Incidental Mutation 'R2132:Myh8'
| ID |
233426 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh8
|
| Ensembl Gene |
ENSMUSG00000055775 |
| Gene Name |
myosin, heavy polypeptide 8, skeletal muscle, perinatal |
| Synonyms |
Myhsp, MyHC-pn, Myhs-p, 4832426G23Rik |
| MMRRC Submission |
040135-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.825)
|
| Stock # |
R2132 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
67167950-67199460 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 67183702 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 777
(E777G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000019625
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019625]
|
| AlphaFold |
P13542 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000019625
AA Change: E777G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000019625
Gene: ENSMUSG00000055775
AA Change: E777G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
37 |
76 |
2.1e-13 |
PFAM |
|
MYSc
|
82 |
782 |
N/A |
SMART |
|
IQ
|
783 |
805 |
5.44e-3 |
SMART |
|
Pfam:Myosin_tail_1
|
846 |
1927 |
2.4e-164 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000108686
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139052
|
| Meta Mutation Damage Score |
0.7679 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.3%
|
| Validation Efficiency |
94% (117/124) |
| MGI Phenotype |
FUNCTION: This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 122 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310003L06Rik |
A |
G |
5: 88,112,335 (GRCm39) |
|
probably benign |
Het |
| 4930562C15Rik |
A |
C |
16: 4,653,835 (GRCm39) |
Q128P |
unknown |
Het |
| Abcc3 |
T |
A |
11: 94,258,426 (GRCm39) |
K473M |
probably benign |
Het |
| Acacb |
TGGGG |
TGGG |
5: 114,347,828 (GRCm39) |
|
probably null |
Het |
| Adgrg7 |
C |
A |
16: 56,588,281 (GRCm39) |
A199S |
probably damaging |
Het |
| Akap13 |
G |
T |
7: 75,261,182 (GRCm39) |
A1269S |
probably benign |
Het |
| Aox3 |
A |
G |
1: 58,209,002 (GRCm39) |
H845R |
probably damaging |
Het |
| Ap2b1 |
T |
A |
11: 83,215,587 (GRCm39) |
|
probably benign |
Het |
| Atat1 |
A |
G |
17: 36,220,331 (GRCm39) |
S54P |
probably damaging |
Het |
| Atp13a2 |
T |
A |
4: 140,732,327 (GRCm39) |
M864K |
probably damaging |
Het |
| B3gnt3 |
G |
A |
8: 72,145,971 (GRCm39) |
T186M |
probably damaging |
Het |
| Cars1 |
C |
A |
7: 143,146,211 (GRCm39) |
R71M |
probably damaging |
Het |
| Castor2 |
G |
A |
5: 134,164,992 (GRCm39) |
C187Y |
probably damaging |
Het |
| Ccdc157 |
A |
T |
11: 4,100,004 (GRCm39) |
V116E |
probably damaging |
Het |
| Ccdc85a |
G |
A |
11: 28,384,151 (GRCm39) |
T408I |
probably benign |
Het |
| Celf1 |
G |
T |
2: 90,840,791 (GRCm39) |
G353W |
probably damaging |
Het |
| Celsr1 |
T |
A |
15: 85,916,168 (GRCm39) |
I602F |
possibly damaging |
Het |
| Cenpb |
C |
T |
2: 131,021,226 (GRCm39) |
V191M |
probably damaging |
Het |
| Cenpn |
G |
A |
8: 117,661,536 (GRCm39) |
|
probably null |
Het |
| Cfap65 |
A |
C |
1: 74,946,850 (GRCm39) |
C1287G |
probably damaging |
Het |
| Cmya5 |
G |
A |
13: 93,205,891 (GRCm39) |
T3326I |
probably damaging |
Het |
| Cnn3 |
A |
T |
3: 121,245,584 (GRCm39) |
E100V |
probably damaging |
Het |
| Col4a4 |
G |
A |
1: 82,475,581 (GRCm39) |
R583C |
unknown |
Het |
| Commd7 |
A |
C |
2: 153,463,586 (GRCm39) |
|
probably benign |
Het |
| Csmd3 |
T |
C |
15: 48,320,899 (GRCm39) |
T304A |
probably benign |
Het |
| Cyp4a14 |
A |
T |
4: 115,348,588 (GRCm39) |
S325R |
probably damaging |
Het |
| Dclk2 |
T |
C |
3: 86,827,353 (GRCm39) |
N42S |
probably benign |
Het |
| Dmrta1 |
A |
T |
4: 89,576,946 (GRCm39) |
Q134L |
probably damaging |
Het |
| Dnaaf3 |
T |
A |
7: 4,526,800 (GRCm39) |
I426L |
probably benign |
Het |
| Dnah17 |
G |
A |
11: 117,924,573 (GRCm39) |
L3999F |
probably damaging |
Het |
| Dock6 |
A |
G |
9: 21,757,814 (GRCm39) |
