Incidental Mutation 'R2146:Dennd3'
ID 233862
Institutional Source Beutler Lab
Gene Symbol Dennd3
Ensembl Gene ENSMUSG00000036661
Gene Name DENN/MADD domain containing 3
Synonyms E030003N15Rik
MMRRC Submission 040149-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.162) question?
Stock # R2146 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 73512560-73572242 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 73523496 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 146 (T146M)
Ref Sequence ENSEMBL: ENSMUSP00000134002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043414] [ENSMUST00000173292]
AlphaFold A2RT67
Predicted Effect probably damaging
Transcript: ENSMUST00000043414
AA Change: T146M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000046774
Gene: ENSMUSG00000036661
AA Change: T146M

DomainStartEndE-ValueType
Blast:uDENN 12 161 3e-78 BLAST
DENN 187 373 1.54e-62 SMART
dDENN 436 499 6.81e-14 SMART
WD40 1015 1054 3.68e1 SMART
WD40 1057 1098 3.32e-5 SMART
WD40 1232 1272 1.1e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162488
SMART Domains Protein: ENSMUSP00000125657
Gene: ENSMUSG00000036661

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
Blast:DENN 33 104 5e-28 BLAST
DENN 116 302 1.54e-62 SMART
dDENN 312 376 5.63e-6 SMART
WD40 892 931 3.68e1 SMART
WD40 934 975 3.32e-5 SMART
WD40 1109 1149 1.1e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162824
Predicted Effect probably damaging
Transcript: ENSMUST00000173292
AA Change: T146M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134002
Gene: ENSMUSG00000036661
AA Change: T146M

DomainStartEndE-ValueType
Blast:uDENN 12 161 2e-78 BLAST
DENN 187 373 1.54e-62 SMART
dDENN 436 499 6.81e-14 SMART
WD40 1015 1054 3.68e1 SMART
WD40 1057 1098 3.32e-5 SMART
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 99% (84/85)
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013D24Rik A T 6: 124,347,844 (GRCm38) probably null Het
4933406M09Rik T A 1: 134,390,513 (GRCm38) M341K probably damaging Het
9530002B09Rik T A 4: 122,689,405 (GRCm38) C13* probably null Het
Abca12 C A 1: 71,263,488 (GRCm38) V2191L probably benign Het
Adamts18 G C 8: 113,845,003 (GRCm38) A116G possibly damaging Het
Anxa2 TCCC TCC 9: 69,489,754 (GRCm38) probably null Het
Arfgef1 C T 1: 10,199,878 (GRCm38) A349T probably benign Het
Arhgap6 A G X: 168,796,500 (GRCm38) T94A probably benign Het
Arhgef5 T C 6: 43,283,318 (GRCm38) S1413P probably damaging Het
Atg4c C A 4: 99,221,226 (GRCm38) N143K possibly damaging Het
BC005561 T C 5: 104,518,991 (GRCm38) F460L probably benign Het
C1qtnf12 A G 4: 155,966,465 (GRCm38) N297S probably benign Het
Cadps2 G T 6: 23,838,999 (GRCm38) probably benign Het
Ccdc185 G T 1: 182,747,520 (GRCm38) H535N possibly damaging Het
Ccdc57 A G 11: 120,885,225 (GRCm38) probably benign Het
Cd163 A G 6: 124,309,208 (GRCm38) H239R probably damaging Het
Ceacam2 G T 7: 25,527,943 (GRCm38) C166* probably null Het
Ces5a T A 8: 93,534,699 (GRCm38) E33D probably benign Het
Chl1 T C 6: 103,715,401 (GRCm38) probably null Het
Chsy3 G A 18: 59,176,472 (GRCm38) V266I probably benign Het
Cpa5 G T 6: 30,626,822 (GRCm38) R251L probably damaging Het
Cps1 A C 1: 67,152,379 (GRCm38) probably benign Het
Csmd3 CCTTTGCGCTT CCTT 15: 47,741,236 (GRCm38) probably null Het
