Mutagenetix > Incidental Mutation

Incidental Mutation 'R0195:Itpr3'

23400

Institutional Source

Beutler Lab

Gene Symbol

Itpr3

Ensembl Gene

ENSMUSG00000042644

Gene Name

inositol 1,4,5-triphosphate receptor 3

Synonyms

tf, Ip3r3, Itpr-3

MMRRC Submission

038454-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0195 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

27057304-27122223 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 27114114 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 1900 (Y1900C)

Ref Sequence

ENSEMBL: ENSMUSP00000038150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049308]

AlphaFold

P70227

PDB Structure

Crystal structure of the ligand binding suppressor domain of type 3 inositol 1,4,5-trisphosphate receptor [X-RAY DIFFRACTION]

Predicted Effect

probably damaging
Transcript: ENSMUST00000049308
AA Change: Y1900C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000038150
Gene: ENSMUSG00000042644
AA Change: Y1900C

Domain	Start	End	E-Value	Type
MIR	113	167	7.75e-6	SMART
MIR	174	224	1.16e-4	SMART
MIR	232	288	1.21e-7	SMART
MIR	295	402	9.38e-14	SMART
Pfam:RYDR_ITPR	473	670	7.8e-64	PFAM
low complexity region	881	889	N/A	INTRINSIC
Pfam:RYDR_ITPR	1175	1333	5.8e-16	PFAM
low complexity region	1549	1567	N/A	INTRINSIC
low complexity region	1831	1851	N/A	INTRINSIC
Pfam:RIH_assoc	1863	1973	2.6e-34	PFAM
transmembrane domain	2203	2225	N/A	INTRINSIC
Pfam:Ion_trans	2235	2527	8.1e-20	PFAM
coiled coil region	2631	2660	N/A	INTRINSIC

