Incidental Mutation 'R2096:Tdrd3'
ID 232132
Institutional Source Beutler Lab
Gene Symbol Tdrd3
Ensembl Gene ENSMUSG00000022019
Gene Name tudor domain containing 3
Synonyms 4732418C03Rik
MMRRC Submission 040100-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.429) question?
Stock # R2096 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 87654075-87782940 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 87743788 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 573 (Q573*)
Ref Sequence ENSEMBL: ENSMUSP00000126189 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168275] [ENSMUST00000169504] [ENSMUST00000170865]
AlphaFold Q91W18
Predicted Effect probably null
Transcript: ENSMUST00000168275
AA Change: Q579*
SMART Domains Protein: ENSMUSP00000129019
Gene: ENSMUSG00000022019
AA Change: Q579*

DomainStartEndE-ValueType
DUF1767 6 88 4.85e-24 SMART
low complexity region 269 280 N/A INTRINSIC
UBA 288 325 1.67e-7 SMART
low complexity region 338 348 N/A INTRINSIC
low complexity region 446 460 N/A INTRINSIC
TUDOR 646 705 1.07e-7 SMART
Predicted Effect probably null
Transcript: ENSMUST00000169504
AA Change: Q579*
SMART Domains Protein: ENSMUSP00000131542
Gene: ENSMUSG00000022019
AA Change: Q579*

DomainStartEndE-ValueType
DUF1767 6 88 4.85e-24 SMART
low complexity region 269 280 N/A INTRINSIC
UBA 288 325 1.67e-7 SMART
low complexity region 338 348 N/A INTRINSIC
low complexity region 446 460 N/A INTRINSIC
TUDOR 646 705 1.07e-7 SMART
Predicted Effect probably null
Transcript: ENSMUST00000170865
AA Change: Q573*
SMART Domains Protein: ENSMUSP00000126189
Gene: ENSMUSG00000022019
AA Change: Q573*

