Incidental Mutation 'R2145:Fer1l6'
ID 233773
Institutional Source Beutler Lab
Gene Symbol Fer1l6
Ensembl Gene ENSMUSG00000037106
Gene Name fer-1 like family member 6
Synonyms EG631797
MMRRC Submission 040148-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R2145 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 58381897-58536936 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 58499383 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1251 (M1251K)
Ref Sequence ENSEMBL: ENSMUSP00000125718 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161028]
AlphaFold E0CZ42
Predicted Effect probably benign
Transcript: ENSMUST00000161028
AA Change: M1251K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000125718
Gene: ENSMUSG00000037106
AA Change: M1251K

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
C2 83 179 4.09e-12 SMART
FerI 165 235 2.06e-36 SMART
C2 243 354 5.19e-14 SMART
low complexity region 412 449 N/A INTRINSIC
FerB 714 787 2.53e-45 SMART
C2 829 936 8.84e-8 SMART
C2 1000 1099 3.05e0 SMART
low complexity region 1189 1203 N/A INTRINSIC
low complexity region 1256 1270 N/A INTRINSIC
C2 1361 1460 5.78e-12 SMART
low complexity region 1518 1529 N/A INTRINSIC
C2 1601 1731 1.01e-2 SMART
Pfam:Ferlin_C 1765 1857 2.3e-40 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency 97% (101/104)
Allele List at MGI
Other mutations in this stock
Total: 104 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 A G 7: 119,953,701 (GRCm39) N535S probably benign Het
Abcc6 A T 7: 45,648,165 (GRCm39) L717Q probably benign Het
Abraxas2 C A 7: 132,484,790 (GRCm39) Q278K probably benign Het
Acap2 A T 16: 30,924,342 (GRCm39) D637E probably benign Het
AI661453 A G 17: 47,777,023 (GRCm39) probably benign Het
Aoah A T 13: 21,024,266 (GRCm39) E74V probably damaging Het
Aoc1l1 A T 6: 48,953,629 (GRCm39) D518V probably damaging Het
Appl1 A G 14: 26,671,576 (GRCm39) L292S possibly damaging Het
Astl T A 2: 127,189,109 (GRCm39) V166E probably damaging Het
Bbs1 T G 19: 4,953,735 (GRCm39) K143Q possibly damaging Het
Bbx T C 16: 50,094,907 (GRCm39) probably benign Het
Birc6 A T 17: 74,967,408 (GRCm39) Q4103L possibly damaging Het
C1qtnf2 T G 11: 43,381,811 (GRCm39) F178V probably damaging Het
Camta2 A G 11: 70,562,401 (GRCm39) F999L probably benign Het
Cfap68 T C 9: 50,676,174 (GRCm39) Y32C probably damaging Het
Clcn7 A G 17: 25,363,425 (GRCm39) I34V probably benign Het
Cntn5 G T 9: 9,748,420 (GRCm39) P487Q probably damaging Het
Ctu2 T A 8: 123,205,891 (GRCm39) I213K probably benign Het
Des C A 1: 75,340,108 (GRCm39) probably benign Het
Dgcr8 A T 16: 18,098,094 (GRCm39) D432E probably benign Het
Dlgap5 G A 14: 47,633,380 (GRCm39) R549* probably null Het
Dmac2l A G 12: 69,787,828 (GRCm39) Q88R probably damaging Het
Dmxl2 T C 9: 54,323,194 (GRCm39) T1397A probably damaging Het
