Incidental Mutation 'R2117:Meis1'
ID 231099
Institutional Source Beutler Lab
Gene Symbol Meis1
Ensembl Gene ENSMUSG00000020160
Gene Name Meis homeobox 1
Synonyms C530044H18Rik
MMRRC Submission 040121-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2117 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 18830428-18968992 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 18831679 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Glutamine at position 453 (P453Q)
Ref Sequence ENSEMBL: ENSMUSP00000139219 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068264] [ENSMUST00000102878] [ENSMUST00000144988] [ENSMUST00000177417] [ENSMUST00000185131]
AlphaFold Q60954
Predicted Effect probably benign
Transcript: ENSMUST00000068264
SMART Domains Protein: ENSMUSP00000069277
Gene: ENSMUSG00000020160

DomainStartEndE-ValueType
low complexity region 225 241 N/A INTRINSIC
HOX 272 337 1.05e-11 SMART
low complexity region 372 385 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000102878
SMART Domains Protein: ENSMUSP00000099942
Gene: ENSMUSG00000020160

DomainStartEndE-ValueType
internal_repeat_1 12 59 8.66e-5 PROSPERO
Pfam:Meis_PKNOX_N 108 192 5.5e-48 PFAM
low complexity region 225 241 N/A INTRINSIC
HOX 272 337 1.05e-11 SMART
internal_repeat_1 384 428 8.66e-5 PROSPERO
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118661
SMART Domains Protein: ENSMUSP00000112809
Gene: ENSMUSG00000020160

DomainStartEndE-ValueType
low complexity region 45 61 N/A INTRINSIC
HOX 92 157 5.3e-14 SMART
low complexity region 192 205 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000144988
SMART Domains Protein: ENSMUSP00000134969
Gene: ENSMUSG00000020160

DomainStartEndE-ValueType
low complexity region 225 241 N/A INTRINSIC
HOX 272 337 1.05e-11 SMART
low complexity region 358 369 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177357
Predicted Effect probably benign
Transcript: ENSMUST00000177417
SMART Domains Protein: ENSMUSP00000135726
Gene: ENSMUSG00000020160

DomainStartEndE-ValueType
low complexity region 225 241 N/A INTRINSIC
HOX 272 337 1.05e-11 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000185131
AA Change: P453Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000139219
Gene: ENSMUSG00000020160
AA Change: P453Q

