Mutagenetix > Incidental Mutation

Incidental Mutation 'R2116:Atm'

233169

Institutional Source

Beutler Lab

Gene Symbol

Atm

Ensembl Gene

ENSMUSG00000034218

Gene Name

ataxia telangiectasia mutated

Synonyms

C030026E19Rik

MMRRC Submission

040120-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.928) question?

Stock #

R2116 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

53439149-53536740 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 53500969 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Lysine at position 960 (E960K)

Ref Sequence

ENSEMBL: ENSMUSP00000156344 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000118282] [ENSMUST00000232179]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000118282
AA Change: E960K

PolyPhen 2 Score 0.363 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000113388
Gene: ENSMUSG00000034218
AA Change: E960K

Domain	Start	End	E-Value	Type
TAN	1	166	5.07e-68	SMART
low complexity region	431	445	N/A	INTRINSIC
low complexity region	830	846	N/A	INTRINSIC
low complexity region	929	940	N/A	INTRINSIC
SCOP:d1gw5a_	1039	1568	2e-4	SMART
coiled coil region	1615	1644	N/A	INTRINSIC
low complexity region	1650	1662	N/A	INTRINSIC
Pfam:FAT	2102	2499	4.4e-50	PFAM
low complexity region	2587	2599	N/A	INTRINSIC
PI3Kc	2723	3026	1.11e-117	SMART
FATC	3034	3066	3.71e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000232179
AA Change: E960K

PolyPhen 2 Score 0.363 (Sensitivity: 0.90; Specificity: 0.89)