Cstf1 T C 2: 172,375,763 (GRCm38) Y99H probably damaging Het
Cyp2j11 G A 4: 96,316,358 (GRCm38) T317I probably damaging Het
Dnah2 T C 11: 69,515,761 (GRCm38) M552V probably benign Het
Dnajc22 T C 15: 99,104,383 (GRCm38) V303A probably benign Het
Dtx2 T G 5: 136,030,610 (GRCm38) L458R probably benign Het
Elmsan1 G T 12: 84,173,035 (GRCm38) P382T probably damaging Het
Fat3 A T 9: 15,990,512 (GRCm38) F3072L probably benign Het
Fgf5 T C 5: 98,275,550 (GRCm38) *265R probably null Het
Fndc11 A G 2: 181,222,125 (GRCm38) E241G probably damaging Het
Glb1 T C 9: 114,450,648 (GRCm38) Y375H probably damaging Het
Gm4922 T G 10: 18,783,516 (GRCm38) Q486P probably benign Het
Gm5786 A T 12: 59,081,298 (GRCm38) noncoding transcript Het
Hepacam2 A T 6: 3,463,378 (GRCm38) probably benign Het
Ints9 G A 14: 64,986,343 (GRCm38) G89R possibly damaging Het
Iqcm T A 8: 75,888,613 (GRCm38) W441R probably damaging Het
Itga10 G T 3: 96,653,723 (GRCm38) G635W probably damaging Het
Itga10 T C 3: 96,651,492 (GRCm38) L382P possibly damaging Het
Kbtbd2 A G 6: 56,779,090 (GRCm38) Y554H probably damaging Het
Kif1b T C 4: 149,184,309 (GRCm38) K1649R probably damaging Het
L1cam A T X: 73,861,141 (GRCm38) F536Y probably damaging Het
Magee1 A T X: 105,122,958 (GRCm38) D783V probably damaging Het
Marveld3 A T 8: 109,959,802 (GRCm38) V144E probably benign Het
Mcam T C 9: 44,136,635 (GRCm38) V59A probably damaging Het
Mdga2 C T 12: 66,868,741 (GRCm38) E47K probably damaging Het
Metrn T A 17: 25,796,627 (GRCm38) E38V probably damaging Het
Mfrp T C 9: 44,103,718 (GRCm38) L314P probably benign Het
Mospd2 A G X: 164,956,477 (GRCm38) probably null Het
Mycbp2 G A 14: 103,155,922 (GRCm38) H3068Y probably damaging Het
Myh6 C T 14: 54,953,771 (GRCm38) R871H probably damaging Het
Nup214 C T 2: 32,034,466 (GRCm38) S1669F probably damaging Het
Olfr1104 T A 2: 87,021,665 (GRCm38) N293I probably damaging Het
Olfr1465 T C 19: 13,314,121 (GRCm38) T55A probably benign Het
Olfr156 A G 4: 43,821,178 (GRCm38) F61S probably damaging Het
Parvb A G 15: 84,232,168 (GRCm38) K33E possibly damaging Het
Pdcd11 A G 19: 47,104,752 (GRCm38) M490V probably benign Het
Pet2 T C X: 89,406,277 (GRCm38) D82G possibly damaging Het
Pkd2 A C 5: 104,455,590 (GRCm38) probably benign Het
Reps1 T A 10: 18,093,313 (GRCm38) D206E probably benign Het
Rimkla T A 4: 119,474,582 (GRCm38) M140L possibly damaging Het
Rnf13 T G 3: 57,802,486 (GRCm38) I150S probably null Het
Rxfp4 C T 3: 88,652,893 (GRCm38) A84T probably damaging Het
Serpinb8 T A 1: 107,605,927 (GRCm38) D237E probably benign Het
Sgo2b T G 8: 63,928,023 (GRCm38) T592P probably benign Het
Slc35d1 A T 4: 103,205,152 (GRCm38) I228N probably damaging Het
Slc39a1 T G 3: 90,249,450 (GRCm38) H104Q probably benign Het
Slc6a6 T C 6: 91,735,180 (GRCm38) V230A probably benign Het
Slc9a3 A G 13: 74,121,603 (GRCm38) E30G probably benign Het
Slc9c1 A G 16: 45,593,464 (GRCm38) Y985C probably benign Het
Supt6 A G 11: 78,230,932 (GRCm38) F298S probably damaging Het
Tada2a T C 11: 84,079,629 (GRCm38) D432G probably damaging Het
Tmem131 C A 1: 36,812,609 (GRCm38) V938L probably benign Het
Tnpo3 A G 6: 29,589,036 (GRCm38) V105A probably benign Het
Ttc7 T C 17: 87,346,707 (GRCm38) probably benign Het