Meta Mutation Damage Score

0.9677

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.6%
20x: 89.4%

Validation Efficiency

98% (156/160)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse and low sweet preference. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acly	C	G	11: 100,512,974 (GRCm38)	R362P	possibly damaging	Het
Adam24	T	A	8: 40,681,766 (GRCm38)	W758R	probably benign	Het
Adam26b	G	T	8: 43,520,270 (GRCm38)	T565K	probably damaging	Het
Adam7	T	G	14: 68,527,627 (GRCm38)		probably benign	Het
Adamts19	A	G	18: 58,969,870 (GRCm38)		probably benign	Het
Add1	A	G	5: 34,610,646 (GRCm38)		probably benign	Het
Ago1	A	G	4: 126,463,691 (GRCm38)	C64R	probably benign	Het
Ankrd12	C	T	17: 66,049,948 (GRCm38)		probably null	Het
Arhgef33	A	G	17: 80,381,434 (GRCm38)	K820E	probably damaging	Het
Arl9	T	C	5: 77,006,494 (GRCm38)	V8A	probably damaging	Het
Aspm	T	C	1: 139,479,135 (GRCm38)	L1920P	probably damaging	Het
Atad2	A	G	15: 58,099,954 (GRCm38)		probably benign	Het
Atp2b2	A	T	6: 113,793,874 (GRCm38)	V358E	probably benign	Het
C3ar1	A	C	6: 122,851,155 (GRCm38)	C34W	possibly damaging	Het
C6	G	A	15: 4,763,471 (GRCm38)	V353M	probably benign	Het
Capn7	T	C	14: 31,365,581 (GRCm38)	I593T	probably damaging	Het
Casc3	T	A	11: 98,821,493 (GRCm38)	D119E	probably damaging	Het
Ccna1	T	A	3: 55,054,364 (GRCm38)	E45V	probably damaging	Het
Cdc37	A	G	9: 21,142,280 (GRCm38)	V180A	probably benign	Het
Cdh23	A	G	10: 60,317,059 (GRCm38)	I2393T	probably damaging	Het
Cnbd1	T	C	4: 18,906,988 (GRCm38)		probably benign	Het
Cngb3	A	T	4: 19,280,975 (GRCm38)	M15L	probably benign	Het
Crygn	A	G	5: 24,756,038 (GRCm38)	M90T	possibly damaging	Het
Cse1l	T	A	2: 166,940,088 (GRCm38)	S661R	probably benign	Het
D830013O20Rik	C	T	12: 73,364,321 (GRCm38)		noncoding transcript	Het
Ddx24	C	T	12: 103,418,961 (GRCm38)		probably null	Het
Dnah3	A	T	7: 120,077,775 (GRCm38)		probably null	Het
Dnah9	C	T	11: 65,895,905 (GRCm38)	G3634E	probably benign	Het
Dnttip2	A	T	3: 122,276,161 (GRCm38)	T342S	probably benign	Het
Evx2	G	T	2: 74,659,044 (GRCm38)	R125S	probably damaging	Het
Fbxl5	A	T	5: 43,770,798 (GRCm38)	L40Q	probably damaging	Het
Git1	T	A	11: 77,501,073 (GRCm38)	D240E	probably benign	Het
Glp2r	T	A	11: 67,709,708 (GRCm38)	K438N	probably damaging	Het
Gm4778	A	G	3: 94,265,922 (GRCm38)	Y79C	possibly damaging	Het
Hivep1	T	A	13: 42,156,153 (GRCm38)	I623N	probably benign	Het
Il17re	A	G	6: 113,466,137 (GRCm38)	E312G	probably damaging	Het
Itgb7	G	A	15: 102,222,183 (GRCm38)		probably benign	Het
Krt2	G	A	15: 101,813,191 (GRCm38)	Q472*	probably null	Het
Krtap5-1	A	C	7: 142,296,697 (GRCm38)	C125G	unknown	Het
Macf1	A	G	4: 123,434,916 (GRCm38)	S2554P	probably damaging	Het
March10	C	T	11: 105,385,525 (GRCm38)	G646R	probably damaging	Het
Mrpl48	A	C	7: 100,546,353 (GRCm38)		probably benign	Het
Myo16	A	T	8: 10,315,538 (GRCm38)		probably benign	Het
Nrcam	A	T	12: 44,584,845 (GRCm38)	E1060D	probably benign	Het
Nsd3	T	A	8: 25,680,693 (GRCm38)	C731S	probably damaging	Het
Nup85	T	G	11: 115,564,531 (GRCm38)	M1R	probably null	Het
Nxnl2	G	T	13: 51,171,447 (GRCm38)	R42L	probably damaging	Het
Oas3	G	A	5: 120,756,145 (GRCm38)	R39C	probably damaging	Het
Olfr272	G	A	4: 52,910,849 (GRCm38)	T315M	probably benign	Het
Orc1	C	T	4: 108,614,308 (GRCm38)	R786*	probably null	Het
P2ry6	A	T	7: 100,938,697 (GRCm38)	W152R	probably damaging	Het
Pex5l	T	C	3: 32,992,953 (GRCm38)	N283D	possibly damaging	Het
Pgk2	T	C	17: 40,207,731 (GRCm38)	I269V	probably benign	Het
Phgdh	T	G	3: 98,316,550 (GRCm38)		probably benign	Het
Pzp	A	T	6: 128,487,478 (GRCm38)	L1362Q	probably damaging	Het
Rbbp9	T	C	2: 144,548,106 (GRCm38)		probably benign	Het
Rffl	A	G	11: 82,810,163 (GRCm38)	L244P	probably damaging	Het
Serpina11	T	C	12: 103,985,872 (GRCm38)	Y213C	probably damaging	Het
Srsf11	A	G	3: 158,036,535 (GRCm38)		probably benign	Het
Sspo	T	A	6: 48,486,636 (GRCm38)	V3785E	probably benign	Het
Svep1	A	T	4: 58,089,514 (GRCm38)	S1632T	possibly damaging	Het
Tm4sf1	T	A	3: 57,293,059 (GRCm38)	D74V	probably damaging	Het
Tmprss15	T	A	16: 79,034,334 (GRCm38)	T393S	probably benign	Het
Tnfaip3	A	G	10: 19,005,713 (GRCm38)	L275P	probably damaging	Het
Trim30c	A	G	7: 104,382,429 (GRCm38)	V393A	probably benign	Het
Tssk2	T	A	16: 17,899,575 (GRCm38)	S281T	probably benign	Het
Tubb4a	A	G	17: 57,081,499 (GRCm38)	S176P	probably damaging	Het
Unc45b	T	A	11: 82,937,828 (GRCm38)	M785K	probably damaging	Het
Vldlr	A	T	19: 27,238,386 (GRCm38)	D261V	probably damaging	Het
Vmn1r176	G	T	7: 23,835,585 (GRCm38)	Q48K	probably benign	Het
Vmn2r110	A	T	17: 20,574,055 (GRCm38)	L784Q	probably benign	Het
Vps13b	A	G	15: 35,471,899 (GRCm38)	T783A	probably benign	Het
Zfp800	A	G	6: 28,243,847 (GRCm38)	M373T	probably damaging	Het
Zmym1	A	G	4: 127,047,911 (GRCm38)	F895L	possibly damaging	Het

