|Institutional Source||Beutler Lab|
|Gene Name||annexin A2|
|Synonyms||lipocortin II, annexin II, Cal1h, 36-kDa calelectrin|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R2146 (G1)|
|Chromosomal Location||69453620-69491795 bp(+) (GRCm38)|
|Type of Mutation||frame shift|
|DNA Base Change (assembly)||TCCC to TCC at 69489754 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000117855 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000034756] [ENSMUST00000123470] [ENSMUST00000136282]|
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||99% (84/85)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene are viable and fertile but suffer from growth deficits, impaired angiogenesis, and increased susceptibility to thrombosis. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Anxa2||
(F):5'- ATCACGACCCACATGAGTGC -3'
(R):5'- AGGTCACCACTCTGCCATTG -3'
(F):5'- CAGCTTTAGGGGATCTGACACTC -3'
(R):5'- GCCATTGTTCTCTACAGCCAC -3'