,037,463 (GRCm38)	V3804E	probably benign	Het
Fbxw28	T	C	9: 109,330,917 (GRCm38)	T190A	probably benign	Het
Fer1l4	T	C	2: 156,039,118 (GRCm38)	T843A	probably benign	Het
Fnip1	A	T	11: 54,500,624 (GRCm38)	H461L	probably damaging	Het
Gcn1l1	A	T	5: 115,598,825 (GRCm38)	M1276L	probably benign	Het
Gemin4	A	G	11: 76,211,001 (GRCm38)	V978A	possibly damaging	Het
Gm7247	A	T	14: 51,365,335 (GRCm38)	I43F	probably damaging	Het
Gm853	C	A	4: 130,215,363 (GRCm38)	V295L	possibly damaging	Het
Gm9978	C	T	10: 78,486,897 (GRCm38)		noncoding transcript	Het
Gpr4	T	C	7: 19,223,145 (GRCm38)	S331P	probably damaging	Het
Hspa1a	T	A	17: 34,970,479 (GRCm38)	N483Y	probably damaging	Het
Ift74	A	G	4: 94,627,259 (GRCm38)	T138A	probably benign	Het
Ints14	T	G	9: 64,979,795 (GRCm38)	L336R	probably damaging	Het
Irak1	G	T	X: 74,022,612 (GRCm38)	P197Q	possibly damaging	Het
Kif4	A	G	X: 100,665,717 (GRCm38)	S315G	probably benign	Het
L3mbtl1	T	A	2: 162,960,070 (GRCm38)		probably null	Het
Lamb3	A	G	1: 193,334,181 (GRCm38)	R657G	probably benign	Het
Lrp2	A	C	2: 69,483,385 (GRCm38)	V2334G	probably benign	Het
Lrwd1	T	A	5: 136,130,478 (GRCm38)	Y431F	probably damaging	Het
Map3k21	A	T	8: 125,924,042 (GRCm38)	H261L	probably benign	Het
Meis1	G	T	11: 18,881,679 (GRCm38)	P453Q	probably damaging	Het
Mettl16	G	T	11: 74,802,929 (GRCm38)	M255I	probably benign	Het
Mllt10	A	G	2: 18,162,569 (GRCm38)	N435S	probably benign	Het
Mpp5	T	C	12: 78,809,922 (GRCm38)	F180L	possibly damaging	Het
Mta2	T	C	19: 8,943,516 (GRCm38)	I27T	probably damaging	Het
Nav2	A	G	7: 49,464,580 (GRCm38)	I771V	probably benign	Het
Nisch	A	T	14: 31,177,285 (GRCm38)		probably benign	Het
Npc1	G	A	18: 12,196,556 (GRCm38)	P990L	probably damaging	Het
Nrxn1	A	T	17: 90,704,277 (GRCm38)	I308K	probably damaging	Het
Olfr1378	A	T	11: 50,969,320 (GRCm38)	I101F	probably damaging	Het
Olfr1402	C	A	3: 97,410,449 (GRCm38)	C244F	probably damaging	Het
Olfr183	T	C	16: 59,000,420 (GRCm38)	L245P	possibly damaging	Het
P2rx7	A	G	5: 122,681,266 (GRCm38)	T584A	probably benign	Het
Pank1	T	A	19: 34,841,086 (GRCm38)	I18F	probably damaging	Het
Pgap3	A	G	11: 98,391,107 (GRCm38)	L126P	probably damaging	Het
Phka1	C	T	X: 102,610,201 (GRCm38)	R290H	probably damaging	Het
Pkd2	G	A	5: 104,483,176 (GRCm38)	E489K	probably damaging	Het
Prdm16	T	A	4: 154,347,925 (GRCm38)	S296C	probably null	Het
Prex2	T	A	1: 11,186,713 (GRCm38)	N1216K	probably damaging	Het
Prmt7	A	G	8: 106,227,298 (GRCm38)	T124A	probably damaging	Het
Ptpra	G	T	2: 130,539,735 (GRCm38)	R372L	probably damaging	Het
Ptpro	T	A	6: 137,443,594 (GRCm38)	V1007D	probably damaging	Het