S97P |
probably benign |
Het |
| Dsg1a |
T |
A |
18: 20,473,854 (GRCm39) |
S976T |
probably damaging |
Het |
| Dstyk |
T |
A |
1: 132,377,222 (GRCm39) |
M29K |
probably null |
Het |
| Eif3i |
A |
T |
4: 129,490,719 (GRCm39) |
H18Q |
probably benign |
Het |
| Epm2a |
A |
G |
10: 11,219,426 (GRCm39) |
E71G |
probably benign |
Het |
| Eps15l1 |
A |
T |
8: 73,140,712 (GRCm39) |
V260D |
probably benign |
Het |
| Faf1 |
A |
G |
4: 109,568,042 (GRCm39) |
N34S |
probably damaging |
Het |
| Fat3 |
A |
G |
9: 16,158,015 (GRCm39) |
|
probably null |
Het |
| Fbxw10 |
T |
A |
11: 62,750,683 (GRCm39) |
I422N |
probably damaging |
Het |
| Fcgbpl1 |
C |
T |
7: 27,854,899 (GRCm39) |
P1842S |
probably damaging |
Het |
| Fkbp15 |
C |
A |
4: 62,246,136 (GRCm39) |
G431W |
probably damaging |
Het |
| Flnb |
A |
C |
14: 7,873,376 (GRCm38) |
D224A |
probably benign |
Het |
| Flnc |
G |
A |
6: 29,443,675 (GRCm39) |
V566M |
probably damaging |
Het |
| Gli3 |
T |
A |
13: 15,900,134 (GRCm39) |
S1174T |
possibly damaging |
Het |
| Glmn |
A |
T |
5: 107,726,321 (GRCm39) |
V93E |
probably damaging |
Het |
| Glrx2 |
T |
C |
1: 143,620,842 (GRCm39) |
S74P |
possibly damaging |
Het |
| Gm5422 |
G |
A |
10: 31,124,929 (GRCm39) |
|
noncoding transcript |
Het |
| Gpi1 |
T |
C |
7: 33,905,339 (GRCm39) |
K362E |
probably damaging |
Het |
| Gtpbp2 |
T |
C |
17: 46,472,128 (GRCm39) |
M21T |
probably benign |
Het |
| Gxylt1 |
A |
G |
15: 93,142,851 (GRCm39) |
*405R |
probably null |
Het |
| Heyl |
T |
C |
4: 123,139,876 (GRCm39) |
V145A |
probably damaging |
Het |
| Hhipl1 |
A |
C |
12: 108,277,949 (GRCm39) |
E92D |
probably damaging |
Het |
| Ifi207 |
A |
G |
1: 173,557,337 (GRCm39) |
F467S |
possibly damaging |
Het |
| Ift70b |
G |
T |
2: 75,767,129 (GRCm39) |
H541Q |
probably damaging |
Het |
| Igf2r |
A |
T |
17: 12,941,095 (GRCm39) |
I462N |
probably benign |
Het |
| Inpp5b |
A |
T |
4: 124,678,961 (GRCm39) |
|
probably benign |
Het |
| Kansl2 |
A |
G |
15: 98,427,278 (GRCm39) |
I201T |
probably damaging |
Het |
| Kcnh8 |
T |
C |
17: 53,200,961 (GRCm39) |
V465A |
probably damaging |
Het |
| Kcnu1 |
T |
A |
8: 26,341,928 (GRCm39) |
I91N |
probably damaging |
Het |
| Kif5c |
T |
A |
2: 49,648,817 (GRCm39) |
|
probably benign |
Het |
| Klrc3 |
T |
A |
6: 129,618,501 (GRCm39) |
Y94F |
probably benign |
Het |
| Lgals3bp |
T |
A |
11: 118,284,113 (GRCm39) |
T489S |
probably benign |
Het |
| Lmo2 |
T |
C |
2: 103,811,407 (GRCm39) |
Y147H |
probably damaging |
Het |
| Lmtk2 |
C |
T |
5: 144,111,806 (GRCm39) |
T842I |
possibly damaging |
Het |
| Magel2 |
A |
T |
7: 62,027,486 (GRCm39) |
H130L |
unknown |
Het |
| Magi1 |
T |
C |
6: 93,674,255 (GRCm39) |
E951G |
probably damaging |
Het |
| Mcm7 |
T |
C |
5: 138,167,364 (GRCm39) |
Q86R |
probably damaging |
Het |
| Med12l |
G |
T |
3: 59,172,703 (GRCm39) |
|
probably null |
Het |
| Morc2a |
A |
G |
11: 3,629,787 (GRCm39) |
E402G |
possibly damaging |
Het |
| Mphosph8 |
T |
C |
14: 56,916,161 (GRCm39) |
C486R |
probably benign |
Het |
| Mpo |
A |
G |
11: 87,688,187 (GRCm39) |
D282G |
possibly damaging |
Het |
| Mtcl1 |
G |
T |
17: 66,650,618 (GRCm39) |
H1616N |
probably benign |
Het |
| Myh10 |
A |
G |
11: 68,698,115 (GRCm39) |
|
probably benign |
Het |
| Nid1 |
A |
G |
13: 13,684,071 (GRCm39) |
H1186R |
probably benign |
Het |
| Nppb |
T |
A |
4: 148,070,454 (GRCm39) |
S8T |
probably benign |
Het |
| Nrp1 |
A |
T |
8: 129,224,997 (GRCm39) |
E782D |
probably damaging |
Het |
| Ntrk3 |
G |
A |
7: 78,127,683 (GRCm39) |
|
probably benign |
Het |
| Or1ak2 |
A |
G |
2: 36,827,704 (GRCm39) |
N191S |
probably benign |
Het |
| Or1j13 |
A |
G |
2: 36,370,059 (GRCm39) |
S28P |
possibly damaging |
Het |
| Or2f1 |
C |
A |
6: 42,721,069 (GRCm39) |
L33M |
possibly damaging |
Het |
| Or5al5 |
A |
G |
2: 85,961,605 (GRCm39) |
V134A |
possibly damaging |
Het |
| Or5b99 |
T |
A |
