Incidental Mutation 'R2115:Parp14'
| ID |
233076 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Parp14
|
| Ensembl Gene |
ENSMUSG00000034422 |
| Gene Name |
poly (ADP-ribose) polymerase family, member 14 |
| Synonyms |
CoaSt6, collaborator of Stat6, 1600029O10Rik |
| MMRRC Submission |
040119-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.466)
|
| Stock # |
R2115 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
35653244-35691914 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 35678904 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 355
(T355A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000037657
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042665]
|
| AlphaFold |
Q2EMV9 |
| PDB Structure |
Solution structure of WWE domain in Parp14 protein [SOLUTION NMR]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000042665
AA Change: T355A
PolyPhen 2
Score 0.160 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000037657
Gene: ENSMUSG00000034422
AA Change: T355A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
38 |
49 |
N/A |
INTRINSIC |
|
low complexity region
|
93 |
115 |
N/A |
INTRINSIC |
|
RRM
|
228 |
297 |
4.71e-2 |
SMART |
|
coiled coil region
|
443 |
468 |
N/A |
INTRINSIC |
|
Blast:A1pp
|
693 |
746 |
6e-6 |
BLAST |
|
low complexity region
|
771 |
795 |
N/A |
INTRINSIC |
|
A1pp
|
814 |
948 |
7.62e-41 |
SMART |
|
A1pp
|
1026 |
1160 |
5.88e-24 |
SMART |
|
A1pp
|
1239 |
1358 |
6.82e-20 |
SMART |
|
PDB:1X4R|A
|
1532 |
1619 |
9e-53 |
PDB |
|
Pfam:PARP
|
1632 |
1817 |
2.5e-29 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142946
|
| Meta Mutation Damage Score |
0.1406 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
98% (95/97) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit altered B cell subsets and inability to respond to the apoptosis protective affects of IL4. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aatk |
T |
C |
11: 119,900,562 (GRCm39) |
T1195A |
probably benign |
Het |
| Abca12 |
A |
T |
1: 71,283,930 (GRCm39) |
N2547K |
probably benign |
Het |
| Abca16 |
A |
C |
7: 120,139,868 (GRCm39) |
E1510A |
probably damaging |
Het |
| Adam5 |
A |
G |
8: 25,234,161 (GRCm39) |
|
probably benign |
Het |
| Akna |
G |
A |
4: 63,313,397 (GRCm39) |
P242L |
probably benign |
Het |
| Akr1b7 |
G |
A |
6: 34,395,929 (GRCm39) |
A144T |
possibly damaging |
Het |
| Ankhd1 |
T |
A |
18: 36,767,361 (GRCm39) |
S1167T |
probably damaging |
Het |
| Arf5 |
C |
T |
6: 28,424,783 (GRCm39) |
Q71* |
probably null |
Het |
| Ark2n |
T |
C |
18: 77,762,168 (GRCm39) |
D48G |
possibly damaging |
Het |
| Arl15 |
C |
T |
13: 114,104,196 (GRCm39) |
S111F |
probably damaging |
Het |
| Atxn1l |
C |
T |
8: 110,459,240 (GRCm39) |
A341T |
probably benign |
Het |
| Birc7 |
C |
A |
2: 180,572,642 (GRCm39) |
Q138K |
possibly damaging |
Het |
| Blvra |
G |
T |
2: 126,927,989 (GRCm39) |
E80* |
probably null |
Het |
| Ccdc148 |
T |
C |
2: 58,892,128 (GRCm39) |
E188G |
probably damaging |
Het |
| Chad |
C |
T |
11: 94,459,052 (GRCm39) |
A318V |
probably benign |
Het |
| Cntfr |
A |
G |
4: 41,663,534 (GRCm39) |
|
probably null |
Het |
| Dnah17 |
C |
T |
11: 118,010,628 (GRCm39) |
C230Y |
probably benign |
Het |
| Dnmt3l |
C |
A |
10: 77,899,130 (GRCm39) |
L110I |
probably damaging |
Het |
| Dusp11 |
T |
C |
6: 85,935,651 (GRCm39) |
D74G |
probably damaging |
Het |
| Duxf4 |
T |
C |
10: 58,072,073 (GRCm39) |
D47G |
possibly damaging |
Het |
| Eif3m |
T |
C |
