Incidental Mutation 'R2145:Dnmt1'
| ID |
233741 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dnmt1
|
| Ensembl Gene |
ENSMUSG00000004099 |
| Gene Name |
DNA methyltransferase 1 |
| Synonyms |
MTase, Dnmt1o, Cxxc9, MommeD2 |
| MMRRC Submission |
040148-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2145 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
20818501-20871084 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to A
at 20848451 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150433
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000004202]
[ENSMUST00000177754]
[ENSMUST00000178110]
[ENSMUST00000216540]
|
| AlphaFold |
P13864 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000004202
|
| SMART Domains |
Protein: ENSMUSP00000004202
Gene: ENSMUSG00000004099
| Domain | Start | End | E-Value | Type |
|---|
|
DMAP_binding
|
16 |
106 |
1.7e-13 |
SMART |
|
low complexity region
|
121 |
143 |
N/A |
INTRINSIC |
|
low complexity region
|
156 |
166 |
N/A |
INTRINSIC |
|
low complexity region
|
180 |
194 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
low complexity region
|
306 |
328 |
N/A |
INTRINSIC |
|
Pfam:DNMT1-RFD
|
405 |
540 |
4.8e-46 |
PFAM |
|
low complexity region
|
610 |
625 |
N/A |
INTRINSIC |
|
Pfam:zf-CXXC
|
648 |
694 |
2.7e-17 |
PFAM |
|
low complexity region
|
701 |
711 |
N/A |
INTRINSIC |
|
low complexity region
|
719 |
731 |
N/A |
INTRINSIC |
|
BAH
|
758 |
884 |
4.62e-31 |
SMART |
|
BAH
|
935 |
1103 |
1.79e-37 |
SMART |
|
low complexity region
|
1110 |
1124 |
N/A |
INTRINSIC |
|
Pfam:DNA_methylase
|
1142 |
1596 |
1.3e-49 |
PFAM |
|
low complexity region
|
1600 |
1619 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177754
|
| SMART Domains |
Protein: ENSMUSP00000136982
Gene: ENSMUSG00000004099
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
25 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
61 |
75 |
N/A |
INTRINSIC |
|
low complexity region
|
154 |
171 |
N/A |
INTRINSIC |
|
low complexity region
|
187 |
209 |
N/A |
INTRINSIC |
|
Pfam:DNMT1-RFD
|
286 |
421 |
3.4e-40 |
PFAM |
|
low complexity region
|
491 |
506 |
N/A |
INTRINSIC |
|
Pfam:zf-CXXC
|
529 |
575 |
2.3e-17 |
PFAM |
|
low complexity region
|
582 |
592 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
612 |
N/A |
INTRINSIC |
|
BAH
|
639 |
765 |
4.62e-31 |
SMART |
|
BAH
|
816 |
984 |
1.79e-37 |
SMART |
|
low complexity region
|
991 |
1005 |
N/A |
INTRINSIC |
|
Pfam:DNA_methylase
|
1023 |
1477 |
1.3e-49 |
PFAM |
|
low complexity region
|
1481 |
1500 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178110
|
| SMART Domains |
Protein: ENSMUSP00000136669
Gene: ENSMUSG00000004099
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
25 |
N/A |
INTRINSIC |
|
low complexity region
|
38 |
48 |
N/A |
INTRINSIC |
|
low complexity region
|
62 |
76 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
188 |
210 |
N/A |
INTRINSIC |
|
Pfam:DNMT1-RFD
|
287 |
422 |
2.6e-40 |
PFAM |
|
low complexity region
|
492 |
507 |
N/A |
INTRINSIC |
|
Pfam:zf-CXXC
|
530 |
576 |
4.7e-17 |
PFAM |
|
low complexity region
|
583 |
593 |
N/A |
INTRINSIC |
|
low complexity region
|
601 |
613 |
