Incidental Mutation 'R2089:Ptger4'
ID 231671
Institutional Source Beutler Lab
Gene Symbol Ptger4
Ensembl Gene ENSMUSG00000039942
Gene Name prostaglandin E receptor 4 (subtype EP4)
Synonyms Ptgerep4, EP4
MMRRC Submission 040094-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.180) question?
Stock # R2089 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 5262880-5273668 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 5272326 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 98 (I98F)
Ref Sequence ENSEMBL: ENSMUSP00000112858 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047379] [ENSMUST00000120563]
AlphaFold P32240
Predicted Effect possibly damaging
Transcript: ENSMUST00000047379
AA Change: I123F

PolyPhen 2 Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000048736
Gene: ENSMUSG00000039942
AA Change: I123F

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 50 258 1.3e-7 PFAM
Pfam:7tm_1 59 357 1.3e-35 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000120563
AA Change: I98F

PolyPhen 2 Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000112858
Gene: ENSMUSG00000039942
AA Change: I98F

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 25 233 1.9e-7 PFAM
Pfam:7tm_1 34 332 8.5e-45 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133966
Meta Mutation Damage Score 0.3674 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 96% (51/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
PHENOTYPE: Most homozygous targeted null mutants die shortly after birth due to failed closure of the ductus arteriosis. Survivors show decreased migration of Langerhans cells to lymph nodes, contact hypersensitivity and decreased incidence of induced arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921504E06Rik G C 2: 19,522,357 (GRCm39) N247K probably damaging Het
4930402F06Rik T C 2: 35,266,079 (GRCm39) K197R probably benign Het
Adgrl1 T C 8: 84,661,093 (GRCm39) I862T probably damaging Het
Agbl1 G A 7: 76,239,248 (GRCm39) V583M probably damaging Het
Apba2 T A 7: 64,345,341 (GRCm39) V177D probably benign Het
Atg14 A T 14: 47,780,352 (GRCm39) I474N probably damaging Het
Bicdl1 A G 5: 115,862,638 (GRCm39) S206P probably damaging Het
Bltp1 C T 3: 37,042,405 (GRCm39) T2797I probably damaging Het
Calhm3 T A 19: 47,140,430 (GRCm39) D221V probably damaging Het
Ccdc93 T A 1: 121,411,071 (GRCm39) probably null Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dido1 A T 2: 180,303,677 (GRCm39) V1409E probably benign Het
Dsc2 G A 18: 20,166,351 (GRCm39) T760I possibly damaging Het
Etnk2 T G 1: 133,304,791 (GRCm39) probably null Het
Gbp7 A T 3: 142,240,383 (GRCm39) I34F probably damaging Het
Gbp7 A T 3: 142,251,316 (GRCm39) probably benign Het
Gpr37 A G 6: 25,689,062 (GRCm39) S12P possibly damaging Het
Grxcr1 T C 5: 68,267,755 (GRCm39) I168T probably damaging Het
Hat1 T C 2: 71,264,378 (GRCm39) V272A probably benign Het
Igkv8-30 A C 6: 70,094,070 (GRCm39) C114G probably damaging Het
Lrrc4 T G 6: 28,830,586 (GRCm39) D343A probably benign Het
Mars1 A G 10: 127,135,154 (GRCm39) S646P probably damaging Het
Micu3 G A 8: 40,761,413 (GRCm39) G108R probably benign Het
Mterf1b A T 5: 4,247,057 (GRCm39) T233S possibly damaging Het
Myrf A T 19: 10,201,964 (GRCm39) V171D possibly damaging Het
Nbas G A 12: 13,411,046 (GRCm39) D897N probably benign Het
Nfx1 T C 4: 40,977,004 (GRCm39) V226A probably benign Het
Nrros C T 16: 31,962,975 (GRCm39) W311* probably null Het
Ntrk2 A G 13: 59,007,115 (GRCm39) H239R possibly damaging Het
Or10g9 T C 9: 39,912,500 (GRCm39) T8A probably benign Het