2: 104,837,141 (GRCm39) |
T61A |
probably damaging |
Het |
| Esyt1 |
T |
A |
10: 128,357,973 (GRCm39) |
D212V |
probably damaging |
Het |
| Exoc4 |
T |
A |
6: 33,324,760 (GRCm39) |
N351K |
possibly damaging |
Het |
| F13a1 |
A |
T |
13: 37,172,831 (GRCm39) |
I183N |
probably damaging |
Het |
| Fam83f |
T |
G |
15: 80,576,468 (GRCm39) |
V373G |
possibly damaging |
Het |
| Fam83h |
A |
T |
15: 75,874,146 (GRCm39) |
Y1064N |
probably damaging |
Het |
| Flrt3 |
G |
T |
2: 140,503,423 (GRCm39) |
N68K |
probably damaging |
Het |
| Fut7 |
C |
A |
2: 25,315,343 (GRCm39) |
Y153* |
probably null |
Het |
| Gm10277 |
TC |
T |
11: 77,676,828 (GRCm39) |
|
probably null |
Het |
| Gm1527 |
T |
C |
3: 28,972,098 (GRCm39) |
L405P |
probably benign |
Het |
| Heatr6 |
T |
A |
11: 83,648,281 (GRCm39) |
|
probably benign |
Het |
| Herc2 |
T |
C |
7: 55,835,576 (GRCm39) |
|
probably benign |
Het |
| Ints14 |
T |
G |
9: 64,887,077 (GRCm39) |
L336R |
probably damaging |
Het |
| Irak1 |
G |
T |
X: 73,066,218 (GRCm39) |
P197Q |
possibly damaging |
Het |
| Kat7 |
C |
T |
11: 95,194,120 (GRCm39) |
R60Q |
probably benign |
Het |
| Katnal2 |
T |
C |
18: 77,067,787 (GRCm39) |
R385G |
probably damaging |
Het |
| Kcnt2 |
G |
T |
1: 140,480,701 (GRCm39) |
L755F |
probably damaging |
Het |
| Kif4 |
A |
G |
X: 99,709,323 (GRCm39) |
S315G |
probably benign |
Het |
| Kifc3 |
A |
G |
8: 95,835,341 (GRCm39) |
Y178H |
probably damaging |
Het |
| Krit1 |
A |
T |
5: 3,872,108 (GRCm39) |
R378* |
probably null |
Het |
| L3mbtl1 |
T |
A |
2: 162,801,990 (GRCm39) |
|
probably null |
Het |
| Lama3 |
C |
A |
18: 12,535,906 (GRCm39) |
T204N |
possibly damaging |
Het |
| Lama5 |
A |
G |
2: 179,828,678 (GRCm39) |
C2090R |
probably damaging |
Het |
| Mb |
G |
T |
15: 76,906,759 (GRCm39) |
Q9K |
probably benign |
Het |
| Mipep |
T |
C |
14: 61,024,829 (GRCm39) |
V90A |
probably damaging |
Het |
| Myo3a |
A |
T |
2: 22,250,342 (GRCm39) |
I70F |
probably damaging |
Het |
| Napa |
A |
G |
7: 15,848,134 (GRCm39) |
D217G |
possibly damaging |
Het |
| Nectin2 |
T |
C |
7: 19,451,489 (GRCm39) |
D515G |
probably damaging |
Het |
| Nkx2-6 |
T |
A |
14: 69,409,288 (GRCm39) |
V13E |
probably damaging |
Het |
| Nmi |
T |
C |
2: 51,838,719 (GRCm39) |
T272A |
probably benign |
Het |
| Nptx2 |
G |
C |
5: 144,492,216 (GRCm39) |
G331A |
probably damaging |
Het |
| Or2q1 |
A |
G |
6: 42,794,431 (GRCm39) |
T9A |
possibly damaging |
Het |
| Or4c122 |
T |
C |
2: 89,079,874 (GRCm39) |
I55V |
probably damaging |
Het |
| Or5h17 |
T |
C |
16: 58,820,783 (GRCm39) |
L245P |
possibly damaging |
Het |
| Or7g34 |
T |
C |
9: 19,478,618 (GRCm39) |
T18A |
probably benign |
Het |
| Pcdh12 |
T |
C |
18: 38,417,039 (GRCm39) |
T29A |
probably damaging |
Het |
| Pced1b |
T |
A |
15: 97,282,505 (GRCm39) |
C181* |
probably null |
Het |
| Phka1 |
C |
T |
X: 101,653,807 (GRCm39) |
R290H |
probably damaging |
Het |
| Pick1 |
T |
A |
15: 79,139,781 (GRCm39) |
|
probably benign |
Het |
| Pitrm1 |
A |
T |
13: 6,607,809 (GRCm39) |
Y268F |
probably damaging |
Het |
| Polr2h |
T |
C |
16: 20,537,737 (GRCm39) |
|
probably benign |
Het |
| Ppfia2 |
A |
T |
10: 106,597,972 (GRCm39) |
K178N |
probably damaging |
Het |
| Prkag1 |
T |
C |
15: 98,712,433 (GRCm39) |
Y133C |
probably damaging |
Het |
| Ptk2 |
A |
G |
15: 73,114,255 (GRCm39) |
V701A |
possibly damaging |
Het |
| Ptpra |
G |
T |
2: 130,381,655 (GRCm39) |
R372L |
probably damaging |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Qrich2 |
