Incidental Mutation 'R2116:Nlrp1a'
| ID |
233178 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nlrp1a
|
| Ensembl Gene |
ENSMUSG00000069830 |
| Gene Name |
NLR family, pyrin domain containing 1A |
| Synonyms |
Nalp1 |
| MMRRC Submission |
040120-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R2116 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
70983062-71035530 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 71005326 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 630
(K630*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104158
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048514]
[ENSMUST00000108518]
|
| AlphaFold |
Q2LKU9 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000048514
AA Change: K630*
|
| SMART Domains |
Protein: ENSMUSP00000038186
Gene: ENSMUSG00000069830
AA Change: K630*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
11 |
N/A |
INTRINSIC |
|
Pfam:NACHT
|
133 |
302 |
4.6e-41 |
PFAM |
|
low complexity region
|
482 |
494 |
N/A |
INTRINSIC |
|
LRR
|
632 |
659 |
4.53e-1 |
SMART |
|
LRR
|
742 |
769 |
3.04e-5 |
SMART |
|
low complexity region
|
856 |
870 |
N/A |
INTRINSIC |
|
Pfam:FIIND
|
921 |
1173 |
1.6e-102 |
PFAM |
|
Pfam:CARD
|
1209 |
1292 |
2.3e-20 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000108518
AA Change: K630*
|
| SMART Domains |
Protein: ENSMUSP00000104158
Gene: ENSMUSG00000069830
AA Change: K630*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
11 |
N/A |
INTRINSIC |
|
Pfam:NACHT
|
133 |
302 |
1.1e-40 |
PFAM |
|
low complexity region
|
482 |
494 |
N/A |
INTRINSIC |
|
LRR
|
632 |
659 |
4.53e-1 |
SMART |
|
LRR
|
661 |
688 |
2.85e1 |
SMART |
|
LRR
|
689 |
716 |
3.04e-5 |
SMART |
|
Pfam:FIIND
|
819 |
1073 |
3e-136 |
PFAM |
|
Pfam:CARD
|
1091 |
1174 |
8.2e-20 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.5%
- 20x: 95.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice heterozygous for an ENU-induced allele develop a multi-organ neutrophilic inflammatory disease. Homozygotes for the same ENU-induced allele develop a similar but lethal condition and exhibit neutrophilia, lymphopenia, splenomegaly, loss of peritoneal macrophages, and premature death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts20 |
A |
G |
15: 94,253,243 (GRCm39) |
C377R |
probably damaging |
Het |
| Adgrv1 |
T |
C |
13: 81,677,132 (GRCm39) |
K1180E |
probably benign |
Het |
| Ankle1 |
A |
G |
8: 71,860,562 (GRCm39) |
T340A |
probably benign |
Het |
| Armc2 |
A |
T |
10: 41,839,663 (GRCm39) |
L434Q |
probably damaging |
Het |
| Ash1l |
C |
T |
3: 88,890,571 (GRCm39) |
L817F |
probably benign |
Het |
| Atm |
C |
T |
9: 53,412,269 (GRCm39) |
E960K |
probably benign |
Het |
| Bend5 |
G |
T |
4: 111,272,436 (GRCm39) |
R22L |
probably benign |
Het |
| Cacng6 |
C |
T |
7: 3,479,020 (GRCm39) |
T133I |
probably damaging |
Het |
| Cep120 |
G |
A |
18: 53,873,208 (GRCm39) |
T41I |
probably damaging |
Het |
| Ciz1 |
T |
C |
2: 32,257,477 (GRCm39) |
L174P |
probably damaging |
Het |
| Cmah |
G |
A |
13: 24,612,880 (GRCm39) |
D26N |
probably benign |
Het |
| Cnot1 |
A |
C |
8: 96,452,781 (GRCm39) |
D2098E |
probably damaging |
Het |
| Cnot10 |
A |
C |
9: 114,455,504 (GRCm39) |
S207R |
probably damaging |
Het |
| Col14a1 |
A |
G |
15: 55,271,160 (GRCm39) |
T638A |
unknown |
Het |
| Coro1a |
T |
C |
7: 126,301,194 (GRCm39) |
E102G |
probably damaging |
Het |
| Ddx27 |
A |
C |
2: 166,869,684 (GRCm39) |
D373A |
probably benign |
Het |
| Defb38 |
A |
T |
8: 19,073,483 (GRCm39) |
Y63* |
probably null |
Het |
| Dhx37 |
A |
G |
5: 125,498,166 (GRCm39) |
V681A |
probably damaging |
Het |
| Dmxl1 |
T |
A |
18: 50,011,884 (GRCm39) |
L1347H |
probably damaging |
Het |
| Dnmt3l |
C |
A |
10: 77,899,130 (GRCm39) |
L110I |
probably damaging |
Het |
| Gcn1 |
A |
T |
5: 115,736,884 (GRCm39) |
M1276L |
probably benign |