Rap2b	G	T	3: 61,365,091 (GRCm38)	G12V	probably damaging	Het
Rapgef5	T	A	12: 117,714,064 (GRCm38)		probably null	Het
Rassf4	A	G	6: 116,645,127 (GRCm38)	F168S	possibly damaging	Het
Rtf1	T	A	2: 119,705,518 (GRCm38)	H184Q	probably benign	Het
Sacs	A	G	14: 61,213,771 (GRCm38)	K4422R	probably benign	Het
Sec11c	A	T	18: 65,800,649 (GRCm38)	T9S	probably benign	Het
Sema3d	C	T	5: 12,563,273 (GRCm38)	T439I	probably benign	Het
Sephs1	A	G	2: 4,899,540 (GRCm38)	N243S	probably benign	Het
Setd2	TTGGGA	T	9: 110,604,144 (GRCm38)		probably null	Het
Setx	A	G	2: 29,130,301 (GRCm38)	D100G	probably benign	Het
Slc22a7	C	A	17: 46,433,972 (GRCm38)	V383L	possibly damaging	Het
Slc25a40	T	C	5: 8,430,417 (GRCm38)	C56R	probably damaging	Het
Stk38l	T	A	6: 146,768,846 (GRCm38)	L229I	probably damaging	Het
Sult2a5	T	C	7: 13,625,434 (GRCm38)	S112P	probably damaging	Het
Syt4	A	G	18: 31,440,467 (GRCm38)	Y332H	probably damaging	Het
Tcof1	T	C	18: 60,832,785 (GRCm38)	E415G	possibly damaging	Het
Tenm2	A	G	11: 36,024,854 (GRCm38)	L1951P	probably damaging	Het
Tlr9	A	G	9: 106,225,337 (GRCm38)	N609S	probably damaging	Het
Tmem120a	A	T	5: 135,736,123 (GRCm38)	S266T	possibly damaging	Het
Tmem132b	A	G	5: 125,622,551 (GRCm38)	E92G	probably damaging	Het
Tmem8	C	T	17: 26,117,884 (GRCm38)	L259F	possibly damaging	Het
Tnfrsf18	T	A	4: 156,028,516 (GRCm38)	V196E	probably damaging	Het
Trpc1	A	T	9: 95,717,584 (GRCm38)	L474H	probably damaging	Het
Trpm6	T	C	19: 18,829,952 (GRCm38)	V1020A	probably damaging	Het
Usp20	T	A	2: 31,016,305 (GRCm38)	C562S	probably damaging	Het
Usp47	T	A	7: 112,067,236 (GRCm38)		probably null	Het
Vgll1	A	C	X: 57,092,430 (GRCm38)	K53T	probably damaging	Het
Vmn1r26	T	C	6: 58,008,350 (GRCm38)	N285D	possibly damaging	Het
Zfp445	T	A	9: 122,853,437 (GRCm38)	K480*	probably null	Het
Zfp786	A	G	6: 47,826,997 (GRCm38)	V37A	probably damaging	Het
Zfp821	A	G	8: 109,721,219 (GRCm38)	E64G	probably damaging	Het
Zfp994	T	A	17: 22,200,981 (GRCm38)	D329V	probably damaging	Het
Zkscan8	T	C	13: 21,520,318 (GRCm38)	S484G	probably damaging	Het

Other mutations in Otogl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
H8562:Otogl	UTSW	10	107,910,956 (GRCm38)	missense	probably benign	0.00
R0084:Otogl	UTSW	10	107,901,341 (GRCm38)	missense	probably damaging	0.96
R0164:Otogl	UTSW	10	107,874,530 (GRCm38)	missense	probably damaging	0.97
R0164:Otogl	UTSW	10	107,874,530 (GRCm38)	missense	probably damaging	0.97
R0238:Otogl	UTSW	10	107,806,696 (GRCm38)	missense	probably damaging	0.98
R0238:Otogl	UTSW	10	107,806,696 (GRCm38)	missense	probably damaging	0.98
R0239:Otogl	UTSW	10	107,806,696 (GRCm38)	missense	probably damaging	0.98