A |
G |
11: 116,337,982 (GRCm39) |
V1887A |
probably damaging |
Het |
| Ralgapa1 |
T |
C |
12: 55,833,134 (GRCm39) |
|
probably null |
Het |
| Rassf9 |
A |
G |
10: 102,380,806 (GRCm39) |
T63A |
probably benign |
Het |
| Rdh11 |
G |
T |
12: 79,222,996 (GRCm39) |
Q292K |
probably benign |
Het |
| Rere |
C |
A |
4: 150,697,018 (GRCm39) |
|
probably benign |
Het |
| Rgs18 |
G |
T |
1: 144,629,629 (GRCm39) |
T210K |
possibly damaging |
Het |
| Rnf213 |
A |
G |
11: 119,318,839 (GRCm39) |
N1099S |
probably benign |
Het |
| Ros1 |
T |
C |
10: 52,004,651 (GRCm39) |
I969V |
probably benign |
Het |
| Rrh |
T |
C |
3: 129,604,336 (GRCm39) |
I288M |
probably damaging |
Het |
| Rrp12 |
C |
T |
19: 41,879,533 (GRCm39) |
V174I |
probably benign |
Het |
| Rtf1 |
T |
A |
2: 119,535,999 (GRCm39) |
H184Q |
probably benign |
Het |
| Sbk3 |
A |
G |
7: 4,970,415 (GRCm39) |
L318S |
possibly damaging |
Het |
| Scn9a |
T |
C |
2: 66,314,396 (GRCm39) |
E1774G |
probably damaging |
Het |
| Sec11c |
A |
T |
18: 65,933,720 (GRCm39) |
T9S |
probably benign |
Het |
| Sec23ip |
G |
A |
7: 128,364,185 (GRCm39) |
V488I |
probably benign |
Het |
| Serpine3 |
T |
C |
14: 62,910,459 (GRCm39) |
L184P |
probably damaging |
Het |
| Slc26a2 |
T |
C |
18: 61,331,896 (GRCm39) |
T512A |
possibly damaging |
Het |
| Slc49a4 |
T |
C |
16: 35,518,309 (GRCm39) |
D468G |
probably benign |
Het |
| Smpd4 |
T |
C |
16: 17,444,729 (GRCm39) |
Y118H |
probably benign |
Het |
| Tcof1 |
T |
C |
18: 60,965,857 (GRCm39) |
E415G |
possibly damaging |
Het |
| Ttc33 |
G |
A |
15: 5,241,534 (GRCm39) |
V120I |
probably benign |
Het |
| Usp20 |
T |
A |
2: 30,906,317 (GRCm39) |
C562S |
probably damaging |
Het |
| Utp20 |
T |
C |
10: 88,621,865 (GRCm39) |
D1136G |
probably benign |
Het |
| Vgll1 |
A |
C |
X: 56,137,790 (GRCm39) |
K53T |
probably damaging |
Het |
| Yars1 |
T |
G |
4: 129,101,716 (GRCm39) |
|
probably null |
Het |
| Zfp472 |
A |
G |
17: 33,196,988 (GRCm39) |
I354M |
possibly damaging |
Het |
| Zfp786 |
A |
G |
6: 47,803,931 (GRCm39) |
V37A |
probably damaging |
Het |
|
| Other mutations in Parp14 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00337:Parp14
|
APN |
16 |
35,661,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00497:Parp14
|
APN |
16 |
35,655,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00754:Parp14
|
APN |
16 |
35,659,741 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL00960:Parp14
|
APN |
16 |
35,661,589 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL01321:Parp14
|
APN |
16 |
35,676,929 (GRCm39) |
missense |
probably benign |
|
|
IGL01397:Parp14
|
APN |
16 |
35,679,098 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01591:Parp14
|
APN |
16 |
35,678,877 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL01728:Parp14
|
APN |
16 |
35,677,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01734:Parp14
|
APN |
16 |
35,678,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02156:Parp14
|
APN |
16 |
35,678,967 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02951:Parp14
|
APN |
16 |
35,678,903 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03067:Parp14
|
APN |
16 |
35,676,878 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03135:Parp14
|
APN |
16 |
35,678,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03141:Parp14
|
APN |
16 |
35,659,663 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03146:Parp14
|
APN |
16 |
35,678,823 (GRCm39) |
nonsense |
probably null |
|
|
