Incidental Mutation 'R0193:Ints1'
| ID |
23215 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ints1
|
| Ensembl Gene |
ENSMUSG00000029547 |
| Gene Name |
integrator complex subunit 1 |
| Synonyms |
1110015K06Rik |
| MMRRC Submission |
038452-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0193 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
5 |
| Chromosomal Location |
139737037-139761429 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 139737485 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 2176
(E2176G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000072406
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072607]
[ENSMUST00000197187]
[ENSMUST00000200393]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000072607
AA Change: E2176G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000072406
Gene: ENSMUSG00000029547
AA Change: E2176G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
88 |
102 |
N/A |
INTRINSIC |
|
Pfam:DUF3677
|
379 |
459 |
6.4e-37 |
PFAM |
|
low complexity region
|
854 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
876 |
N/A |
INTRINSIC |
|
low complexity region
|
946 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
965 |
988 |
N/A |
INTRINSIC |
|
low complexity region
|
1034 |
1045 |
N/A |
INTRINSIC |
|
low complexity region
|
1058 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1347 |
1361 |
N/A |
INTRINSIC |
|
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
|
low complexity region
|
1615 |
1624 |
N/A |
INTRINSIC |
|
low complexity region
|
1763 |
1776 |
N/A |
INTRINSIC |
|
low complexity region
|
1840 |
1855 |
N/A |
INTRINSIC |
|
low complexity region
|
2062 |
2076 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197187
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000198615
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000200393
AA Change: E2178G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000143789
Gene: ENSMUSG00000029547
AA Change: E2178G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
88 |
102 |
N/A |
INTRINSIC |
|
Pfam:DUF3677
|
379 |
459 |
6.4e-37 |
PFAM |
|
low complexity region
|
854 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
876 |
N/A |
INTRINSIC |
|
low complexity region
|
946 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
965 |
988 |
N/A |
INTRINSIC |
|
low complexity region
|
1034 |
1045 |
N/A |
INTRINSIC |
|
low complexity region
|
1058 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1347 |
1361 |
N/A |
INTRINSIC |
|
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
|
low complexity region
|
1615 |
1624 |
N/A |
INTRINSIC |
|
low complexity region
|
1763 |
1776 |
N/A |
INTRINSIC |
|
low complexity region
|
1840 |
1855 |
N/A |
INTRINSIC |
|
low complexity region
|
2062 |
2076 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.5949 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 94.7%
- 20x: 85.3%
|
| Validation Efficiency |
95% (186/196) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygous mutation of this gene results in embryonic lethality at the blastocyst stage. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(10) : Targeted, knock-out(1) Gene trapped(9) |
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb1 |
T |
C |
15: 74,444,005 (GRCm39) |
S96P |
probably damaging |
Het |
| Akr1c20 |
A |
G |
13: 4,561,292 (GRCm39) |
|
probably benign |
Het |
| Atp2a3 |
G |
T |
11: 72,863,046 (GRCm39) |
V99L |
possibly damaging |