DomainStartEndE-ValueType
internal_repeat_1 12 59 8.66e-5 PROSPERO
low complexity region 225 241 N/A INTRINSIC
HOX 272 337 1.05e-11 SMART
internal_repeat_1 384 428 8.66e-5 PROSPERO
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194952
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutant mice die during gestation and exhibit eye, vasculature, and hematopoietic defects. Mice homozygous for a conditional allele activated in HSCs exhibit altered bone marrow cell development, altered HSC physiology and increased reactive oxygen species production. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 101 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A T 13: 81,640,656 (GRCm39) C3357S probably benign Het
Ago1 T A 4: 126,357,650 (GRCm39) probably null Het
Akap10 A T 11: 61,781,129 (GRCm39) D562E possibly damaging Het
Akr1b7 G A 6: 34,395,929 (GRCm39) A144T possibly damaging Het
Ankle1 A G 8: 71,860,562 (GRCm39) T340A probably benign Het
Arf5 C T 6: 28,424,783 (GRCm39) Q71* probably null Het
Arl15 C T 13: 114,104,196 (GRCm39) S111F probably damaging Het
Asph G A 4: 9,517,671 (GRCm39) Q468* probably null Het
Bcam G T 7: 19,492,352 (GRCm39) A581E possibly damaging Het
Blvra G T 2: 126,927,989 (GRCm39) E80* probably null Het
Ccr6 T C 17: 8,474,914 (GRCm39) F40L possibly damaging Het
Cfap161 A T 7: 83,425,184 (GRCm39) N302K possibly damaging Het
Ckmt2 T A 13: 92,003,964 (GRCm39) I345F probably benign Het
Cpsf6 A G 10: 117,202,025 (GRCm39) probably benign Het
Ctnna1 A G 18: 35,285,678 (GRCm39) N8S possibly damaging Het
Cyp2d11 A G 15: 82,275,954 (GRCm39) L209P probably damaging Het
Dab2 T C 15: 6,465,096 (GRCm39) V628A probably damaging Het
Dcstamp C T 15: 39,618,571 (GRCm39) Q327* probably null Het
Defb38 A T 8: 19,073,483 (GRCm39) Y63* probably null Het
Dlg5 A T 14: 24,227,826 (GRCm39) L365* probably null Het
Dnai7 C T 6: 145,150,967 (GRCm39) probably null Het
Dnmt3l C A 10: 77,899,130 (GRCm39) L110I probably damaging Het
Exoc3l2 G T 7: 19,228,907 (GRCm39) L108F possibly damaging Het
Exoc4 T A 6: 33,324,760 (GRCm39) N351K possibly damaging Het
Fam83h C A 15: 75,876,582 (GRCm39) E252* probably null Het
Fancm A G 12: 65,123,948 (GRCm39) D202G probably damaging Het
Fat1 T A 8: 45,490,500 (GRCm39) V3804E probably benign Het
Fbxw28 T C 9: 109,159,985 (GRCm39) T190A probably benign Het
Fer1l4 T C 2: 155,881,038 (GRCm39) T843A probably benign Het
Fnip1 A T 11: 54,391,450 (GRCm39) H461L probably damaging Het
Gcn1 A T 5: 115,736,884 (GRCm39) M1276L probably benign Het
Gemin4 A G 11: 76,101,827 (GRCm39) V978A possibly damaging Het
Gm7247 A T 14: 51,602,792 (GRCm39) I43F probably damaging Het
Gm9978 C T 10: 78,322,731 (GRCm39) noncoding transcript Het
Gpr4 T C 7: 18,957,070 (GRCm39) S331P probably damaging Het
Hspa1a T A 17: 35,189,455 (GRCm39) N483Y probably damaging Het
Ift74 A G 4: 94,515,496 (GRCm39) T138A probably benign Het
Ints14 T G 9: 64,887,077 (GRCm39) L336R probably damaging Het
Irak1 G T X: 73,066,218 (GRCm39) P197Q possibly damaging Het
Kif4 A G X: 99,709,323 (GRCm39) S315G probably benign Het
L3mbtl1 T A 2: 162,801,990 (GRCm39) probably null Het
Lamb3 A G 1: 193,016,489 (GRCm39) R657G probably benign Het
Ldc1 C A 4: 130,109,156 (GRCm39) V295L possibly damaging Het