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.5%
20x: 95.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
PHENOTYPE: Homozygotes for null mutations may exhibit locomotor abnormalities, motor learning deficits, growth retardation, sterility due to meiotic arrest, and susceptibility to thymic lymphomas. Mice homozygous for a kinase dead allele exhibit early embryonic lethality associated with genetic instability. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 96 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700123L14Rik	A	T	6: 96,164,860 (GRCm38)	V401E	probably damaging	Het
4833427G06Rik	A	G	9: 51,101,084 (GRCm38)	S79P	possibly damaging	Het
Adamts20	A	G	15: 94,355,362 (GRCm38)	C377R	probably damaging	Het
Adgrv1	T	C	13: 81,529,013 (GRCm38)	K1180E	probably benign	Het
Ankle1	A	G	8: 71,407,918 (GRCm38)	T340A	probably benign	Het
Armc2	A	T	10: 41,963,667 (GRCm38)	L434Q	probably damaging	Het
Ash1l	C	T	3: 88,983,264 (GRCm38)	L817F	probably benign	Het
Bend5	G	T	4: 111,415,239 (GRCm38)	R22L	probably benign	Het
Cacng6	C	T	7: 3,430,504 (GRCm38)	T133I	probably damaging	Het
Cep120	G	A	18: 53,740,136 (GRCm38)	T41I	probably damaging	Het
Ciz1	T	C	2: 32,367,465 (GRCm38)	L174P	probably damaging	Het
Cmah	G	A	13: 24,428,897 (GRCm38)	D26N	probably benign	Het
Cnot1	A	C	8: 95,726,153 (GRCm38)	D2098E	probably damaging	Het
Cnot10	A	C	9: 114,626,436 (GRCm38)	S207R	probably damaging	Het
Col14a1	A	G	15: 55,407,764 (GRCm38)	T638A	unknown	Het
Coro1a	T	C	7: 126,702,022 (GRCm38)	E102G	probably damaging	Het
Ddx27	A	C	2: 167,027,764 (GRCm38)	D373A	probably benign	Het
Defb38	A	T	8: 19,023,467 (GRCm38)	Y63*	probably null	Het
Dhx37	A	G	5: 125,421,102 (GRCm38)	V681A	probably damaging	Het
Dmxl1	T	A	18: 49,878,817 (GRCm38)	L1347H	probably damaging	Het
Dnmt3l	C	A	10: 78,063,296 (GRCm38)	L110I	probably damaging	Het
Gcn1l1	A	T	5: 115,598,825 (GRCm38)	M1276L	probably benign	Het
Gm10277	TC	T	11: 77,786,002 (GRCm38)		probably null	Het
Gm12790	G	A	4: 101,967,651 (GRCm38)	T140I	possibly damaging	Het
Golga3	A	T	5: 110,187,395 (GRCm38)	M192L	probably damaging	Het
H2-T22	A	T	17: 36,039,057 (GRCm38)		probably null	Het
Hectd2	C	A	19: 36,614,424 (GRCm38)	T675K	probably damaging	Het
Hinfp	T	C	9: 44,299,615 (GRCm38)	N116S	probably damaging	Het
Hs6st3	T	A	14: 119,869,287 (GRCm38)	L369Q	probably damaging	Het
Ift74	A	G	4: 94,627,259 (GRCm38)	T138A	probably benign	Het
Ipo7	T	A	7: 110,051,118 (GRCm38)	Y792N	probably damaging	Het
Jak1	A	T	4: 101,179,675 (GRCm38)	I256N	probably damaging	Het
Kcnd2	T	A	6: 21,216,432 (GRCm38)	L45Q	probably damaging	Het
Klhl3	A	T	13: 58,018,991 (GRCm38)	V342E	probably damaging	Het
Krt28	A	C	11: 99,365,117 (GRCm38)	S439A	probably benign	Het
L3mbtl1	T	A	2: 162,960,070 (GRCm38)		probably null	Het
Lrch1	G	A	14: 74,785,531 (GRCm38)	P634L	probably damaging	Het
Lrp1	C	T	10: 127,576,493 (GRCm38)	W1314*	probably null	Het
Lrwd1	T	A	5: 136,130,478 (GRCm38)	Y431F	probably damaging	Het
Lyst	A	G	13: 13,635,701 (GRCm38)	E652G	probably damaging	Het
Mageb3	A	G	2: 121,954,552 (GRCm38)	V223A	probably damaging	Het
Map1b	G	T	13: 99,430,644 (GRCm38)	S1856R	unknown	Het
Mecom	T	A	3: 29,965,458 (GRCm38)	Q759L	probably damaging	Het
Mfsd6	T	A	1: 52,660,975 (GRCm38)	R671S	probably benign	Het
