Incidental Mutation 'R0194:Pappa2'
| ID |
23250 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pappa2
|
| Ensembl Gene |
ENSMUSG00000073530 |
| Gene Name |
pappalysin 2 |
| Synonyms |
pregnancy-associated plasma preproprotein-A2, placenta-specific 3, pregnancy-associated plasma protein-E, PAPP-A2, PLAC3, Pappe |
| MMRRC Submission |
038453-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0194 (G1)
|
| Quality Score |
188 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
158711727-158980490 bp(-) (GRCm38) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to A
at 158765101 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159861]
|
| AlphaFold |
E9PZ87 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159861
|
| SMART Domains |
Protein: ENSMUSP00000124022
Gene: ENSMUSG00000073530
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Laminin_G_3
|
271 |
440 |
1.2e-25 |
PFAM |
|
NL
|
572 |
614 |
2.81e-5 |
SMART |
|
Pfam:Peptidase_M43
|
669 |
832 |
1.5e-12 |
PFAM |
|
Blast:FN3
|
844 |
1103 |
1e-169 |
BLAST |
|
low complexity region
|
1130 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1361 |
1370 |
N/A |
INTRINSIC |
|
CCP
|
1394 |
1457 |
4.97e0 |
SMART |
|
CCP
|
1462 |
1519 |
4.81e-1 |
SMART |
|
CCP
|
1523 |
1588 |
2.58e-4 |
SMART |
|
CCP
|
1593 |
1644 |
1.13e0 |
SMART |
|
NL
|
1720 |
1757 |
2.66e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161589
|
| SMART Domains |
Protein: ENSMUSP00000124316
Gene: ENSMUSG00000073530
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
32 |
N/A |
INTRINSIC |
|
CCP
|
67 |
130 |
4.97e0 |
SMART |
|
CCP
|
135 |
192 |
4.81e-1 |
SMART |
|
CCP
|
196 |
245 |
2.84e0 |
SMART |
|
| Coding Region Coverage |
- 1x: 98.6%
- 3x: 97.3%
- 10x: 91.4%
- 20x: 70.1%
|
| Validation Efficiency |
91% (439/482) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3110043O21Rik |
T |
A |
4: 35,197,207 (GRCm38) |
D122V |
probably damaging |
Het |
| 4930553M12Rik |
T |
A |
4: 88,868,243 (GRCm38) |
D46V |
unknown |
Het |
| Abcb9 |
A |
G |
5: 124,077,295 (GRCm38) |
V461A |
probably damaging |
Het |
| Ackr4 |
T |
A |
9: 104,099,480 (GRCm38) |
L89F |
probably benign |
Het |
| Acsf2 |
T |
C |
11: 94,561,370 (GRCm38) |
T449A |
probably benign |
Het |
| Acsl4 |
C |
G |
X: 142,333,718 (GRCm38) |
G489R |
probably damaging |
Het |
| Actl6a |
T |
A |
3: 32,725,320 (GRCm38) |
I399N |
probably damaging |
Het |
| Adamts19 |
G |
A |
18: 59,011,148 (GRCm38) |
C934Y |
probably null |
Het |
| Adsl |
A |
G |
15: 80,961,360 (GRCm38) |
E40G |
possibly damaging |
Het |
| AI481877 |
T |
A |
4: 59,066,534 (GRCm38) |
|
probably benign |
Het |
| Alppl2 |
T |
G |
1: 87,088,743 (GRCm38) |
D203A |
probably damaging |
Het |
| Asb10 |
C |
A |
5: 24,537,932 (GRCm38) |
A268S |
probably benign |
Het |
| Atp9a |
T |
C |
2: 168,643,885 (GRCm38) |
S832G |
probably benign |
Het |
| Bckdha |
A |
T |
7: 25,631,450 (GRCm38) |
I297N |
probably damaging |
Het |
| Blm |
G |
A |
7: 80,464,946 (GRCm38) |
|
probably benign |
Het |
| Cacna1h |
A |
G |
17: 25,380,924 (GRCm38) |
|
probably benign |
Het |
| Camsap2 |
G |
A |
1: 136,292,948 (GRCm38) |
Q298* |
probably null |
Het |
| Ccdc38 |
A |
T |
10: 93,565,912 (GRCm38) |
K145* |
probably null |
Het |
| Cfap45 |
C |
T |
1: 172,541,327 (GRCm38) |
T434M |
probably benign |
Het |
| Cfap54 |
A |
T |
10: 93,034,662 (GRCm38) |
|
probably benign |
Het |