Dnmt1 T A 9: 20,848,451 (GRCm39) probably benign Het
Dstyk T A 1: 132,391,113 (GRCm39) M838K probably damaging Het
Dtwd1 C A 2: 126,001,904 (GRCm39) T208N probably damaging Het
Dvl1 G A 4: 155,932,273 (GRCm39) V28I possibly damaging Het
Dync1i2 T A 2: 71,044,907 (GRCm39) probably benign Het
Fmod T C 1: 133,968,256 (GRCm39) Y99H probably benign Het
Fn1 A T 1: 71,645,163 (GRCm39) V1552D probably damaging Het
Fnip2 A T 3: 79,407,739 (GRCm39) S281T probably damaging Het
Glb1 A G 9: 114,293,233 (GRCm39) H536R probably benign Het
Glis2 T A 16: 4,431,506 (GRCm39) S344R possibly damaging Het
Gm4847 A T 1: 166,462,472 (GRCm39) S339R probably benign Het
Gpr155 A G 2: 73,187,002 (GRCm39) S44P probably benign Het
Gprin1 G A 13: 54,886,445 (GRCm39) P610S probably damaging Het
Gvin3 T A 7: 106,202,215 (GRCm39) H343L possibly damaging Het
H2-Ob A T 17: 34,461,554 (GRCm39) M98L probably benign Het
H3c6 T C 13: 23,746,530 (GRCm39) T4A probably benign Het
Hmcn2 T C 2: 31,223,943 (GRCm39) probably benign Het
Ikbke C A 1: 131,201,211 (GRCm39) V176L probably damaging Het
Il13 T C 11: 53,523,351 (GRCm39) T85A possibly damaging Het
Inpp5k A T 11: 75,538,017 (GRCm39) probably null Het
Irgm2 T C 11: 58,111,355 (GRCm39) S361P possibly damaging Het
Itga11 C T 9: 62,639,486 (GRCm39) probably benign Het
Kalrn G T 16: 33,829,632 (GRCm39) probably benign Het
Kcng1 C A 2: 168,110,952 (GRCm39) G71C probably damaging Het
Kcnq5 T A 1: 21,575,573 (GRCm39) D291V probably damaging Het
Klhl7 A T 5: 24,305,861 (GRCm39) M37L probably benign Het
Letm1 A AG 5: 33,926,859 (GRCm39) probably null Het
Lhx6 C T 2: 35,977,478 (GRCm39) V325I probably benign Het
Lipc A G 9: 70,841,817 (GRCm39) I9T possibly damaging Het
Lsmem1 GTACATACATACATACATACATACATACA GTACATACATACATACATACATACATACATACA 12: 40,235,260 (GRCm39) probably null Het
Mast1 C A 8: 85,648,107 (GRCm39) G458V probably damaging Het
Mga T C 2: 119,794,638 (GRCm39) V2565A possibly damaging Het
Mpzl2 C G 9: 44,955,471 (GRCm39) D127E probably benign Het
Mrtfb T C 16: 13,230,450 (GRCm39) I1045T probably damaging Het
Myh3 T A 11: 66,981,882 (GRCm39) C793S probably benign Het
Nomo1 T C 7: 45,715,928 (GRCm39) L765P probably damaging Het
Nup210 A G 6: 91,005,858 (GRCm39) I1335T possibly damaging Het
Or52b3 T C 7: 102,204,267 (GRCm39) probably null Het
Oxr1 T A 15: 41,683,340 (GRCm39) S254R probably damaging Het
Pan3 A G 5: 147,466,908 (GRCm39) I592V possibly damaging Het
Pask C T 1: 93,249,019 (GRCm39) A794T probably benign Het
Pex2 T C 3: 5,626,650 (GRCm39) E53G probably damaging Het
Pfkfb2 T C 1: 130,626,460 (GRCm39) T438A probably benign Het
Phactr4 T C 4: 132,098,095 (GRCm39) E391G probably damaging Het
Pira2 A T 7: 3,847,344 (GRCm39) L115Q probably damaging Het
Pkhd1l1 A T 15: 44,376,273 (GRCm39) probably null Het
Pnlip A G 19: 58,664,876 (GRCm39) S235G probably benign Het