Ttn T C 2: 76,897,188 (GRCm38) probably benign Het
Usp16 T C 16: 87,473,187 (GRCm38) probably null Het
Usp36 A G 11: 118,268,665 (GRCm38) L486S probably benign Het
Uty T C Y: 1,239,816 (GRCm38) I72V probably benign Het
Vps51 A G 19: 6,068,134 (GRCm38) V777A probably benign Het
Zfp160 A G 17: 21,026,982 (GRCm38) K598R probably benign Het
Zfp39 T C 11: 58,890,332 (GRCm38) N535D probably benign Het
Zfp804a A G 2: 82,258,664 (GRCm38) T946A probably benign Het
Other mutations in Dennd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Dennd3 APN 15 73,567,133 (GRCm38) missense probably benign 0.26
IGL00579:Dennd3 APN 15 73,540,842 (GRCm38) missense possibly damaging 0.63
IGL02101:Dennd3 APN 15 73,527,945 (GRCm38) missense possibly damaging 0.81
IGL02164:Dennd3 APN 15 73,544,448 (GRCm38) missense probably benign 0.26
IGL02389:Dennd3 APN 15 73,567,056 (GRCm38) missense probably damaging 1.00
IGL02604:Dennd3 APN 15 73,556,403 (GRCm38) missense probably damaging 1.00
IGL02697:Dennd3 APN 15 73,524,236 (GRCm38) missense possibly damaging 0.82
IGL02885:Dennd3 APN 15 73,568,696 (GRCm38) missense probably benign
IGL03356:Dennd3 APN 15 73,568,633 (GRCm38) missense probably benign 0.19
IGL03388:Dennd3 APN 15 73,544,359 (GRCm38) missense probably damaging 0.98
BB006:Dennd3 UTSW 15 73,564,574 (GRCm38) missense probably damaging 1.00
BB016:Dennd3 UTSW 15 73,564,574 (GRCm38) missense probably damaging 1.00
R0118:Dennd3 UTSW 15 73,565,076 (GRCm38) missense probably damaging 1.00
R0925:Dennd3 UTSW 15 73,533,435 (GRCm38) missense probably damaging 1.00
R1076:Dennd3 UTSW 15 73,540,733 (GRCm38) missense probably damaging 1.00
R1355:Dennd3 UTSW 15 73,540,854 (GRCm38) splice site probably benign
R1370:Dennd3 UTSW 15 73,540,854 (GRCm38) splice site probably benign
R1480:Dennd3 UTSW 15 73,532,846 (GRCm38) missense probably benign 0.20
R1727:Dennd3 UTSW 15 73,565,128 (GRCm38) missense possibly damaging 0.95
R1732:Dennd3 UTSW 15 73,537,418 (GRCm38) splice site probably benign
R1771:Dennd3 UTSW 15 73,555,101 (GRCm38) missense possibly damaging 0.71
R1776:Dennd3 UTSW 15 73,555,101 (GRCm38) missense possibly damaging 0.71
R1779:Dennd3 UTSW 15 73,522,508 (GRCm38) critical splice donor site probably null
R1838:Dennd3 UTSW 15 73,565,100 (GRCm38) missense probably damaging 1.00
R2146:Dennd3 UTSW 15 73,555,060 (GRCm38) missense probably benign 0.35
R2147:Dennd3 UTSW 15 73,523,487 (GRCm38) missense probably damaging 1.00
R2148:Dennd3 UTSW 15 73,555,060 (GRCm38) missense probably benign 0.35
R2149:Dennd3 UTSW 15 73,555,060 (GRCm38) missense probably benign 0.35
R2150:Dennd3 UTSW 15 73,555,060 (GRCm38) missense probably benign 0.35
R2174:Dennd3 UTSW 15 73,555,305 (GRCm38) missense probably damaging 1.00
R2295:Dennd3 UTSW 15 73,523,555 (GRCm38) critical splice donor site probably null
R2905:Dennd3 UTSW 15 73,557,646 (GRCm38) missense probably damaging 1.00
R3106:Dennd3 UTSW 15 73,565,124 (GRCm38) nonsense probably null
R3757:Dennd3 UTSW 15 73,522,234 (GRCm38) missense probably benign 0.00
R3785:Dennd3 UTSW 15 73,547,577 (GRCm38) missense possibly damaging 0.89
R3786:Dennd3 UTSW 15 73,547,577 (GRCm38) missense possibly damaging 0.89
R3787:Dennd3 UTSW 15 73,547,577 (GRCm38) missense possibly damaging 0.89
