Incidental Mutation 'R2095:Armc3'
ID 232015
Institutional Source Beutler Lab
Gene Symbol Armc3
Ensembl Gene ENSMUSG00000037683
Gene Name armadillo repeat containing 3
Synonyms 4921513G22Rik
MMRRC Submission 040099-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R2095 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 19204113-19315052 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19293740 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 510 (D510E)
Ref Sequence ENSEMBL: ENSMUSP00000048784 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049255] [ENSMUST00000114640]
AlphaFold A2AU72
Predicted Effect possibly damaging
Transcript: ENSMUST00000049255
AA Change: D510E

PolyPhen 2 Score 0.648 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000048784
Gene: ENSMUSG00000037683
AA Change: D510E

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
low complexity region 544 557 N/A INTRINSIC
low complexity region 583 595 N/A INTRINSIC
low complexity region 620 639 N/A INTRINSIC
low complexity region 675 696 N/A INTRINSIC
Pfam:EDR1 723 857 3.1e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114640
AA Change: D510E

PolyPhen 2 Score 0.080 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000110287
Gene: ENSMUSG00000037683
AA Change: D510E

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
Pfam:EDR1 549 868 1.4e-41 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency 97% (58/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 [PubMed 16915934]).[supplied by OMIM, Mar 2008]
Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530002B09Rik C A 4: 122,596,151 (GRCm39) Y127* probably null Het
Adam33 C T 2: 130,895,629 (GRCm39) G562D probably damaging Het
Adh1 T C 3: 137,988,557 (GRCm39) F177L probably damaging Het
Arhgef17 T C 7: 100,530,470 (GRCm39) T1439A probably damaging Het
Arl5c C T 11: 97,884,277 (GRCm39) E105K probably damaging Het
Bbx T C 16: 50,045,052 (GRCm39) E395G possibly damaging Het
Cacna2d2 G A 9: 107,404,364 (GRCm39) E1087K probably benign Het
Casq1 T C 1: 172,043,529 (GRCm39) N113S probably benign Het
Cbfa2t3 A G 8: 123,361,727 (GRCm39) S432P probably benign Het
Ccn2 T C 10: 24,472,377 (GRCm39) V140A probably benign Het
Cd163 A G 6: 124,294,781 (GRCm39) D615G probably damaging Het
Chrnb2 A T 3: 89,668,744 (GRCm39) D190E probably benign Het
Clec9a T C 6: 129,393,321 (GRCm39) L115P possibly damaging Het
Cluh C T 11: 74,552,550 (GRCm39) R532* probably null Het
Cntnap5a T A 1: 116,369,990 (GRCm39) L869Q probably damaging Het
Cyp3a57 A T 5: 145,305,944 (GRCm39) K143* probably null Het
Dcaf12 G T 4: 41,294,085 (GRCm39) H351N probably benign Het
Dtna T A 18: 23,702,805 (GRCm39) L112Q probably damaging Het
Fnta G A 8: 26,489,907 (GRCm39) Q303* probably null Het
Frs2 T C 10: 116,910,507 (GRCm39) E285G probably benign Het
Gabra4 T C 5: 71,781,455 (GRCm39) I293V probably damaging Het
Gm2431 A T 7: 141,811,518 (GRCm39) C129S unknown Het
Gnl2 C T 4: 124,928,111 (GRCm39) R49C probably damaging Het
Helz T A 11: 107,536,972 (GRCm39) Y275N probably damaging Het
Hydin A G 8: 111,189,289 (GRCm39) E1231G probably damaging Het
Kctd11 T A 11: 69,770,402 (GRCm39) D212V probably damaging Het