N/A |
INTRINSIC |
|
BAH
|
640 |
766 |
4.62e-31 |
SMART |
|
BAH
|
817 |
985 |
1.79e-37 |
SMART |
|
low complexity region
|
992 |
1006 |
N/A |
INTRINSIC |
|
Pfam:DNA_methylase
|
1024 |
1478 |
8e-50 |
PFAM |
|
low complexity region
|
1482 |
1501 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215545
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000216135
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000216540
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.6%
|
| Validation Efficiency |
97% (101/104) |
| MGI Phenotype |
FUNCTION: This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This enzyme plays roles in diverse cellular processes including cell cycle regulation, DNA repair, and telomere maintenance. The encoded protein is composed of an N-terminal domain with a nuclear localization sequence and replication fork-targeting domain, a DNA-binding CXXC domain, two bromo-adjacent homology domains, and a C-terminal catalytic domain. Mouse embryonic stem cells mutant for this gene are viable, but when introduced into the germ line, cause a recessive lethal phenotype with mutant embryos displaying stunted growth and developmental defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
PHENOTYPE: Mutations causing partial or severe loss of function were homozygous lethal by embryonic day 9.5, with lack of appropriate genomic imprinting observed at several loci. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(109) : Targeted, knock-out(5) Targeted, other(11) Gene trapped(92) Chemically induced(1)
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca15 |
A |
G |
7: 119,953,701 (GRCm39) |
N535S |
probably benign |
Het |
| Abcc6 |
A |
T |
7: 45,648,165 (GRCm39) |
L717Q |
probably benign |
Het |
| Abraxas2 |
C |
A |
7: 132,484,790 (GRCm39) |
Q278K |
probably benign |
Het |
| Acap2 |
A |
T |
16: 30,924,342 (GRCm39) |
D637E |
probably benign |
Het |
| AI661453 |
A |
G |
17: 47,777,023 (GRCm39) |
|
probably benign |
Het |
| Aoah |
A |
T |
13: 21,024,266 (GRCm39) |
E74V |
probably damaging |
Het |
| Aoc1l1 |
A |
T |
6: 48,953,629 (GRCm39) |
D518V |
probably damaging |
Het |
| Appl1 |
A |
G |
14: 26,671,576 (GRCm39) |
L292S |
possibly damaging |
Het |
| Astl |
T |
A |
2: 127,189,109 (GRCm39) |
V166E |
probably damaging |
Het |
| Bbs1 |
T |
G |
19: 4,953,735 (GRCm39) |
K143Q |
possibly damaging |
Het |
| Bbx |
T |
C |
16: 50,094,907 (GRCm39) |
|
probably benign |
Het |
| Birc6 |
A |
T |
17: 74,967,408 (GRCm39) |
Q4103L |
possibly damaging |
Het |
| C1qtnf2 |
T |
G |
11: 43,381,811 (GRCm39) |
F178V |
probably damaging |
Het |
| Camta2 |
A |
G |
11: 70,562,401 (GRCm39) |
F999L |
probably benign |
Het |
| Cfap68 |
T |
C |
9: 50,676,174 (GRCm39) |
Y32C |
probably damaging |
Het |
| Clcn7 |
A |
G |
17: 25,363,425 (GRCm39) |
I34V |
probably benign |
Het |
| Cntn5 |
G |
T |
9: 9,748,420 (GRCm39) |
P487Q |
probably damaging |
Het |
| Ctu2 |
T |
A |
8: 123,205,891 (GRCm39) |
I213K |
probably benign |
Het |
| Des |
C |
A |
1: 75,340,108 (GRCm39) |
|
probably benign |
Het |
| Dgcr8 |
A |
T |
16: 18,098,094 (GRCm39) |
D432E |
probably benign |
Het |
| Dlgap5 |
G |
A |
14: 47,633,380 (GRCm39) |
