Incidental Mutation 'R2092:Vmn1r176'
ID 231831
Institutional Source Beutler Lab
Gene Symbol Vmn1r176
Ensembl Gene ENSMUSG00000096859
Gene Name vomeronasal 1 receptor 176
Synonyms Gm5998
MMRRC Submission 040097-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R2092 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 23534237-23535151 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 23534578 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 192 (D192N)
Ref Sequence ENSEMBL: ENSMUSP00000153879 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171073] [ENSMUST00000226319] [ENSMUST00000226767] [ENSMUST00000227129] [ENSMUST00000227661] [ENSMUST00000228280] [ENSMUST00000228793]
AlphaFold G3UW31
Predicted Effect probably damaging
Transcript: ENSMUST00000171073
AA Change: D192N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000132168
Gene: ENSMUSG00000096859
AA Change: D192N

DomainStartEndE-ValueType
Pfam:7tm_1 5 288 5.4e-6 PFAM
Pfam:TAS2R 8 295 1.8e-13 PFAM
Pfam:V1R 41 295 1.7e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226319
AA Change: D192N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226767
AA Change: D192N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227129
AA Change: D192N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227661
AA Change: D192N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228280
AA Change: D192N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228793
AA Change: D192N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T A 6: 121,651,896 (GRCm39) C1321* probably null Het
Abca8b A G 11: 109,857,534 (GRCm39) F673L possibly damaging Het
Adam19 T G 11: 45,951,731 (GRCm39) probably null Het
AI987944 T C 7: 41,024,041 (GRCm39) T313A possibly damaging Het
Akap13 A T 7: 75,260,318 (GRCm39) I178F probably benign Het
Alb G GA 5: 90,611,842 (GRCm39) probably null Het
Bod1l A G 5: 41,988,860 (GRCm39) S416P probably damaging Het
Casr A T 16: 36,330,405 (GRCm39) Y310N possibly damaging Het
Cela3a T C 4: 137,131,737 (GRCm39) N152S probably benign Het
Chrdl2 T A 7: 99,670,184 (GRCm39) C102* probably null Het
Col4a4 G A 1: 82,476,667 (GRCm39) S554L unknown Het
Col6a4 T C 9: 105,937,530 (GRCm39) K1392R probably damaging Het
Dab1 T G 4: 104,535,974 (GRCm39) Y128D probably damaging Het
Dars1 A T 1: 128,301,755 (GRCm39) M293K probably damaging Het
Dlec1 T C 9: 118,950,912 (GRCm39) F493L possibly damaging Het
Dmbt1 G T 7: 130,651,748 (GRCm39) W330L probably damaging Het
Dnah11 A T 12: 117,976,451 (GRCm39) M831K possibly damaging Het
Dock7 T C 4: 98,897,545 (GRCm39) N715S possibly damaging Het
Edc4 T A 8: 106,614,160 (GRCm39) L12Q probably damaging Het
Edem2 T C 2: 155,550,969 (GRCm39) M333V probably benign Het
Fpr-rs4 CAGGAA CA 17: 18,242,596 (GRCm39) probably null Het
Fto C A 8: 92,136,315 (GRCm39) Y194* probably null Het
Gnptab T G 10: 88,276,167 (GRCm39) Y1151* probably null Het
Grm1 A G 10: 10,564,969 (GRCm39) L1113P probably benign Het
Hnrnpa0 T C 13: 58,275,614 (GRCm39) K172E probably damaging Het
Ifitm1 A G 7: 140,549,427 (GRCm39) D70G probably damaging Het
Irx4 C A 13: 73,413,605 (GRCm39) T25K probably damaging Het
Kif22 C T 7: 126,632,802 (GRCm39) D195N probably damaging Het
Lrp2 C T 2: 69,366,365 (GRCm39) D245N probably benign Het
Lyz1 C T 10: 117,124,504 (GRCm39) R144Q probably benign Het
Macf1 T A 4: 123,276,971 (GRCm39) T6055S probably damaging Het
Mrgpra2b C T 7: 47,113,908 (GRCm39) V249I probably benign Het
Myh9 G A 15: 77,648,550 (GRCm39) Q80* probably null Het
Myo6 G T 9: 80,152,964 (GRCm39) R199L probably damaging Het
Naglu G A 11: 100,967,546 (GRCm39) V499I possibly damaging Het
Nfkbie T C 17: 45,869,465 (GRCm39) F140S probably benign Het
Or4p8 A G 2: 88,727,611 (GRCm39) F110S probably damaging Het