19: 12,976,402 (GRCm39) |
D17E |
probably benign |
Het |
| Or6f1 |
C |
T |
7: 85,970,687 (GRCm39) |
V158M |
possibly damaging |
Het |
| Osbpl6 |
T |
A |
2: 76,416,558 (GRCm39) |
I546K |
probably damaging |
Het |
| Pard6g |
T |
C |
18: 80,160,523 (GRCm39) |
V212A |
probably damaging |
Het |
| Pate6 |
T |
G |
9: 35,701,039 (GRCm39) |
|
probably benign |
Het |
| Pdlim4 |
A |
G |
11: 53,954,563 (GRCm39) |
L48S |
possibly damaging |
Het |
| Phactr3 |
T |
C |
2: 177,925,759 (GRCm39) |
F345L |
probably benign |
Het |
| Plcb1 |
T |
A |
2: 135,167,587 (GRCm39) |
Y460* |
probably null |
Het |
| Prcp |
T |
A |
7: 92,550,488 (GRCm39) |
V95D |
probably benign |
Het |
| Rfwd3 |
A |
T |
8: 112,024,034 (GRCm39) |
V96E |
probably benign |
Het |
| Ror1 |
A |
G |
4: 100,267,222 (GRCm39) |
N308D |
probably benign |
Het |
| Sdccag8 |
C |
A |
1: 176,783,455 (GRCm39) |
Q655K |
probably damaging |
Het |
| Senp1 |
T |
A |
15: 97,973,848 (GRCm39) |
T132S |
probably benign |
Het |
| Skap1 |
T |
C |
11: 96,355,559 (GRCm39) |
I10T |
possibly damaging |
Het |
| Slc9a4 |
T |
G |
1: 40,646,901 (GRCm39) |
|
probably null |
Het |
| Smad2 |
T |
A |
18: 76,421,155 (GRCm39) |
C161* |
probably null |
Het |
| Spata31d1a |
G |
T |
13: 59,848,857 (GRCm39) |
D1090E |
probably damaging |
Het |
| Stard13 |
T |
C |
5: 150,968,633 (GRCm39) |
Y879C |
probably damaging |
Het |
| Tdrd6 |
T |
C |
17: 43,935,724 (GRCm39) |
T1775A |
probably benign |
Het |
| Tecpr1 |
T |
A |
5: 144,145,463 (GRCm39) |
T595S |
probably benign |
Het |
| Terf1 |
A |
G |
1: 15,875,909 (GRCm39) |
E3G |
probably benign |
Het |
| Tjp3 |
T |
A |
10: 81,113,888 (GRCm39) |
M457L |
possibly damaging |
Het |
| Tnfrsf26 |
C |
T |
7: 143,171,577 (GRCm39) |
|
probably null |
Het |
| Tor1aip1 |
A |
C |
1: 155,883,308 (GRCm39) |
M180R |
probably damaging |
Het |
| Trabd2b |
A |
T |
4: 114,467,205 (GRCm39) |
Q478L |
probably benign |
Het |
| Trim41 |
C |
A |
11: 48,698,419 (GRCm39) |
G516W |
probably damaging |
Het |
| Ttc39a |
A |
G |
4: 109,299,903 (GRCm39) |
Y464C |
probably damaging |
Het |
| Unc5a |
A |
G |
13: 55,138,896 (GRCm39) |
S92G |
probably damaging |
Het |
| Unc5d |
A |
C |
8: 29,365,557 (GRCm39) |
S143A |
possibly damaging |
Het |
| Usp34 |
A |
T |
11: 23,414,556 (GRCm39) |
H2833L |
possibly damaging |
Het |
| Vps35l |
T |
C |
7: 118,393,798 (GRCm39) |
Y516H |
probably damaging |
Het |
| Wdr17 |
T |
G |
8: 55,125,541 (GRCm39) |
K446N |
probably damaging |
Het |
| Xirp2 |
A |
T |
2: 67,338,392 (GRCm39) |
Q211L |
possibly damaging |
Het |
| Xkr7 |
G |
A |
2: 152,894,816 (GRCm39) |
R256Q |
probably benign |
Het |
| Zfp236 |
T |
C |
18: 82,639,429 (GRCm39) |
M1225V |
probably benign |
Het |
| Zfp268 |
T |
A |
4: 145,350,803 (GRCm39) |
|
probably benign |
Het |
| Zfp280d |
T |
C |
9: 72,215,287 (GRCm39) |
F133L |
probably damaging |
Het |
| Zfp747l1 |
T |
C |
7: 126,986,107 (GRCm39) |
D8G |
probably benign |
Het |
| Zfp758 |
A |
G |
17: 22,594,951 (GRCm39) |
H479R |
probably damaging |
Het |
| Zfp827 |
A |
G |
8: 79,912,350 (GRCm39) |
N284S |
possibly damaging |
Het |
| Zfyve26 |
T |
A |
12: 79,315,208 (GRCm39) |
I1423F |
possibly damaging |
Het |
|
| Other mutations in Myh8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00236:Myh8
|
APN |
11 |
67,174,644 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01020:Myh8
|
APN |
11 |
67,174,229 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01348:Myh8
|
APN |
11 |
67,188,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01382:Myh8
|
APN |
11 |
67,192,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01454:Myh8
|
APN |
11 |
67,174,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01457:Myh8
|
APN |
11 |
67,183,505 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01472:Myh8
|
APN |
11 |
67,179,205 (GRCm39) |
splice site |
probably benign |
|
|
IGL01473:Myh8
|
APN |
11 |