Mllt10	A	G	2: 18,162,569 (GRCm38)	N435S	probably benign	Het
Mta2	T	C	19: 8,943,516 (GRCm38)	I27T	probably damaging	Het
Ndufab1	A	G	7: 122,101,764 (GRCm38)	L20P	probably benign	Het
Nfatc2ip	T	A	7: 126,385,108 (GRCm38)	Y371F	probably damaging	Het
Nhlrc1	A	C	13: 47,014,185 (GRCm38)	S199A	probably benign	Het
Nipa1	G	T	7: 55,985,525 (GRCm38)	N113K	possibly damaging	Het
Nlgn1	T	A	3: 26,133,265 (GRCm38)	N157I	probably damaging	Het
Nlrp1a	T	A	11: 71,114,500 (GRCm38)	K630*	probably null	Het
Nmi	T	C	2: 51,948,707 (GRCm38)	T272A	probably benign	Het
Nr1i3	T	A	1: 171,218,594 (GRCm38)	L181Q	probably damaging	Het
Nrxn1	A	T	17: 90,704,277 (GRCm38)	I308K	probably damaging	Het
Olfr1043	A	T	2: 86,162,729 (GRCm38)	Y73*	probably null	Het
Olfr150	T	A	9: 39,737,304 (GRCm38)	M163K	probably damaging	Het
Olfr294	T	C	7: 86,616,078 (GRCm38)	D189G	probably benign	Het
Olfr625-ps1	T	C	7: 103,683,312 (GRCm38)	I188T	probably damaging	Het
Osgin2	G	A	4: 16,008,648 (GRCm38)	T51M	probably damaging	Het
Pkd1l2	T	A	8: 117,030,722 (GRCm38)	T1526S	possibly damaging	Het
Pkhd1l1	G	T	15: 44,569,482 (GRCm38)	A3378S	probably damaging	Het
Plg	A	T	17: 12,384,477 (GRCm38)	D90V	probably damaging	Het
Plppr3	A	T	10: 79,865,738 (GRCm38)	D423E	probably benign	Het
Prpf8	T	C	11: 75,487,721 (GRCm38)	V66A	possibly damaging	Het
Psg19	A	T	7: 18,794,255 (GRCm38)	Y188N	probably damaging	Het
Ptgs1	C	A	2: 36,237,696 (GRCm38)	S89*	probably null	Het
Ptx3	T	A	3: 66,224,766 (GRCm38)	I236N	probably damaging	Het
Pygm	A	G	19: 6,386,408 (GRCm38)	N100S	probably damaging	Het
Reps1	A	G	10: 18,124,920 (GRCm38)	E760G	probably damaging	Het
Rgs7	T	A	1: 175,091,073 (GRCm38)	N235I	probably damaging	Het
Rgsl1	T	A	1: 153,817,549 (GRCm38)	M629L	probably benign	Het
Rrh	T	C	3: 129,810,687 (GRCm38)	I288M	probably damaging	Het
Sctr	A	T	1: 120,031,582 (GRCm38)	D70V	probably damaging	Het
Sec11c	A	T	18: 65,800,649 (GRCm38)	T9S	probably benign	Het
Spty2d1	C	T	7: 46,996,185 (GRCm38)	G570D	probably damaging	Het
Stx1b	T	C	7: 127,810,905 (GRCm38)	E153G	probably damaging	Het
Synm	G	A	7: 67,733,595 (GRCm38)	R1440W	probably benign	Het
Tcof1	T	C	18: 60,832,785 (GRCm38)	E415G	possibly damaging	Het
Tgfb1i1	G	A	7: 128,252,805 (GRCm38)	R353H	probably damaging	Het
Thbs3	T	C	3: 89,219,392 (GRCm38)	F271S	probably damaging	Het
Tlr5	T	C	1: 182,975,629 (GRCm38)	W833R	probably damaging	Het
Tmem132b	A	G	5: 125,622,551 (GRCm38)	E92G	probably damaging	Het
Tmem221	T	C	8: 71,557,828 (GRCm38)	Y133C	probably damaging	Het
Tmem229b-ps	A	G	10: 53,475,456 (GRCm38)		noncoding transcript	Het
Tnxb	T	C	17: 34,672,227 (GRCm38)	C515R	probably damaging	Het
Trp53rka	T	A	2: 165,491,495 (GRCm38)	N158I	probably damaging	Het
Tsta3	A	G	15: 75,926,142 (GRCm38)	F223S	probably damaging	Het
Usp20	T	A	2: 31,016,305 (GRCm38)	C562S	probably damaging	Het
Usp31	C	T	7: 121,648,696 (GRCm38)	V1175M	probably benign	Het
Veph1	G	T	3: 66,057,189 (GRCm38)	N806K	probably benign	Het
Vmn1r223	G	T	13: 23,249,662 (GRCm38)	C142F	probably damaging	Het
Vmn2r80	A	T	10: 79,194,724 (GRCm38)	S795C	probably benign	Het
Wdr41	A	G	13: 95,015,029 (GRCm38)		probably null	Het
Zfp617	A	T	8: 71,932,165 (GRCm38)	H113L	probably benign	Het
Zfp715	T	A	7: 43,297,946 (GRCm38)	R863S	possibly damaging	Het