Prkd1 A G 12: 50,536,694 (GRCm39) V130A possibly damaging Het
Ptpn13 A G 5: 103,703,999 (GRCm39) T1344A probably benign Het
Ptprc T C 1: 138,001,419 (GRCm39) Y780C probably damaging Het
Pxn T A 5: 115,690,815 (GRCm39) probably benign Het
Rap1gap2 G A 11: 74,316,802 (GRCm39) T245M probably damaging Het
Rc3h1 G T 1: 160,757,827 (GRCm39) K48N probably damaging Het
Rfwd3 T C 8: 112,009,245 (GRCm39) I444V probably benign Het
Rictor C T 15: 6,794,588 (GRCm39) R293C probably damaging Het
Rif1 T A 2: 52,001,412 (GRCm39) I1622N possibly damaging Het
Rnf213 T C 11: 119,306,019 (GRCm39) V609A probably benign Het
Scgb1b2 G T 7: 30,991,188 (GRCm39) probably benign Het
Serac1 A T 17: 6,101,060 (GRCm39) I448N probably damaging Het
Sh3kbp1 C A X: 158,607,492 (GRCm39) T200K probably benign Het
Sned1 T A 1: 93,199,406 (GRCm39) F495L probably damaging Het
Socs7 T C 11: 97,263,950 (GRCm39) F281L probably benign Het
Spta1 C T 1: 174,040,180 (GRCm39) L1214F probably benign Het
Ssu72 A G 4: 155,789,900 (GRCm39) E21G probably damaging Het
Syngr4 A G 7: 45,536,464 (GRCm39) V186A probably benign Het
Tars3 G A 7: 65,305,539 (GRCm39) M254I possibly damaging Het
Tmem130 C A 5: 144,680,595 (GRCm39) V270L probably benign Het
Trim66 A T 7: 109,074,320 (GRCm39) I647N probably damaging Het
Tspyl2 A T X: 151,121,890 (GRCm39) D572E probably benign Het
Unc45b G A 11: 82,808,580 (GRCm39) R222H probably benign Het
Uxs1 T C 1: 43,866,783 (GRCm39) Y29C probably damaging Het
Virma T A 4: 11,548,726 (GRCm39) probably benign Het
Vmn1r202 C T 13: 22,685,953 (GRCm39) G155S possibly damaging Het
Vmn2r24 T A 6: 123,755,972 (GRCm39) F15I probably benign Het
Wdr64 A G 1: 175,594,661 (GRCm39) T471A probably benign Het
Zfa-ps T A 10: 52,419,373 (GRCm39) noncoding transcript Het
Zfp260 A G 7: 29,804,765 (GRCm39) K222E probably damaging Het
Zfp300 A G X: 20,948,190 (GRCm39) S525P possibly damaging Het
Zfp821 A G 8: 110,450,979 (GRCm39) D324G probably damaging Het
Zfp934 T C 13: 62,665,648 (GRCm39) D331G probably damaging Het
Zscan29 T C 2: 121,000,587 (GRCm39) R7G probably damaging Het
Other mutations in Fer1l6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0009:Fer1l6 UTSW 15 58,534,636 (GRCm39) missense probably damaging 1.00
R0141:Fer1l6 UTSW 15 58,430,251 (GRCm39) missense probably damaging 1.00
R0178:Fer1l6 UTSW 15 58,509,763 (GRCm39) splice site probably null
R0304:Fer1l6 UTSW 15 58,462,411 (GRCm39) missense probably benign 0.08
R0379:Fer1l6 UTSW 15 58,420,187 (GRCm39) missense probably benign 0.05
R0457:Fer1l6 UTSW 15 58,509,943 (GRCm39) critical splice donor site probably null
R0546:Fer1l6 UTSW 15 58,430,257 (GRCm39) splice site probably null
R0602:Fer1l6 UTSW 15 58,449,794 (GRCm39) missense probably damaging 0.98
R0619:Fer1l6 UTSW 15 58,534,784 (GRCm39) splice site probably null