R549* |
probably null |
Het |
| Dmac2l |
A |
G |
12: 69,787,828 (GRCm39) |
Q88R |
probably damaging |
Het |
| Dmxl2 |
T |
C |
9: 54,323,194 (GRCm39) |
T1397A |
probably damaging |
Het |
| Dstyk |
T |
A |
1: 132,391,113 (GRCm39) |
M838K |
probably damaging |
Het |
| Dtwd1 |
C |
A |
2: 126,001,904 (GRCm39) |
T208N |
probably damaging |
Het |
| Dvl1 |
G |
A |
4: 155,932,273 (GRCm39) |
V28I |
possibly damaging |
Het |
| Dync1i2 |
T |
A |
2: 71,044,907 (GRCm39) |
|
probably benign |
Het |
| Fer1l6 |
T |
A |
15: 58,499,383 (GRCm39) |
M1251K |
probably benign |
Het |
| Fmod |
T |
C |
1: 133,968,256 (GRCm39) |
Y99H |
probably benign |
Het |
| Fn1 |
A |
T |
1: 71,645,163 (GRCm39) |
V1552D |
probably damaging |
Het |
| Fnip2 |
A |
T |
3: 79,407,739 (GRCm39) |
S281T |
probably damaging |
Het |
| Glb1 |
A |
G |
9: 114,293,233 (GRCm39) |
H536R |
probably benign |
Het |
| Glis2 |
T |
A |
16: 4,431,506 (GRCm39) |
S344R |
possibly damaging |
Het |
| Gm4847 |
A |
T |
1: 166,462,472 (GRCm39) |
S339R |
probably benign |
Het |
| Gpr155 |
A |
G |
2: 73,187,002 (GRCm39) |
S44P |
probably benign |
Het |
| Gprin1 |
G |
A |
13: 54,886,445 (GRCm39) |
P610S |
probably damaging |
Het |
| Gvin3 |
T |
A |
7: 106,202,215 (GRCm39) |
H343L |
possibly damaging |
Het |
| H2-Ob |
A |
T |
17: 34,461,554 (GRCm39) |
M98L |
probably benign |
Het |
| H3c6 |
T |
C |
13: 23,746,530 (GRCm39) |
T4A |
probably benign |
Het |
| Hmcn2 |
T |
C |
2: 31,223,943 (GRCm39) |
|
probably benign |
Het |
| Ikbke |
C |
A |
1: 131,201,211 (GRCm39) |
V176L |
probably damaging |
Het |
| Il13 |
T |
C |
11: 53,523,351 (GRCm39) |
T85A |
possibly damaging |
Het |
| Inpp5k |
A |
T |
11: 75,538,017 (GRCm39) |
|
probably null |
Het |
| Irgm2 |
T |
C |
11: 58,111,355 (GRCm39) |
S361P |
possibly damaging |
Het |
| Itga11 |
C |
T |
9: 62,639,486 (GRCm39) |
|
probably benign |
Het |
| Kalrn |
G |
T |
16: 33,829,632 (GRCm39) |
|
probably benign |
Het |
| Kcng1 |
C |
A |
2: 168,110,952 (GRCm39) |
G71C |
probably damaging |
Het |
| Kcnq5 |
T |
A |
1: 21,575,573 (GRCm39) |
D291V |
probably damaging |
Het |
| Klhl7 |
A |
T |
5: 24,305,861 (GRCm39) |
M37L |
probably benign |
Het |
| Letm1 |
A |
AG |
5: 33,926,859 (GRCm39) |
|
probably null |
Het |
| Lhx6 |
C |
T |
2: 35,977,478 (GRCm39) |
V325I |
probably benign |
Het |
| Lipc |
A |
G |
9: 70,841,817 (GRCm39) |
I9T |
possibly damaging |
Het |
| Lsmem1 |
GTACATACATACATACATACATACATACA |
GTACATACATACATACATACATACATACATACA |
12: 40,235,260 (GRCm39) |
|
probably null |
Het |
| Mast1 |
C |
A |
8: 85,648,107 (GRCm39) |
G458V |
probably damaging |
Het |
| Mga |
T |
C |
2: 119,794,638 (GRCm39) |
V2565A |
possibly damaging |
Het |
| Mpzl2 |
C |
G |
9: 44,955,471 (GRCm39) |
D127E |
probably benign |
Het |
| Mrtfb |
T |
C |
16: 13,230,450 (GRCm39) |
I1045T |
probably damaging |
Het |
| Myh3 |
T |
A |
11: 66,981,882 (GRCm39) |
C793S |
probably benign |
Het |
| Nomo1 |
T |
C |
7: 45,715,928 (GRCm39) |
L765P |
probably damaging |
Het |
| Nup210 |
A |
G |
6: 91,005,858 (GRCm39) |
I1335T |
possibly damaging |
Het |
| Or52b3 |
T |
C |
7: 102,204,267 (GRCm39) |
|
probably null |
Het |
| Oxr1 |
T |
A |
15: 41,683,340 (GRCm39) |