67,192,651 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01613:Myh8
|
APN |
11 |
67,192,536 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL01763:Myh8
|
APN |
11 |
67,177,245 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01828:Myh8
|
APN |
11 |
67,194,652 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01862:Myh8
|
APN |
11 |
67,180,520 (GRCm39) |
nonsense |
probably null |
|
|
IGL01905:Myh8
|
APN |
11 |
67,175,477 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02280:Myh8
|
APN |
11 |
67,174,198 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02386:Myh8
|
APN |
11 |
67,185,266 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02449:Myh8
|
APN |
11 |
67,185,440 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02500:Myh8
|
APN |
11 |
67,196,536 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02745:Myh8
|
APN |
11 |
67,188,327 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02799:Myh8
|
APN |
11 |
67,192,418 (GRCm39) |
splice site |
probably benign |
|
|
IGL03063:Myh8
|
APN |
11 |
67,179,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03223:Myh8
|
APN |
11 |
67,174,644 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03336:Myh8
|
APN |
11 |
67,175,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03338:Myh8
|
APN |
11 |
67,189,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03351:Myh8
|
APN |
11 |
67,194,739 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03392:Myh8
|
APN |
11 |
67,185,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB003:Myh8
|
UTSW |
11 |
67,169,732 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
BB009:Myh8
|
UTSW |
11 |
67,185,430 (GRCm39) |
missense |
probably benign |
0.00 |
|
BB013:Myh8
|
UTSW |
11 |
67,169,732 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
BB019:Myh8
|
UTSW |
11 |
67,185,430 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4354001:Myh8
|
UTSW |
11 |
67,180,456 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0012:Myh8
|
UTSW |
11 |
67,190,847 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0016:Myh8
|
UTSW |
11 |
67,189,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0016:Myh8
|
UTSW |
11 |
67,189,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0115:Myh8
|
UTSW |
11 |
67,197,090 (GRCm39) |
splice site |
probably benign |
|
|
R0131:Myh8
|
UTSW |
11 |
67,183,014 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0131:Myh8
|
UTSW |
11 |
67,183,014 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0132:Myh8
|
UTSW |
11 |
67,183,014 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0238:Myh8
|
UTSW |
11 |
67,192,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0238:Myh8
|
UTSW |
11 |
67,192,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0239:Myh8
|
UTSW |
11 |
67,192,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0239:Myh8
|
UTSW |
11 |
67,192,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0393:Myh8
|
UTSW |
11 |
67,196,843 (GRCm39) |
splice site |
probably benign |
|
|
R0453:Myh8
|
UTSW |
11 |
67,183,731 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0454:Myh8
|
UTSW |
11 |
67,194,591 (GRCm39) |
nonsense |
probably null |
|
|
R0466:Myh8
|
UTSW |
11 |
67,189,405 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0487:Myh8
|
UTSW |
11 |
67,192,837 (GRCm39) |
missense |
probably benign |
|
|
R0511:Myh8
|
UTSW |
11 |
67,175,333 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0557:Myh8
|
UTSW |
11 |
67,192,624 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0589:Myh8
|
UTSW |
11 |
67,189,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0658:Myh8
|
UTSW |
11 |
67,175,358 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0782:Myh8
|
UTSW |
11 |
67,180,580 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0829:Myh8
|
UTSW |
11 |
67,174,326 (GRCm39) |
unclassified |
probably benign |