| Clcn6 |
G |
A |
4: 148,012,756 (GRCm38) |
P618L |
probably damaging |
Het |
| Copg1 |
T |
C |
6: 87,904,197 (GRCm38) |
|
probably benign |
Het |
| Dctd |
T |
A |
8: 48,112,078 (GRCm38) |
N79K |
probably benign |
Het |
| Dgkq |
A |
G |
5: 108,654,644 (GRCm38) |
|
probably benign |
Het |
| Dntt |
A |
T |
19: 41,038,970 (GRCm38) |
T159S |
possibly damaging |
Het |
| Doc2g |
G |
A |
19: 4,003,656 (GRCm38) |
R29Q |
probably benign |
Het |
| Dsg3 |
A |
G |
18: 20,540,142 (GRCm38) |
T957A |
probably damaging |
Het |
| Eif3c |
T |
A |
7: 126,558,623 (GRCm38) |
|
probably benign |
Het |
| Ephb3 |
T |
A |
16: 21,218,109 (GRCm38) |
D107E |
probably benign |
Het |
| Esrrb |
A |
T |
12: 86,470,481 (GRCm38) |
D108V |
probably damaging |
Het |
| Exo1 |
A |
G |
1: 175,892,030 (GRCm38) |
K214E |
probably damaging |
Het |
| Fam186a |
G |
A |
15: 99,941,763 (GRCm38) |
T2200I |
possibly damaging |
Het |
| Fam227a |
C |
T |
15: 79,640,669 (GRCm38) |
W194* |
probably null |
Het |
| Foxn4 |
A |
G |
5: 114,259,748 (GRCm38) |
|
probably null |
Het |
| Gabbr2 |
T |
C |
4: 46,787,565 (GRCm38) |
K366R |
possibly damaging |
Het |
| Garem2 |
T |
A |
5: 30,113,930 (GRCm38) |
V130E |
probably damaging |
Het |
| Grin2b |
A |
G |
6: 135,779,305 (GRCm38) |
F474S |
probably damaging |
Het |
| H2-M10.6 |
G |
T |
17: 36,814,042 (GRCm38) |
V284F |
probably damaging |
Het |
| Helz2 |
C |
A |
2: 181,232,759 (GRCm38) |
G1981C |
probably damaging |
Het |
| Hivep1 |
G |
T |
13: 42,155,435 (GRCm38) |
V384F |
probably damaging |
Het |
| Hmox1 |
A |
G |
8: 75,097,108 (GRCm38) |
T135A |
probably damaging |
Het |
| Hpse |
T |
C |
5: 100,719,512 (GRCm38) |
D28G |
probably benign |
Het |
| Itm2b |
G |
T |
14: 73,364,618 (GRCm38) |
D213E |
probably benign |
Het |
| Jakmip1 |
T |
A |
5: 37,134,283 (GRCm38) |
M692K |
possibly damaging |
Het |
| Kdm3a |
T |
C |
6: 71,624,594 (GRCm38) |
Q151R |
probably null |
Het |
| Limch1 |
C |
A |
5: 66,999,273 (GRCm38) |
A517E |
probably benign |
Het |
| Lrit1 |
T |
A |
14: 37,061,720 (GRCm38) |
L335Q |
probably damaging |
Het |
| Lrrc37a |
A |
G |
11: 103,499,790 (GRCm38) |
V1603A |
possibly damaging |
Het |
| Mbtps1 |
T |
A |
8: 119,535,369 (GRCm38) |
N347I |
probably damaging |
Het |
| Mier1 |
A |
T |
4: 103,139,519 (GRCm38) |
|
probably null |
Het |
| Mt2 |
A |
T |
8: 94,172,848 (GRCm38) |
M1L |
probably damaging |
Het |
| Mug1 |
A |
T |
6: 121,840,107 (GRCm38) |
E45V |
probably damaging |
Het |
| Mybphl |
A |
G |
3: 108,374,168 (GRCm38) |
K67E |
probably benign |
Het |
| Myh4 |
A |
G |
11: 67,252,336 (GRCm38) |
K1030R |
probably damaging |
Het |
| Myl3 |
T |
A |
9: 110,769,121 (GRCm38) |
D176E |
probably benign |
Het |
| Ncapg2 |
A |
G |
12: 116,420,683 (GRCm38) |
|
probably null |
Het |
| Ndor1 |
T |
C |
2: 25,248,706 (GRCm38) |
|
probably null |
Het |
| Nedd4 |
T |
G |
9: 72,670,053 (GRCm38) |
N53K |
possibly damaging |
Het |
| Nek11 |
C |
A |
9: 105,392,952 (GRCm38) |
A24S |
probably benign |
Het |
| Nudt19 |
G |
T |
7: 35,551,514 (GRCm38) |
P267T |
probably benign |
Het |
| Olfml2b |
T |
C |
1: 170,681,115 (GRCm38) |
M514T |
possibly damaging |
Het |
| Olfr304 |
A |
T |
7: 86,386,374 (GRCm38) |
C95* |
probably null |
Het |
| Olfr424 |
A |
T |
1: 174,136,761 (GRCm38) |
T6S |
probably benign |
Het |
| Olfr556 |
A |
G |
7: 102,670,199 (GRCm38) |
D93G |
probably benign |
Het |
| Olfr699 |
C |
A |