S254R |
probably damaging |
Het |
| Pan3 |
A |
G |
5: 147,466,908 (GRCm39) |
I592V |
possibly damaging |
Het |
| Pask |
C |
T |
1: 93,249,019 (GRCm39) |
A794T |
probably benign |
Het |
| Pex2 |
T |
C |
3: 5,626,650 (GRCm39) |
E53G |
probably damaging |
Het |
| Pfkfb2 |
T |
C |
1: 130,626,460 (GRCm39) |
T438A |
probably benign |
Het |
| Phactr4 |
T |
C |
4: 132,098,095 (GRCm39) |
E391G |
probably damaging |
Het |
| Pira2 |
A |
T |
7: 3,847,344 (GRCm39) |
L115Q |
probably damaging |
Het |
| Pkhd1l1 |
A |
T |
15: 44,376,273 (GRCm39) |
|
probably null |
Het |
| Pnlip |
A |
G |
19: 58,664,876 (GRCm39) |
S235G |
probably benign |
Het |
| Prkd1 |
A |
G |
12: 50,536,694 (GRCm39) |
V130A |
possibly damaging |
Het |
| Ptpn13 |
A |
G |
5: 103,703,999 (GRCm39) |
T1344A |
probably benign |
Het |
| Ptprc |
T |
C |
1: 138,001,419 (GRCm39) |
Y780C |
probably damaging |
Het |
| Pxn |
T |
A |
5: 115,690,815 (GRCm39) |
|
probably benign |
Het |
| Rap1gap2 |
G |
A |
11: 74,316,802 (GRCm39) |
T245M |
probably damaging |
Het |
| Rc3h1 |
G |
T |
1: 160,757,827 (GRCm39) |
K48N |
probably damaging |
Het |
| Rfwd3 |
T |
C |
8: 112,009,245 (GRCm39) |
I444V |
probably benign |
Het |
| Rictor |
C |
T |
15: 6,794,588 (GRCm39) |
R293C |
probably damaging |
Het |
| Rif1 |
T |
A |
2: 52,001,412 (GRCm39) |
I1622N |
possibly damaging |
Het |
| Rnf213 |
T |
C |
11: 119,306,019 (GRCm39) |
V609A |
probably benign |
Het |
| Scgb1b2 |
G |
T |
7: 30,991,188 (GRCm39) |
|
probably benign |
Het |
| Serac1 |
A |
T |
17: 6,101,060 (GRCm39) |
I448N |
probably damaging |
Het |
| Sh3kbp1 |
C |
A |
X: 158,607,492 (GRCm39) |
T200K |
probably benign |
Het |
| Sned1 |
T |
A |
1: 93,199,406 (GRCm39) |
F495L |
probably damaging |
Het |
| Socs7 |
T |
C |
11: 97,263,950 (GRCm39) |
F281L |
probably benign |
Het |
| Spta1 |
C |
T |
1: 174,040,180 (GRCm39) |
L1214F |
probably benign |
Het |
| Ssu72 |
A |
G |
4: 155,789,900 (GRCm39) |
E21G |
probably damaging |
Het |
| Syngr4 |
A |
G |
7: 45,536,464 (GRCm39) |
V186A |
probably benign |
Het |
| Tars3 |
G |
A |
7: 65,305,539 (GRCm39) |
M254I |
possibly damaging |
Het |
| Tmem130 |
C |
A |
5: 144,680,595 (GRCm39) |
V270L |
probably benign |
Het |
| Trim66 |
A |
T |
7: 109,074,320 (GRCm39) |
I647N |
probably damaging |
Het |
| Tspyl2 |
A |
T |
X: 151,121,890 (GRCm39) |
D572E |
probably benign |
Het |
| Unc45b |
G |
A |
11: 82,808,580 (GRCm39) |
R222H |
probably benign |
Het |
| Uxs1 |
T |
C |
1: 43,866,783 (GRCm39) |
Y29C |
probably damaging |
Het |
| Virma |
T |
A |
4: 11,548,726 (GRCm39) |
|
probably benign |
Het |
| Vmn1r202 |
C |
T |
13: 22,685,953 (GRCm39) |
G155S |
possibly damaging |
Het |
| Vmn2r24 |
T |
A |
6: 123,755,972 (GRCm39) |
F15I |
probably benign |
Het |
| Wdr64 |
A |
G |
1: 175,594,661 (GRCm39) |
T471A |
probably benign |
Het |
| Zfa-ps |
T |
A |
10: 52,419,373 (GRCm39) |
|
noncoding transcript |
Het |
| Zfp260 |
A |
G |
7: 29,804,765 (GRCm39) |
K222E |
probably damaging |
Het |
| Zfp300 |
A |
G |
X: 20,948,190 (GRCm39) |
S525P |
possibly damaging |
Het |
| Zfp821 |
A |
G |
8: 110,450,979 (GRCm39) |
D324G |
probably damaging |
Het |
| Zfp934 |
T |
C |
13: 62,665,648 (GRCm39) |
D331G |