|
|
R0845:Myh8
|
UTSW |
11 |
67,177,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Myh8
|
UTSW |
11 |
67,196,824 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0972:Myh8
|
UTSW |
11 |
67,188,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1132:Myh8
|
UTSW |
11 |
67,187,957 (GRCm39) |
nonsense |
probably null |
|
|
R1417:Myh8
|
UTSW |
11 |
67,197,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1478:Myh8
|
UTSW |
11 |
67,183,551 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1497:Myh8
|
UTSW |
11 |
67,180,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1605:Myh8
|
UTSW |
11 |
67,192,497 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1701:Myh8
|
UTSW |
11 |
67,170,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1950:Myh8
|
UTSW |
11 |
67,169,830 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1989:Myh8
|
UTSW |
11 |
67,183,550 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2010:Myh8
|
UTSW |
11 |
67,187,990 (GRCm39) |
nonsense |
probably null |
|
|
R2095:Myh8
|
UTSW |
11 |
67,177,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2152:Myh8
|
UTSW |
11 |
67,185,295 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2229:Myh8
|
UTSW |
11 |
67,199,174 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2302:Myh8
|
UTSW |
11 |
67,177,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2364:Myh8
|
UTSW |
11 |
67,185,344 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2429:Myh8
|
UTSW |
11 |
67,194,723 (GRCm39) |
missense |
probably benign |
0.21 |
|
R2880:Myh8
|
UTSW |
11 |
67,188,090 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3692:Myh8
|
UTSW |
11 |
67,192,744 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3756:Myh8
|
UTSW |
11 |
67,175,443 (GRCm39) |
unclassified |
probably benign |
|
|
R3924:Myh8
|
UTSW |
11 |
67,187,963 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4172:Myh8
|
UTSW |
11 |
67,183,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4255:Myh8
|
UTSW |
11 |
67,190,560 (GRCm39) |
missense |
probably benign |
|
|
R4621:Myh8
|
UTSW |
11 |
67,177,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4623:Myh8
|
UTSW |
11 |
67,177,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4790:Myh8
|
UTSW |
11 |
67,170,789 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4914:Myh8
|
UTSW |
11 |
67,183,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5074:Myh8
|
UTSW |
11 |
67,196,742 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5119:Myh8
|
UTSW |
11 |
67,189,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5159:Myh8
|
UTSW |
11 |
67,179,179 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5229:Myh8
|
UTSW |
11 |
67,175,310 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5320:Myh8
|
UTSW |
11 |
67,177,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5455:Myh8
|
UTSW |
11 |
67,192,244 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R5523:Myh8
|
UTSW |
11 |
67,196,788 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5540:Myh8
|
UTSW |
11 |
67,177,266 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5726:Myh8
|
UTSW |
11 |
67,185,392 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5770:Myh8
|
UTSW |
11 |
67,188,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6135:Myh8
|
UTSW |
11 |
67,188,326 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6253:Myh8
|
UTSW |
11 |
67,192,793 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6318:Myh8
|
UTSW |
11 |
67,190,167 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6432:Myh8
|
UTSW |
11 |
67,189,405 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6452:Myh8
|
UTSW |
11 |
67,196,565 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6452:Myh8
|
UTSW |
11 |
67,183,275 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6512:Myh8
|
UTSW |
11 |
67,180,488 (GRCm39) |
nonsense |
