Incidental Mutation 'R2115:Akna'
ID 233009
Institutional Source Beutler Lab
Gene Symbol Akna
Ensembl Gene ENSMUSG00000039158
Gene Name AT-hook transcription factor
Synonyms
MMRRC Submission 040119-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R2115 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 63285362-63321591 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 63313397 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 242 (P242L)
Ref Sequence ENSEMBL: ENSMUSP00000041614 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035724]
AlphaFold Q80VW7
Predicted Effect probably benign
Transcript: ENSMUST00000035724
AA Change: P242L

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000041614
Gene: ENSMUSG00000039158
AA Change: P242L

DomainStartEndE-ValueType
low complexity region 140 153 N/A INTRINSIC
coiled coil region 423 458 N/A INTRINSIC
Pfam:AKNA 584 681 4.6e-37 PFAM
low complexity region 760 774 N/A INTRINSIC
low complexity region 1015 1029 N/A INTRINSIC
coiled coil region 1044 1066 N/A INTRINSIC
low complexity region 1296 1317 N/A INTRINSIC
low complexity region 1319 1343 N/A INTRINSIC
coiled coil region 1353 1386 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144095
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 98% (95/97)
MGI Phenotype PHENOTYPE: Mice homozygous for a hypomorphic or a knock-out allele exhibit partial postnatal lethality, pathogen-induced acute neutrophil responses leading to systemic inflammation and alveolar destruction, and increased susceptibility to fungal infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 93 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk T C 11: 119,900,562 (GRCm39) T1195A probably benign Het
Abca12 A T 1: 71,283,930 (GRCm39) N2547K probably benign Het
Abca16 A C 7: 120,139,868 (GRCm39) E1510A probably damaging Het
Adam5 A G 8: 25,234,161 (GRCm39) probably benign Het
Akr1b7 G A 6: 34,395,929 (GRCm39) A144T possibly damaging Het
Ankhd1 T A 18: 36,767,361 (GRCm39) S1167T probably damaging Het
Arf5 C T 6: 28,424,783 (GRCm39) Q71* probably null Het
Ark2n T C 18: 77,762,168 (GRCm39) D48G possibly damaging Het
Arl15 C T 13: 114,104,196 (GRCm39) S111F probably damaging Het
Atxn1l C T 8: 110,459,240 (GRCm39) A341T probably benign Het
Birc7 C A 2: 180,572,642 (GRCm39) Q138K possibly damaging Het
Blvra G T 2: 126,927,989 (GRCm39) E80* probably null Het
Ccdc148 T C 2: 58,892,128 (GRCm39) E188G probably damaging Het
Chad C T 11: 94,459,052 (GRCm39) A318V probably benign Het
Cntfr A G 4: 41,663,534 (GRCm39) probably null Het
Dnah17 C T 11: 118,010,628 (GRCm39) C230Y probably benign Het
Dnmt3l C A 10: 77,899,130 (GRCm39) L110I probably damaging Het
Dusp11 T C 6: 85,935,651 (GRCm39) D74G probably damaging Het
Duxf4 T C 10: 58,072,073 (GRCm39) D47G possibly damaging Het
Eif3m T C 2: 104,837,141 (GRCm39) T61A probably damaging Het
Esyt1 T A 10: 128,357,973 (GRCm39) D212V probably damaging Het