probably damaging |
Het |
| Zscan29 |
T |
C |
2: 121,000,587 (GRCm39) |
R7G |
probably damaging |
Het |
|
| Other mutations in Dnmt1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00334:Dnmt1
|
APN |
9 |
20,821,566 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01093:Dnmt1
|
APN |
9 |
20,821,081 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL01160:Dnmt1
|
APN |
9 |
20,828,615 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01704:Dnmt1
|
APN |
9 |
20,821,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02105:Dnmt1
|
APN |
9 |
20,819,178 (GRCm39) |
missense |
unknown |
|
|
IGL02124:Dnmt1
|
APN |
9 |
20,819,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02188:Dnmt1
|
APN |
9 |
20,853,034 (GRCm39) |
nonsense |
probably null |
|
|
IGL02409:Dnmt1
|
APN |
9 |
20,837,793 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02579:Dnmt1
|
APN |
9 |
20,829,416 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02625:Dnmt1
|
APN |
9 |
20,838,442 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02794:Dnmt1
|
APN |
9 |
20,847,847 (GRCm39) |
missense |
probably benign |
|
|
IGL02795:Dnmt1
|
APN |
9 |
20,838,407 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02938:Dnmt1
|
APN |
9 |
20,852,669 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL03245:Dnmt1
|
APN |
9 |
20,827,056 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03303:Dnmt1
|
APN |
9 |
20,838,006 (GRCm39) |
missense |
probably benign |
|
|
Blankslate
|
UTSW |
9 |
20,823,521 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Midrash
|
UTSW |
9 |
20,821,089 (GRCm39) |
nonsense |
probably null |
|
|
Rashi
|
UTSW |
9 |
20,833,408 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
B5639:Dnmt1
|
UTSW |
9 |
20,819,264 (GRCm39) |
splice site |
probably benign |
|
|
BB003:Dnmt1
|
UTSW |
9 |
20,818,855 (GRCm39) |
missense |
unknown |
|
|
BB013:Dnmt1
|
UTSW |
9 |
20,818,855 (GRCm39) |
missense |
unknown |
|
|
PIT4576001:Dnmt1
|
UTSW |
9 |
20,823,071 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0071:Dnmt1
|
UTSW |
9 |
20,819,916 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0180:Dnmt1
|
UTSW |
9 |
20,819,916 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0368:Dnmt1
|
UTSW |
9 |
20,853,053 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0387:Dnmt1
|
UTSW |
9 |
20,829,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0529:Dnmt1
|
UTSW |
9 |
20,822,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Dnmt1
|
UTSW |
9 |
20,829,852 (GRCm39) |
splice site |
probably benign |
|
|
R0612:Dnmt1
|
UTSW |
9 |
20,829,489 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1109:Dnmt1
|
UTSW |
9 |
20,833,684 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1298:Dnmt1
|
UTSW |
9 |
20,852,752 (GRCm39) |
missense |
probably benign |
|
|
R1345:Dnmt1
|
UTSW |
9 |
20,819,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1472:Dnmt1
|
UTSW |
9 |
20,843,472 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1654:Dnmt1
|
UTSW |
9 |
20,847,870 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1817:Dnmt1
|
UTSW |
9 |
20,838,422 (GRCm39) |
missense |
probably benign |
|
|
R1836:Dnmt1
|