R0239:Otogl	UTSW	10	107,806,696 (GRCm38)	missense	probably damaging	0.98
R0294:Otogl	UTSW	10	107,777,228 (GRCm38)	missense	probably damaging	1.00
R0360:Otogl	UTSW	10	107,770,650 (GRCm38)	splice site	probably benign
R0442:Otogl	UTSW	10	107,876,855 (GRCm38)	missense	probably damaging	1.00
R0488:Otogl	UTSW	10	107,803,605 (GRCm38)	missense	probably benign	0.02
R0507:Otogl	UTSW	10	107,866,740 (GRCm38)	missense	possibly damaging	0.51
R0573:Otogl	UTSW	10	107,780,988 (GRCm38)	missense	probably benign	0.00
R0581:Otogl	UTSW	10	107,789,040 (GRCm38)	missense	possibly damaging	0.79
R0613:Otogl	UTSW	10	107,817,070 (GRCm38)	missense	probably damaging	0.99
R0614:Otogl	UTSW	10	107,798,355 (GRCm38)	missense	probably benign	0.14
R0742:Otogl	UTSW	10	107,866,740 (GRCm38)	missense	possibly damaging	0.51
R0846:Otogl	UTSW	10	107,772,296 (GRCm38)	missense	probably benign	0.40
R1146:Otogl	UTSW	10	107,886,513 (GRCm38)	missense	probably damaging	1.00
R1146:Otogl	UTSW	10	107,886,513 (GRCm38)	missense	probably damaging	1.00
R1439:Otogl	UTSW	10	107,779,252 (GRCm38)	missense	probably benign	0.02
R1457:Otogl	UTSW	10	107,878,152 (GRCm38)	splice site	probably null
R1526:Otogl	UTSW	10	107,869,526 (GRCm38)	missense	probably damaging	1.00
R1662:Otogl	UTSW	10	107,798,357 (GRCm38)	missense	possibly damaging	0.84
R1664:Otogl	UTSW	10	107,806,576 (GRCm38)	missense	probably benign	0.00
R1667:Otogl	UTSW	10	107,813,965 (GRCm38)	nonsense	probably null
R1695:Otogl	UTSW	10	107,814,017 (GRCm38)	missense	probably damaging	0.99
R1731:Otogl	UTSW	10	107,817,111 (GRCm38)	missense	probably damaging	1.00
R1733:Otogl	UTSW	10	107,783,712 (GRCm38)	missense	possibly damaging	0.46
R1764:Otogl	UTSW	10	107,899,461 (GRCm38)	nonsense	probably null
R1824:Otogl	UTSW	10	107,779,831 (GRCm38)	missense	probably benign
R1850:Otogl	UTSW	10	107,878,064 (GRCm38)	missense	probably damaging	1.00
R1856:Otogl	UTSW	10	107,854,264 (GRCm38)	missense	possibly damaging	0.92
R1875:Otogl	UTSW	10	107,899,590 (GRCm38)	missense	probably damaging	1.00
R1938:Otogl	UTSW	10	107,777,575 (GRCm38)	missense	probably damaging	0.98
R1986:Otogl	UTSW	10	107,794,190 (GRCm38)	critical splice acceptor site	probably null
R2072:Otogl	UTSW	10	107,781,043 (GRCm38)	missense	probably damaging	1.00
R2219:Otogl	UTSW	10	107,856,977 (GRCm38)	missense	probably damaging	1.00
R2508:Otogl	UTSW	10	107,874,500 (GRCm38)	missense	probably damaging	0.99
R2883:Otogl	UTSW	10	107,768,981 (GRCm38)	missense	probably damaging	1.00
R2931:Otogl	UTSW	10	107,820,004 (GRCm38)	missense	possibly damaging	0.85