Exoc4 T A 6: 33,324,760 (GRCm39) N351K possibly damaging Het
F13a1 A T 13: 37,172,831 (GRCm39) I183N probably damaging Het
Fam83f T G 15: 80,576,468 (GRCm39) V373G possibly damaging Het
Fam83h A T 15: 75,874,146 (GRCm39) Y1064N probably damaging Het
Flrt3 G T 2: 140,503,423 (GRCm39) N68K probably damaging Het
Fut7 C A 2: 25,315,343 (GRCm39) Y153* probably null Het
Gm10277 TC T 11: 77,676,828 (GRCm39) probably null Het
Gm1527 T C 3: 28,972,098 (GRCm39) L405P probably benign Het
Heatr6 T A 11: 83,648,281 (GRCm39) probably benign Het
Herc2 T C 7: 55,835,576 (GRCm39) probably benign Het
Ints14 T G 9: 64,887,077 (GRCm39) L336R probably damaging Het
Irak1 G T X: 73,066,218 (GRCm39) P197Q possibly damaging Het
Kat7 C T 11: 95,194,120 (GRCm39) R60Q probably benign Het
Katnal2 T C 18: 77,067,787 (GRCm39) R385G probably damaging Het
Kcnt2 G T 1: 140,480,701 (GRCm39) L755F probably damaging Het
Kif4 A G X: 99,709,323 (GRCm39) S315G probably benign Het
Kifc3 A G 8: 95,835,341 (GRCm39) Y178H probably damaging Het
Krit1 A T 5: 3,872,108 (GRCm39) R378* probably null Het
L3mbtl1 T A 2: 162,801,990 (GRCm39) probably null Het
Lama3 C A 18: 12,535,906 (GRCm39) T204N possibly damaging Het
Lama5 A G 2: 179,828,678 (GRCm39) C2090R probably damaging Het
Mb G T 15: 76,906,759 (GRCm39) Q9K probably benign Het
Mipep T C 14: 61,024,829 (GRCm39) V90A probably damaging Het
Myo3a A T 2: 22,250,342 (GRCm39) I70F probably damaging Het
Napa A G 7: 15,848,134 (GRCm39) D217G possibly damaging Het
Nectin2 T C 7: 19,451,489 (GRCm39) D515G probably damaging Het
Nkx2-6 T A 14: 69,409,288 (GRCm39) V13E probably damaging Het
Nmi T C 2: 51,838,719 (GRCm39) T272A probably benign Het
Nptx2 G C 5: 144,492,216 (GRCm39) G331A probably damaging Het
Or2q1 A G 6: 42,794,431 (GRCm39) T9A possibly damaging Het
Or4c122 T C 2: 89,079,874 (GRCm39) I55V probably damaging Het
Or5h17 T C 16: 58,820,783 (GRCm39) L245P possibly damaging Het
Or7g34 T C 9: 19,478,618 (GRCm39) T18A probably benign Het
Parp14 T C 16: 35,678,904 (GRCm39) T355A probably benign Het
Pcdh12 T C 18: 38,417,039 (GRCm39) T29A probably damaging Het
Pced1b T A 15: 97,282,505 (GRCm39) C181* probably null Het
Phka1 C T X: 101,653,807 (GRCm39) R290H probably damaging Het
Pick1 T A 15: 79,139,781 (GRCm39) probably benign Het
Pitrm1 A T 13: 6,607,809 (GRCm39) Y268F probably damaging Het
Polr2h T C 16: 20,537,737 (GRCm39) probably benign Het
Ppfia2 A T 10: 106,597,972 (GRCm39) K178N probably damaging Het
Prkag1 T C 15: 98,712,433 (GRCm39) Y133C probably damaging Het
Ptk2 A G 15: 73,114,255 (GRCm39) V701A possibly damaging Het
Ptpra G T 2: 130,381,655 (GRCm39) R372L probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Qrich2 A G 11: 116,337,982 (GRCm39) V1887A probably damaging Het
Ralgapa1 T C 12: 55,833,134 (GRCm39) probably null Het
Rassf9 A G 10: 102,380,806 (GRCm39) T63A probably benign Het