IGL03333:Parp14
|
APN |
16 |
35,661,800 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL03391:Parp14
|
APN |
16 |
35,678,640 (GRCm39) |
missense |
probably benign |
|
|
thurston
|
UTSW |
16 |
35,664,785 (GRCm39) |
splice site |
probably benign |
|
|
PIT4585001:Parp14
|
UTSW |
16 |
35,678,975 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0306:Parp14
|
UTSW |
16 |
35,676,944 (GRCm39) |
missense |
probably benign |
|
|
R0506:Parp14
|
UTSW |
16 |
35,661,779 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0586:Parp14
|
UTSW |
16 |
35,661,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0606:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0612:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0699:Parp14
|
UTSW |
16 |
35,680,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0786:Parp14
|
UTSW |
16 |
35,661,172 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0883:Parp14
|
UTSW |
16 |
35,678,888 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0900:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1087:Parp14
|
UTSW |
16 |
35,678,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1104:Parp14
|
UTSW |
16 |
35,664,785 (GRCm39) |
splice site |
probably benign |
|
|
R1120:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1134:Parp14
|
UTSW |
16 |
35,655,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1153:Parp14
|
UTSW |
16 |
35,678,041 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1159:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1160:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1237:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1238:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1239:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1423:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1511:Parp14
|
UTSW |
16 |
35,677,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1518:Parp14
|
UTSW |
16 |
35,677,008 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1619:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1707:Parp14
|
UTSW |
16 |
35,678,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1792:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1831:Parp14
|
UTSW |
16 |
35,678,958 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1840:Parp14
|
UTSW |
16 |
35,683,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1889:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1902:Parp14
|
UTSW |
16 |
35,673,888 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1943:Parp14
|
UTSW |
16 |
35,656,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1954:Parp14
|
UTSW |
16 |
35,678,671 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2216:Parp14
|
UTSW |
16 |
35,677,575 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2519:Parp14
|
UTSW |
16 |
35,678,573 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3851:Parp14
|
UTSW |
16 |
35,674,118 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4052:Parp14
|
UTSW |
16 |
35,678,771 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4671:Parp14
|
UTSW |
16 |
35,678,691 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4867:Parp14
|
UTSW |
16 |
35,677,697 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4941:Parp14
|
UTSW |
16 |
35,666,403 (GRCm39) |
missense |
probably benign |
|
|
R4992:Parp14
|
UTSW |
16 |
35,661,512 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5055:Parp14
|
UTSW |
16 |
35,664,733 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5073:Parp14
|
UTSW |
16 |
35,655,077 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5170:Parp14
|
UTSW |
16 |
35,677,649 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5422:Parp14
|
UTSW |
16 |
35,686,545 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5543:Parp14
|
UTSW |
16 |
35,655,137 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5549:Parp14
|
UTSW |
16 |
35,661,505 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5553:Parp14
|
UTSW |
16 |
35,677,306 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5691:Parp14
|
UTSW |
16 |
35,683,909 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5774:Parp14
|
UTSW |
16 |
35,678,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5855:Parp14
|
UTSW |
16 |
35,661,297 (GRCm39) |
nonsense |
probably null |
|
|
R5942:Parp14
|
UTSW |
16 |
35,659,737 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5990:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5991:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6018:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6022:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6075:Parp14
|
UTSW |
16 |
35,677,389 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6395:Parp14
|
UTSW |
16 |
35,676,918 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6525:Parp14
|
UTSW |
16 |
35,680,811 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6683:Parp14
|
UTSW |
16 |
35,655,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Parp14
|
UTSW |
16 |
35,677,861 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8011:Parp14
|
UTSW |
16 |
35,677,004 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8192:Parp14
|
UTSW |
16 |
35,691,584 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8367:Parp14
|
UTSW |
16 |
35,678,124 (GRCm39) |
missense |
probably benign |
0.36 |
|
R8526:Parp14
|
UTSW |
16 |
35,661,307 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8751:Parp14
|
UTSW |
16 |
35,677,181 (GRCm39) |
missense |
probably benign |
0.32 |
|
R8962:Parp14
|
UTSW |
16 |
35,677,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9231:Parp14
|
UTSW |
16 |
35,661,583 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9363:Parp14
|
UTSW |
16 |
35,678,586 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9366:Parp14
|
UTSW |
16 |
35,659,630 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9379:Parp14
|
UTSW |
16 |
35,680,853 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9562:Parp14
|
UTSW |
16 |
35,677,775 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9565:Parp14
|
UTSW |
16 |
35,677,775 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9696:Parp14
|
UTSW |
16 |
35,661,252 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9696:Parp14
|
UTSW |
16 |
35,661,251 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
X0026:Parp14
|
UTSW |
16 |
35,677,527 (GRCm39) |
nonsense |
probably null |
|
|
X0060:Parp14
|
UTSW |
16 |
35,655,077 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Parp14
|
UTSW |
16 |
35,661,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Parp14
|
UTSW |
16 |
35,665,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Parp14
|
UTSW |
16 |
35,691,573 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTATGATGTCCCATACTGGCG -3'
(R):5'- TTAGACACCGTCATGGCCAAG -3'
Sequencing Primer
(F):5'- TACTGGCGAGCACACTTC -3'
(R):5'- GTTACAACAAGATGCCACTGTCTGTC -3'
|
| Posted On |
2014-09-18 |
Incidental Mutation