Or52ab7 G A 7: 102,978,316 (GRCm39) V208M probably damaging Het
Or52z1 A T 7: 103,437,279 (GRCm39) F68L possibly damaging Het
Or5b102 T A 19: 13,041,166 (GRCm39) Y130* probably null Het
Or5p81 CAAATA CA 7: 108,266,869 (GRCm39) probably null Het
Or8g21 A T 9: 38,906,485 (GRCm39) L82Q probably damaging Het
Otop1 A T 5: 38,457,110 (GRCm39) I290F probably damaging Het
P2rx2 C T 5: 110,489,007 (GRCm39) D203N probably damaging Het
Pcdhb10 T A 18: 37,547,240 (GRCm39) I772N probably benign Het
Pnliprp1 A G 19: 58,729,616 (GRCm39) H423R probably benign Het
Ptk2 A T 15: 73,108,040 (GRCm39) Y56* probably null Het
Rapgef3 T C 15: 97,658,604 (GRCm39) D134G probably damaging Het
Scaf11 A C 15: 96,313,708 (GRCm39) S1358A probably damaging Het
Scn9a T C 2: 66,363,720 (GRCm39) M844V probably damaging Het
Sh3tc1 T C 5: 35,858,002 (GRCm39) E1121G probably damaging Het
Slc25a15 T C 8: 22,870,950 (GRCm39) T176A probably damaging Het
Slc29a4 T A 5: 142,704,610 (GRCm39) I384N probably damaging Het
Slc40a1 A T 1: 45,948,614 (GRCm39) D555E probably benign Het
Smc5 T C 19: 23,216,263 (GRCm39) I446V probably benign Het
St6gal2 T C 17: 55,817,267 (GRCm39) Y477H probably damaging Het
Syngr1 A T 15: 80,000,141 (GRCm39) Q84L possibly damaging Het
Tedc1 T C 12: 113,121,340 (GRCm39) L187P probably damaging Het
Tg A G 15: 66,721,456 (GRCm39) I322V probably null Het
Thap12 T C 7: 98,365,656 (GRCm39) V608A possibly damaging Het
Tmbim6 T C 15: 99,299,949 (GRCm39) S22P probably damaging Het
Ttc3 C T 16: 94,243,691 (GRCm39) P1232S probably benign Het
Upk3a A G 15: 84,902,286 (GRCm39) T38A probably damaging Het
Utrn A T 10: 12,554,442 (GRCm39) M1549K probably benign Het
Vmn1r198 A G 13: 22,538,885 (GRCm39) T35A possibly damaging Het
Xkr7 C T 2: 152,895,983 (GRCm39) S279L probably damaging Het
Zer1 G A 2: 29,998,286 (GRCm39) L342F probably damaging Het
Zfp641 G T 15: 98,191,593 (GRCm39) T31N probably benign Het
Zfp74 G A 7: 29,653,349 (GRCm39) probably benign Het
Other mutations in Vmn1r176
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01100:Vmn1r176 APN 7 23,535,049 (GRCm39) missense probably benign 0.04
IGL03004:Vmn1r176 APN 7 23,534,702 (GRCm39) missense probably damaging 1.00
PIT4151001:Vmn1r176 UTSW 7 23,534,808 (GRCm39) missense probably damaging 1.00
R0195:Vmn1r176 UTSW 7 23,535,010 (GRCm39) missense probably benign 0.10
R1186:Vmn1r176 UTSW 7 23,535,051 (GRCm39) missense probably damaging 1.00
R1531:Vmn1r176 UTSW 7 23,534,536 (GRCm39) missense possibly damaging 0.95
R1680:Vmn1r176 UTSW 7 23,534,806 (GRCm39) missense probably damaging 0.99
R1770:Vmn1r176 UTSW 7 23,534,946 (GRCm39) missense probably benign 0.06
R1803:Vmn1r176 UTSW 7 23,534,609 (GRCm39) missense probably damaging 1.00
R1970:Vmn1r176 UTSW 7 23,534,373 (GRCm39) missense probably benign 0.01
R3498:Vmn1r176 UTSW 7 23,534,667 (GRCm39) missense probably benign 0.12
R4832:Vmn1r176 UTSW 7 23,534,463 (GRCm39) missense possibly damaging 0.67
R5712:Vmn1r176 UTSW 7 23,534,925 (GRCm39) missense probably benign 0.00
R6965:Vmn1r176 UTSW 7 23,535,099 (GRCm39) missense possibly damaging 0.78
R7105:Vmn1r176 UTSW 7 23,534,748 (GRCm39) nonsense probably null
R7839:Vmn1r176 UTSW 7 23,534,394 (GRCm39) missense possibly damaging 0.91
R8262:Vmn1r176 UTSW 7 23,534,878 (GRCm39) missense probably benign 0.29
R8870:Vmn1r176 UTSW 7 23,534,480 (GRCm39) missense probably damaging 1.00
R9147:Vmn1r176 UTSW 7 23,534,785 (GRCm39) missense probably benign 0.12
R9432:Vmn1r176 UTSW 7 23,534,743 (GRCm39) missense probably damaging 1.00
Z1088:Vmn1r176 UTSW 7 23,534,598 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACAGTCTAGAAGATAACAGGTCAC -3'
(R):5'- AACATGTGCTCCACCTGCTC -3'

Sequencing Primer
(F):5'- CTAGAAGATAACAGGTCACAAATGTG -3'
(R):5'- GTGATGCTCCCTGGAAGAG -3'
Posted On 2014-09-18