Lrp2 A C 2: 69,313,729 (GRCm39) V2334G probably benign Het
Lrwd1 T A 5: 136,159,332 (GRCm39) Y431F probably damaging Het
Map3k21 A T 8: 126,650,781 (GRCm39) H261L probably benign Het
Mettl16 G T 11: 74,693,755 (GRCm39) M255I probably benign Het
Mllt10 A G 2: 18,167,380 (GRCm39) N435S probably benign Het
Mta2 T C 19: 8,920,880 (GRCm39) I27T probably damaging Het
Nav2 A G 7: 49,114,328 (GRCm39) I771V probably benign Het
Nisch A T 14: 30,899,242 (GRCm39) probably benign Het
Npc1 G A 18: 12,329,613 (GRCm39) P990L probably damaging Het
Nrxn1 A T 17: 91,011,705 (GRCm39) I308K probably damaging Het
Or13l2 C A 3: 97,317,765 (GRCm39) C244F probably damaging Het
Or1ad6 A T 11: 50,860,147 (GRCm39) I101F probably damaging Het
Or5h17 T C 16: 58,820,783 (GRCm39) L245P possibly damaging Het
Otogl T C 10: 107,694,779 (GRCm39) D823G probably benign Het
P2rx7 A G 5: 122,819,329 (GRCm39) T584A probably benign Het
Pals1 T C 12: 78,856,696 (GRCm39) F180L possibly damaging Het
Pank1 T A 19: 34,818,486 (GRCm39) I18F probably damaging Het
Pgap3 A G 11: 98,281,933 (GRCm39) L126P probably damaging Het
Pgap6 C T 17: 26,336,858 (GRCm39) L259F possibly damaging Het
Phka1 C T X: 101,653,807 (GRCm39) R290H probably damaging Het
Pkd2 G A 5: 104,631,042 (GRCm39) E489K probably damaging Het
Prdm16 T A 4: 154,432,382 (GRCm39) S296C probably null Het
Prex2 T A 1: 11,256,937 (GRCm39) N1216K probably damaging Het
Prmt7 A G 8: 106,953,930 (GRCm39) T124A probably damaging Het
Ptpra G T 2: 130,381,655 (GRCm39) R372L probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rap2b G T 3: 61,272,512 (GRCm39) G12V probably damaging Het
Rapgef5 T A 12: 117,677,799 (GRCm39) probably null Het
Rassf4 A G 6: 116,622,088 (GRCm39) F168S possibly damaging Het
Rtf1 T A 2: 119,535,999 (GRCm39) H184Q probably benign Het
Sacs A G 14: 61,451,220 (GRCm39) K4422R probably benign Het
Sec11c A T 18: 65,933,720 (GRCm39) T9S probably benign Het
Sema3d C T 5: 12,613,240 (GRCm39) T439I probably benign Het
Sephs1 A G 2: 4,904,351 (GRCm39) N243S probably benign Het
Setd2 TTGGGA T 9: 110,433,212 (GRCm39) probably null Het
Setx A G 2: 29,020,313 (GRCm39) D100G probably benign Het
Slc22a7 C A 17: 46,744,898 (GRCm39) V383L possibly damaging Het
Slc25a40 T C 5: 8,480,417 (GRCm39) C56R probably damaging Het
Stk38l T A 6: 146,670,344 (GRCm39) L229I probably damaging Het
Sult2a5 T C 7: 13,359,359 (GRCm39) S112P probably damaging Het
Syt4 A G 18: 31,573,520 (GRCm39) Y332H probably damaging Het
Tcof1 T C 18: 60,965,857 (GRCm39) E415G possibly damaging Het
Tenm2 A G 11: 35,915,681 (GRCm39) L1951P probably damaging Het
Tlr9 A G 9: 106,102,536 (GRCm39) N609S probably damaging Het
Tmem120a A T 5: 135,764,977 (GRCm39) S266T possibly damaging Het
Tmem132b A G 5: 125,699,615 (GRCm39) E92G probably damaging Het
Tnfrsf18 T A 4: 156,112,973 (GRCm39) V196E probably damaging Het
Trpc1 A T 9: 95,599,637 (GRCm39) L474H probably damaging Het
Trpm6 T C 19: 18,807,316 (GRCm39) V1020A probably damaging Het
Usp20 T A 2: 30,906,317 (GRCm39) C562S probably damaging Het
Usp47 T A 7: 111,666,443 (GRCm39) probably null Het
Vgll1 A C X: 56,137,790 (GRCm39) K53T probably damaging Het
Vmn1r26 T C 6: 57,985,335 (GRCm39) N285D possibly damaging Het
Zfp445 T A 9: 122,682,502 (GRCm39) K480* probably null Het