Het |
| Gfus |
A |
G |
15: 75,797,991 (GRCm39) |
F223S |
probably damaging |
Het |
| Gm10277 |
TC |
T |
11: 77,676,828 (GRCm39) |
|
probably null |
Het |
| Gm12790 |
G |
A |
4: 101,824,848 (GRCm39) |
T140I |
possibly damaging |
Het |
| Golga3 |
A |
T |
5: 110,335,261 (GRCm39) |
M192L |
probably damaging |
Het |
| H2-T22 |
A |
T |
17: 36,349,949 (GRCm39) |
|
probably null |
Het |
| Hectd2 |
C |
A |
19: 36,591,824 (GRCm39) |
T675K |
probably damaging |
Het |
| Hinfp |
T |
C |
9: 44,210,912 (GRCm39) |
N116S |
probably damaging |
Het |
| Hoatz |
A |
G |
9: 51,012,384 (GRCm39) |
S79P |
possibly damaging |
Het |
| Hs6st3 |
T |
A |
14: 120,106,699 (GRCm39) |
L369Q |
probably damaging |
Het |
| Ift74 |
A |
G |
4: 94,515,496 (GRCm39) |
T138A |
probably benign |
Het |
| Ipo7 |
T |
A |
7: 109,650,325 (GRCm39) |
Y792N |
probably damaging |
Het |
| Jak1 |
A |
T |
4: 101,036,872 (GRCm39) |
I256N |
probably damaging |
Het |
| Kcnd2 |
T |
A |
6: 21,216,431 (GRCm39) |
L45Q |
probably damaging |
Het |
| Klhl3 |
A |
T |
13: 58,166,805 (GRCm39) |
V342E |
probably damaging |
Het |
| Krt28 |
A |
C |
11: 99,255,943 (GRCm39) |
S439A |
probably benign |
Het |
| L3mbtl1 |
T |
A |
2: 162,801,990 (GRCm39) |
|
probably null |
Het |
| Lrch1 |
G |
A |
14: 75,022,971 (GRCm39) |
P634L |
probably damaging |
Het |
| Lrp1 |
C |
T |
10: 127,412,362 (GRCm39) |
W1314* |
probably null |
Het |
| Lrwd1 |
T |
A |
5: 136,159,332 (GRCm39) |
Y431F |
probably damaging |
Het |
| Lyst |
A |
G |
13: 13,810,286 (GRCm39) |
E652G |
probably damaging |
Het |
| Mageb3 |
A |
G |
2: 121,785,033 (GRCm39) |
V223A |
probably damaging |
Het |
| Map1b |
G |
T |
13: 99,567,152 (GRCm39) |
S1856R |
unknown |
Het |
| Mecom |
T |
A |
3: 30,019,607 (GRCm39) |
Q759L |
probably damaging |
Het |
| Mfsd6 |
T |
A |
1: 52,700,134 (GRCm39) |
R671S |
probably benign |
Het |
| Mllt10 |
A |
G |
2: 18,167,380 (GRCm39) |
N435S |
probably benign |
Het |
| Mta2 |
T |
C |
19: 8,920,880 (GRCm39) |
I27T |
probably damaging |
Het |
| Ndufab1 |
A |
G |
7: 121,700,987 (GRCm39) |
L20P |
probably benign |
Het |
| Nfatc2ip |
T |
A |
7: 125,984,280 (GRCm39) |
Y371F |
probably damaging |
Het |
| Nhlrc1 |
A |
C |
13: 47,167,661 (GRCm39) |
S199A |
probably benign |
Het |
| Nipa1 |
G |
T |
7: 55,635,273 (GRCm39) |
N113K |
possibly damaging |
Het |
| Nlgn1 |
T |
A |
3: 26,187,414 (GRCm39) |
N157I |
probably damaging |
Het |
| Nmi |
T |
C |
2: 51,838,719 (GRCm39) |
T272A |
probably benign |
Het |
| Nr1i3 |
T |
A |
1: 171,046,163 (GRCm39) |
L181Q |
probably damaging |
Het |
| Nrxn1 |
A |
T |
17: 91,011,705 (GRCm39) |
I308K |
probably damaging |
Het |
| Nup50l |
A |
T |
6: 96,141,841 (GRCm39) |
V401E |
probably damaging |
Het |
| Or14a256 |
T |
C |
7: 86,265,286 (GRCm39) |
D189G |
probably benign |
Het |
| Or52z15 |
T |
C |
7: 103,332,519 (GRCm39) |
I188T |
probably damaging |
Het |
| Or5al7 |
A |
T |
2: 85,993,073 (GRCm39) |
Y73* |
probably null |
Het |
| Or8g50 |
T |
A |
9: 39,648,600 (GRCm39) |
M163K |
probably damaging |
Het |
| Osgin2 |
G |
A |
4: 16,008,648 (GRCm39) |
T51M |
probably damaging |
Het |
| Pkd1l2 |
T |
A |
8: 117,757,461 (GRCm39) |
T1526S |
possibly damaging |
Het |
| Pkhd1l1 |
G |
T |
15: 44,432,878 (GRCm39) |
A3378S |
probably damaging |
Het |
| Plg |
A |
T |
17: 12,603,364 (GRCm39) |
D90V |
probably damaging |
Het |
| Plppr3 |
A |
T |
10: 79,701,572 (GRCm39) |
D423E |
probably benign |
Het |
| Prpf8 |
T |
C |
11: 75,378,547 (GRCm39) |
V66A |
possibly damaging |
Het |
| Psg19 |
A |
T |
7: 18,528,180 (GRCm39) |
Y188N |
probably damaging |
Het |
| Ptgs1 |
C |
A |
2: 36,127,708 (GRCm39) |
S89* |
probably null |
Het |
| Ptx3 |
T |
A |
3: 66,132,187 (GRCm39) |
I236N |
probably damaging |
Het |
| Pygm |
A |
G |
19: 6,436,438 (GRCm39) |
N100S |
probably damaging |
Het |
| Reps1 |
A |
G |
10: 18,000,668 (GRCm39) |
E760G |
probably damaging |
Het |
| Rgs7 |
T |
A |
1: 174,918,639 (GRCm39) |
N235I |
probably damaging |
Het |
| Rgsl1 |
T |
A |
1: 153,693,295 (GRCm39) |
M629L |
probably benign |
Het |
| Rrh |
T |
C |
3: 129,604,336 (GRCm39) |
I288M |
probably damaging |
Het |
| Sctr |
A |
T |
1: 119,959,312 (GRCm39) |
D70V |
probably damaging |
Het |
| Sec11c |
A |
T |
18: 65,933,720 (GRCm39) |
T9S |
probably benign |
Het |
| Spty2d1 |
C |
T |
7: 46,645,933 (GRCm39) |
G570D |
probably damaging |
Het |
| Stx1b |
T |
C |
7: 127,410,077 (GRCm39) |
E153G |
probably damaging |
Het |
| Synm |
G |
A |
7: 67,383,343 (GRCm39) |
R1440W |
probably benign |
Het |
| Tcof1 |
T |
C |
18: 60,965,857 (GRCm39) |
E415G |
possibly damaging |
Het |
| Tgfb1i1 |
G |
A |
7: 127,851,977 (GRCm39) |
R353H |
probably damaging |
Het |
| Thbs3 |
T |
C |
3: 89,126,699 (GRCm39) |
F271S |
probably damaging |
Het |
| Tlr5 |
T |
C |
1: 182,803,194 (GRCm39) |
W833R |
probably damaging |
Het |
| Tmem132b |
A |
G |
5: 125,699,615 (GRCm39) |
E92G |
probably damaging |
Het |
| Tmem221 |
T |
C |
8: 72,010,472 (GRCm39) |
Y133C |
probably damaging |
Het |
| Tmem229b-ps |
A |
G |
10: 53,351,552 (GRCm39) |
|
noncoding transcript |
Het |
| Tnxb |
T |
C |
17: 34,891,201 (GRCm39) |
C515R |
probably damaging |
Het |
| Trp53rka |
T |
A |
2: 165,333,415 (GRCm39) |
N158I |
probably damaging |
Het |
| Usp20 |
T |
A |
2: 30,906,317 (GRCm39) |
C562S |
probably damaging |
Het |
| Usp31 |
C |
T |
7: 121,247,919 (GRCm39) |
V1175M |
probably benign |
Het |
| Veph1 |
G |
T |
3: 65,964,610 (GRCm39) |
N806K |
probably benign |
Het |
| Vmn1r223 |
G |
T |
13: 23,433,832 (GRCm39) |
C142F |
probably damaging |
Het |
| Vmn2r80 |
A |
T |
10: 79,030,558 (GRCm39) |
S795C |
probably benign |
Het |
| Wdr41 |
A |
G |
13: 95,151,537 (GRCm39) |
|
probably null |
Het |
| Zfp617 |
A |
T |
8: 72,686,009 (GRCm39) |
H113L |
probably benign |
Het |
| Zfp715 |
T |
A |
7: 42,947,370 (GRCm39) |
R863S |
possibly damaging |
Het |
|
| Other mutations in Nlrp1a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00648:Nlrp1a
|
APN |
11 |
70,983,783 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00771:Nlrp1a
|
APN |
11 |
71,013,567 (GRCm39) |
nonsense |
probably null |
|
|
IGL01408:Nlrp1a
|
APN |
11 |
71,013,742 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01886:Nlrp1a
|
APN |
11 |
71,014,327 (GRCm39) |
missense |
probably benign |
|
|
IGL02221:Nlrp1a
|
APN |
11 |
71,013,944 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02291:Nlrp1a
|
APN |
11 |
71,013,415 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02375:Nlrp1a
|
APN |
11 |
71,004,339 (GRCm39) |
nonsense |
probably null |
|
|
IGL02408:Nlrp1a
|
APN |
11 |
71,013,456 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02516:Nlrp1a
|
APN |
11 |
71,005,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02583:Nlrp1a
|
APN |
11 |
71,014,227 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02622:Nlrp1a
|
APN |
11 |
71,013,826 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02642:Nlrp1a
|
APN |
11 |
71,014,358 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02823:Nlrp1a
|
APN |
11 |
70,983,249 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02859:Nlrp1a
|
APN |
11 |
70,996,912 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
IGL02997:Nlrp1a
|
APN |
11 |
71,014,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03342:Nlrp1a
|
APN |
11 |
71,013,617 (GRCm39) |
missense |
probably benign |
0.19 |
|
Ants
|
UTSW |
11 |
71,033,164 (GRCm39) |
missense |
probably benign |
0.01 |
|
dreary
|
UTSW |
11 |
71,004,466 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
picnic
|
UTSW |
11 |
71,013,573 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
seedless
|
UTSW |
11 |
71,014,378 (GRCm39) |
missense |
probably benign |
0.44 |
|
watermelon
|
UTSW |
11 |
71,013,531 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0022:Nlrp1a
|
UTSW |
11 |
71,014,207 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0345:Nlrp1a
|
UTSW |
11 |
71,014,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0360:Nlrp1a
|
UTSW |
11 |
71,004,830 (GRCm39) |
intron |
probably benign |
|
|
R0364:Nlrp1a
|
UTSW |
11 |
71,004,830 (GRCm39) |
intron |
probably benign |
|
|
R0566:Nlrp1a
|
UTSW |
11 |
71,013,768 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1177:Nlrp1a
|
UTSW |
11 |
70,998,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1240:Nlrp1a
|
UTSW |
11 |
71,004,292 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1263:Nlrp1a
|
UTSW |
11 |
70,987,948 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1681:Nlrp1a
|
UTSW |
11 |
71,033,184 (GRCm39) |
missense |
unknown |
|
|
R1743:Nlrp1a
|
UTSW |
11 |
71,015,032 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1826:Nlrp1a
|
UTSW |
11 |
71,013,573 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1826:Nlrp1a
|
UTSW |
11 |
70,998,806 (GRCm39) |
intron |
probably benign |
|
|
R1981:Nlrp1a
|
UTSW |
11 |
70,989,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2083:Nlrp1a
|
UTSW |
11 |
71,015,046 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R2134:Nlrp1a
|
UTSW |
11 |
71,015,014 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2148:Nlrp1a
|
UTSW |
11 |
71,013,733 (GRCm39) |
nonsense |
probably null |
|
|
R2301:Nlrp1a
|
UTSW |
11 |
70,996,927 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3029:Nlrp1a
|
UTSW |
11 |
71,014,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3113:Nlrp1a
|
UTSW |
11 |
71,014,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3801:Nlrp1a
|
UTSW |
11 |
71,013,529 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3898:Nlrp1a
|
UTSW |
11 |
71,013,700 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4254:Nlrp1a
|
UTSW |
11 |
71,013,854 (GRCm39) |
nonsense |
probably null |
|
|
R4397:Nlrp1a
|
UTSW |
11 |
70,988,030 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4647:Nlrp1a
|
UTSW |
11 |
70,987,952 (GRCm39) |
splice site |
probably null |
|
|
R4740:Nlrp1a
|
UTSW |
11 |
71,004,466 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4965:Nlrp1a
|
UTSW |
11 |
70,983,141 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5009:Nlrp1a
|
UTSW |
11 |
71,013,531 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5103:Nlrp1a
|
UTSW |
11 |
70,990,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5355:Nlrp1a
|
UTSW |
11 |
71,015,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5577:Nlrp1a
|
UTSW |
11 |
70,990,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5892:Nlrp1a
|
UTSW |
11 |
70,990,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5949:Nlrp1a
|
UTSW |
11 |
70,989,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5964:Nlrp1a
|
UTSW |
11 |
71,013,846 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6220:Nlrp1a
|
UTSW |
11 |
71,033,164 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6564:Nlrp1a
|
UTSW |
11 |
71,014,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6586:Nlrp1a
|
UTSW |
11 |
70,996,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6925:Nlrp1a
|
UTSW |
11 |
70,983,339 (GRCm39) |
missense |
probably null |
0.99 |
|
R7013:Nlrp1a
|
UTSW |
11 |
71,014,378 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7155:Nlrp1a
|
UTSW |
11 |
71,014,905 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7214:Nlrp1a
|
UTSW |
11 |
71,014,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7268:Nlrp1a
|
UTSW |
11 |
71,015,068 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7388:Nlrp1a
|
UTSW |
11 |
71,014,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7404:Nlrp1a
|
UTSW |
11 |
70,987,919 (GRCm39) |
nonsense |
probably null |
|
|
R7409:Nlrp1a
|
UTSW |
11 |
