Mutagenetix > Incidental Mutation

Incidental Mutation 'R0193:Coro7'

23253

Institutional Source

Beutler Lab

Gene Symbol

Coro7

Ensembl Gene

ENSMUSG00000039637

Gene Name

coronin 7

Synonyms

0610011B16Rik

MMRRC Submission

038452-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

R0193 (G1)

Quality Score

206

Status

Validated

Chromosome

Chromosomal Location

4444748-4497584 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to A at 4445368 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000119723 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000014445] [ENSMUST00000038552] [ENSMUST00000135823] [ENSMUST00000156889]

AlphaFold

Q9D2V7

Predicted Effect

probably benign
Transcript: ENSMUST00000014445

SMART Domains

Protein: ENSMUSP00000014445
Gene: ENSMUSG00000014301

Domain	Start	End	E-Value	Type
Pfam:Pam16	1	125	4.9e-63	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000038552

SMART Domains

Protein: ENSMUSP00000048489
Gene: ENSMUSG00000039637

Domain	Start	End	E-Value	Type
DUF1899	3	64	6.41e-15	SMART
WD40	66	106	1.83e-7	SMART
WD40	115	154	4.13e0	SMART
WD40	157	196	1.78e-5	SMART
DUF1900	251	385	4.49e-60	SMART
low complexity region	427	456	N/A	INTRINSIC
DUF1899	463	528	1.2e-19	SMART
WD40	531	570	3.64e-2	SMART
WD40	580	620	8.55e-8	SMART
WD40	623	662	1.16e-9	SMART
low complexity region	667	679	N/A	INTRINSIC
DUF1900	718	854	6.69e-68	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127120

Predicted Effect

probably benign
Transcript: ENSMUST00000135823

SMART Domains

Protein: ENSMUSP00000118310
Gene: ENSMUSG00000039637

Domain	Start	End	E-Value	Type
DUF1899	3	64	6.41e-15	SMART
WD40	66	106	1.83e-7	SMART
WD40	115	154	4.13e0	SMART
WD40	157	196	1.78e-5	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139072