Het |
| Atp6v0a1 |
T |
A |
11: 100,939,308 (GRCm39) |
I691N |
possibly damaging |
Het |
| Atp8b1 |
C |
T |
18: 64,694,707 (GRCm39) |
R525Q |
probably benign |
Het |
| Aurkb |
A |
G |
11: 68,939,370 (GRCm39) |
D151G |
probably damaging |
Het |
| Bank1 |
A |
T |
3: 135,772,279 (GRCm39) |
|
probably benign |
Het |
| Bcl9l |
T |
C |
9: 44,418,703 (GRCm39) |
L847P |
probably damaging |
Het |
| Bscl2 |
T |
A |
19: 8,824,793 (GRCm39) |
M292K |
probably benign |
Het |
| Cacna1c |
C |
T |
6: 118,579,363 (GRCm39) |
|
probably benign |
Het |
| Cadps2 |
T |
C |
6: 23,599,439 (GRCm39) |
K260R |
probably benign |
Het |
| Cc2d2a |
T |
C |
5: 43,893,460 (GRCm39) |
S1419P |
probably damaging |
Het |
| Ccdc180 |
G |
A |
4: 45,914,803 (GRCm39) |
E145K |
probably benign |
Het |
| Ccno |
C |
T |
13: 113,125,418 (GRCm39) |
|
probably benign |
Het |
| Cd300a |
A |
G |
11: 114,784,202 (GRCm39) |
D70G |
probably benign |
Het |
| Cenpc1 |
T |
C |
5: 86,180,262 (GRCm39) |
D670G |
probably benign |
Het |
| Cenpl |
A |
G |
1: 160,913,558 (GRCm39) |
I323V |
probably damaging |
Het |
| Cfap44 |
A |
G |
16: 44,269,573 (GRCm39) |
|
probably null |
Het |
| Cfap74 |
C |
T |
4: 155,510,572 (GRCm39) |
R386C |
probably benign |
Het |
| Cic |
T |
A |
7: 24,986,565 (GRCm39) |
S1299T |
probably damaging |
Het |
| Cic |
C |
A |
7: 24,986,566 (GRCm39) |
S1299Y |
probably damaging |
Het |
| Clcnkb |
T |
C |
4: 141,139,627 (GRCm39) |
E125G |
possibly damaging |
Het |
| Clstn1 |
G |
A |
4: 149,719,253 (GRCm39) |
V361M |
probably damaging |
Het |
| Coro7 |
G |
A |
16: 4,445,368 (GRCm39) |
|
probably benign |
Het |
| Dchs1 |
C |
T |
7: 105,414,190 (GRCm39) |
R875H |
probably benign |
Het |
| Eif3j1 |
A |
C |
2: 121,882,508 (GRCm39) |
M239L |
probably benign |
Het |
| Eif4g3 |
G |
T |
4: 137,873,687 (GRCm39) |
|
probably benign |
Het |
| Elapor2 |
A |
T |
5: 9,472,359 (GRCm39) |
Q352L |
probably damaging |
Het |
| Erbb4 |
T |
C |
1: 68,083,119 (GRCm39) |
|
probably benign |
Het |
| Erlin2 |
T |
G |
8: 27,521,792 (GRCm39) |
V164G |
possibly damaging |
Het |
| Fbxo43 |
G |
T |
15: 36,162,029 (GRCm39) |
Q393K |
probably benign |
Het |
| Fcgr4 |
A |
T |
1: 170,853,329 (GRCm39) |
N178I |
possibly damaging |
Het |
| Grid2 |
A |
G |
6: 64,040,937 (GRCm39) |
N293S |
possibly damaging |
Het |
| H2-M1 |
C |
T |
17: 36,982,224 (GRCm39) |
V126I |
probably benign |
Het |
| Htr1f |
T |
A |
16: 64,747,112 (GRCm39) |
Y60F |
probably damaging |
Het |
| Ilf2 |
A |
G |
3: 90,388,646 (GRCm39) |
|
probably null |
Het |
| Impg2 |
A |
T |
16: 56,085,412 (GRCm39) |
K931* |
probably null |
Het |
| Iqsec2 |
T |
C |
X: 151,006,399 (GRCm39) |
V1319A |
probably benign |
Het |
| Iqsec3 |
G |
T |
6: 121,387,683 (GRCm39) |
D685E |
probably damaging |
Het |
| Itgbl1 |
G |
A |
14: 124,083,958 (GRCm39) |
V279I |
probably benign |
Het |
| Kdm4b |
C |
T |
17: 56,700,952 (GRCm39) |
A541V |
probably benign |
Het |
| Kif14 |
A |
T |
1: 136,396,176 (GRCm39) |
T161S |
probably benign |
Het |
| Krt86 |
T |
C |
15: 101,377,244 (GRCm39) |
|
probably benign |
Het |
| Kyat1 |
C |
T |
2: 30,077,198 (GRCm39) |
|
probably null |
Het |
| Limch1 |
T |
C |
5: 67,184,882 (GRCm39) |
W791R |
probably damaging |
Het |
| Map3k11 |
T |
A |
19: 5,745,874 (GRCm39) |
M396K |
probably damaging |
Het |
| Mat2a |
A |
G |
6: 72,413,178 (GRCm39) |
|
probably null |
Het |
| Mbnl2 |
A |
G |
14: 120,616,649 (GRCm39) |
I88V |
possibly damaging |
Het |
| Mib2 |
T |
C |
4: 155,740,130 (GRCm39) |
T708A |
probably benign |