Klf3 T A 5: 64,979,245 (GRCm39) M29K probably benign Het
Klhl21 T C 4: 152,093,850 (GRCm39) S151P probably benign Het
Lsm14b A T 2: 179,673,580 (GRCm39) probably benign Het
Mlxipl T C 5: 135,150,974 (GRCm39) probably benign Het
Mov10 G A 3: 104,708,847 (GRCm39) R389C probably damaging Het
Msh6 A G 17: 88,295,661 (GRCm39) M1071V possibly damaging Het
Myh8 G T 11: 67,177,050 (GRCm39) A401S probably benign Het
Ndufv3 T C 17: 31,746,460 (GRCm39) S117P possibly damaging Het
Obscn A T 11: 58,984,410 (GRCm39) probably null Het
Or1e22 T A 11: 73,377,420 (GRCm39) T77S probably damaging Het
Or2l13 T C 16: 19,305,681 (GRCm39) I31T probably benign Het
Or4c11c T C 2: 88,661,634 (GRCm39) Y58H probably damaging Het
Or8g50 T A 9: 39,648,557 (GRCm39) Y149N probably damaging Het
Pcdhb17 T A 18: 37,619,375 (GRCm39) D388E probably benign Het
Pgm3 T C 9: 86,438,394 (GRCm39) T423A probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
S1pr5 T A 9: 21,156,154 (GRCm39) T91S probably benign Het
Sgcz T C 8: 38,007,546 (GRCm39) probably benign Het
Slc33a1 A G 3: 63,871,376 (GRCm39) L79P probably damaging Het
Slco2a1 A G 9: 102,954,167 (GRCm39) T383A probably benign Het
Slit1 G A 19: 41,594,819 (GRCm39) R1184W probably damaging Het
Spta1 T A 1: 174,071,764 (GRCm39) M2248K possibly damaging Het
Stub1 A G 17: 26,049,864 (GRCm39) Y304H probably damaging Het
Taar7e T A 10: 23,913,949 (GRCm39) Y146* probably null Het
Tbc1d1 C T 5: 64,473,844 (GRCm39) S660L probably benign Het
Tcea2 C A 2: 181,328,725 (GRCm39) F259L probably damaging Het
Tcp11l1 T A 2: 104,512,185 (GRCm39) K482N probably damaging Het
Trpv6 C T 6: 41,598,690 (GRCm39) R645Q probably damaging Het
Uaca T A 9: 60,748,125 (GRCm39) S30T probably benign Het
Ubap2 C G 4: 41,206,901 (GRCm39) V492L possibly damaging Het
Ube3c T C 5: 29,873,038 (GRCm39) F1026S probably damaging Het
Vmn2r8 T G 5: 108,956,487 (GRCm39) D45A possibly damaging Het
Zfp738 G T 13: 67,819,422 (GRCm39) L180I probably damaging Het
Other mutations in Armc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00535:Armc3 APN 2 19,308,669 (GRCm39) missense possibly damaging 0.48
IGL01123:Armc3 APN 2 19,206,616 (GRCm39) missense possibly damaging 0.87
IGL01142:Armc3 APN 2 19,302,709 (GRCm39) splice site probably benign
IGL01556:Armc3 APN 2 19,273,957 (GRCm39) missense probably damaging 1.00
IGL02145:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02145:Armc3 APN 2 19,301,671 (GRCm39) missense possibly damaging 0.81
IGL02152:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02154:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02243:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02244:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02516:Armc3 APN 2 19,305,317 (GRCm39) missense possibly damaging 0.94
IGL02691:Armc3 APN 2 19,240,295 (GRCm39) missense probably damaging 1.00
IGL03151:Armc3 APN 2 19,243,509 (GRCm39) missense probably damaging 1.00
IGL03190:Armc3 APN 2 19,293,761 (GRCm39) missense probably damaging 0.99
IGL03288:Armc3 APN 2 19,240,293 (GRCm39) missense probably damaging 1.00
IGL03338:Armc3 APN 2 19,253,512 (GRCm39) missense possibly damaging 0.88
R0015:Armc3 UTSW 2 19,301,132 (GRCm39) critical splice acceptor site probably null