71,013,634 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7410:Nlrp1a
|
UTSW |
11 |
71,014,683 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7440:Nlrp1a
|
UTSW |
11 |
70,983,150 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7447:Nlrp1a
|
UTSW |
11 |
70,983,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7450:Nlrp1a
|
UTSW |
11 |
70,998,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7569:Nlrp1a
|
UTSW |
11 |
70,999,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7600:Nlrp1a
|
UTSW |
11 |
70,989,740 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7634:Nlrp1a
|
UTSW |
11 |
70,990,354 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7734:Nlrp1a
|
UTSW |
11 |
70,998,826 (GRCm39) |
missense |
unknown |
|
|
R7747:Nlrp1a
|
UTSW |
11 |
71,014,234 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8471:Nlrp1a
|
UTSW |
11 |
71,013,885 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8482:Nlrp1a
|
UTSW |
11 |
70,999,901 (GRCm39) |
splice site |
probably null |
|
|
R9008:Nlrp1a
|
UTSW |
11 |
71,014,735 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9028:Nlrp1a
|
UTSW |
11 |
71,013,819 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9441:Nlrp1a
|
UTSW |
11 |
71,013,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Nlrp1a
|
UTSW |
11 |
70,998,488 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9701:Nlrp1a
|
UTSW |
11 |
70,987,946 (GRCm39) |
missense |
probably benign |
0.08 |
|
X0026:Nlrp1a
|
UTSW |
11 |
71,033,142 (GRCm39) |
missense |
probably benign |
0.18 |
|
Z1177:Nlrp1a
|
UTSW |
11 |
71,013,995 (GRCm39) |
missense |
probably benign |
0.27 |
|
Z1186:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1186:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1186:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1186:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1186:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1187:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1187:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1187:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1187:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1187:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1188:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1188:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1188:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1188:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1188:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1189:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1189:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1189:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1189:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1189:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1190:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1190:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1190:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1190:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1190:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1191:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1191:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1191:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1191:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1191:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1192:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1192:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1192:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1192:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1192:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACAAGTCTGGCATGTGTTATAGG -3'
(R):5'- TGAATTCTGGGGATGGCATACC -3'
Sequencing Primer
(F):5'- ATATTAAGCCTCCCTCTAGAGTTATC -3'
(R):5'- CCTTGCACATGCATGTCA -3'
|
| Posted On |
2014-09-18 |
Incidental Mutation