R0669:Fer1l6 UTSW 15 58,425,573 (GRCm39) splice site probably null
R0854:Fer1l6 UTSW 15 58,431,037 (GRCm39) missense probably benign 0.00
R0948:Fer1l6 UTSW 15 58,435,924 (GRCm39) missense probably benign 0.00
R1180:Fer1l6 UTSW 15 58,474,160 (GRCm39) splice site probably benign
R1483:Fer1l6 UTSW 15 58,509,819 (GRCm39) missense possibly damaging 0.84
R1627:Fer1l6 UTSW 15 58,513,728 (GRCm39) missense probably benign 0.41
R1635:Fer1l6 UTSW 15 58,518,930 (GRCm39) missense probably damaging 1.00
R1834:Fer1l6 UTSW 15 58,429,718 (GRCm39) missense possibly damaging 0.58
R1921:Fer1l6 UTSW 15 58,497,080 (GRCm39) missense probably damaging 1.00
R2000:Fer1l6 UTSW 15 58,474,160 (GRCm39) splice site probably benign
R2041:Fer1l6 UTSW 15 58,430,155 (GRCm39) missense probably damaging 1.00
R2144:Fer1l6 UTSW 15 58,499,383 (GRCm39) missense probably benign
R2981:Fer1l6 UTSW 15 58,435,926 (GRCm39) missense probably damaging 0.99
R4164:Fer1l6 UTSW 15 58,431,087 (GRCm39) missense possibly damaging 0.83
R4192:Fer1l6 UTSW 15 58,518,998 (GRCm39) missense probably damaging 1.00
R4273:Fer1l6 UTSW 15 58,499,371 (GRCm39) missense probably benign 0.41
R4573:Fer1l6 UTSW 15 58,498,129 (GRCm39) critical splice donor site probably null
R4581:Fer1l6 UTSW 15 58,512,075 (GRCm39) missense probably damaging 1.00
R4624:Fer1l6 UTSW 15 58,425,554 (GRCm39) missense probably damaging 1.00
R4755:Fer1l6 UTSW 15 58,512,060 (GRCm39) missense probably benign 0.09
R4774:Fer1l6 UTSW 15 58,449,798 (GRCm39) missense probably damaging 0.99
R4894:Fer1l6 UTSW 15 58,490,751 (GRCm39) missense probably damaging 1.00
R4896:Fer1l6 UTSW 15 58,509,869 (GRCm39) missense probably damaging 1.00
R4921:Fer1l6 UTSW 15 58,472,160 (GRCm39) critical splice acceptor site probably null
R4962:Fer1l6 UTSW 15 58,443,250 (GRCm39) missense probably benign 0.03
R5029:Fer1l6 UTSW 15 58,515,769 (GRCm39) missense probably benign 0.00
R5134:Fer1l6 UTSW 15 58,512,003 (GRCm39) missense probably damaging 1.00
R5175:Fer1l6 UTSW 15 58,422,126 (GRCm39) missense probably damaging 1.00
R5227:Fer1l6 UTSW 15 58,453,752 (GRCm39) nonsense probably null
R5561:Fer1l6 UTSW 15 58,532,674 (GRCm39) missense probably damaging 0.97
R5621:Fer1l6 UTSW 15 58,430,175 (GRCm39) missense probably damaging 1.00
R5670:Fer1l6 UTSW 15 58,494,331 (GRCm39) missense probably benign 0.00
R5745:Fer1l6 UTSW 15 58,443,238 (GRCm39) missense probably benign 0.01
R5807:Fer1l6 UTSW 15 58,462,399 (GRCm39) nonsense probably null
R5823:Fer1l6 UTSW 15 58,462,352 (GRCm39) nonsense probably null
R5892:Fer1l6 UTSW 15 58,435,917 (GRCm39) missense probably benign
R6006:Fer1l6 UTSW 15 58,518,893 (GRCm39) missense probably damaging 1.00
R6137:Fer1l6 UTSW 15 58,431,055 (GRCm39) missense probably damaging 0.97
R6195:Fer1l6 UTSW 15 58,509,806 (GRCm39) missense probably damaging 1.00
R6234:Fer1l6 UTSW 15 58,432,488 (GRCm39) missense probably damaging 1.00