R3620:Otogl	UTSW	10	107,874,371 (GRCm38)	missense	probably damaging	0.99
R3621:Otogl	UTSW	10	107,874,371 (GRCm38)	missense	probably damaging	0.99
R3735:Otogl	UTSW	10	107,899,529 (GRCm38)	nonsense	probably null
R3812:Otogl	UTSW	10	107,899,471 (GRCm38)	missense	probably damaging	1.00
R3880:Otogl	UTSW	10	107,827,704 (GRCm38)	missense	probably damaging	0.96
R3958:Otogl	UTSW	10	107,821,925 (GRCm38)	missense	probably damaging	1.00
R4063:Otogl	UTSW	10	107,790,649 (GRCm38)	missense	probably benign	0.02
R4064:Otogl	UTSW	10	107,790,649 (GRCm38)	missense	probably benign	0.02
R4108:Otogl	UTSW	10	107,771,244 (GRCm38)	missense	probably benign	0.01
R4352:Otogl	UTSW	10	107,869,535 (GRCm38)	missense	probably damaging	1.00
R4526:Otogl	UTSW	10	107,886,980 (GRCm38)	missense	probably damaging	1.00
R4614:Otogl	UTSW	10	107,892,124 (GRCm38)	nonsense	probably null
R4703:Otogl	UTSW	10	107,821,924 (GRCm38)	missense	probably damaging	1.00
R4741:Otogl	UTSW	10	107,779,260 (GRCm38)	missense	probably benign	0.00
R4790:Otogl	UTSW	10	107,822,033 (GRCm38)	critical splice acceptor site	probably null
R4801:Otogl	UTSW	10	107,901,336 (GRCm38)	missense	probably damaging	1.00
R4802:Otogl	UTSW	10	107,901,336 (GRCm38)	missense	probably damaging	1.00
R4910:Otogl	UTSW	10	107,879,517 (GRCm38)	missense	probably benign	0.05
R4913:Otogl	UTSW	10	107,876,855 (GRCm38)	missense	probably damaging	0.98
R5238:Otogl	UTSW	10	107,768,973 (GRCm38)	missense	probably damaging	1.00
R5261:Otogl	UTSW	10	107,777,592 (GRCm38)	missense	probably benign	0.16
R5387:Otogl	UTSW	10	107,780,933 (GRCm38)	missense	probably benign	0.03
R5395:Otogl	UTSW	10	107,817,138 (GRCm38)	missense	probably benign	0.39
R5403:Otogl	UTSW	10	107,808,756 (GRCm38)	missense	probably benign	0.08
R5482:Otogl	UTSW	10	107,821,941 (GRCm38)	missense	probably damaging	0.99
R5547:Otogl	UTSW	10	107,782,048 (GRCm38)	missense	possibly damaging	0.55
R5611:Otogl	UTSW	10	107,786,769 (GRCm38)	missense	probably damaging	1.00
R5642:Otogl	UTSW	10	107,886,552 (GRCm38)	missense	probably benign	0.44
R5690:Otogl	UTSW	10	107,777,117 (GRCm38)	synonymous	silent
R5711:Otogl	UTSW	10	107,777,117 (GRCm38)	synonymous	silent
R5731:Otogl	UTSW	10	107,881,464 (GRCm38)	missense	probably damaging	0.98
R5743:Otogl	UTSW	10	107,857,001 (GRCm38)	missense	possibly damaging	0.67
R5782:Otogl	UTSW	10	107,777,117 (GRCm38)	synonymous	silent
R5820:Otogl	UTSW	10	107,777,117 (GRCm38)	synonymous	silent
R5897:Otogl	UTSW	10	107,777,117 (GRCm38)	synonymous	silent
R6004:Otogl	UTSW	10	107,879,529 (GRCm38)	missense	probably damaging	1.00
R6145:Otogl	UTSW	10	107,777,117 (GRCm38)	synonymous	silent