Pcdhb18 T C 18: 37,623,653 (GRCm39) S328P probably damaging Het
Pigm T C 1: 172,205,100 (GRCm39) Y279H probably damaging Het
Pik3cd A G 4: 149,737,156 (GRCm39) L880P probably damaging Het
Plaat3 A G 19: 7,556,474 (GRCm39) I92V probably damaging Het
Rasl11a T A 5: 146,783,927 (GRCm39) I124N probably damaging Het
Rest A G 5: 77,429,126 (GRCm39) K515R possibly damaging Het
Ryr1 A G 7: 28,785,474 (GRCm39) L1746P probably damaging Het
Ryr2 G T 13: 11,960,863 (GRCm39) T25K probably benign Het
Serpina3g A T 12: 104,205,417 (GRCm39) D52V probably damaging Het
Skint6 T C 4: 112,703,881 (GRCm39) N998S probably benign Het
Sntg1 T A 1: 8,665,763 (GRCm39) T184S probably benign Het
Ssbp1 A G 6: 40,453,433 (GRCm39) Y73C probably null Het
Suclg1 A G 6: 73,241,259 (GRCm39) K193R probably benign Het
Tnrc18 A C 5: 142,759,396 (GRCm39) S813R unknown Het
Tnrc6a T C 7: 122,771,343 (GRCm39) probably null Het
Trap1 A C 16: 3,863,903 (GRCm39) Y472* probably null Het
Trpm8 T C 1: 88,271,048 (GRCm39) I446T probably damaging Het
Tti2 T C 8: 31,644,294 (GRCm39) L297P probably damaging Het
Umodl1 A G 17: 31,190,893 (GRCm39) M247V probably benign Het
Unc80 T A 1: 66,710,874 (GRCm39) probably benign Het
Zfp174 A G 16: 3,672,506 (GRCm39) R352G possibly damaging Het
Other mutations in Ptger4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00562:Ptger4 APN 15 5,272,614 (GRCm39) missense probably benign 0.00
IGL00848:Ptger4 APN 15 5,264,589 (GRCm39) missense probably benign 0.16
IGL01309:Ptger4 APN 15 5,272,239 (GRCm39) missense probably damaging 1.00
IGL02083:Ptger4 APN 15 5,272,655 (GRCm39) missense probably benign 0.00
IGL03245:Ptger4 APN 15 5,264,588 (GRCm39) missense probably damaging 1.00
R0369:Ptger4 UTSW 15 5,272,491 (GRCm39) missense probably benign 0.06
R0427:Ptger4 UTSW 15 5,272,382 (GRCm39) missense probably benign 0.25
R1399:Ptger4 UTSW 15 5,264,412 (GRCm39) missense possibly damaging 0.81
R1778:Ptger4 UTSW 15 5,264,576 (GRCm39) missense probably damaging 1.00
R1801:Ptger4 UTSW 15 5,272,281 (GRCm39) missense possibly damaging 0.95
R2091:Ptger4 UTSW 15 5,272,326 (GRCm39) missense possibly damaging 0.80
R2091:Ptger4 UTSW 15 5,272,326 (GRCm39) missense possibly damaging 0.80
R2484:Ptger4 UTSW 15 5,264,654 (GRCm39) missense probably benign 0.06
R2873:Ptger4 UTSW 15 5,264,286 (GRCm39) missense probably benign 0.02
R4515:Ptger4 UTSW 15 5,271,860 (GRCm39) missense probably damaging 1.00
R4572:Ptger4 UTSW 15 5,272,614 (GRCm39) missense probably benign 0.00
R4655:Ptger4 UTSW 15 5,272,545 (GRCm39) missense probably benign 0.06
R4860:Ptger4 UTSW 15 5,272,087 (GRCm39) missense probably benign 0.02
R4860:Ptger4 UTSW 15 5,272,087 (GRCm39) missense probably benign 0.02
R6429:Ptger4 UTSW 15 5,272,478 (GRCm39) missense possibly damaging 0.76
R6960:Ptger4 UTSW 15 5,264,196 (GRCm39) missense probably benign
R7992:Ptger4 UTSW 15 5,264,381 (GRCm39) missense probably damaging 0.99
R8471:Ptger4 UTSW 15 5,271,800 (GRCm39) missense probably damaging 1.00
R8768:Ptger4 UTSW 15 5,272,138 (GRCm39) missense probably benign 0.00
R9245:Ptger4 UTSW 15 5,273,193 (GRCm39) start gained probably benign
R9638:Ptger4 UTSW 15 5,264,693 (GRCm39) missense probably damaging 1.00
R9790:Ptger4 UTSW 15 5,273,178 (GRCm39) start codon destroyed probably null 0.00
R9791:Ptger4 UTSW 15 5,273,178 (GRCm39) start codon destroyed probably null 0.00
Predicted Primers PCR Primer
(F):5'- AGTCGATGAAGCACCAGGTG -3'
(R):5'- ATCGTAGTATTGTGCAAGTCGC -3'

Sequencing Primer
(F):5'- ATCTGCCCAGGCCCATGTTG -3'
(R):5'- CAAGTCGCGCAAGGAGC -3'
Posted On 2014-09-18