R3847:Dennd3 UTSW 15 73,542,732 (GRCm38) missense possibly damaging 0.64
R4369:Dennd3 UTSW 15 73,540,809 (GRCm38) missense probably damaging 0.98
R4601:Dennd3 UTSW 15 73,567,160 (GRCm38) missense probably damaging 0.99
R4666:Dennd3 UTSW 15 73,570,860 (GRCm38) missense probably damaging 1.00
R4680:Dennd3 UTSW 15 73,533,376 (GRCm38) missense possibly damaging 0.82
R4708:Dennd3 UTSW 15 73,523,495 (GRCm38) missense probably damaging 1.00
R4789:Dennd3 UTSW 15 73,522,282 (GRCm38) missense probably damaging 1.00
R4920:Dennd3 UTSW 15 73,540,725 (GRCm38) missense probably benign 0.13
R5043:Dennd3 UTSW 15 73,527,936 (GRCm38) missense probably benign 0.00
R5074:Dennd3 UTSW 15 73,547,295 (GRCm38) missense probably damaging 1.00
R5410:Dennd3 UTSW 15 73,547,448 (GRCm38) missense probably benign 0.02
R5421:Dennd3 UTSW 15 73,567,115 (GRCm38) missense probably benign
R5560:Dennd3 UTSW 15 73,532,895 (GRCm38) missense probably damaging 1.00
R6008:Dennd3 UTSW 15 73,567,080 (GRCm38) missense possibly damaging 0.88
R6357:Dennd3 UTSW 15 73,556,472 (GRCm38) missense possibly damaging 0.49
R6563:Dennd3 UTSW 15 73,544,380 (GRCm38) missense probably damaging 0.98
R6687:Dennd3 UTSW 15 73,556,366 (GRCm38) missense possibly damaging 0.64
R6837:Dennd3 UTSW 15 73,557,693 (GRCm38) missense probably damaging 1.00
R6910:Dennd3 UTSW 15 73,555,116 (GRCm38) missense probably benign 0.01
R7125:Dennd3 UTSW 15 73,533,291 (GRCm38) missense possibly damaging 0.50
R7297:Dennd3 UTSW 15 73,557,610 (GRCm38) missense probably damaging 1.00
R7524:Dennd3 UTSW 15 73,524,246 (GRCm38) nonsense probably null
R7580:Dennd3 UTSW 15 73,556,447 (GRCm38) missense possibly damaging 0.89
R7653:Dennd3 UTSW 15 73,562,426 (GRCm38) missense probably damaging 0.99
R7731:Dennd3 UTSW 15 73,562,367 (GRCm38) missense probably damaging 0.99
R7767:Dennd3 UTSW 15 73,522,230 (GRCm38) missense probably benign
R7806:Dennd3 UTSW 15 73,570,775 (GRCm38) missense possibly damaging 0.87
R7860:Dennd3 UTSW 15 73,540,808 (GRCm38) missense probably damaging 0.97
R7902:Dennd3 UTSW 15 73,568,115 (GRCm38) critical splice donor site probably benign
R7929:Dennd3 UTSW 15 73,564,574 (GRCm38) missense probably damaging 1.00
R8218:Dennd3 UTSW 15 73,512,773 (GRCm38) missense probably benign 0.31
R8436:Dennd3 UTSW 15 73,562,349 (GRCm38) missense probably damaging 1.00
R8444:Dennd3 UTSW 15 73,570,823 (GRCm38) missense probably benign 0.09
R8698:Dennd3 UTSW 15 73,522,305 (GRCm38) missense possibly damaging 0.52
R8967:Dennd3 UTSW 15 73,547,577 (GRCm38) missense possibly damaging 0.89
R9147:Dennd3 UTSW 15 73,557,614 (GRCm38) missense probably damaging 1.00
R9148:Dennd3 UTSW 15 73,557,614 (GRCm38) missense probably damaging 1.00
R9194:Dennd3 UTSW 15 73,547,304 (GRCm38) missense probably benign 0.04
R9449:Dennd3 UTSW 15 73,557,628 (GRCm38) missense probably damaging 1.00
R9501:Dennd3 UTSW 15 73,547,192 (GRCm38) missense probably benign 0.01
R9616:Dennd3 UTSW 15 73,568,714 (GRCm38) missense probably benign
R9730:Dennd3 UTSW 15 73,555,110 (GRCm38) missense probably damaging 1.00
RF006:Dennd3 UTSW 15 73,547,592 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAAAGCTCCGGGTGGTTAG -3'
(R):5'- CAAGAAAATGTTCTGGAGGCC -3'

Sequencing Primer
(F):5'- GTAGGGGAAGTGTGCTCTCCAC -3'
(R):5'- TGGAAACTCAACGTCTCAGAGTC -3'
Posted On 2014-10-01