R6146:Otogl	UTSW	10	107,777,117 (GRCm38)	synonymous	silent
R6147:Otogl	UTSW	10	107,777,117 (GRCm38)	synonymous	silent
R6149:Otogl	UTSW	10	107,881,453 (GRCm38)	missense	probably benign	0.36
R6226:Otogl	UTSW	10	107,771,206 (GRCm38)	nonsense	probably null
R6283:Otogl	UTSW	10	107,790,500 (GRCm38)	missense	probably damaging	0.98
R6414:Otogl	UTSW	10	107,782,050 (GRCm38)	missense	probably damaging	1.00
R6604:Otogl	UTSW	10	107,822,034 (GRCm38)	splice site	probably null
R6634:Otogl	UTSW	10	107,862,304 (GRCm38)	missense	probably damaging	1.00
R6727:Otogl	UTSW	10	107,777,117 (GRCm38)	synonymous	silent
R6755:Otogl	UTSW	10	107,853,303 (GRCm38)	nonsense	probably null
R6795:Otogl	UTSW	10	107,777,117 (GRCm38)	synonymous	silent
R6797:Otogl	UTSW	10	107,777,117 (GRCm38)	synonymous	silent
R6864:Otogl	UTSW	10	107,827,806 (GRCm38)	missense	probably damaging	0.96
R6924:Otogl	UTSW	10	107,808,641 (GRCm38)	missense	probably damaging	1.00
R6967:Otogl	UTSW	10	107,814,050 (GRCm38)	missense	probably benign	0.01
R7000:Otogl	UTSW	10	107,779,831 (GRCm38)	missense	probably benign
R7075:Otogl	UTSW	10	107,778,929 (GRCm38)	missense	probably benign	0.16
R7122:Otogl	UTSW	10	107,866,654 (GRCm38)	missense	probably benign	0.08
R7176:Otogl	UTSW	10	107,778,911 (GRCm38)	missense	probably damaging	1.00
R7184:Otogl	UTSW	10	107,763,200 (GRCm38)	missense	probably damaging	1.00
R7199:Otogl	UTSW	10	107,874,533 (GRCm38)	missense	possibly damaging	0.88
R7252:Otogl	UTSW	10	107,821,943 (GRCm38)	missense	probably benign	0.06
R7286:Otogl	UTSW	10	107,770,610 (GRCm38)	missense	probably benign	0.00
R7373:Otogl	UTSW	10	107,901,251 (GRCm38)	missense	probably damaging	1.00
R7449:Otogl	UTSW	10	107,803,663 (GRCm38)	missense	probably damaging	1.00
R7486:Otogl	UTSW	10	107,821,988 (GRCm38)	missense	probably damaging	1.00
R7493:Otogl	UTSW	10	107,886,982 (GRCm38)	missense	probably benign	0.06
R7659:Otogl	UTSW	10	107,777,120 (GRCm38)	missense	probably benign	0.19
R7732:Otogl	UTSW	10	107,806,664 (GRCm38)	missense	probably benign	0.01
R7754:Otogl	UTSW	10	107,869,546 (GRCm38)	missense	probably damaging	0.99
R7757:Otogl	UTSW	10	107,876,921 (GRCm38)	missense	probably damaging	1.00
R7800:Otogl	UTSW	10	107,886,515 (GRCm38)	missense	probably damaging	0.99
R7864:Otogl	UTSW	10	107,869,567 (GRCm38)	missense	probably damaging	1.00
R7879:Otogl	UTSW	10	107,777,109 (GRCm38)	missense	probably benign	0.00
R7941:Otogl	UTSW	10	107,806,802 (GRCm38)	splice site	probably null
R7956:Otogl	UTSW	10	107,878,026 (GRCm38)	missense	possibly damaging	0.62
R7988:Otogl	UTSW	10	107,895,776 (GRCm38)	missense	probably damaging	1.00