Rdh11 G T 12: 79,222,996 (GRCm39) Q292K probably benign Het
Rere C A 4: 150,697,018 (GRCm39) probably benign Het
Rgs18 G T 1: 144,629,629 (GRCm39) T210K possibly damaging Het
Rnf213 A G 11: 119,318,839 (GRCm39) N1099S probably benign Het
Ros1 T C 10: 52,004,651 (GRCm39) I969V probably benign Het
Rrh T C 3: 129,604,336 (GRCm39) I288M probably damaging Het
Rrp12 C T 19: 41,879,533 (GRCm39) V174I probably benign Het
Rtf1 T A 2: 119,535,999 (GRCm39) H184Q probably benign Het
Sbk3 A G 7: 4,970,415 (GRCm39) L318S possibly damaging Het
Scn9a T C 2: 66,314,396 (GRCm39) E1774G probably damaging Het
Sec11c A T 18: 65,933,720 (GRCm39) T9S probably benign Het
Sec23ip G A 7: 128,364,185 (GRCm39) V488I probably benign Het
Serpine3 T C 14: 62,910,459 (GRCm39) L184P probably damaging Het
Slc26a2 T C 18: 61,331,896 (GRCm39) T512A possibly damaging Het
Slc49a4 T C 16: 35,518,309 (GRCm39) D468G probably benign Het
Smpd4 T C 16: 17,444,729 (GRCm39) Y118H probably benign Het
Tcof1 T C 18: 60,965,857 (GRCm39) E415G possibly damaging Het
Ttc33 G A 15: 5,241,534 (GRCm39) V120I probably benign Het
Usp20 T A 2: 30,906,317 (GRCm39) C562S probably damaging Het
Utp20 T C 10: 88,621,865 (GRCm39) D1136G probably benign Het
Vgll1 A C X: 56,137,790 (GRCm39) K53T probably damaging Het
Yars1 T G 4: 129,101,716 (GRCm39) probably null Het
Zfp472 A G 17: 33,196,988 (GRCm39) I354M possibly damaging Het
Zfp786 A G 6: 47,803,931 (GRCm39) V37A probably damaging Het
Other mutations in Akna
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00533:Akna APN 4 63,316,110 (GRCm39) critical splice donor site probably null
IGL00590:Akna APN 4 63,290,115 (GRCm39) missense probably benign 0.00
IGL01567:Akna APN 4 63,300,087 (GRCm39) missense probably benign
IGL01667:Akna APN 4 63,297,396 (GRCm39) missense probably benign 0.34
IGL01820:Akna APN 4 63,304,495 (GRCm39) missense probably benign 0.30
IGL01956:Akna APN 4 63,297,527 (GRCm39) missense probably benign 0.04
IGL02148:Akna APN 4 63,300,716 (GRCm39) splice site probably benign
IGL02502:Akna APN 4 63,286,440 (GRCm39) missense probably benign 0.28
IGL02674:Akna APN 4 63,289,181 (GRCm39) nonsense probably null
IGL02792:Akna APN 4 63,295,943 (GRCm39) missense possibly damaging 0.73
IGL02956:Akna APN 4 63,304,516 (GRCm39) missense probably benign 0.05
R0035:Akna UTSW 4 63,300,682 (GRCm39) missense probably benign 0.16
R0049:Akna UTSW 4 63,312,872 (GRCm39) missense probably damaging 0.97
R0133:Akna UTSW 4 63,297,598 (GRCm39) nonsense probably null
R0396:Akna UTSW 4 63,310,363 (GRCm39) splice site probably benign
R0422:Akna UTSW 4 63,310,391 (GRCm39) missense probably damaging 1.00
R0578:Akna UTSW 4 63,289,147 (GRCm39) missense probably benign
R0784:Akna UTSW 4 63,295,125 (GRCm39) missense probably benign
R1264:Akna UTSW 4 63,299,962 (GRCm39) splice site probably null
R1539:Akna UTSW 4 63,297,547 (GRCm39) missense probably benign 0.00
R1575:Akna UTSW 4 63,297,570 (GRCm39) missense probably benign 0.01