probably null |
|
|
R6714:Myh8
|
UTSW |
11 |
67,197,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6842:Myh8
|
UTSW |
11 |
67,175,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7007:Myh8
|
UTSW |
11 |
67,179,142 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7025:Myh8
|
UTSW |
11 |
67,188,365 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7086:Myh8
|
UTSW |
11 |
67,183,453 (GRCm39) |
splice site |
probably null |
|
|
R7098:Myh8
|
UTSW |
11 |
67,169,879 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7498:Myh8
|
UTSW |
11 |
67,174,263 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7716:Myh8
|
UTSW |
11 |
67,189,478 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7765:Myh8
|
UTSW |
11 |
67,194,481 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7825:Myh8
|
UTSW |
11 |
67,194,538 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7921:Myh8
|
UTSW |
11 |
67,174,644 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7926:Myh8
|
UTSW |
11 |
67,169,732 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7932:Myh8
|
UTSW |
11 |
67,185,430 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8003:Myh8
|
UTSW |
11 |
67,190,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8028:Myh8
|
UTSW |
11 |
67,194,502 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8121:Myh8
|
UTSW |
11 |
67,180,647 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8125:Myh8
|
UTSW |
11 |
67,190,598 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8170:Myh8
|
UTSW |
11 |
67,179,092 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8277:Myh8
|
UTSW |
11 |
67,183,735 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8304:Myh8
|
UTSW |
11 |
67,195,162 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8431:Myh8
|
UTSW |
11 |
67,174,440 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8535:Myh8
|
UTSW |
11 |
67,169,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8795:Myh8
|
UTSW |
11 |
67,174,203 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R8858:Myh8
|
UTSW |
11 |
67,192,820 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8927:Myh8
|
UTSW |
11 |
67,174,081 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8928:Myh8
|
UTSW |
11 |
67,174,081 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9031:Myh8
|
UTSW |
11 |
67,190,141 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R9172:Myh8
|
UTSW |
11 |
67,183,260 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9252:Myh8
|
UTSW |
11 |
67,177,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9365:Myh8
|
UTSW |
11 |
67,174,632 (GRCm39) |
missense |
probably benign |
0.42 |
|
R9468:Myh8
|
UTSW |
11 |
67,197,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9564:Myh8
|
UTSW |
11 |
67,177,215 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9565:Myh8
|
UTSW |
11 |
67,177,215 (GRCm39) |
missense |
probably benign |
0.40 |
|
T0722:Myh8
|
UTSW |
11 |
67,195,262 (GRCm39) |
missense |
probably benign |
0.41 |
|
Z1088:Myh8
|
UTSW |
11 |
67,189,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh8
|
UTSW |
11 |
67,194,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Myh8
|
UTSW |
11 |
67,199,181 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
Z1177:Myh8
|
UTSW |
11 |
67,192,250 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1187:Myh8
|
UTSW |
11 |
67,188,312 (GRCm39) |
missense |
probably benign |
|
|
Z1188:Myh8
|
UTSW |
11 |
67,188,312 (GRCm39) |
missense |
probably benign |
|
|
Z1190:Myh8
|
UTSW |
11 |
67,188,312 (GRCm39) |
missense |
probably benign |
|
|
Z1191:Myh8
|
UTSW |
11 |
67,188,312 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTTCTGGGCTCTATTGATATCG -3'
(R):5'- TGTAGGGGTGAAAGCTCATGC -3'
Sequencing Primer
(F):5'- GGGCTCTATTGATATCGATCACAC -3'
(R):5'- GCTCATGCTAATCTCAGAATCAGAGG -3'
|
| Posted On |
2014-10-01 |
Incidental Mutation