Mutagenetix > Incidental Mutations

Incidental Mutation 'R2092:Olfr935'

231850

Institutional Source

Beutler Lab

Gene Symbol

Olfr935

Ensembl Gene

ENSMUSG00000059595

Gene Name

olfactory receptor 935

Synonyms

GA_x6K02T2PVTD-32691280-32690354, MOR171-11

MMRRC Submission

040097-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R2092 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

38993971-38999683 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 38995189 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 82 (L82Q)

Ref Sequence

ENSEMBL: ENSMUSP00000149193 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080748] [ENSMUST00000214157]

AlphaFold

Q8VG16

Predicted Effect

probably damaging
Transcript: ENSMUST00000080748
AA Change: L82Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000079572
Gene: ENSMUSG00000059595
AA Change: L82Q

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	4e-53	PFAM
Pfam:7tm_1	41	290	1.2e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000214157
AA Change: L82Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.2%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	A	6: 121,674,937	C1321*	probably null	Het
Abca8b	A	G	11: 109,966,708	F673L	possibly damaging	Het
Adam19	T	G	11: 46,060,904		probably null	Het
AI987944	T	C	7: 41,374,617	T313A	possibly damaging	Het
Akap13	A	T	7: 75,610,570	I178F	probably benign	Het
Alb	G	GA	5: 90,463,983		probably null	Het
Bod1l	A	G	5: 41,831,517	S416P	probably damaging	Het
Casr	A	T	16: 36,510,043	Y310N	possibly damaging	Het
Cela3a	T	C	4: 137,404,426	N152S	probably benign	Het
Chrdl2	T	A	7: 100,020,977	C102*	probably null	Het
Col4a4	G	A	1: 82,498,946	S554L	unknown	Het
Col6a4	T	C	9: 106,060,331	K1392R	probably damaging	Het
Dab1	T	G	4: 104,678,777	Y128D	probably damaging	Het
Dars	A	T	1: 128,374,018	M293K	probably damaging	Het
Dlec1	T	C	9: 119,121,844	F493L	possibly damaging	Het
Dmbt1	G	T	7: 131,050,018	W330L	probably damaging	Het
Dnah11	A	T	12: 118,012,716	M831K	possibly damaging	Het
Dock7	T	C	4: 99,009,308	N715S	possibly damaging	Het
Edc4	T	A	8: 105,887,528	L12Q	probably damaging	Het
Edem2	T	C	2: 155,709,049	M333V	probably benign	Het
Fpr-rs4	CAGGAA	CA	17: 18,022,334		probably null	Het
Fto	C	A	8: 91,409,687	Y194*	probably null	Het
Gnptab	T	G	10: 88,440,305	Y1151*	probably null	Het
Grm1	A	G	10: 10,689,225	L1113P	probably benign	Het
Hnrnpa0	T	C	13: 58,127,800	K172E	probably damaging	Het
Ifitm1	A	G	7: 140,969,514	D70G	probably damaging	Het
Irx4	C	A	13: 73,265,486	T25K	probably damaging	Het
Kif22	C	T	7: 127,033,630	D195N	probably damaging	Het
Lrp2	C	T	2: 69,536,021	D245N	probably benign	Het
Lyz1	C	T	10: 117,288,599	R144Q	probably benign	Het
Macf1	T	A	4: 123,383,178	T6055S	probably damaging	Het
Mrgpra2b	C	T	7: 47,464,160	V249I	probably benign	Het
Myh9	G	A	15: 77,764,350	Q80*	probably null	Het
Myo6	G	T	9: 80,245,682	R199L	probably damaging	Het
Naglu	G	A	11: 101,076,720	V499I	possibly damaging	Het
Nfkbie	T	C	17: 45,558,539	F140S	probably benign	Het
Olfr1208	A	G	2: 88,897,267	F110S	probably damaging	Het
Olfr1454	T	A	19: 13,063,802	Y130*	probably null	Het
Olfr510	CAAATA	CA	7: 108,667,662		probably null	Het
Olfr598	G	A	7: 103,329,109	V208M	probably damaging	Het
Olfr67	A	T	7: 103,788,072	F68L	possibly damaging	Het
Otop1	A	T	5: 38,299,766	I290F	probably damaging	Het
P2rx2	C	T	5: 110,341,141	D203N	probably damaging	Het
Pcdhb10	T	A	18: 37,414,187	I772N	probably benign	Het
Pnliprp1	A	G	19: 58,741,184	H423R	probably benign	Het
Ptk2	A	T	15: 73,236,191	Y56*	probably null	Het
Rapgef3	T	C	15: 97,760,723	D134G	probably damaging	Het
Scaf11	A	C	15: 96,415,827	S1358A	probably damaging	Het
Scn9a	T	C	2: 66,533,376	M844V	probably damaging	Het
Sh3tc1	T	C	5: 35,700,658	E1121G	probably damaging	Het
Slc25a15	T	C	8: 22,380,934	T176A	probably damaging	Het
Slc29a4	T	A	5: 142,718,855	I384N	probably damaging	Het
Slc40a1	A	T	1: 45,909,454	D555E	probably benign	Het
Smc5	T	C	19: 23,238,899	I446V	probably benign	Het
St6gal2	T	C	17: 55,510,266	Y477H	probably damaging	Het
Syngr1	A	T	15: 80,115,940	Q84L	possibly damaging	Het
Tedc1	T	C	12: 113,157,720	L187P	probably damaging	Het
Tg	A	G	15: 66,849,607	I322V	probably null	Het
Thap12	T	C	7: 98,716,449	V608A	possibly damaging	Het
Tmbim6	T	C	15: 99,402,068	S22P	probably damaging	Het
Ttc3	C	T	16: 94,442,832	P1232S	probably benign	Het
Upk3a	A	G	15: 85,018,085	T38A	probably damaging	Het
Utrn	A	T	10: 12,678,698	M1549K	probably benign	Het
Vmn1r176	C	T	7: 23,835,153	D192N	probably damaging	Het
Vmn1r198	A	G	13: 22,354,715	T35A	possibly damaging	Het
Xkr7	C	T	2: 153,054,063	S279L	probably damaging	Het
Zer1	G	A	2: 30,108,274	L342F	probably damaging	Het
Zfp641	G	T	15: 98,293,712	T31N	probably benign	Het
Zfp74	G	A	7: 29,953,924		probably benign	Het