Other mutations in Atm

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00090:Atm	APN	9	53,524,443 (GRCm38)	missense	probably damaging	1.00
IGL00466:Atm	APN	9	53,499,112 (GRCm38)	splice site	probably benign
IGL00567:Atm	APN	9	53,503,116 (GRCm38)	nonsense	probably null
IGL00702:Atm	APN	9	53,511,831 (GRCm38)	missense	probably benign	0.02
IGL00743:Atm	APN	9	53,513,116 (GRCm38)	missense	probably benign	0.00
IGL00771:Atm	APN	9	53,493,054 (GRCm38)	missense	probably benign	0.01
IGL00773:Atm	APN	9	53,522,144 (GRCm38)	missense	probably benign	0.00
IGL00819:Atm	APN	9	53,518,531 (GRCm38)	missense	probably damaging	1.00
IGL00864:Atm	APN	9	53,533,933 (GRCm38)	missense	probably damaging	0.99
IGL00985:Atm	APN	9	53,459,816 (GRCm38)	missense	probably damaging	0.98
IGL01109:Atm	APN	9	53,490,293 (GRCm38)	missense	probably damaging	1.00
IGL01120:Atm	APN	9	53,461,122 (GRCm38)	critical splice acceptor site	probably null
IGL01369:Atm	APN	9	53,515,317 (GRCm38)	missense	probably benign
IGL01374:Atm	APN	9	53,531,724 (GRCm38)	missense	possibly damaging	0.58
IGL01406:Atm	APN	9	53,439,746 (GRCm38)	makesense	probably null
IGL01409:Atm	APN	9	53,499,171 (GRCm38)	missense	probably benign	0.01
IGL01434:Atm	APN	9	53,507,807 (GRCm38)	missense	probably benign	0.04
IGL01486:Atm	APN	9	53,510,213 (GRCm38)	missense	probably benign
IGL01583:Atm	APN	9	53,484,247 (GRCm38)	splice site	probably benign
IGL01861:Atm	APN	9	53,494,612 (GRCm38)	missense	probably null	0.89
IGL01865:Atm	APN	9	53,461,002 (GRCm38)	missense	probably damaging	1.00
IGL02026:Atm	APN	9	53,442,417 (GRCm38)	splice site	probably null
IGL02072:Atm	APN	9	53,459,796 (GRCm38)	missense	probably benign	0.01
IGL02075:Atm	APN	9	53,527,237 (GRCm38)	missense	probably damaging	1.00
IGL02127:Atm	APN	9	53,487,983 (GRCm38)	missense	probably damaging	1.00
IGL02175:Atm	APN	9	53,480,665 (GRCm38)	missense	probably damaging	0.99
IGL02246:Atm	APN	9	53,527,185 (GRCm38)	missense	probably benign	0.12
IGL02259:Atm	APN	9	53,518,494 (GRCm38)	splice site	probably benign
IGL02351:Atm	APN	9	53,522,176 (GRCm38)	missense	probably benign	0.04
IGL02358:Atm	APN	9	53,522,176 (GRCm38)	missense	probably benign	0.04
IGL02387:Atm	APN	9	53,479,766 (GRCm38)	splice site	probably null
IGL02417:Atm	APN	9	53,479,695 (GRCm38)	missense	probably benign	0.00
IGL02422:Atm	APN	9	53,500,792 (GRCm38)	missense	probably damaging	1.00
IGL02445:Atm	APN	9	53,454,330 (GRCm38)	missense	probably benign	0.00
IGL02492:Atm	APN	9	53,455,859 (GRCm38)	missense	probably damaging	0.99
IGL02513:Atm	APN	9	53,497,262 (GRCm38)	splice site	probably benign
IGL02633:Atm	APN	9	53,448,153 (GRCm38)	missense	probably damaging	1.00
IGL02634:Atm	APN	9	53,516,563 (GRCm38)	missense	probably benign	0.00
IGL02948:Atm	APN	9	53,453,440 (GRCm38)	splice site	probably benign
IGL02959:Atm	APN	9	53,471,418 (GRCm38)	missense	probably damaging	1.00
IGL02965:Atm	APN	9	53,453,563 (GRCm38)	missense	probably damaging	1.00
IGL03085:Atm	APN	9	53,484,171 (GRCm38)	missense	possibly damaging	0.89
antebellum	UTSW	9	53,518,559 (GRCm38)	nonsense	probably null
bull_run	UTSW	9	53,487,922 (GRCm38)	missense	probably benign	0.09
Civil	UTSW	9	53,492,268 (GRCm38)	missense	possibly damaging	0.78
gettysburg	UTSW	9	53,455,988 (GRCm38)	splice site	probably null
Grant	UTSW	9	53,511,917 (GRCm38)	nonsense	probably null
Indicative	UTSW	9	53,445,376 (GRCm38)	splice site	probably null
Marker	UTSW	9	53,454,279 (GRCm38)	splice site	probably benign
maunder	UTSW	9	53,499,197 (GRCm38)	nonsense	probably null
mockingbird	UTSW	9	53,516,467 (GRCm38)	nonsense	probably null
mockingbird2	UTSW	9	53,488,587 (GRCm38)	missense	probably damaging	1.00
osphere	UTSW	9	53,479,673 (GRCm38)	missense	probably damaging	0.99
shiloh	UTSW	9	53,465,298 (GRCm38)	missense	probably damaging	1.00
Strato	UTSW	9	53,503,018 (GRCm38)	missense	probably damaging	1.00
thrasher	UTSW	9	53,445,507 (GRCm38)	missense	probably benign	0.01
Tropo	UTSW	9	53,531,648 (GRCm38)	missense	probably damaging	1.00
P0019:Atm	UTSW	9	53,465,028 (GRCm38)	splice site	probably benign
PIT4403001:Atm	UTSW	9	53,500,982 (GRCm38)	missense	probably benign
PIT4687001:Atm	UTSW	9	53,486,812 (GRCm38)	critical splice donor site	probably null
R0004:Atm	UTSW	9	53,453,528 (GRCm38)	splice site	probably benign
R0035:Atm	UTSW	9	53,513,180 (GRCm38)	missense	probably benign	0.01
R0098:Atm	UTSW	9	53,518,569 (GRCm38)	missense	probably benign	0.10
R0098:Atm	UTSW	9	53,518,569 (GRCm38)	missense	probably benign	0.10
R0201:Atm	UTSW	9	53,454,279 (GRCm38)	splice site	probably benign
R0304:Atm	UTSW	9	53,516,344 (GRCm38)	missense	probably benign	0.34
R0308:Atm	UTSW	9	53,454,473 (GRCm38)	splice site	probably null
R0362:Atm	UTSW	9	53,458,838 (GRCm38)	missense	possibly damaging	0.90
R0470:Atm	UTSW	9	53,460,966 (GRCm38)	missense	probably damaging	1.00
R0513:Atm	UTSW	9	53,503,948 (GRCm38)	missense	probably benign	0.00
R0589:Atm	UTSW	9	53,490,192 (GRCm38)	missense	possibly damaging	0.51
R0617:Atm	UTSW	9	53,458,941 (GRCm38)	nonsense	probably null
R0630:Atm	UTSW	9	53,531,622 (GRCm38)	splice site	probably benign
R0652:Atm	UTSW	9	53,486,014 (GRCm38)	missense	probably damaging	0.98
R0698:Atm	UTSW	9	53,515,239 (GRCm38)	missense	probably damaging	1.00
R0737:Atm	UTSW	9	53,456,566 (GRCm38)	missense	probably damaging	1.00
R0885:Atm	UTSW	9	53,459,823 (GRCm38)	missense	probably benign
R0947:Atm	UTSW	9	53,504,092 (GRCm38)	missense	probably benign	0.01
R0948:Atm	UTSW	9	53,495,958 (GRCm38)	missense	probably benign
R1144:Atm	UTSW	9	53,511,698 (GRCm38)	splice site	probably benign
R1252:Atm	UTSW	9	53,455,840 (GRCm38)	missense	probably damaging	1.00
R1295:Atm	UTSW	9	53,456,530 (GRCm38)	missense	probably damaging	1.00
R1296:Atm	UTSW	9	53,456,530 (GRCm38)	missense	probably damaging	1.00
R1419:Atm	UTSW	9	53,457,489 (GRCm38)	missense	probably benign	0.00
R1477:Atm	UTSW	9	53,464,273 (GRCm38)	missense	probably benign	0.00
R1596:Atm	UTSW	9	53,453,378 (GRCm38)	missense	probably damaging	1.00
R1630:Atm	UTSW	9	53,479,673 (GRCm38)	missense	probably damaging	0.99
R1667:Atm	UTSW	9	53,500,932 (GRCm38)	missense	probably damaging	1.00
R1681:Atm	UTSW	9	53,522,155 (GRCm38)	missense	possibly damaging	0.94
R1703:Atm	UTSW	9	53,500,700 (GRCm38)	missense	probably benign
R1817:Atm	UTSW	9	53,492,233 (GRCm38)	splice site	probably benign
R1840:Atm	UTSW	9	53,456,530 (GRCm38)	missense	probably damaging	1.00
R1848:Atm	UTSW	9	53,468,012 (GRCm38)	missense	probably benign	0.06
R1906:Atm	UTSW	9	53,506,568 (GRCm38)	missense	probably damaging	1.00
R1958:Atm	UTSW	9	53,471,418 (GRCm38)	missense	probably damaging	1.00
R2108:Atm	UTSW	9	53,443,997 (GRCm38)	missense	probably damaging	1.00
R2134:Atm	UTSW	9	53,467,964 (GRCm38)	critical splice donor site	probably null
R2137:Atm	UTSW	9	53,453,375 (GRCm38)	missense	probably damaging	1.00
R2291:Atm	UTSW	9	53,490,909 (GRCm38)	splice site	probably null
R2348:Atm	UTSW	9	53,492,268 (GRCm38)	missense	possibly damaging	0.78
R2483:Atm	UTSW	9	53,510,266 (GRCm38)	missense	probably damaging	1.00
R2567:Atm	UTSW	9	53,457,470 (GRCm38)	missense	possibly damaging	0.72
R2897:Atm	UTSW	9	53,507,805 (GRCm38)	missense	probably damaging	0.99
R2939:Atm	UTSW	9	53,494,711 (GRCm38)	missense	probably damaging	1.00
R3008:Atm	UTSW	9	53,480,750 (GRCm38)	missense	probably benign	0.00
R3236:Atm	UTSW	9	53,479,748 (GRCm38)	missense	probably benign	0.15
R3847:Atm	UTSW	9	53,503,075 (GRCm38)	missense	possibly damaging	0.94
R3889:Atm	UTSW	9	53,506,636 (GRCm38)	splice site	probably benign
R3919:Atm	UTSW	9	53,492,278 (GRCm38)	missense	probably benign	0.00
R4125:Atm	UTSW	9	53,450,621 (GRCm38)	missense	probably damaging	1.00
R4222:Atm	UTSW	9	53,480,669 (GRCm38)	missense	probably benign
R4395:Atm	UTSW	9	53,465,227 (GRCm38)	missense	probably benign	0.09
R4466:Atm	UTSW	9	53,448,169 (GRCm38)	nonsense	probably null
R4502:Atm	UTSW	9	53,495,946 (GRCm38)	missense	possibly damaging	0.92