R8057:Otogl	UTSW	10	107,808,615 (GRCm38)	missense	probably benign	0.00
R8058:Otogl	UTSW	10	107,762,426 (GRCm38)	missense	probably damaging	1.00
R8127:Otogl	UTSW	10	107,895,752 (GRCm38)	missense	probably damaging	1.00
R8143:Otogl	UTSW	10	107,806,666 (GRCm38)	missense	probably damaging	1.00
R8310:Otogl	UTSW	10	107,777,600 (GRCm38)	missense	possibly damaging	0.94
R8319:Otogl	UTSW	10	107,853,266 (GRCm38)	critical splice donor site	probably null
R8339:Otogl	UTSW	10	107,789,536 (GRCm38)	missense	probably benign	0.34
R8339:Otogl	UTSW	10	107,789,535 (GRCm38)	missense	probably damaging	0.99
R8394:Otogl	UTSW	10	107,886,465 (GRCm38)	critical splice donor site	probably null
R8428:Otogl	UTSW	10	107,798,736 (GRCm38)	missense	probably damaging	1.00
R8444:Otogl	UTSW	10	107,857,114 (GRCm38)	missense	probably benign	0.01
R8501:Otogl	UTSW	10	107,790,560 (GRCm38)	missense	probably benign
R8503:Otogl	UTSW	10	107,892,126 (GRCm38)	missense	probably damaging	1.00
R8680:Otogl	UTSW	10	107,912,075 (GRCm38)	critical splice donor site	probably null
R9025:Otogl	UTSW	10	107,777,571 (GRCm38)	missense	probably damaging	0.99
R9090:Otogl	UTSW	10	107,817,113 (GRCm38)	missense	probably null	0.99
R9223:Otogl	UTSW	10	107,854,344 (GRCm38)	missense	probably damaging	0.99
R9268:Otogl	UTSW	10	107,781,056 (GRCm38)	missense	probably damaging	1.00
R9271:Otogl	UTSW	10	107,817,113 (GRCm38)	missense	probably null	0.99
R9356:Otogl	UTSW	10	107,782,029 (GRCm38)	missense	probably damaging	1.00
R9484:Otogl	UTSW	10	107,901,295 (GRCm38)	missense	probably damaging	1.00
R9484:Otogl	UTSW	10	107,822,033 (GRCm38)	critical splice acceptor site	probably null
R9571:Otogl	UTSW	10	107,762,503 (GRCm38)	missense	possibly damaging	0.94
R9731:Otogl	UTSW	10	107,899,467 (GRCm38)	missense	probably damaging	1.00
X0065:Otogl	UTSW	10	107,895,782 (GRCm38)	missense	probably damaging	1.00
X0067:Otogl	UTSW	10	107,866,677 (GRCm38)	missense	probably damaging	1.00
Z1176:Otogl	UTSW	10	107,778,873 (GRCm38)	missense	probably damaging	0.97
Z1176:Otogl	UTSW	10	107,777,213 (GRCm38)	missense	probably benign
Z1176:Otogl	UTSW	10	107,789,032 (GRCm38)	missense	probably benign	0.00
Z1177:Otogl	UTSW	10	107,853,397 (GRCm38)	missense	possibly damaging	0.78
Z1177:Otogl	UTSW	10	107,763,258 (GRCm38)	nonsense	probably null
Z1177:Otogl	UTSW	10	107,876,903 (GRCm38)	missense	probably benign	0.14

Predicted Primers

PCR Primer
(F):5'- AGTCGGGAATCATTGGAACG -3'
(R):5'- ATAAGCATTTGGGTCAGGCTAG -3'

Sequencing Primer
(F):5'- CGTGGTTCTGAATGCATGATACTAC -3'
(R):5'- TTGGGTCAGGCTAGTAACAATACC -3'

Posted On

2014-09-18