DomainStartEndE-ValueType
DUF1767 3 82 1.36e-18 SMART
low complexity region 263 274 N/A INTRINSIC
UBA 282 319 1.67e-7 SMART
low complexity region 332 342 N/A INTRINSIC
low complexity region 440 454 N/A INTRINSIC
TUDOR 640 699 1.07e-7 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mice for a hypomorphic allele show increased genomic instability, and increased c-Myc/Igh translocation and R loop formation in B cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb10 A G 8: 124,709,195 (GRCm39) S120P probably benign Het
Actr3b T A 5: 26,036,743 (GRCm39) Y185* probably null Het
Atg101 T A 15: 101,188,382 (GRCm39) H162Q possibly damaging Het
Btf3 T A 13: 98,449,659 (GRCm39) Q109L possibly damaging Het
Camk2d G A 3: 126,574,091 (GRCm39) G166D probably damaging Het
Capn7 T G 14: 31,071,844 (GRCm39) probably null Het
Cd209f A G 8: 4,155,537 (GRCm39) V17A probably benign Het
Cenpf A G 1: 189,385,656 (GRCm39) V2208A possibly damaging Het
Cnga1 C T 5: 72,776,404 (GRCm39) V20I possibly damaging Het
Comp T C 8: 70,828,713 (GRCm39) C182R probably damaging Het
Ctsl A G 13: 64,516,840 (GRCm39) probably null Het
Cyp3a44 G T 5: 145,725,215 (GRCm39) Q329K probably damaging Het
Dcpp1 A T 17: 24,099,971 (GRCm39) probably null Het
Dhx38 A G 8: 110,280,891 (GRCm39) V831A probably damaging Het
Dkk2 T C 3: 131,791,858 (GRCm39) M22T probably benign Het
Dnah2 C T 11: 69,346,742 (GRCm39) E2615K probably damaging Het
Dpy19l3 A G 7: 35,426,713 (GRCm39) probably null Het
Gm12888 T G 4: 121,176,655 (GRCm39) I49L probably benign Het
Insyn2b C A 11: 34,352,936 (GRCm39) S326Y probably benign Het
Kif15 T A 9: 122,815,252 (GRCm39) M194K probably damaging Het
Mael G T 1: 166,053,244 (GRCm39) Q254K probably benign Het
Nek9 T C 12: 85,361,322 (GRCm39) D461G probably benign Het
Nlrp12 T C 7: 3,281,825 (GRCm39) N819S probably benign Het
Ntng1 T A 3: 109,739,871 (GRCm39) N390Y probably damaging Het
Or5g25 A G 2: 85,478,434 (GRCm39) I77T probably benign Het
P2ry14 C T 3: 59,022,738 (GRCm39) V250I probably damaging Het
Pcnx2 A T 8: 126,485,987 (GRCm39) D1870E probably benign Het
Phf2 T A 13: 48,985,589 (GRCm39) K64* probably null Het
Phip T C 9: 82,797,392 (GRCm39) H537R possibly damaging Het
Ppa2 A G 3: 133,032,445 (GRCm39) T97A probably damaging Het
Psd G A 19: 46,313,088 (GRCm39) probably null Het
Psg23 T A 7: 18,348,668 (GRCm39) E46D probably damaging Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Rab11b A G 17: 33,967,976 (GRCm39) Y74H probably damaging Het
Rfc3 A T 5: 151,568,383 (GRCm39) S194R probably benign Het
Sema4d A T 13: 51,864,037 (GRCm39) I414N probably damaging Het
Serpinb1a A T 13: 33,031,437 (GRCm39) D120E probably damaging Het
Snai2 T A 16: 14,524,861 (GRCm39) H122Q possibly damaging Het
Spats2l T C 1: 57,985,458 (GRCm39) S504P probably benign Het
Sprr2j-ps T C 3: 92,326,412 (GRCm39) S96P unknown Het
Sspo G T 6: 48,438,608 (GRCm39) V1559L probably benign Het
Tas2r118 T G 6: 23,969,912 (GRCm39) I50L possibly damaging Het
Thoc2l T C 5: 104,667,835 (GRCm39) S786P possibly damaging Het
Tlnrd1 G A 7: 83,532,062 (GRCm39) T123I probably benign Het
Tmem214 T A 5: 31,033,714 (GRCm39) L555H probably damaging Het
Tmprss12 T A 15: 100,183,117 (GRCm39) M153K probably benign Het
Tmprss9 G A 10: 80,725,268 (GRCm39) G410S probably damaging Het
Trpm6 T A 19: 18,803,116 (GRCm39) M853K probably damaging Het
Vmn1r35 A G 6: 66,655,929 (GRCm39) I247T possibly damaging Het
Zcchc7 C A 4: 44,931,059 (GRCm39) P404T probably damaging Het
Zzef1 T C 11: 72,763,465 (GRCm39) F1371L probably benign Het
Other mutations in Tdrd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Tdrd3 APN 14 87,709,618 (GRCm39) missense probably damaging 1.00
IGL01339:Tdrd3 APN 14 87,718,230 (GRCm39) missense possibly damaging 0.75
IGL01565:Tdrd3 APN 14 87,709,668 (GRCm39) missense probably benign 0.01
IGL02505:Tdrd3 APN 14 87,749,118 (GRCm39) missense probably damaging 1.00
R0121:Tdrd3 UTSW 14 87,776,915 (GRCm39) missense probably damaging 1.00
R0550:Tdrd3 UTSW 14 87,723,656 (GRCm39) missense probably damaging 1.00
R0648:Tdrd3 UTSW 14 87,709,618 (GRCm39) missense probably damaging 1.00
R1080:Tdrd3 UTSW 14 87,743,834 (GRCm39) missense probably benign 0.00
R1099:Tdrd3 UTSW 14 87,724,675 (GRCm39) missense probably damaging 1.00
R1126:Tdrd3 UTSW 14 87,718,210 (GRCm39) missense probably damaging 1.00
R1370:Tdrd3 UTSW 14 87,695,490 (GRCm39) intron probably benign
R1592:Tdrd3 UTSW 14 87,743,322 (GRCm39) missense probably damaging 1.00
R1881:Tdrd3 UTSW 14 87,723,783 (GRCm39) splice site probably null
R2162:Tdrd3 UTSW 14 87,718,221 (GRCm39) missense probably damaging 0.98
R3833:Tdrd3 UTSW 14 87,718,221 (GRCm39) missense probably damaging 0.98
R3947:Tdrd3 UTSW 14 87,744,035 (GRCm39) missense probably damaging 1.00
R4421:Tdrd3 UTSW 14 87,723,719 (GRCm39) missense probably damaging 1.00
R4783:Tdrd3 UTSW 14 87,709,537 (GRCm39) missense probably damaging 1.00
R4957:Tdrd3 UTSW 14 87,743,223 (GRCm39) missense probably benign 0.06
R5212:Tdrd3 UTSW 14 87,743,651 (GRCm39) missense probably damaging 0.98
R5291:Tdrd3 UTSW 14 87,743,234 (GRCm39) missense probably benign 0.21
R5318:Tdrd3 UTSW 14 87,714,899 (GRCm39) critical splice donor site probably null
R5383:Tdrd3 UTSW 14 87,718,227 (GRCm39) nonsense probably null
R5718:Tdrd3 UTSW 14 87,743,876 (GRCm39) missense probably benign 0.05
R6240:Tdrd3 UTSW 14 87,743,322 (GRCm39) missense probably damaging 1.00
R6292:Tdrd3 UTSW 14 87,743,690 (GRCm39) missense probably benign
R6532:Tdrd3 UTSW 14 87,743,252 (GRCm39) missense probably damaging 0.98
R6850:Tdrd3 UTSW 14 87,695,515 (GRCm39) intron probably benign
R6958:Tdrd3 UTSW 14 87,694,532 (GRCm39) missense probably damaging 1.00
R7224:Tdrd3 UTSW 14 87,714,839 (GRCm39) missense probably damaging 1.00
R7240:Tdrd3 UTSW 14 87,696,239 (GRCm39) missense probably benign 0.06
R7565:Tdrd3 UTSW 14 87,744,029 (GRCm39) nonsense probably null
R7818:Tdrd3 UTSW 14 87,709,636 (GRCm39) missense probably damaging 1.00
R7861:Tdrd3 UTSW 14 87,709,590 (GRCm39) missense probably damaging 1.00
R8108:Tdrd3 UTSW 14 87,723,702 (GRCm39) missense possibly damaging 0.95
R8206:Tdrd3 UTSW 14 87,749,214 (GRCm39) missense probably benign 0.11
R8383:Tdrd3 UTSW 14 87,743,744 (GRCm39) missense probably benign 0.26
R8786:Tdrd3 UTSW 14 87,709,637 (GRCm39) nonsense probably null
R8985:Tdrd3 UTSW 14 87,743,597 (GRCm39) missense possibly damaging 0.69
R9081:Tdrd3 UTSW 14 87,743,717 (GRCm39) missense probably benign 0.00
R9520:Tdrd3 UTSW 14 87,724,696 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGCCCTTTGTATGCAGAGG -3'
(R):5'- ACACTTTTGCATACTCCACAGG -3'

Sequencing Primer
(F):5'- CCCTTTGTATGCAGAGGCCAAAG -3'
(R):5'- TGCATACTCCACAGGAATAGATG -3'
Posted On 2014-09-18