UTSW |
9 |
20,829,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1957:Dnmt1
|
UTSW |
9 |
20,838,442 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1958:Dnmt1
|
UTSW |
9 |
20,838,442 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2097:Dnmt1
|
UTSW |
9 |
20,821,084 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2326:Dnmt1
|
UTSW |
9 |
20,835,442 (GRCm39) |
splice site |
probably benign |
|
|
R4199:Dnmt1
|
UTSW |
9 |
20,849,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4456:Dnmt1
|
UTSW |
9 |
20,821,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4518:Dnmt1
|
UTSW |
9 |
20,823,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4586:Dnmt1
|
UTSW |
9 |
20,837,989 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4836:Dnmt1
|
UTSW |
9 |
20,819,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5014:Dnmt1
|
UTSW |
9 |
20,823,550 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5338:Dnmt1
|
UTSW |
9 |
20,864,015 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5385:Dnmt1
|
UTSW |
9 |
20,829,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5579:Dnmt1
|
UTSW |
9 |
20,831,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5645:Dnmt1
|
UTSW |
9 |
20,833,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5719:Dnmt1
|
UTSW |
9 |
20,823,891 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5881:Dnmt1
|
UTSW |
9 |
20,864,013 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6039:Dnmt1
|
UTSW |
9 |
20,837,716 (GRCm39) |
intron |
probably benign |
|
|
R6039:Dnmt1
|
UTSW |
9 |
20,837,716 (GRCm39) |
intron |
probably benign |
|
|
R6143:Dnmt1
|
UTSW |
9 |
20,838,430 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6342:Dnmt1
|
UTSW |
9 |
20,821,089 (GRCm39) |
nonsense |
probably null |
|
|
R6374:Dnmt1
|
UTSW |
9 |
20,835,341 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6953:Dnmt1
|
UTSW |
9 |
20,829,822 (GRCm39) |
missense |
probably benign |
|
|
R6990:Dnmt1
|
UTSW |
9 |
20,827,110 (GRCm39) |
nonsense |
probably null |
|
|
R7089:Dnmt1
|
UTSW |
9 |
20,819,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7463:Dnmt1
|
UTSW |
9 |
20,823,521 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7522:Dnmt1
|
UTSW |
9 |
20,831,498 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7695:Dnmt1
|
UTSW |
9 |
20,825,281 (GRCm39) |
missense |
probably null |
1.00 |
|
R7785:Dnmt1
|
UTSW |
9 |
20,833,345 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7926:Dnmt1
|
UTSW |
9 |
20,818,855 (GRCm39) |
missense |
unknown |
|
|
R8037:Dnmt1
|
UTSW |
9 |
20,852,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8038:Dnmt1
|
UTSW |
9 |
20,852,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8424:Dnmt1
|
UTSW |
9 |
20,829,836 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8692:Dnmt1
|
UTSW |
9 |
20,853,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Dnmt1
|
UTSW |
9 |
20,847,855 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9101:Dnmt1
|
UTSW |
9 |
20,852,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9200:Dnmt1
|
UTSW |
9 |
20,819,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9248:Dnmt1
|
UTSW |
9 |