Zfp786 A G 6: 47,803,931 (GRCm39) V37A probably damaging Het
Zfp821 A G 8: 110,447,851 (GRCm39) E64G probably damaging Het
Zfp994 T A 17: 22,419,962 (GRCm39) D329V probably damaging Het
Zkscan8 T C 13: 21,704,488 (GRCm39) S484G probably damaging Het
Other mutations in Meis1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01927:Meis1 APN 11 18,831,811 (GRCm39) missense probably benign 0.25
IGL02156:Meis1 APN 11 18,961,292 (GRCm39) missense probably benign 0.03
IGL02376:Meis1 APN 11 18,831,752 (GRCm39) missense probably benign 0.06
R0505:Meis1 UTSW 11 18,961,360 (GRCm39) missense probably damaging 0.99
R0833:Meis1 UTSW 11 18,831,767 (GRCm39) missense possibly damaging 0.91
R1477:Meis1 UTSW 11 18,831,665 (GRCm39) nonsense probably null
R1512:Meis1 UTSW 11 18,831,682 (GRCm39) missense probably damaging 0.97
R1643:Meis1 UTSW 11 18,966,278 (GRCm39) missense probably benign 0.00
R1717:Meis1 UTSW 11 18,960,608 (GRCm39) intron probably benign
R2342:Meis1 UTSW 11 18,831,647 (GRCm39) missense probably damaging 1.00
R2426:Meis1 UTSW 11 18,938,356 (GRCm39) missense possibly damaging 0.64
R3076:Meis1 UTSW 11 18,961,254 (GRCm39) missense probably benign 0.01
R3078:Meis1 UTSW 11 18,961,254 (GRCm39) missense probably benign 0.01
R4368:Meis1 UTSW 11 18,960,656 (GRCm39) intron probably benign
R4915:Meis1 UTSW 11 18,959,222 (GRCm39) intron probably benign
R4916:Meis1 UTSW 11 18,831,776 (GRCm39) missense possibly damaging 0.91
R4917:Meis1 UTSW 11 18,959,222 (GRCm39) intron probably benign
R4918:Meis1 UTSW 11 18,959,222 (GRCm39) intron probably benign
R4948:Meis1 UTSW 11 18,966,308 (GRCm39) missense probably benign 0.00
R5093:Meis1 UTSW 11 18,831,785 (GRCm39) missense probably benign 0.13
R5506:Meis1 UTSW 11 18,891,747 (GRCm39) missense possibly damaging 0.52
R5507:Meis1 UTSW 11 18,966,168 (GRCm39) missense probably benign 0.27
R5521:Meis1 UTSW 11 18,938,260 (GRCm39) splice site probably benign
R5673:Meis1 UTSW 11 18,962,812 (GRCm39) missense probably damaging 1.00
R5813:Meis1 UTSW 11 18,966,229 (GRCm39) missense probably benign 0.11
R6347:Meis1 UTSW 11 18,855,631 (GRCm39) splice site probably null
R6354:Meis1 UTSW 11 18,966,184 (GRCm39) missense possibly damaging 0.89
R6383:Meis1 UTSW 11 18,891,741 (GRCm39) missense probably benign
R6624:Meis1 UTSW 11 18,966,215 (GRCm39) missense probably benign
R7292:Meis1 UTSW 11 18,961,351 (GRCm39) missense probably damaging 1.00
R7413:Meis1 UTSW 11 18,938,357 (GRCm39) missense probably damaging 1.00
R7434:Meis1 UTSW 11 18,835,542 (GRCm39) missense unknown
R7571:Meis1 UTSW 11 18,891,702 (GRCm39) missense probably damaging 1.00
R8719:Meis1 UTSW 11 18,835,587 (GRCm39) missense probably benign
R9013:Meis1 UTSW 11 18,966,354 (GRCm39) missense probably benign 0.00
R9043:Meis1 UTSW 11 18,831,916 (GRCm39) missense possibly damaging 0.58
R9410:Meis1 UTSW 11 18,833,987 (GRCm39) critical splice donor site probably null
R9571:Meis1 UTSW 11 18,961,378 (GRCm39) missense probably damaging 1.00
Z1176:Meis1 UTSW 11 18,964,317 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACTTCGGATGGTTCTCCTGC -3'
(R):5'- CCAATGGGTGTGAGTATGGGAC -3'

Sequencing Primer
(F):5'- CCTGCATTTTAAGAGTCCCTATGAAG -3'
(R):5'- TGGGACAGCCGAGTTATACC -3'
Posted On 2014-09-18