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150028

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150724

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151156

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229767

Predicted Effect

probably benign
Transcript: ENSMUST00000156889

Coding Region Coverage

1x: 98.9%
3x: 98.0%
10x: 94.7%
20x: 85.3%

Validation Efficiency

95% (186/196)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele are viable and overtly normal but exhibit disruption of the Golgi apparatus. Mutant fibroblasts show increased cell spreading and cellular F-actin content, increased cell polarization and migration, and enhanced wound healing in a scratch-wound assay. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 91 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb1	T	C	15: 74,444,005 (GRCm39)	S96P	probably damaging	Het
Akr1c20	A	G	13: 4,561,292 (GRCm39)		probably benign	Het
Atp2a3	G	T	11: 72,863,046 (GRCm39)	V99L	possibly damaging	Het
Atp6v0a1	T	A	11: 100,939,308 (GRCm39)	I691N	possibly damaging	Het
Atp8b1	C	T	18: 64,694,707 (GRCm39)	R525Q	probably benign	Het
Aurkb	A	G	11: 68,939,370 (GRCm39)	D151G	probably damaging	Het
Bank1	A	T	3: 135,772,279 (GRCm39)		probably benign	Het
Bcl9l	T	C	9: 44,418,703 (GRCm39)	L847P	probably damaging	Het
Bscl2	T	A	19: 8,824,793 (GRCm39)	M292K	probably benign	Het
Cacna1c	C	T	6: 118,579,363 (GRCm39)		probably benign	Het
Cadps2	T	C	6: 23,599,439 (GRCm39)	K260R	probably benign	Het
Cc2d2a	T	C	5: 43,893,460 (GRCm39)	S1419P	probably damaging	Het
Ccdc180	G	A	4: 45,914,803 (GRCm39)	E145K	probably benign	Het
Ccno	C	T	13: 113,125,418 (GRCm39)		probably benign	Het
Cd300a	A	G	11: 114,784,202 (GRCm39)	D70G	probably benign	Het
Cenpc1	T	C	5: 86,180,262 (GRCm39)	D670G	probably benign	Het
Cenpl	A	G	1: 160,913,558 (GRCm39)	I323V	probably damaging	Het
Cfap44	A	G	16: 44,269,573 (GRCm39)		probably null	Het
Cfap74	C	T	4: 155,510,572 (GRCm39)	R386C	probably benign	Het
Cic	T	A	7: 24,986,565 (GRCm39)	S1299T	probably damaging	Het
Cic	C	A	7: 24,986,566 (GRCm39)	S1299Y	probably damaging	Het
Clcnkb	T	C	4: 141,139,627 (GRCm39)	E125G	possibly damaging	Het
Clstn1	G	A	4: 149,719,253 (GRCm39)	V361M	probably damaging	Het
Dchs1	C	T	7: 105,414,190 (GRCm39)	R875H	probably benign	Het
Eif3j1	A	C	2: 121,882,508 (GRCm39)	M239L	probably benign	Het
Eif4g3	G	T	4: 137,873,687 (GRCm39)		probably benign	Het
Elapor2	A	T	5: 9,472,359 (GRCm39)	Q352L	probably damaging	Het
Erbb4	T	C	1: 68,083,119 (GRCm39)		probably benign	Het
Erlin2	T	G	8: 27,521,792 (GRCm39)	V164G	possibly damaging	Het
Fbxo43	G	T	15: 36,162,029 (GRCm39)	Q393K	probably benign	Het
Fcgr4	A	T	1: 170,853,329 (GRCm39)	N178I	possibly damaging	Het
Grid2	A	G	6: 64,040,937 (GRCm39)	N293S	possibly damaging	Het
H2-M1	C	T	17: 36,982,224 (GRCm39)	V126I	probably benign	Het
Htr1f	T	A	16: 64,747,112 (GRCm39)	Y60F	probably damaging	Het
Ilf2	A	G	3: 90,388,646 (GRCm39)		probably null	Het
Impg2	A	T	16: 56,085,412 (GRCm39)	K931*	probably null	Het
Ints1	T	C	5: 139,737,485 (GRCm39)	E2176G	probably damaging	Het
Iqsec2	T	C	X: 151,006,399 (GRCm39)	V1319A	probably benign	Het
Iqsec3	G	T	6: 121,387,683 (GRCm39)	D685E	probably damaging	Het