7: 106,790,823 (GRCm38) |
M59I |
probably benign |
Het |
| P3h1 |
T |
A |
4: 119,237,952 (GRCm38) |
F302Y |
probably damaging |
Het |
| Pex2 |
A |
C |
3: 5,561,364 (GRCm38) |
H128Q |
probably benign |
Het |
| Phf11d |
A |
C |
14: 59,352,731 (GRCm38) |
L214R |
probably damaging |
Het |
| Plcg2 |
G |
A |
8: 117,573,397 (GRCm38) |
|
probably benign |
Het |
| Ppargc1b |
A |
C |
18: 61,307,945 (GRCm38) |
L634R |
possibly damaging |
Het |
| Prune1 |
A |
T |
3: 95,262,360 (GRCm38) |
I177N |
probably damaging |
Het |
| Puf60 |
T |
C |
15: 76,070,485 (GRCm38) |
D496G |
probably damaging |
Het |
| Rasl11b |
A |
G |
5: 74,196,163 (GRCm38) |
|
probably null |
Het |
| Sdr42e1 |
A |
T |
8: 117,663,109 (GRCm38) |
F264L |
probably damaging |
Het |
| Sec24b |
A |
T |
3: 129,984,165 (GRCm38) |
|
probably null |
Het |
| Sgta |
G |
T |
10: 81,051,059 (GRCm38) |
P79T |
probably benign |
Het |
| Shisa9 |
C |
T |
16: 11,984,954 (GRCm38) |
T125M |
probably damaging |
Het |
| Slc12a2 |
A |
G |
18: 57,930,211 (GRCm38) |
D921G |
probably damaging |
Het |
| Slc13a5 |
T |
A |
11: 72,262,130 (GRCm38) |
I42L |
possibly damaging |
Het |
| Slc13a5 |
C |
T |
11: 72,245,233 (GRCm38) |
V494I |
probably benign |
Het |
| Spire2 |
G |
A |
8: 123,363,011 (GRCm38) |
|
probably benign |
Het |
| Sptbn4 |
G |
A |
7: 27,404,911 (GRCm38) |
R962C |
probably benign |
Het |
| St8sia5 |
G |
A |
18: 77,254,724 (GRCm38) |
V377I |
probably benign |
Het |
| Stag2 |
T |
G |
X: 42,206,137 (GRCm38) |
|
probably benign |
Het |
| Syne1 |
C |
A |
10: 5,424,311 (GRCm38) |
M165I |
probably benign |
Het |
| Synm |
C |
A |
7: 67,734,924 (GRCm38) |
V997L |
probably damaging |
Het |
| Tacc1 |
A |
G |
8: 25,182,376 (GRCm38) |
S279P |
probably benign |
Het |
| Tbc1d10a |
T |
C |
11: 4,212,901 (GRCm38) |
|
probably null |
Het |
| Tbc1d19 |
A |
G |
5: 53,860,156 (GRCm38) |
T302A |
probably damaging |
Het |
| Tecpr1 |
A |
C |
5: 144,218,517 (GRCm38) |
N74K |
probably damaging |
Het |
| Tmem120a |
T |
C |
5: 135,742,398 (GRCm38) |
E28G |
possibly damaging |
Het |
| Tnfrsf1b |
A |
T |
4: 145,224,812 (GRCm38) |
I186N |
probably benign |
Het |
| Trim55 |
A |
G |
3: 19,661,861 (GRCm38) |
D195G |
probably benign |
Het |
| Trpm3 |
G |
T |
19: 22,715,356 (GRCm38) |
|
probably null |
Het |
| Ttc39a |
T |
A |
4: 109,444,179 (GRCm38) |
S571T |
probably benign |
Het |
| Vwf |
T |
G |
6: 125,643,297 (GRCm38) |
I1646S |
probably benign |
Het |
| Wbp2nl |
T |
C |
15: 82,314,282 (GRCm38) |
F340S |
possibly damaging |
Het |
| Yeats2 |
T |
C |
16: 20,152,969 (GRCm38) |
M1T |
probably null |
Het |
| Zfp236 |
T |
A |
18: 82,656,987 (GRCm38) |
E460V |
probably damaging |
Het |
| Zfp277 |
G |
A |
12: 40,378,877 (GRCm38) |
|
probably benign |
Het |
| Zfp975 |
T |
A |
7: 42,662,492 (GRCm38) |
K232N |
probably benign |
Het |
| Zxdc |
T |
C |
6: 90,372,537 (GRCm38) |
|
probably benign |
Het |
|
| Other mutations in Pappa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Pappa2
|
APN |
1 |
158,857,148 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01394:Pappa2
|
APN |
1 |
158,765,104 (GRCm38) |
splice site |
probably benign |
|
|
IGL01570:Pappa2
|
APN |
1 |
158,814,540 (GRCm38) |
nonsense |
probably null |
|
|
IGL01618:Pappa2
|
APN |
1 |
158,857,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01717:Pappa2
|
APN |
1 |
158,857,132 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01804:Pappa2
|
APN |
1 |
158,936,519 (GRCm38) |
missense |
probably benign |
|
|
IGL01904:Pappa2
|
APN |
1 |
158,783,941 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02116:Pappa2
|
APN |
1 |
158,845,125 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02174:Pappa2
|
APN |
1 |
158,761,618 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02302:Pappa2
|
APN |
1 |
158,715,001 (GRCm38) |
missense |
probably benign |
0.38 |
|
IGL02422:Pappa2
|
APN |
1 |
158,936,933 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02572:Pappa2
|
APN |
1 |
158,851,216 (GRCm38) |
missense |
probably benign |
|
|
IGL02659:Pappa2
|
APN |
1 |
158,936,794 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02887:Pappa2
|
APN |
1 |
158,782,259 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02981:Pappa2
|
APN |
1 |
158,851,144 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03128:Pappa2
|
APN |
1 |
158,936,484 (GRCm38) |
missense |
probably benign |
0.16 |
|
IGL03142:Pappa2
|
APN |
1 |
158,854,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03270:Pappa2
|
APN |
1 |
158,765,067 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
Fritas
|
UTSW |
1 |
158,847,963 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
Gulliver
|
UTSW |
1 |
158,857,136 (GRCm38) |
missense |
probably null |
1.00 |
|
Lilliputian
|
UTSW |
1 |
158,716,990 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Lilliputian2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
lilliputian3
|
UTSW |
1 |
158,782,403 (GRCm38) |
splice site |
probably null |
|
|
Pitzel
|
UTSW |
1 |
158,956,645 (GRCm38) |
missense |
probably damaging |
1.00 |
|
shrink
|
UTSW |
1 |
158,763,192 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,714,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,714,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0172:Pappa2
|
UTSW |
1 |
158,854,849 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0418:Pappa2
|
UTSW |
1 |
158,716,990 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0421:Pappa2
|
UTSW |
1 |
158,848,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0441:Pappa2
|
UTSW |
1 |
158,763,058 (GRCm38) |
unclassified |
probably benign |
|
|
R0602:Pappa2
|
UTSW |
1 |
158,763,055 (GRCm38) |
unclassified |
probably benign |
|
|
R0630:Pappa2
|
UTSW |
1 |
158,832,773 (GRCm38) |
missense |
probably benign |
|
|
R0760:Pappa2
|
UTSW |
1 |
158,716,961 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1146:Pappa2
|
UTSW |
1 |
158,854,982 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1146:Pappa2
|
UTSW |
1 |
158,854,982 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1243:Pappa2
|
UTSW |
1 |
158,845,100 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1413:Pappa2
|
UTSW |
1 |
158,936,554 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1502:Pappa2
|
UTSW |
1 |
158,957,288 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1599:Pappa2
|
UTSW |
1 |
158,857,172 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1689:Pappa2
|
UTSW |
1 |
158,957,398 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1750:Pappa2
|
UTSW |
1 |
158,763,150 (GRCm38) |
nonsense |
probably null |
|
|
R1772:Pappa2
|
UTSW |
1 |
158,814,368 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R1832:Pappa2
|
UTSW |
1 |
158,857,316 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1905:Pappa2
|
UTSW |
1 |
158,803,503 (GRCm38) |
splice site |
probably null |
|
|
R1914:Pappa2
|
UTSW |
1 |
158,750,563 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2013:Pappa2
|
UTSW |
1 |
158,834,928 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2037:Pappa2
|
UTSW |
1 |
158,956,644 (GRCm38) |
nonsense |
probably null |
|
|
R2118:Pappa2
|
UTSW |
1 |
158,857,266 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2268:Pappa2
|
UTSW |
1 |
158,857,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2269:Pappa2
|
UTSW |
1 |
158,857,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2347:Pappa2
|
UTSW |
1 |
158,765,043 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3024:Pappa2
|
UTSW |
1 |
158,936,225 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3706:Pappa2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
R3707:Pappa2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
R3708:Pappa2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
R4600:Pappa2
|
UTSW |
1 |
158,814,445 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4737:Pappa2
|
UTSW |
1 |
158,957,012 (GRCm38) |
missense |
probably benign |
|
|
R4738:Pappa2
|
UTSW |
1 |
158,957,012 (GRCm38) |
missense |
probably benign |
|
|
R4739:Pappa2
|
UTSW |
1 |
158,957,002 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4739:Pappa2
|
UTSW |
1 |
158,957,012 (GRCm38) |
missense |
probably benign |
|
|
R4788:Pappa2
|
UTSW |
1 |
158,783,917 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4798:Pappa2
|
UTSW |
1 |
158,857,379 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4952:Pappa2
|
UTSW |
1 |
158,857,136 (GRCm38) |
missense |
probably null |
1.00 |
|
R5121:Pappa2
|
UTSW |
1 |
158,838,627 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5144:Pappa2
|
UTSW |
1 |
158,957,133 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5159:Pappa2
|
UTSW |
1 |
158,761,619 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5278:Pappa2
|
UTSW |
1 |
158,782,403 (GRCm38) |
splice site |
probably null |
|
|
R5428:Pappa2
|
UTSW |
1 |
158,814,785 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R5452:Pappa2
|
UTSW |
1 |
158,838,602 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5477:Pappa2
|
UTSW |
1 |
158,956,738 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5504:Pappa2
|
UTSW |
1 |
158,848,045 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5852:Pappa2
|
UTSW |
1 |
158,717,014 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6003:Pappa2
|
UTSW |
1 |
158,936,250 (GRCm38) |
missense |
probably benign |
0.23 |
|
R6129:Pappa2
|
UTSW |
1 |
158,714,997 (GRCm38) |
nonsense |
probably null |
|
|
R6137:Pappa2
|
UTSW |
1 |
158,871,543 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6374:Pappa2
|
UTSW |
1 |
158,956,645 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6472:Pappa2
|
UTSW |
1 |
158,834,799 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6804:Pappa2
|
UTSW |
1 |
158,936,868 (GRCm38) |
missense |
probably benign |
0.24 |
|
R7020:Pappa2
|
UTSW |
1 |
158,848,009 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7051:Pappa2
|
UTSW |
1 |
158,957,183 (GRCm38) |
missense |
unknown |
|
|
R7082:Pappa2
|
UTSW |
1 |
158,763,119 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R7111:Pappa2
|
UTSW |
1 |
158,956,526 (GRCm38) |
missense |
probably benign |
0.38 |
|
R7213:Pappa2
|
UTSW |
1 |
158,936,886 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7575:Pappa2
|
UTSW |
1 |
158,814,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7587:Pappa2
|
UTSW |
1 |
158,851,131 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7826:Pappa2
|
UTSW |
1 |
158,936,440 (GRCm38) |
nonsense |
probably null |
|
|
R7957:Pappa2
|
UTSW |
1 |
158,761,561 (GRCm38) |
nonsense |
probably null |
|
|
R8007:Pappa2
|
UTSW |
1 |
158,782,304 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8050:Pappa2
|
UTSW |
1 |
158,848,400 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8063:Pappa2
|
UTSW |
1 |
158,936,556 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R8068:Pappa2
|
UTSW |
1 |
158,935,985 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R8128:Pappa2
|
UTSW |
1 |
158,936,664 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R8264:Pappa2
|
UTSW |
1 |
158,854,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8317:Pappa2
|
UTSW |
1 |
158,764,960 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8499:Pappa2
|
UTSW |
1 |
158,936,522 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8744:Pappa2
|
UTSW |
1 |
158,783,917 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R8793:Pappa2
|
UTSW |
1 |
158,851,161 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8932:Pappa2
|
UTSW |
1 |
158,763,192 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9004:Pappa2
|
UTSW |
1 |
158,936,948 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R9004:Pappa2
|
UTSW |
1 |
158,936,409 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9088:Pappa2
|
UTSW |
1 |
158,936,357 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9191:Pappa2
|
UTSW |
1 |
158,857,418 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9243:Pappa2
|
UTSW |
1 |
158,936,193 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9280:Pappa2
|
UTSW |
1 |
158,847,963 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R9301:Pappa2
|
UTSW |
1 |
158,845,044 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9306:Pappa2
|
UTSW |
1 |
158,936,922 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9367:Pappa2
|
UTSW |
1 |
158,956,972 (GRCm38) |
missense |
probably benign |
0.40 |
|
R9471:Pappa2
|
UTSW |
1 |
158,814,459 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9544:Pappa2
|
UTSW |
1 |
158,957,247 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9680:Pappa2
|
UTSW |
1 |
158,782,248 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R9762:Pappa2
|
UTSW |
1 |
158,857,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9774:Pappa2
|
UTSW |
1 |
158,848,350 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9776:Pappa2
|
UTSW |
1 |
158,783,911 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0058:Pappa2
|
UTSW |
1 |
158,814,397 (GRCm38) |
missense |
probably null |
|
|
X0061:Pappa2
|
UTSW |
1 |
158,936,618 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,956,933 (GRCm38) |
missense |
probably benign |
|
|
Z1176:Pappa2
|
UTSW |
1 |
158,814,816 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,814,814 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTTGAGCACACACTGGCTGTC -3'
(R):5'- TCAATTTCATGGCCCACAATGGGAC -3'
Sequencing Primer
(F):5'- TGTCCAGCTTGAAGCCATCAG -3'
(R):5'- ctctctctctctctctctctctc -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation