Incidental Mutation 'R2115:Kcnt2'
| ID |
232988 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kcnt2
|
| Ensembl Gene |
ENSMUSG00000052726 |
| Gene Name |
potassium channel, subfamily T, member 2 |
| Synonyms |
E330038N15Rik |
| MMRRC Submission |
040119-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
R2115 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
140173896-140539805 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 140480701 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Phenylalanine
at position 755
(L755F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113535
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119786]
[ENSMUST00000120709]
[ENSMUST00000120796]
|
| AlphaFold |
D3Z649 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000060201
AA Change: L836F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000054623
Gene: ENSMUSG00000052726
AA Change: L836F
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.8e-15 |
PFAM |
|
Pfam:BK_channel_a
|
424 |
533 |
1.3e-31 |
PFAM |
|
low complexity region
|
655 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
689 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000119786
AA Change: L755F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000113535
Gene: ENSMUSG00000052726
AA Change: L755F
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.6e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
476 |
2.3e-16 |
PFAM |
|
low complexity region
|
598 |
613 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
699 |
714 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000120709
AA Change: L805F
PolyPhen 2
Score 0.591 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000112887
Gene: ENSMUSG00000052726
AA Change: L805F
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.7e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
527 |
1.5e-39 |
PFAM |
|
low complexity region
|
648 |
663 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
682 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
764 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120796
AA Change: L829F
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000113333
Gene: ENSMUSG00000052726
AA Change: L829F
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.8e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
527 |
1.5e-39 |
PFAM |
|
low complexity region
|
648 |
663 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
682 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000193606
AA Change: V63F
|
| Meta Mutation Damage Score |
0.0906 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
98% (95/97) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele are viable with normal pain and itch responses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aatk |
T |
C |
11: 119,900,562 (GRCm39) |
T1195A |
probably benign |
Het |
| Abca12 |
A |
T |
1: 71,283,930 (GRCm39) |
N2547K |
probably benign |
Het |
| Abca16 |
A |
C |
7: 120,139,868 (GRCm39) |
E1510A |
probably damaging |
Het |
| Adam5 |
A |
G |
8: 25,234,161 (GRCm39) |
|
probably benign |
Het |
| Akna |
G |
A |
4: 63,313,397 (GRCm39) |
P242L |
probably benign |
Het |
| Akr1b7 |
G |
A |
6: 34,395,929 (GRCm39) |
A144T |
possibly damaging |
Het |
| Ankhd1 |
T |
A |
18: 36,767,361 (GRCm39) |
S1167T |
probably damaging |
Het |
| Arf5 |
C |
T |
6: 28,424,783 (GRCm39) |
Q71* |
probably null |
Het |
| Ark2n |
T |
C |
18: 77,762,168 (GRCm39) |
D48G |
possibly damaging |
Het |
| Arl15 |
C |
T |
13: 114,104,196 (GRCm39) |
S111F |
probably damaging |
Het |
| Atxn1l |
C |
T |
8: 110,459,240 (GRCm39) |
A341T |
probably benign |
Het |
| Birc7 |
C |
A |
2: 180,572,642 (GRCm39) |
Q138K |
possibly damaging |
Het |
| Blvra |
G |
T |
2: 126,927,989 (GRCm39) |
E80* |
probably null |
Het |
| Ccdc148 |
T |
C |
2: 58,892,128 (GRCm39) |
E188G |
probably damaging |
Het |
| Chad |
C |
T |
11: 94,459,052 (GRCm39) |
A318V |
probably benign |
Het |
| Cntfr |
A |
G |
4: 41,663,534 (GRCm39) |
|
probably null |
Het |
| Dnah17 |
C |
T |
11: 118,010,628 (GRCm39) |
C230Y |
probably benign |
Het |
| Dnmt3l |
C |
A |
10: 77,899,130 (GRCm39) |
L110I |
probably damaging |
Het |
| Dusp11 |
T |
C |
6: 85,935,651 (GRCm39) |
D74G |
probably damaging |
Het |
| Duxf4 |
T |
C |
10: 58,072,073 (GRCm39) |
D47G |
possibly damaging |
Het |
| Eif3m |
T |
C |
2: 104,837,141 (GRCm39) |
T61A |
probably damaging |
Het |
| Esyt1 |
T |
A |
10: 128,357,973 (GRCm39) |
D212V |
probably damaging |
Het |
| Exoc4 |
T |
A |
6: 33,324,760 (GRCm39) |
N351K |
possibly damaging |
Het |
| F13a1 |
A |
T |
13: 37,172,831 (GRCm39) |
I183N |
probably damaging |
Het |
| Fam83f |
T |
G |
15: 80,576,468 (GRCm39) |
V373G |
possibly damaging |
Het |
| Fam83h |
A |
T |
15: 75,874,146 (GRCm39) |
Y1064N |
probably damaging |
Het |
| Flrt3 |
G |
T |
2: 140,503,423 (GRCm39) |
N68K |
probably damaging |
Het |
| Fut7 |
C |
A |
2: 25,315,343 (GRCm39) |
Y153* |
probably null |
Het |
| Gm10277 |
TC |
T |
11: 77,676,828 (GRCm39) |
|
probably null |
Het |
| Gm1527 |
T |
C |
3: 28,972,098 (GRCm39) |
L405P |
probably benign |
Het |
| Heatr6 |
T |
A |
11: 83,648,281 (GRCm39) |
|
probably benign |
Het |
| Herc2 |
T |
C |
7: 55,835,576 (GRCm39) |
|
probably benign |
Het |
| Ints14 |
T |
G |
9: 64,887,077 (GRCm39) |
L336R |
probably damaging |
Het |
| Irak1 |
G |
T |
X: 73,066,218 (GRCm39) |
P197Q |
possibly damaging |
Het |
| Kat7 |
C |
T |
11: 95,194,120 (GRCm39) |
R60Q |
probably benign |
Het |
| Katnal2 |
T |
C |
18: 77,067,787 (GRCm39) |
R385G |
probably damaging |
Het |
| Kif4 |
A |
G |
X: 99,709,323 (GRCm39) |
S315G |
probably benign |
Het |
| Kifc3 |
A |
G |
8: 95,835,341 (GRCm39) |
Y178H |
probably damaging |
Het |
| Krit1 |
A |
T |
5: 3,872,108 (GRCm39) |
R378* |
probably null |
Het |
| L3mbtl1 |
T |
A |
2: 162,801,990 (GRCm39) |
|
probably null |
Het |
| Lama3 |
C |
A |
18: 12,535,906 (GRCm39) |
T204N |
possibly damaging |
Het |
| Lama5 |
A |
G |
2: 179,828,678 (GRCm39) |
C2090R |
probably damaging |
Het |
| Mb |
G |
T |
15: 76,906,759 (GRCm39) |
Q9K |
probably benign |
Het |
| Mipep |
T |
C |
14: 61,024,829 (GRCm39) |
V90A |
probably damaging |
Het |
| Myo3a |
A |
T |
2: 22,250,342 (GRCm39) |
I70F |
probably damaging |
Het |
| Napa |
A |
G |
7: 15,848,134 (GRCm39) |
D217G |
possibly damaging |
Het |
| Nectin2 |
T |
C |
7: 19,451,489 (GRCm39) |
D515G |
probably damaging |
Het |
| Nkx2-6 |
T |
A |
14: 69,409,288 (GRCm39) |
V13E |
probably damaging |
Het |
| Nmi |
T |
C |
2: 51,838,719 (GRCm39) |
T272A |
probably benign |
Het |
| Nptx2 |
G |
C |
5: 144,492,216 (GRCm39) |
G331A |
probably damaging |
Het |
| Or2q1 |
A |
G |
6: 42,794,431 (GRCm39) |
T9A |
possibly damaging |
Het |
| Or4c122 |
T |
C |
2: 89,079,874 (GRCm39) |
I55V |
probably damaging |
Het |
| Or5h17 |
T |
C |
16: 58,820,783 (GRCm39) |
L245P |
possibly damaging |
Het |
| Or7g34 |
T |
C |
9: 19,478,618 (GRCm39) |
T18A |
probably benign |
Het |
| Parp14 |
T |
C |
16: 35,678,904 (GRCm39) |
T355A |
probably benign |
Het |
| Pcdh12 |
T |
C |
18: 38,417,039 (GRCm39) |
T29A |
probably damaging |
Het |
| Pced1b |
T |
A |
15: 97,282,505 (GRCm39) |
C181* |
probably null |
Het |
| Phka1 |
C |
T |
X: 101,653,807 (GRCm39) |
R290H |
probably damaging |
Het |
| Pick1 |
T |
A |
15: 79,139,781 (GRCm39) |
|
probably benign |
Het |
| Pitrm1 |
A |
T |
13: 6,607,809 (GRCm39) |
Y268F |
probably damaging |
Het |
| Polr2h |
T |
C |
16: 20,537,737 (GRCm39) |
|
probably benign |
Het |
| Ppfia2 |
A |
T |
10: 106,597,972 (GRCm39) |
K178N |
probably damaging |
Het |
| Prkag1 |
T |
C |
15: 98,712,433 (GRCm39) |
Y133C |
probably damaging |
Het |
| Ptk2 |
A |
G |
15: 73,114,255 (GRCm39) |
V701A |
possibly damaging |
Het |
| Ptpra |
G |
T |
2: 130,381,655 (GRCm39) |
R372L |
probably damaging |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Qrich2 |
A |
G |
11: 116,337,982 (GRCm39) |
V1887A |
probably damaging |
Het |
| Ralgapa1 |
T |
C |
12: 55,833,134 (GRCm39) |
|
probably null |
Het |
| Rassf9 |
A |
G |
10: 102,380,806 (GRCm39) |
T63A |
probably benign |
Het |
| Rdh11 |
G |
T |
12: 79,222,996 (GRCm39) |
Q292K |
probably benign |
Het |
| Rere |
C |
A |
4: 150,697,018 (GRCm39) |
|
probably benign |
Het |
| Rgs18 |
G |
T |
1: 144,629,629 (GRCm39) |
T210K |
possibly damaging |
Het |
| Rnf213 |
A |
G |
11: 119,318,839 (GRCm39) |
N1099S |
probably benign |
Het |
| Ros1 |
T |
C |
10: 52,004,651 (GRCm39) |
I969V |
probably benign |
Het |
| Rrh |
T |
C |
3: 129,604,336 (GRCm39) |
I288M |
probably damaging |
Het |
| Rrp12 |
C |
T |
19: 41,879,533 (GRCm39) |
V174I |
probably benign |
Het |
| Rtf1 |
T |
A |
2: 119,535,999 (GRCm39) |
H184Q |
probably benign |
Het |
| Sbk3 |
A |
G |
7: 4,970,415 (GRCm39) |
L318S |
possibly damaging |
Het |
| Scn9a |
T |
C |
2: 66,314,396 (GRCm39) |
E1774G |
probably damaging |
Het |
| Sec11c |
A |
T |
18: 65,933,720 (GRCm39) |
T9S |
probably benign |
Het |
| Sec23ip |
G |
A |
7: 128,364,185 (GRCm39) |
V488I |
probably benign |
Het |
| Serpine3 |
T |
C |
14: 62,910,459 (GRCm39) |
L184P |
probably damaging |
Het |
| Slc26a2 |
T |
C |
18: 61,331,896 (GRCm39) |
T512A |
possibly damaging |
Het |
| Slc49a4 |
T |
C |
16: 35,518,309 (GRCm39) |
D468G |
probably benign |
Het |
| Smpd4 |
T |
C |
16: 17,444,729 (GRCm39) |
Y118H |
probably benign |
Het |
| Tcof1 |
T |
C |
18: 60,965,857 (GRCm39) |
E415G |
possibly damaging |
Het |
| Ttc33 |
G |
A |
15: 5,241,534 (GRCm39) |
V120I |
probably benign |
Het |
| Usp20 |
T |
A |
2: 30,906,317 (GRCm39) |
C562S |
probably damaging |
Het |
| Utp20 |
T |
C |
10: 88,621,865 (GRCm39) |
D1136G |
probably benign |
Het |
| Vgll1 |
A |
C |
X: 56,137,790 (GRCm39) |
K53T |
probably damaging |
Het |
| Yars1 |
T |
G |
4: 129,101,716 (GRCm39) |
|
probably null |
Het |
| Zfp472 |
A |
G |
17: 33,196,988 (GRCm39) |
I354M |
possibly damaging |
Het |
| Zfp786 |
A |
G |
6: 47,803,931 (GRCm39) |
V37A |
probably damaging |
Het |
|
| Other mutations in Kcnt2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00561:Kcnt2
|
APN |
1 |
140,450,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00673:Kcnt2
|
APN |
1 |
140,523,789 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
IGL00806:Kcnt2
|
APN |
1 |
140,450,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01135:Kcnt2
|
APN |
1 |
140,282,293 (GRCm39) |
critical splice donor site |
probably null |
0.00 |
|
IGL01412:Kcnt2
|
APN |
1 |
140,498,155 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01777:Kcnt2
|
APN |
1 |
140,523,736 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL01780:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02134:Kcnt2
|
APN |
1 |
140,304,121 (GRCm39) |
missense |
probably benign |
|
|
IGL02350:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02357:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02481:Kcnt2
|
APN |
1 |
140,282,299 (GRCm39) |
splice site |
probably benign |
|
|
IGL02483:Kcnt2
|
APN |
1 |
140,282,299 (GRCm39) |
splice site |
probably benign |
|
|
IGL02866:Kcnt2
|
APN |
1 |
140,352,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02891:Kcnt2
|
APN |
1 |
140,502,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03007:Kcnt2
|
APN |
1 |
140,282,245 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03024:Kcnt2
|
APN |
1 |
140,498,193 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03231:Kcnt2
|
APN |
1 |
140,461,740 (GRCm39) |
intron |
probably benign |
|
|
BB002:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
BB012:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
R0230:Kcnt2
|
UTSW |
1 |
140,174,083 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0367:Kcnt2
|
UTSW |
1 |
140,278,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Kcnt2
|
UTSW |
1 |
140,437,218 (GRCm39) |
nonsense |
probably null |
|
|
R0543:Kcnt2
|
UTSW |
1 |
140,537,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0849:Kcnt2
|
UTSW |
1 |
140,435,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1123:Kcnt2
|
UTSW |
1 |
140,501,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1156:Kcnt2
|
UTSW |
1 |
140,356,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1425:Kcnt2
|
UTSW |
1 |
140,310,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1530:Kcnt2
|
UTSW |
1 |
140,411,970 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Kcnt2
|
UTSW |
1 |
140,359,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1728:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1730:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1739:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1762:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1783:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1784:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1785:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1862:Kcnt2
|
UTSW |
1 |
140,353,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1887:Kcnt2
|
UTSW |
1 |
140,511,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1889:Kcnt2
|
UTSW |
1 |
140,512,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Kcnt2
|
UTSW |
1 |
140,353,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2005:Kcnt2
|
UTSW |
1 |
140,480,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2044:Kcnt2
|
UTSW |
1 |
140,302,892 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2135:Kcnt2
|
UTSW |
1 |
140,356,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Kcnt2
|
UTSW |
1 |
140,437,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2212:Kcnt2
|
UTSW |
1 |
140,458,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2267:Kcnt2
|
UTSW |
1 |
140,501,421 (GRCm39) |
splice site |
probably null |
|
|
R2442:Kcnt2
|
UTSW |
1 |
140,304,091 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R3121:Kcnt2
|
UTSW |
1 |
140,356,622 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3176:Kcnt2
|
UTSW |
1 |
140,537,377 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3276:Kcnt2
|
UTSW |
1 |
140,537,377 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3704:Kcnt2
|
UTSW |
1 |
140,461,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Kcnt2
|
UTSW |
1 |
140,512,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Kcnt2
|
UTSW |
1 |
140,537,368 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4201:Kcnt2
|
UTSW |
1 |
140,353,070 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4501:Kcnt2
|
UTSW |
1 |
140,480,718 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4502:Kcnt2
|
UTSW |
1 |
140,435,485 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4632:Kcnt2
|
UTSW |
1 |
140,450,886 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4758:Kcnt2
|
UTSW |
1 |
140,446,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4790:Kcnt2
|
UTSW |
1 |
140,282,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4892:Kcnt2
|
UTSW |
1 |
140,440,763 (GRCm39) |
nonsense |
probably null |
|
|
R4973:Kcnt2
|
UTSW |
1 |
140,537,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5154:Kcnt2
|
UTSW |
1 |
140,278,994 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5296:Kcnt2
|
UTSW |
1 |
140,537,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5353:Kcnt2
|
UTSW |
1 |
140,354,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Kcnt2
|
UTSW |
1 |
140,502,481 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R5806:Kcnt2
|
UTSW |
1 |
140,437,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5887:Kcnt2
|
UTSW |
1 |
140,353,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5917:Kcnt2
|
UTSW |
1 |
140,461,666 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5961:Kcnt2
|
UTSW |
1 |
140,435,440 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6123:Kcnt2
|
UTSW |
1 |
140,290,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6225:Kcnt2
|
UTSW |
1 |
140,354,661 (GRCm39) |
nonsense |
probably null |
|
|
R6248:Kcnt2
|
UTSW |
1 |
140,437,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6351:Kcnt2
|
UTSW |
1 |
140,302,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6380:Kcnt2
|
UTSW |
1 |
140,437,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6532:Kcnt2
|
UTSW |
1 |
140,511,844 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6693:Kcnt2
|
UTSW |
1 |
140,278,965 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6817:Kcnt2
|
UTSW |
1 |
140,173,931 (GRCm39) |
unclassified |
probably benign |
|
|
R6856:Kcnt2
|
UTSW |
1 |
140,523,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6944:Kcnt2
|
UTSW |
1 |
140,511,803 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6971:Kcnt2
|
UTSW |
1 |
140,440,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7052:Kcnt2
|
UTSW |
1 |
140,310,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7138:Kcnt2
|
UTSW |
1 |
140,523,778 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7261:Kcnt2
|
UTSW |
1 |
140,282,255 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7474:Kcnt2
|
UTSW |
1 |
140,498,216 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7524:Kcnt2
|
UTSW |
1 |
140,511,793 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7541:Kcnt2
|
UTSW |
1 |
140,304,122 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7558:Kcnt2
|
UTSW |
1 |
140,450,928 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7651:Kcnt2
|
UTSW |
1 |
140,498,199 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7730:Kcnt2
|
UTSW |
1 |
140,446,686 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7875:Kcnt2
|
UTSW |
1 |
140,501,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7883:Kcnt2
|
UTSW |
1 |
140,450,888 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7925:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
R8040:Kcnt2
|
UTSW |
1 |
140,377,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8041:Kcnt2
|
UTSW |
1 |
140,537,398 (GRCm39) |
missense |
probably benign |
|
|
R8171:Kcnt2
|
UTSW |
1 |
140,437,203 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8268:Kcnt2
|
UTSW |
1 |
140,450,954 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8905:Kcnt2
|
UTSW |
1 |
140,435,467 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8927:Kcnt2
|
UTSW |
1 |
140,356,535 (GRCm39) |
splice site |
probably null |
|
|
R8988:Kcnt2
|
UTSW |
1 |
140,356,587 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9020:Kcnt2
|
UTSW |
1 |
140,512,049 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9109:Kcnt2
|
UTSW |
1 |
140,353,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9167:Kcnt2
|
UTSW |
1 |
140,506,200 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9232:Kcnt2
|
UTSW |
1 |
140,411,931 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9297:Kcnt2
|
UTSW |
1 |
140,352,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9298:Kcnt2
|
UTSW |
1 |
140,353,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9318:Kcnt2
|
UTSW |
1 |
140,352,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9404:Kcnt2
|
UTSW |
1 |
140,353,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Kcnt2
|
UTSW |
1 |
140,440,729 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
Z1088:Kcnt2
|
UTSW |
1 |
140,511,896 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Kcnt2
|
UTSW |
1 |
140,501,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Kcnt2
|
UTSW |
1 |
140,304,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Kcnt2
|
UTSW |
1 |
140,537,386 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCCTCACAGTACTAACATGTTGG -3'
(R):5'- ATGACTGCAGCAGGAAATCACC -3'
Sequencing Primer
(F):5'- GGTAGTGCCTGCTATTATAAT -3'
(R):5'- CAGGAAATCACCAAAGTGTGTTATTC -3'
|
| Posted On |
2014-09-18 |
Incidental Mutation