R1646:Akna UTSW 4 63,302,129 (GRCm39) missense probably benign
R2121:Akna UTSW 4 63,295,137 (GRCm39) missense probably benign 0.08
R2324:Akna UTSW 4 63,290,039 (GRCm39) missense possibly damaging 0.92
R2961:Akna UTSW 4 63,313,181 (GRCm39) missense probably benign 0.04
R3150:Akna UTSW 4 63,313,590 (GRCm39) missense possibly damaging 0.80
R3552:Akna UTSW 4 63,316,361 (GRCm39) start codon destroyed probably null 0.53
R3855:Akna UTSW 4 63,291,705 (GRCm39) missense probably damaging 0.98
R4023:Akna UTSW 4 63,292,627 (GRCm39) missense probably benign
R4247:Akna UTSW 4 63,313,409 (GRCm39) missense probably benign 0.00
R4299:Akna UTSW 4 63,316,269 (GRCm39) missense possibly damaging 0.59
R4422:Akna UTSW 4 63,305,330 (GRCm39) missense possibly damaging 0.86
R4499:Akna UTSW 4 63,313,278 (GRCm39) missense probably benign
R4723:Akna UTSW 4 63,305,269 (GRCm39) missense probably benign
R4743:Akna UTSW 4 63,296,850 (GRCm39) missense probably damaging 1.00
R4780:Akna UTSW 4 63,297,491 (GRCm39) missense probably benign
R4903:Akna UTSW 4 63,292,274 (GRCm39) missense probably damaging 1.00
R4936:Akna UTSW 4 63,313,502 (GRCm39) missense probably damaging 0.97
R5041:Akna UTSW 4 63,305,381 (GRCm39) missense possibly damaging 0.67
R5276:Akna UTSW 4 63,286,440 (GRCm39) missense possibly damaging 0.95
R5297:Akna UTSW 4 63,300,083 (GRCm39) missense possibly damaging 0.93
R5546:Akna UTSW 4 63,313,803 (GRCm39) missense probably benign
R5546:Akna UTSW 4 63,313,196 (GRCm39) missense probably benign 0.15
R5773:Akna UTSW 4 63,313,307 (GRCm39) missense probably benign 0.41
R5966:Akna UTSW 4 63,313,140 (GRCm39) missense probably damaging 0.99
R6127:Akna UTSW 4 63,286,356 (GRCm39) missense possibly damaging 0.67
R6176:Akna UTSW 4 63,295,969 (GRCm39) missense probably benign 0.04
R6337:Akna UTSW 4 63,292,240 (GRCm39) missense probably benign 0.00
R6701:Akna UTSW 4 63,313,517 (GRCm39) missense probably benign
R6800:Akna UTSW 4 63,316,268 (GRCm39) missense probably benign
R6931:Akna UTSW 4 63,305,339 (GRCm39) missense probably benign 0.02
R7451:Akna UTSW 4 63,296,904 (GRCm39) missense probably benign 0.16
R7644:Akna UTSW 4 63,313,634 (GRCm39) missense possibly damaging 0.48
R7786:Akna UTSW 4 63,313,199 (GRCm39) missense probably benign
R8182:Akna UTSW 4 63,313,034 (GRCm39) missense probably damaging 1.00
R9136:Akna UTSW 4 63,310,392 (GRCm39) missense probably damaging 1.00
R9178:Akna UTSW 4 63,312,846 (GRCm39) missense possibly damaging 0.95
R9563:Akna UTSW 4 63,312,944 (GRCm39) missense probably damaging 1.00
R9687:Akna UTSW 4 63,292,674 (GRCm39) nonsense probably null
R9768:Akna UTSW 4 63,292,636 (GRCm39) missense probably benign
RF048:Akna UTSW 4 63,296,078 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- TATTGCCCCAAGCCGAGTAC -3'
(R):5'- CTGTTGAACATAGCCGCAC -3'

Sequencing Primer
(F):5'- TACTCAGGGGGCTGACAG -3'
(R):5'- TAGCCGCACAAAGTCTTGG -3'
Posted On 2014-09-18