Itgbl1	G	A	14: 124,083,958 (GRCm39)	V279I	probably benign	Het
Kdm4b	C	T	17: 56,700,952 (GRCm39)	A541V	probably benign	Het
Kif14	A	T	1: 136,396,176 (GRCm39)	T161S	probably benign	Het
Krt86	T	C	15: 101,377,244 (GRCm39)		probably benign	Het
Kyat1	C	T	2: 30,077,198 (GRCm39)		probably null	Het
Limch1	T	C	5: 67,184,882 (GRCm39)	W791R	probably damaging	Het
Map3k11	T	A	19: 5,745,874 (GRCm39)	M396K	probably damaging	Het
Mat2a	A	G	6: 72,413,178 (GRCm39)		probably null	Het
Mbnl2	A	G	14: 120,616,649 (GRCm39)	I88V	possibly damaging	Het
Mib2	T	C	4: 155,740,130 (GRCm39)	T708A	probably benign	Het
Mix23	T	C	16: 35,903,184 (GRCm39)	S59P	probably damaging	Het
Mkks	T	C	2: 136,719,526 (GRCm39)		probably null	Het
Mtss1	T	C	15: 58,815,866 (GRCm39)	M565V	probably damaging	Het
Myoc	A	G	1: 162,476,604 (GRCm39)	N436S	probably damaging	Het
Myod1	T	A	7: 46,026,536 (GRCm39)	V147E	probably damaging	Het
Ngef	A	G	1: 87,437,056 (GRCm39)	L144P	probably benign	Het
Ngrn	C	T	7: 79,911,678 (GRCm39)	R92W	probably damaging	Het
Nup153	G	A	13: 46,863,130 (GRCm39)	T349I	probably benign	Het
Or4c15	T	A	2: 88,760,627 (GRCm39)	I11L	probably benign	Het
Or52ad1	G	T	7: 102,995,411 (GRCm39)	S241R	possibly damaging	Het
Pigl	A	G	11: 62,394,574 (GRCm39)	I135M	probably damaging	Het
Pitpnm3	A	G	11: 71,961,318 (GRCm39)		probably benign	Het
Pkhd1	A	T	1: 20,429,141 (GRCm39)	F2420I	probably damaging	Het
Polr2b	C	T	5: 77,467,923 (GRCm39)	T119M	probably damaging	Het
Prr29	A	G	11: 106,267,722 (GRCm39)	Y130C	probably damaging	Het
Rab11fip3	T	C	17: 26,209,973 (GRCm39)	I1048V	probably damaging	Het
Rab12	G	A	17: 66,807,357 (GRCm39)	T124I	probably damaging	Het
Rab44	A	G	17: 29,359,281 (GRCm39)	S490G	probably benign	Het
Rasa3	A	G	8: 13,620,233 (GRCm39)		probably null	Het
Rhbdl3	C	T	11: 80,244,400 (GRCm39)	S369L	possibly damaging	Het
Rimbp2	A	T	5: 128,865,420 (GRCm39)	S643T	probably benign	Het
Rin1	T	G	19: 5,102,680 (GRCm39)	S396R	probably damaging	Het
Rpusd3	C	T	6: 113,396,198 (GRCm39)	G28S	probably damaging	Het
Rtl9	T	A	X: 141,883,274 (GRCm39)	S229T	probably damaging	Het
Rufy1	G	T	11: 50,280,679 (GRCm39)	T701N	probably benign	Het
Scn4a	A	T	11: 106,211,364 (GRCm39)	L1551*	probably null	Het
Sec24b	T	C	3: 129,782,633 (GRCm39)	N1119S	probably null	Het
Serbp1	T	A	6: 67,249,868 (GRCm39)	*75R	probably null	Het
Setx	C	T	2: 29,069,685 (GRCm39)	P2497S	probably benign	Het
Slc26a11	A	T	11: 119,250,140 (GRCm39)	I132F	probably damaging	Het
Slc4a1	A	G	11: 102,243,510 (GRCm39)	V707A	possibly damaging	Het
Slfn1	A	G	11: 83,012,669 (GRCm39)	I262V	probably damaging	Het
Tmem168	T	A	6: 13,583,312 (GRCm39)	D523V	possibly damaging	Het
Traf7	G	T	17: 24,729,525 (GRCm39)	Q469K	probably benign	Het
Trdmt1	C	A	2: 13,549,428 (GRCm39)	V6F	probably damaging	Het
Tsacc	A	T	3: 88,194,395 (GRCm39)		probably benign	Het
Vmn2r5	A	G	3: 64,398,951 (GRCm39)	I589T	possibly damaging	Het
Vmn2r7	T	C	3: 64,598,460 (GRCm39)	D699G	probably damaging	Het
Vmn2r82	T	C	10: 79,217,129 (GRCm39)	V487A	probably damaging	Het
Zbtb47	T	C	9: 121,596,732 (GRCm39)	V696A	probably damaging	Het
Zfp287	A	T	11: 62,605,855 (GRCm39)	S351T	probably benign	Het
Zfp654	T	C	16: 64,606,051 (GRCm39)	H176R	possibly damaging	Het

Other mutations in Coro7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00428:Coro7	APN	16	4,452,500 (GRCm39)	missense	possibly damaging	0.83
IGL00885:Coro7	APN	16	4,452,890 (GRCm39)	missense	probably benign	0.00
IGL02944:Coro7	APN	16	4,453,276 (GRCm39)	missense	probably benign	0.14
IGL03104:Coro7	APN	16	4,446,990 (GRCm39)	missense	probably damaging	1.00
IGL03153:Coro7	APN	16	4,453,246 (GRCm39)	critical splice donor site	probably null
R0022:Coro7	UTSW	16	4,451,168 (GRCm39)	missense	probably benign	0.01
R0022:Coro7	UTSW	16	4,451,168 (GRCm39)	missense	probably benign	0.01
R0071:Coro7	UTSW	16	4,488,391 (GRCm39)	missense	probably damaging	1.00
R0071:Coro7	UTSW	16	4,488,391 (GRCm39)	missense	probably damaging	1.00
R0080:Coro7	UTSW	16	4,448,328 (GRCm39)	missense	probably damaging	1.00
R0242:Coro7	UTSW	16	4,448,042 (GRCm39)	splice site	probably benign
R0318:Coro7	UTSW	16	4,493,671 (GRCm39)	missense	probably benign	0.09
R0554:Coro7	UTSW	16	4,450,121 (GRCm39)	missense	possibly damaging	0.63
R0666:Coro7	UTSW	16	4,449,775 (GRCm39)	missense	possibly damaging	0.70
R0835:Coro7	UTSW	16	4,450,118 (GRCm39)	missense	probably benign	0.12
R0968:Coro7	UTSW	16	4,487,919 (GRCm39)	splice site	probably benign
R1670:Coro7	UTSW	16	4,446,097 (GRCm39)	missense	possibly damaging	0.76
R1709:Coro7	UTSW	16	4,452,305 (GRCm39)	splice site	probably null
R1848:Coro7	UTSW	16	4,448,298 (GRCm39)	missense	probably damaging	0.99
R1884:Coro7	UTSW	16	4,446,683 (GRCm39)	unclassified	probably benign
R1935:Coro7	UTSW	16	4,446,596 (GRCm39)	missense	probably benign
R1937:Coro7	UTSW	16	4,446,596 (GRCm39)	missense	probably benign
R1939:Coro7	UTSW	16	4,446,596 (GRCm39)	missense	probably benign
R1967:Coro7	UTSW	16	4,452,753 (GRCm39)	missense	probably damaging	1.00
R1969:Coro7	UTSW	16	4,451,620 (GRCm39)	missense	probably benign	0.19
R1970:Coro7	UTSW	16	4,451,620 (GRCm39)	missense	probably benign	0.19
R3034:Coro7	UTSW	16	4,450,155 (GRCm39)	missense	probably damaging	0.99
R4638:Coro7	UTSW	16	4,450,151 (GRCm39)	missense	probably damaging	0.96
R4710:Coro7	UTSW	16	4,452,797 (GRCm39)	intron	probably benign
R4723:Coro7	UTSW	16	4,449,858 (GRCm39)	missense	probably benign	0.00
R4789:Coro7	UTSW	16	4,446,085 (GRCm39)	missense	probably damaging	1.00
R5493:Coro7	UTSW	16	4,450,351 (GRCm39)	missense	probably damaging	0.99
R5619:Coro7	UTSW	16	4,494,799 (GRCm39)	critical splice donor site	probably null
R5756:Coro7	UTSW	16	4,450,148 (GRCm39)	missense	probably damaging	0.97
R5974:Coro7	UTSW	16	4,449,753 (GRCm39)	missense	possibly damaging	0.83
R6010:Coro7	UTSW	16	4,487,820 (GRCm39)	missense	possibly damaging	0.68
R6038:Coro7	UTSW	16	4,497,414 (GRCm39)	critical splice donor site	probably null
R6038:Coro7	UTSW	16	4,497,414 (GRCm39)	critical splice donor site	probably null
R6906:Coro7	UTSW	16	4,451,168 (GRCm39)	missense	probably benign	0.00
R6925:Coro7	UTSW	16	4,446,538 (GRCm39)	critical splice donor site	probably null
R7069:Coro7	UTSW	16	4,497,475 (GRCm39)	start codon destroyed	probably damaging	0.99
R7326:Coro7	UTSW	16	4,449,912 (GRCm39)	missense	probably damaging	0.96
R7421:Coro7	UTSW	16	4,486,615 (GRCm39)	missense	probably benign	0.19
R7521:Coro7	UTSW	16	4,449,346 (GRCm39)	missense	probably benign	0.00
R7773:Coro7	UTSW	16	4,449,870 (GRCm39)	missense	probably damaging	1.00
R7846:Coro7	UTSW	16	4,488,400 (GRCm39)	missense	probably damaging	1.00
R8240:Coro7	UTSW	16	4,486,660 (GRCm39)	missense	probably damaging	0.96
R8726:Coro7	UTSW	16	4,486,619 (GRCm39)	missense	possibly damaging	0.95
R8762:Coro7	UTSW	16	4,452,203 (GRCm39)	missense	probably benign
R9383:Coro7	UTSW	16	4,452,888 (GRCm39)	missense	probably damaging	1.00
R9451:Coro7	UTSW	16	4,488,402 (GRCm39)	missense	probably damaging	1.00
R9553:Coro7	UTSW	16	4,486,624 (GRCm39)	missense	possibly damaging	0.55

Predicted Primers

PCR Primer
(F):5'- TGGTGTCACATGCTAACAGGCAG -3'
(R):5'- CGGAGAGTCATTTCTTTCGGTCCC -3'

Sequencing Primer
(F):5'- CTGAAGATAAACAGTTGGCTCC -3'
(R):5'- CATGGTAGCAAAGCTGGGG -3'

Posted On

2013-04-16