Het |
| Mix23 |
T |
C |
16: 35,903,184 (GRCm39) |
S59P |
probably damaging |
Het |
| Mkks |
T |
C |
2: 136,719,526 (GRCm39) |
|
probably null |
Het |
| Mtss1 |
T |
C |
15: 58,815,866 (GRCm39) |
M565V |
probably damaging |
Het |
| Myoc |
A |
G |
1: 162,476,604 (GRCm39) |
N436S |
probably damaging |
Het |
| Myod1 |
T |
A |
7: 46,026,536 (GRCm39) |
V147E |
probably damaging |
Het |
| Ngef |
A |
G |
1: 87,437,056 (GRCm39) |
L144P |
probably benign |
Het |
| Ngrn |
C |
T |
7: 79,911,678 (GRCm39) |
R92W |
probably damaging |
Het |
| Nup153 |
G |
A |
13: 46,863,130 (GRCm39) |
T349I |
probably benign |
Het |
| Or4c15 |
T |
A |
2: 88,760,627 (GRCm39) |
I11L |
probably benign |
Het |
| Or52ad1 |
G |
T |
7: 102,995,411 (GRCm39) |
S241R |
possibly damaging |
Het |
| Pigl |
A |
G |
11: 62,394,574 (GRCm39) |
I135M |
probably damaging |
Het |
| Pitpnm3 |
A |
G |
11: 71,961,318 (GRCm39) |
|
probably benign |
Het |
| Pkhd1 |
A |
T |
1: 20,429,141 (GRCm39) |
F2420I |
probably damaging |
Het |
| Polr2b |
C |
T |
5: 77,467,923 (GRCm39) |
T119M |
probably damaging |
Het |
| Prr29 |
A |
G |
11: 106,267,722 (GRCm39) |
Y130C |
probably damaging |
Het |
| Rab11fip3 |
T |
C |
17: 26,209,973 (GRCm39) |
I1048V |
probably damaging |
Het |
| Rab12 |
G |
A |
17: 66,807,357 (GRCm39) |
T124I |
probably damaging |
Het |
| Rab44 |
A |
G |
17: 29,359,281 (GRCm39) |
S490G |
probably benign |
Het |
| Rasa3 |
A |
G |
8: 13,620,233 (GRCm39) |
|
probably null |
Het |
| Rhbdl3 |
C |
T |
11: 80,244,400 (GRCm39) |
S369L |
possibly damaging |
Het |
| Rimbp2 |
A |
T |
5: 128,865,420 (GRCm39) |
S643T |
probably benign |
Het |
| Rin1 |
T |
G |
19: 5,102,680 (GRCm39) |
S396R |
probably damaging |
Het |
| Rpusd3 |
C |
T |
6: 113,396,198 (GRCm39) |
G28S |
probably damaging |
Het |
| Rtl9 |
T |
A |
X: 141,883,274 (GRCm39) |
S229T |
probably damaging |
Het |
| Rufy1 |
G |
T |
11: 50,280,679 (GRCm39) |
T701N |
probably benign |
Het |
| Scn4a |
A |
T |
11: 106,211,364 (GRCm39) |
L1551* |
probably null |
Het |
| Sec24b |
T |
C |
3: 129,782,633 (GRCm39) |
N1119S |
probably null |
Het |
| Serbp1 |
T |
A |
6: 67,249,868 (GRCm39) |
*75R |
probably null |
Het |
| Setx |
C |
T |
2: 29,069,685 (GRCm39) |
P2497S |
probably benign |
Het |
| Slc26a11 |
A |
T |
11: 119,250,140 (GRCm39) |
I132F |
probably damaging |
Het |
| Slc4a1 |
A |
G |
11: 102,243,510 (GRCm39) |
V707A |
possibly damaging |
Het |
| Slfn1 |
A |
G |
11: 83,012,669 (GRCm39) |
I262V |
probably damaging |
Het |
| Tmem168 |
T |
A |
6: 13,583,312 (GRCm39) |
D523V |
possibly damaging |
Het |
| Traf7 |
G |
T |
17: 24,729,525 (GRCm39) |
Q469K |
probably benign |
Het |
| Trdmt1 |
C |
A |
2: 13,549,428 (GRCm39) |
V6F |
probably damaging |
Het |
| Tsacc |
A |
T |
3: 88,194,395 (GRCm39) |
|
probably benign |
Het |
| Vmn2r5 |
A |
G |
3: 64,398,951 (GRCm39) |
I589T |
possibly damaging |
Het |
| Vmn2r7 |
T |
C |
3: 64,598,460 (GRCm39) |
D699G |
probably damaging |
Het |
| Vmn2r82 |
T |
C |
10: 79,217,129 (GRCm39) |
V487A |
probably damaging |
Het |
| Zbtb47 |
T |
C |
9: 121,596,732 (GRCm39) |
V696A |
probably damaging |
Het |
| Zfp287 |
A |
T |
11: 62,605,855 (GRCm39) |
S351T |
probably benign |
Het |
| Zfp654 |
T |
C |
16: 64,606,051 (GRCm39) |
H176R |
possibly damaging |
Het |
|
| Other mutations in Ints1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01116:Ints1
|
APN |
5 |
139,757,437 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01329:Ints1
|
APN |
5 |
139,753,258 (GRCm39) |
splice site |
probably benign |
|
|
IGL01414:Ints1
|
APN |
5 |
139,744,253 (GRCm39) |
missense |
probably benign |
|
|
IGL01612:Ints1
|
APN |
5 |
139,742,047 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01726:Ints1
|
APN |
5 |
139,754,166 (GRCm39) |
splice site |
probably benign |
|
|
IGL01958:Ints1
|
APN |
5 |
139,745,843 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02122:Ints1
|
APN |
5 |
139,750,905 (GRCm39) |
nonsense |
probably null |
|
|
IGL02149:Ints1
|
APN |
5 |
139,737,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02349:Ints1
|
APN |
5 |
139,754,223 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02557:Ints1
|
APN |
5 |
139,757,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02814:Ints1
|
APN |
5 |
139,758,146 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02815:Ints1
|
APN |
5 |
139,741,037 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02825:Ints1
|
APN |
5 |
139,750,494 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL03000:Ints1
|
APN |
5 |
139,752,261 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03164:Ints1
|
APN |
5 |
139,738,490 (GRCm39) |
missense |
probably damaging |
0.99 |
|
forgiving
|
UTSW |
5 |
139,753,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
restrained
|
UTSW |
5 |
139,753,481 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
A9681:Ints1
|
UTSW |
5 |
139,755,894 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0113:Ints1
|
UTSW |
5 |
139,750,968 (GRCm39) |
missense |
|
|
|
R0372:Ints1
|
UTSW |
5 |
139,758,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1129:Ints1
|
UTSW |
5 |
139,744,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1290:Ints1
|
UTSW |
5 |
139,757,165 (GRCm39) |
nonsense |
probably null |
|
|
R1313:Ints1
|
UTSW |
5 |
139,748,661 (GRCm39) |
missense |
probably benign |
|
|
R1313:Ints1
|
UTSW |
5 |
139,748,661 (GRCm39) |
missense |
probably benign |
|
|
R1691:Ints1
|
UTSW |
5 |
139,754,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1708:Ints1
|
UTSW |
5 |
139,748,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1791:Ints1
|
UTSW |
5 |
139,760,277 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2066:Ints1
|
UTSW |
5 |
139,753,251 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2102:Ints1
|
UTSW |
5 |
139,741,754 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2108:Ints1
|
UTSW |
5 |
139,753,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2238:Ints1
|
UTSW |
5 |
139,750,955 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2426:Ints1
|
UTSW |
5 |
139,757,569 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2913:Ints1
|
UTSW |
5 |
139,743,668 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R3896:Ints1
|
UTSW |
5 |
139,743,399 (GRCm39) |
nonsense |
probably null |
|
|
R4608:Ints1
|
UTSW |
5 |
139,745,599 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4658:Ints1
|
UTSW |
5 |
139,760,054 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4797:Ints1
|
UTSW |
5 |
139,757,631 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4887:Ints1
|
UTSW |
5 |
139,756,911 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4944:Ints1
|
UTSW |
5 |
139,743,847 (GRCm39) |
splice site |
probably null |
|
|
R4956:Ints1
|
UTSW |
5 |
139,742,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4976:Ints1
|
UTSW |
5 |
139,738,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5283:Ints1
|
UTSW |
5 |
139,750,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5354:Ints1
|
UTSW |
5 |
139,752,183 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5496:Ints1
|
UTSW |
5 |
139,740,953 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5517:Ints1
|
UTSW |
5 |
139,738,542 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5696:Ints1
|
UTSW |
5 |
139,740,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5766:Ints1
|
UTSW |
5 |
139,757,900 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6359:Ints1
|
UTSW |
5 |
139,741,972 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6753:Ints1
|
UTSW |
5 |
139,750,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6892:Ints1
|
UTSW |
5 |
139,753,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7009:Ints1
|
UTSW |
5 |
139,754,217 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7047:Ints1
|
UTSW |
5 |
139,744,226 (GRCm39) |
nonsense |
probably null |
|
|
R7216:Ints1
|
UTSW |
5 |
139,754,739 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7220:Ints1
|
UTSW |
5 |
139,747,828 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7263:Ints1
|
UTSW |
5 |
139,749,834 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7291:Ints1
|
UTSW |
5 |
139,750,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7319:Ints1
|
UTSW |
5 |
139,746,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7411:Ints1
|
UTSW |
5 |
139,750,015 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7497:Ints1
|
UTSW |
5 |
139,754,731 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7529:Ints1
|
UTSW |
5 |
139,753,481 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7710:Ints1
|
UTSW |
5 |
139,756,840 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7816:Ints1
|
UTSW |
5 |
139,757,134 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7819:Ints1
|
UTSW |
5 |
139,746,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7992:Ints1
|
UTSW |
5 |
139,742,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8260:Ints1
|
UTSW |
5 |
139,750,968 (GRCm39) |
missense |
|
|
|
R8265:Ints1
|
UTSW |
5 |
139,757,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8782:Ints1
|
UTSW |
5 |
139,744,952 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9016:Ints1
|
UTSW |
5 |
139,744,326 (GRCm39) |
missense |
probably benign |
|
|
R9053:Ints1
|
UTSW |
5 |
139,747,822 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9056:Ints1
|
UTSW |
5 |
139,760,041 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9080:Ints1
|
UTSW |
5 |
139,739,300 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9086:Ints1
|
UTSW |
5 |
139,743,947 (GRCm39) |
missense |
probably benign |
|
|
R9122:Ints1
|
UTSW |
5 |
139,745,930 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9134:Ints1
|
UTSW |
5 |
139,743,351 (GRCm39) |
missense |
probably benign |
|
|
R9135:Ints1
|
UTSW |
5 |
139,737,701 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R9169:Ints1
|
UTSW |
5 |
139,748,586 (GRCm39) |
missense |
probably benign |
|
|
R9280:Ints1
|
UTSW |
5 |
139,750,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9458:Ints1
|
UTSW |
5 |
139,743,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Ints1
|
UTSW |
5 |
139,748,217 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Ints1
|
UTSW |
5 |
139,757,393 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAACAGGAGCAGTTCACATCACAG -3'
(R):5'- TCAGAACAACCCCAGGTAGGTGAAG -3'
Sequencing Primer
(F):5'- ATCACAGCCTCCATGTGTAGG -3'
(R):5'- CAGGTAGGTGAAGCCCCAG -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation