Incidental Mutation 'R2099:Or10d3'
ID 233246
Institutional Source Beutler Lab
Gene Symbol Or10d3
Ensembl Gene ENSMUSG00000050853
Gene Name olfactory receptor family 10 subfamily D member 3
Synonyms GA_x6K02T2PVTD-33247839-33246901, MOR224-9, Olfr958
MMRRC Submission 040103-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # R2099 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39461227-39462165 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39461963 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 68 (V68A)
Ref Sequence ENSEMBL: ENSMUSP00000149788 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062545] [ENSMUST00000215505] [ENSMUST00000217227]
AlphaFold Q8VEY3
Predicted Effect probably benign
Transcript: ENSMUST00000062545
AA Change: V68A

PolyPhen 2 Score 0.173 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000049930
Gene: ENSMUSG00000050853
AA Change: V68A

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1.1e-49 PFAM
Pfam:7TM_GPCR_Srsx 36 236 1.5e-6 PFAM
Pfam:7tm_1 41 288 3.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215505
AA Change: V68A

PolyPhen 2 Score 0.173 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000217227
AA Change: V68A

PolyPhen 2 Score 0.173 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 G A 17: 45,817,820 (GRCm39) R14Q unknown Het
Aga C A 8: 53,974,166 (GRCm39) Y286* probably null Het
Anks1 T C 17: 28,197,465 (GRCm39) probably null Het
Arih2 A T 9: 108,493,937 (GRCm39) F159I probably damaging Het
Asxl1 A T 2: 153,194,187 (GRCm39) M46L possibly damaging Het
Atp23 G T 10: 126,727,595 (GRCm39) probably null Het
Carmil1 T A 13: 24,357,650 (GRCm39) L66F probably benign Het
Chd9 C T 8: 91,760,615 (GRCm39) P2120L probably benign Het
Cramp1 A G 17: 25,192,059 (GRCm39) V1027A probably benign Het
Cx3cr1 G A 9: 119,881,339 (GRCm39) A21V probably benign Het
Dcxr A G 11: 120,616,403 (GRCm39) F221S probably damaging Het
Dio2 T C 12: 90,696,597 (GRCm39) *130W probably null Het
Dnah2 T C 11: 69,384,063 (GRCm39) D1051G probably damaging Het
Ehbp1l1 T C 19: 5,768,429 (GRCm39) E958G possibly damaging Het
Eif3a C A 19: 60,752,551 (GRCm39) probably benign Het
Ephb2 T C 4: 136,388,066 (GRCm39) D678G probably damaging Het
Fpr3 G T 17: 18,191,443 (GRCm39) R238L probably damaging Het
Frem3 A G 8: 81,342,488 (GRCm39) S1594G probably benign Het
Gbp4 A C 5: 105,268,947 (GRCm39) L402W probably damaging Het
Gdpd5 T A 7: 99,097,696 (GRCm39) L164Q probably damaging Het
Il4i1 T C 7: 44,487,616 (GRCm39) probably null Het
Kcp G T 6: 29,496,164 (GRCm39) C723* probably null Het
Klhl18 A G 9: 110,284,486 (GRCm39) F2L probably damaging Het
Lepr T A 4: 101,630,185 (GRCm39) D633E probably damaging Het
Lifr A G 15: 7,186,732 (GRCm39) I79V probably benign Het
Mcrs1 A G 15: 99,147,827 (GRCm39) S27P probably benign Het
Mmp3 A G 9: 7,453,672 (GRCm39) D431G probably benign Het
Mtor T A 4: 148,634,649 (GRCm39) Y2423* probably null Het
Ndc80 A T 17: 71,811,773 (GRCm39) D484E probably benign Het