R0015:Armc3 UTSW 2 19,301,132 (GRCm39) critical splice acceptor site probably null
R0256:Armc3 UTSW 2 19,274,027 (GRCm39) missense probably damaging 1.00
R0621:Armc3 UTSW 2 19,300,204 (GRCm39) missense probably damaging 0.96
R1326:Armc3 UTSW 2 19,314,935 (GRCm39) makesense probably null
R1470:Armc3 UTSW 2 19,243,547 (GRCm39) missense probably benign
R1470:Armc3 UTSW 2 19,243,547 (GRCm39) missense probably benign
R1489:Armc3 UTSW 2 19,314,858 (GRCm39) missense probably benign 0.01
R1990:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R1991:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R1992:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R2002:Armc3 UTSW 2 19,293,747 (GRCm39) missense probably benign 0.01
R2127:Armc3 UTSW 2 19,206,622 (GRCm39) missense probably damaging 1.00
R2158:Armc3 UTSW 2 19,253,444 (GRCm39) missense probably damaging 0.99
R2697:Armc3 UTSW 2 19,308,746 (GRCm39) missense probably damaging 1.00
R3809:Armc3 UTSW 2 19,305,476 (GRCm39) missense probably damaging 1.00
R3897:Armc3 UTSW 2 19,273,988 (GRCm39) missense probably damaging 1.00
R4107:Armc3 UTSW 2 19,293,720 (GRCm39) missense probably benign 0.13
R4326:Armc3 UTSW 2 19,305,284 (GRCm39) missense probably damaging 0.97
R4464:Armc3 UTSW 2 19,253,470 (GRCm39) missense probably damaging 0.99
R4702:Armc3 UTSW 2 19,314,792 (GRCm39) missense probably damaging 1.00
R4923:Armc3 UTSW 2 19,297,791 (GRCm39) critical splice acceptor site probably null
R5370:Armc3 UTSW 2 19,290,873 (GRCm39) missense probably benign 0.00
R5518:Armc3 UTSW 2 19,302,739 (GRCm39) missense probably benign 0.28
R5718:Armc3 UTSW 2 19,308,610 (GRCm39) nonsense probably null
R5739:Armc3 UTSW 2 19,258,728 (GRCm39) missense possibly damaging 0.67
R5913:Armc3 UTSW 2 19,314,858 (GRCm39) missense possibly damaging 0.65
R6211:Armc3 UTSW 2 19,301,614 (GRCm39) critical splice acceptor site probably null
R6245:Armc3 UTSW 2 19,253,516 (GRCm39) missense probably damaging 1.00
R6841:Armc3 UTSW 2 19,206,630 (GRCm39) splice site probably null
R7003:Armc3 UTSW 2 19,274,839 (GRCm39) missense probably damaging 1.00
R7190:Armc3 UTSW 2 19,297,947 (GRCm39) missense probably damaging 1.00
R7499:Armc3 UTSW 2 19,290,790 (GRCm39) missense probably benign 0.03
R7738:Armc3 UTSW 2 19,293,761 (GRCm39) missense probably damaging 0.99
R7844:Armc3 UTSW 2 19,258,829 (GRCm39) missense possibly damaging 0.90
R7919:Armc3 UTSW 2 19,290,906 (GRCm39) missense probably benign 0.00
R8060:Armc3 UTSW 2 19,293,720 (GRCm39) missense probably benign 0.08
R8111:Armc3 UTSW 2 19,301,674 (GRCm39) missense probably benign
R8406:Armc3 UTSW 2 19,240,365 (GRCm39) missense probably damaging 0.98
R8485:Armc3 UTSW 2 19,297,945 (GRCm39) missense probably damaging 1.00
R8773:Armc3 UTSW 2 19,293,667 (GRCm39) missense probably benign 0.01
R8940:Armc3 UTSW 2 19,240,393 (GRCm39) missense probably damaging 1.00
R9441:Armc3 UTSW 2 19,253,426 (GRCm39) missense possibly damaging 0.89
Z1177:Armc3 UTSW 2 19,290,802 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGGCACATTCGAAAACAGTTG -3'
(R):5'- ACTAGGGAAAGATGGCCTGC -3'

Sequencing Primer
(F):5'- ACCCAGGATTCTATGTATGTCAGGC -3'
(R):5'- AAAGATGGCCTGCCCCAG -3'
Posted On 2014-09-18