20,833,408 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9317:Dnmt1
|
UTSW |
9 |
20,829,575 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9352:Dnmt1
|
UTSW |
9 |
20,840,384 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9438:Dnmt1
|
UTSW |
9 |
20,827,190 (GRCm39) |
missense |
probably benign |
|
|
RF003:Dnmt1
|
UTSW |
9 |
20,821,427 (GRCm39) |
nonsense |
probably null |
|
|
RF004:Dnmt1
|
UTSW |
9 |
20,821,423 (GRCm39) |
nonsense |
probably null |
|
|
RF011:Dnmt1
|
UTSW |
9 |
20,821,440 (GRCm39) |
nonsense |
probably null |
|
|
RF011:Dnmt1
|
UTSW |
9 |
20,821,424 (GRCm39) |
nonsense |
probably null |
|
|
RF015:Dnmt1
|
UTSW |
9 |
20,821,425 (GRCm39) |
nonsense |
probably null |
|
|
RF015:Dnmt1
|
UTSW |
9 |
20,821,420 (GRCm39) |
nonsense |
probably null |
|
|
RF017:Dnmt1
|
UTSW |
9 |
20,821,422 (GRCm39) |
nonsense |
probably null |
|
|
RF023:Dnmt1
|
UTSW |
9 |
20,821,427 (GRCm39) |
nonsense |
probably null |
|
|
RF024:Dnmt1
|
UTSW |
9 |
20,821,434 (GRCm39) |
small insertion |
probably benign |
|
|
RF024:Dnmt1
|
UTSW |
9 |
20,821,426 (GRCm39) |
nonsense |
probably null |
|
|
RF025:Dnmt1
|
UTSW |
9 |
20,821,431 (GRCm39) |
nonsense |
probably null |
|
|
RF025:Dnmt1
|
UTSW |
9 |
20,821,416 (GRCm39) |
nonsense |
probably null |
|
|
RF029:Dnmt1
|
UTSW |
9 |
20,821,419 (GRCm39) |
nonsense |
probably null |
|
|
RF034:Dnmt1
|
UTSW |
9 |
20,821,416 (GRCm39) |
nonsense |
probably null |
|
|
RF037:Dnmt1
|
UTSW |
9 |
20,821,437 (GRCm39) |
nonsense |
probably null |
|
|
RF037:Dnmt1
|
UTSW |
9 |
20,821,429 (GRCm39) |
nonsense |
probably null |
|
|
RF037:Dnmt1
|
UTSW |
9 |
20,821,415 (GRCm39) |
critical splice donor site |
probably benign |
|
|
RF042:Dnmt1
|
UTSW |
9 |
20,821,415 (GRCm39) |
nonsense |
probably null |
|
|
RF045:Dnmt1
|
UTSW |
9 |
20,821,433 (GRCm39) |
small insertion |
probably benign |
|
|
RF045:Dnmt1
|
UTSW |
9 |
20,821,425 (GRCm39) |
nonsense |
probably null |
|
|
RF047:Dnmt1
|
UTSW |
9 |
20,821,421 (GRCm39) |
nonsense |
probably null |
|
|
RF048:Dnmt1
|
UTSW |
9 |
20,821,422 (GRCm39) |
nonsense |
probably null |
|
|
RF054:Dnmt1
|
UTSW |
9 |
20,821,435 (GRCm39) |
nonsense |
probably null |
|
|
RF055:Dnmt1
|
UTSW |
9 |
20,821,432 (GRCm39) |
small insertion |
probably benign |
|
|
RF055:Dnmt1
|
UTSW |
9 |
20,821,431 (GRCm39) |
nonsense |
probably null |
|
|
RF055:Dnmt1
|
UTSW |
9 |
20,821,424 (GRCm39) |
nonsense |
probably null |
|
|
RF059:Dnmt1
|
UTSW |
9 |
20,821,434 (GRCm39) |
small insertion |
probably benign |
|
|
RF059:Dnmt1
|
UTSW |
9 |
20,821,435 (GRCm39) |
nonsense |
probably null |
|
|
RF060:Dnmt1
|
UTSW |
9 |
20,821,438 (GRCm39) |
nonsense |
probably null |
|
|
RF061:Dnmt1
|
UTSW |
9 |
20,821,426 (GRCm39) |
nonsense |
probably null |
|
|
X0026:Dnmt1
|
UTSW |
9 |
20,825,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Dnmt1
|
UTSW |
9 |
20,837,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Dnmt1
|
UTSW |
9 |
20,827,159 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAAAGATTCATAATTTGGCCCC -3'
(R):5'- TGGACACGTACAAATATATTGACAG -3'
Sequencing Primer
(F):5'- TTCGAGGCCAGTCTGATCTACAG -3'
(R):5'- ACTGAAGTCTGCCGCTCTAGAAG -3'
|
| Posted On |
2014-10-01 |
Incidental Mutation