Ndufb8 T A 19: 44,543,749 (GRCm39) probably benign Het
Nmur2 A T 11: 55,931,589 (GRCm39) S41T probably benign Het
Notch2 T C 3: 98,022,637 (GRCm39) C819R possibly damaging Het
Or4f7 A G 2: 111,644,177 (GRCm39) I298T probably benign Het
Or6c35 A T 10: 129,169,152 (GRCm39) N134I probably damaging Het
Pheta1 C T 5: 121,991,349 (GRCm39) P237L possibly damaging Het
Phip T C 9: 82,797,392 (GRCm39) H537R possibly damaging Het
Samd7 T C 3: 30,810,709 (GRCm39) V242A probably benign Het
Sde2 T C 1: 180,693,713 (GRCm39) L401P probably damaging Het
Slc20a1 A G 2: 129,049,758 (GRCm39) D340G probably benign Het
Slc2a5 T A 4: 150,227,634 (GRCm39) Y484* probably null Het
Spata31d1a A G 13: 59,853,885 (GRCm39) L27P probably damaging Het
Sqstm1 T C 11: 50,093,811 (GRCm39) T269A possibly damaging Het
Syne2 T C 12: 76,026,747 (GRCm39) V3525A probably benign Het
Tctn1 G A 5: 122,380,772 (GRCm39) P512L probably damaging Het
Tlr1 A G 5: 65,082,411 (GRCm39) F722S probably damaging Het
Treh A G 9: 44,595,943 (GRCm39) Y376C probably damaging Het
Trim47 T C 11: 115,997,170 (GRCm39) N529S probably damaging Het
Trrap T C 5: 144,719,049 (GRCm39) V184A possibly damaging Het
Tyrp1 T A 4: 80,753,616 (GRCm39) N102K possibly damaging Het
Uspl1 T A 5: 149,151,568 (GRCm39) S724T probably damaging Het
Vmn2r2 C A 3: 64,024,474 (GRCm39) K702N probably damaging Het
Zfp267 C T 3: 36,218,361 (GRCm39) T128I possibly damaging Het
Other mutations in Or10d3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0446:Or10d3 UTSW 9 39,461,747 (GRCm39) missense probably damaging 0.96
R0539:Or10d3 UTSW 9 39,461,593 (GRCm39) missense probably damaging 0.99
R1512:Or10d3 UTSW 9 39,461,390 (GRCm39) missense probably damaging 1.00
R1521:Or10d3 UTSW 9 39,462,080 (GRCm39) missense possibly damaging 0.65
R1652:Or10d3 UTSW 9 39,461,591 (GRCm39) missense probably benign 0.03
R2252:Or10d3 UTSW 9 39,461,273 (GRCm39) missense probably damaging 0.99
R2911:Or10d3 UTSW 9 39,462,117 (GRCm39) missense possibly damaging 0.76
R3722:Or10d3 UTSW 9 39,461,418 (GRCm39) missense probably damaging 1.00
R5745:Or10d3 UTSW 9 39,461,987 (GRCm39) missense probably damaging 1.00
R6460:Or10d3 UTSW 9 39,462,088 (GRCm39) frame shift probably null
R6504:Or10d3 UTSW 9 39,461,574 (GRCm39) missense probably damaging 1.00
R7063:Or10d3 UTSW 9 39,461,411 (GRCm39) missense possibly damaging 0.87
R7162:Or10d3 UTSW 9 39,461,525 (GRCm39) missense probably damaging 1.00
R8674:Or10d3 UTSW 9 39,461,675 (GRCm39) missense probably damaging 1.00
R8748:Or10d3 UTSW 9 39,461,712 (GRCm39) nonsense probably null
R8748:Or10d3 UTSW 9 39,461,711 (GRCm39) missense possibly damaging 0.95
R8822:Or10d3 UTSW 9 39,461,812 (GRCm39) missense probably benign 0.11
R9529:Or10d3 UTSW 9 39,461,723 (GRCm39) missense probably benign 0.28
R9631:Or10d3 UTSW 9 39,461,508 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CAAAGCGGTCATAGGCCATC -3'
(R):5'- AAGACTTTCTCCACCACCGATG -3'

Sequencing Primer
(F):5'- GGTCATAGGCCATCACTGTATAC -3'
(R):5'- AGTGGTGACTGAGTTCATCCTCC -3'
Posted On 2014-09-18