R6237:Fer1l6 UTSW 15 58,509,855 (GRCm39) missense probably damaging 1.00
R6237:Fer1l6 UTSW 15 58,497,026 (GRCm39) nonsense probably null
R6271:Fer1l6 UTSW 15 58,513,767 (GRCm39) missense probably benign 0.01
R6336:Fer1l6 UTSW 15 58,431,081 (GRCm39) nonsense probably null
R6784:Fer1l6 UTSW 15 58,443,275 (GRCm39) missense possibly damaging 0.63
R6852:Fer1l6 UTSW 15 58,466,727 (GRCm39) missense probably damaging 1.00
R7030:Fer1l6 UTSW 15 58,501,227 (GRCm39) missense probably damaging 1.00
R7088:Fer1l6 UTSW 15 58,435,899 (GRCm39) missense possibly damaging 0.69
R7181:Fer1l6 UTSW 15 58,447,146 (GRCm39) missense probably benign 0.00
R7226:Fer1l6 UTSW 15 58,462,384 (GRCm39) missense probably benign 0.00
R7266:Fer1l6 UTSW 15 58,499,446 (GRCm39) missense probably benign
R7463:Fer1l6 UTSW 15 58,445,450 (GRCm39) nonsense probably null
R7464:Fer1l6 UTSW 15 58,445,096 (GRCm39) splice site probably null
R7469:Fer1l6 UTSW 15 58,462,419 (GRCm39) splice site probably null
R7483:Fer1l6 UTSW 15 58,513,794 (GRCm39) missense possibly damaging 0.83
R7491:Fer1l6 UTSW 15 58,472,281 (GRCm39) missense probably damaging 1.00
R7534:Fer1l6 UTSW 15 58,509,875 (GRCm39) missense probably damaging 1.00
R7562:Fer1l6 UTSW 15 58,432,331 (GRCm39) missense probably benign 0.00
R7580:Fer1l6 UTSW 15 58,430,245 (GRCm39) missense probably benign 0.41
R7599:Fer1l6 UTSW 15 58,499,438 (GRCm39) missense probably benign
R7607:Fer1l6 UTSW 15 58,534,581 (GRCm39) nonsense probably null
R7677:Fer1l6 UTSW 15 58,474,139 (GRCm39) missense probably benign 0.00
R8202:Fer1l6 UTSW 15 58,502,486 (GRCm39) missense probably damaging 1.00
R8261:Fer1l6 UTSW 15 58,432,345 (GRCm39) missense possibly damaging 0.84
R8847:Fer1l6 UTSW 15 58,414,012 (GRCm39) missense possibly damaging 0.72
R9022:Fer1l6 UTSW 15 58,455,329 (GRCm39) missense probably damaging 0.99
R9030:Fer1l6 UTSW 15 58,502,594 (GRCm39) missense probably damaging 1.00
R9160:Fer1l6 UTSW 15 58,515,715 (GRCm39) missense possibly damaging 0.94
R9180:Fer1l6 UTSW 15 58,494,230 (GRCm39) missense probably benign 0.19
R9289:Fer1l6 UTSW 15 58,490,766 (GRCm39) missense probably damaging 1.00
R9559:Fer1l6 UTSW 15 58,429,759 (GRCm39) missense possibly damaging 0.88
R9562:Fer1l6 UTSW 15 58,490,370 (GRCm39) missense possibly damaging 0.70
R9682:Fer1l6 UTSW 15 58,422,113 (GRCm39) missense probably benign 0.03
R9775:Fer1l6 UTSW 15 58,497,098 (GRCm39) missense probably benign
X0021:Fer1l6 UTSW 15 58,441,051 (GRCm39) nonsense probably null
X0027:Fer1l6 UTSW 15 58,501,189 (GRCm39) missense probably damaging 1.00
X0063:Fer1l6 UTSW 15 58,490,423 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATGGACCTTCTCAATGCCAG -3'
(R):5'- TAGTTCAAAGGAAGGACTCACG -3'

Sequencing Primer
(F):5'- TGTATCCATGCACAGACCTGG -3'
(R):5'- GGAAGGACTCACGACATTTGACC -3'
Posted On 2014-10-01