R4514:Atm	UTSW	9	53,493,039 (GRCm38)	missense	probably damaging	0.99
R4528:Atm	UTSW	9	53,500,759 (GRCm38)	missense	probably benign	0.39
R4593:Atm	UTSW	9	53,453,594 (GRCm38)	missense	possibly damaging	0.55
R4627:Atm	UTSW	9	53,456,506 (GRCm38)	missense	possibly damaging	0.79
R4634:Atm	UTSW	9	53,531,733 (GRCm38)	missense	probably benign	0.01
R4665:Atm	UTSW	9	53,464,229 (GRCm38)	missense	probably benign	0.00
R4672:Atm	UTSW	9	53,522,201 (GRCm38)	missense	probably damaging	0.99
R4741:Atm	UTSW	9	53,453,607 (GRCm38)	missense	probably benign	0.10
R4808:Atm	UTSW	9	53,445,495 (GRCm38)	missense	probably damaging	0.99
R4959:Atm	UTSW	9	53,515,301 (GRCm38)	missense	probably benign
R4996:Atm	UTSW	9	53,524,507 (GRCm38)	missense	probably benign	0.09
R5030:Atm	UTSW	9	53,520,109 (GRCm38)	nonsense	probably null
R5214:Atm	UTSW	9	53,491,027 (GRCm38)	missense	probably benign	0.09
R5260:Atm	UTSW	9	53,506,611 (GRCm38)	missense	probably damaging	0.99
R5311:Atm	UTSW	9	53,518,623 (GRCm38)	missense	probably benign	0.00
R5394:Atm	UTSW	9	53,507,777 (GRCm38)	critical splice donor site	probably null
R5400:Atm	UTSW	9	53,503,018 (GRCm38)	missense	probably damaging	1.00
R5436:Atm	UTSW	9	53,459,804 (GRCm38)	missense	probably benign	0.00
R5441:Atm	UTSW	9	53,516,467 (GRCm38)	nonsense	probably null
R5569:Atm	UTSW	9	53,516,450 (GRCm38)	nonsense	probably null
R5856:Atm	UTSW	9	53,495,955 (GRCm38)	missense	possibly damaging	0.64
R5891:Atm	UTSW	9	53,497,159 (GRCm38)	missense	probably benign
R5910:Atm	UTSW	9	53,448,080 (GRCm38)	missense	probably damaging	0.96
R6054:Atm	UTSW	9	53,459,873 (GRCm38)	missense	probably damaging	1.00
R6062:Atm	UTSW	9	53,488,587 (GRCm38)	missense	probably damaging	1.00
R6092:Atm	UTSW	9	53,524,414 (GRCm38)	missense	probably damaging	1.00
R6127:Atm	UTSW	9	53,524,509 (GRCm38)	missense	probably damaging	1.00
R6160:Atm	UTSW	9	53,490,959 (GRCm38)	missense	probably benign	0.04
R6267:Atm	UTSW	9	53,444,000 (GRCm38)	missense	probably damaging	1.00
R6273:Atm	UTSW	9	53,487,922 (GRCm38)	missense	probably benign	0.09
R6284:Atm	UTSW	9	53,445,376 (GRCm38)	splice site	probably null
R6478:Atm	UTSW	9	53,490,254 (GRCm38)	missense	probably damaging	1.00
R6547:Atm	UTSW	9	53,440,157 (GRCm38)	missense	probably damaging	1.00
R6549:Atm	UTSW	9	53,493,177 (GRCm38)	missense	probably benign	0.00
R6704:Atm	UTSW	9	53,458,853 (GRCm38)	missense	probably benign	0.02
R6715:Atm	UTSW	9	53,531,648 (GRCm38)	missense	probably damaging	1.00
R6737:Atm	UTSW	9	53,486,051 (GRCm38)	missense	probably benign	0.30
R6759:Atm	UTSW	9	53,518,559 (GRCm38)	nonsense	probably null
R6766:Atm	UTSW	9	53,490,282 (GRCm38)	missense	probably damaging	0.99
R6813:Atm	UTSW	9	53,497,235 (GRCm38)	missense	probably benign	0.00
R6852:Atm	UTSW	9	53,482,430 (GRCm38)	missense	possibly damaging	0.93
R7064:Atm	UTSW	9	53,507,881 (GRCm38)	missense	probably benign	0.02
R7208:Atm	UTSW	9	53,512,008 (GRCm38)	splice site	probably null
R7211:Atm	UTSW	9	53,488,560 (GRCm38)	missense	probably benign	0.01
R7220:Atm	UTSW	9	53,511,917 (GRCm38)	nonsense	probably null
R7336:Atm	UTSW	9	53,462,503 (GRCm38)	missense	possibly damaging	0.47
R7363:Atm	UTSW	9	53,465,298 (GRCm38)	missense	probably damaging	1.00
R7378:Atm	UTSW	9	53,453,437 (GRCm38)	critical splice acceptor site	probably null
R7472:Atm	UTSW	9	53,448,125 (GRCm38)	missense	possibly damaging	0.81
R7487:Atm	UTSW	9	53,524,354 (GRCm38)	missense	probably benign
R7497:Atm	UTSW	9	53,511,891 (GRCm38)	missense	probably benign	0.00
R7584:Atm	UTSW	9	53,513,127 (GRCm38)	missense	probably damaging	0.99
R7624:Atm	UTSW	9	53,454,768 (GRCm38)	missense	probably damaging	0.99
R7653:Atm	UTSW	9	53,490,302 (GRCm38)	nonsense	probably null
R7660:Atm	UTSW	9	53,445,507 (GRCm38)	missense	probably benign	0.01
R7679:Atm	UTSW	9	53,442,497 (GRCm38)	missense	probably damaging	1.00
R7720:Atm	UTSW	9	53,522,239 (GRCm38)	missense	possibly damaging	0.54
R8221:Atm	UTSW	9	53,455,988 (GRCm38)	splice site	probably null
R8247:Atm	UTSW	9	53,450,570 (GRCm38)	missense
R8334:Atm	UTSW	9	53,522,273 (GRCm38)	missense	probably benign	0.00
R8503:Atm	UTSW	9	53,488,052 (GRCm38)	missense	probably damaging	0.99
R8552:Atm	UTSW	9	53,524,497 (GRCm38)	missense	probably damaging	1.00
R8749:Atm	UTSW	9	53,499,197 (GRCm38)	nonsense	probably null
R8838:Atm	UTSW	9	53,516,551 (GRCm38)	missense	probably damaging	0.99
R9126:Atm	UTSW	9	53,458,834 (GRCm38)	missense	probably benign	0.01
R9131:Atm	UTSW	9	53,533,744 (GRCm38)	missense	probably benign	0.10
R9191:Atm	UTSW	9	53,527,290 (GRCm38)	missense	probably benign	0.29
R9257:Atm	UTSW	9	53,495,850 (GRCm38)	critical splice donor site	probably null
R9473:Atm	UTSW	9	53,498,972 (GRCm38)	missense	probably benign
R9558:Atm	UTSW	9	53,500,781 (GRCm38)	missense	probably benign	0.00
R9598:Atm	UTSW	9	53,520,081 (GRCm38)	missense	probably benign	0.34
R9717:Atm	UTSW	9	53,516,517 (GRCm38)	missense	probably damaging	1.00
R9794:Atm	UTSW	9	53,518,567 (GRCm38)	missense	probably benign
X0067:Atm	UTSW	9	53,479,694 (GRCm38)	missense	probably benign	0.00
Z1088:Atm	UTSW	9	53,531,687 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGACATCTTGGTCACGTCG -3'
(R):5'- TGTGAGAGAATATGTTTTCCATGGC -3'

Sequencing Primer
(F):5'- TCACGTCGGTGCAGAGAACAC -3'
(R):5'- CCATTTGAGTAAAGTCTGTTATGCTG -3'

Posted On

2014-09-18