Other mutations in Olfr935

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01522:Olfr935	APN	9	38995100	missense	probably benign	0.08
IGL01671:Olfr935	APN	9	38994853	missense	probably benign	0.05
IGL02331:Olfr935	APN	9	38995106	missense	probably damaging	0.99
IGL03069:Olfr935	APN	9	38995432	start codon destroyed	probably null	0.98
IGL03143:Olfr935	APN	9	38995436	utr 5 prime	probably benign
R0149:Olfr935	UTSW	9	38994584	missense	probably benign	0.05
R0400:Olfr935	UTSW	9	38995198	missense	probably damaging	1.00
R1818:Olfr935	UTSW	9	38994606	missense	possibly damaging	0.61
R2151:Olfr935	UTSW	9	38994716	missense	probably damaging	1.00
R2166:Olfr935	UTSW	9	38995217	nonsense	probably null
R2347:Olfr935	UTSW	9	38994509	makesense	probably null
R4404:Olfr935	UTSW	9	38994569	missense	possibly damaging	0.77
R4406:Olfr935	UTSW	9	38994569	missense	possibly damaging	0.77
R5152:Olfr935	UTSW	9	38995177	missense	possibly damaging	0.88
R5467:Olfr935	UTSW	9	38994904	missense	probably benign	0.14
R5509:Olfr935	UTSW	9	38994628	missense	probably benign	0.03
R5954:Olfr935	UTSW	9	38995415	missense	probably damaging	1.00
R6647:Olfr935	UTSW	9	38994914	missense	possibly damaging	0.55
R6680:Olfr935	UTSW	9	38994658	missense	probably damaging	1.00
R6928:Olfr935	UTSW	9	38994632	missense	probably benign	0.03
R7242:Olfr935	UTSW	9	38995141	missense	probably benign	0.31
R7271:Olfr935	UTSW	9	38994657	nonsense	probably null
R7309:Olfr935	UTSW	9	38995280	missense	probably damaging	1.00
R7775:Olfr935	UTSW	9	38994907	missense	probably damaging	1.00
R7778:Olfr935	UTSW	9	38994907	missense	probably damaging	1.00
R7866:Olfr935	UTSW	9	38994731	missense	not run
R8280:Olfr935	UTSW	9	38994779	missense	probably benign
R8334:Olfr935	UTSW	9	38994593	missense	probably benign	0.00
R8841:Olfr935	UTSW	9	38994583	missense	possibly damaging	0.95
R9161:Olfr935	UTSW	9	38994520	missense	possibly damaging	0.70
R9169:Olfr935	UTSW	9	38995277	missense	probably benign	0.23

Predicted Primers

PCR Primer
(F):5'- GCTGATGCACAAACTATGCC -3'
(R):5'- AGAACTACAGCTGCCACTCTTC -3'

Sequencing Primer
(F):5'- CTGATGCACAAACTATGCCTATAATG -3'
(R):5'- CCTCCTCTTTCTTGGAATCTACCTG -3'

Posted On

2014-09-18