Other mutations in Itpr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00715:Itpr3	APN	17	27,083,629 (GRCm38)	missense	probably benign	0.05
IGL00980:Itpr3	APN	17	27,110,956 (GRCm38)	missense	probably benign
IGL01151:Itpr3	APN	17	27,091,529 (GRCm38)	missense	probably damaging	1.00
IGL01289:Itpr3	APN	17	27,099,765 (GRCm38)	missense	probably damaging	0.99
IGL01403:Itpr3	APN	17	27,118,595 (GRCm38)	missense	probably damaging	0.97
IGL01666:Itpr3	APN	17	27,117,178 (GRCm38)	missense	probably benign	0.02
IGL01897:Itpr3	APN	17	27,111,262 (GRCm38)	missense	probably damaging	1.00
IGL02003:Itpr3	APN	17	27,121,475 (GRCm38)	missense	probably damaging	1.00
IGL02012:Itpr3	APN	17	27,104,095 (GRCm38)	missense	probably benign
IGL02063:Itpr3	APN	17	27,120,023 (GRCm38)	missense	probably benign	0.01
IGL02146:Itpr3	APN	17	27,117,275 (GRCm38)	missense	probably damaging	1.00
IGL02158:Itpr3	APN	17	27,098,442 (GRCm38)	missense	probably damaging	1.00
IGL02177:Itpr3	APN	17	27,099,614 (GRCm38)	missense	possibly damaging	0.74
IGL02247:Itpr3	APN	17	27,098,179 (GRCm38)	missense	probably damaging	1.00
IGL02606:Itpr3	APN	17	27,114,512 (GRCm38)	splice site	probably benign
IGL02651:Itpr3	APN	17	27,106,398 (GRCm38)	missense	probably damaging	0.99
IGL02902:Itpr3	APN	17	27,104,556 (GRCm38)	missense	probably benign	0.21
IGL03001:Itpr3	APN	17	27,089,612 (GRCm38)	splice site	probably benign
IGL03004:Itpr3	APN	17	27,097,978 (GRCm38)	missense	possibly damaging	0.90
IGL03065:Itpr3	APN	17	27,091,933 (GRCm38)	missense	probably damaging	1.00
IGL03117:Itpr3	APN	17	27,119,266 (GRCm38)	missense	probably damaging	1.00
IGL03181:Itpr3	APN	17	27,111,268 (GRCm38)	missense	probably benign
IGL03404:Itpr3	APN	17	27,091,518 (GRCm38)	missense	probably damaging	1.00
Allure	UTSW	17	27,107,303 (GRCm38)	missense	probably damaging	1.00
alopecia	UTSW	17	27,095,478 (GRCm38)	missense	probably damaging	0.98
Beauty	UTSW	17	27,106,342 (GRCm38)	missense	probably damaging	1.00
Opuesto	UTSW	17	27,087,592 (GRCm38)	missense	probably damaging	1.00
Paradox	UTSW	17	27,098,171 (GRCm38)	missense	probably damaging	1.00
Pulchritude	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R0010:Itpr3	UTSW	17	27,120,977 (GRCm38)	missense	probably damaging	1.00
R0055:Itpr3	UTSW	17	27,098,322 (GRCm38)	missense	probably damaging	1.00
R0068:Itpr3	UTSW	17	27,104,060 (GRCm38)	splice site	probably benign
R0068:Itpr3	UTSW	17	27,104,060 (GRCm38)	splice site	probably benign
R0104:Itpr3	UTSW	17	27,095,992 (GRCm38)	missense	probably benign	0.01
R0212:Itpr3	UTSW	17	27,089,319 (GRCm38)	missense	probably damaging	1.00
R0454:Itpr3	UTSW	17	27,113,819 (GRCm38)	missense	probably benign
R0485:Itpr3	UTSW	17	27,111,929 (GRCm38)	missense	probably damaging	0.98
R0501:Itpr3	UTSW	17	27,107,289 (GRCm38)	missense	probably benign	0.09
R0781:Itpr3	UTSW	17	27,110,555 (GRCm38)	missense	probably benign	0.00
R0890:Itpr3	UTSW	17	27,089,011 (GRCm38)	nonsense	probably null
R1028:Itpr3	UTSW	17	27,091,369 (GRCm38)	missense	probably benign	0.04
R1144:Itpr3	UTSW	17	27,114,923 (GRCm38)	missense	probably benign	0.01
R1347:Itpr3	UTSW	17	27,111,561 (GRCm38)	missense	probably benign	0.02
R1347:Itpr3	UTSW	17	27,111,561 (GRCm38)	missense	probably benign	0.02
R1458:Itpr3	UTSW	17	27,118,372 (GRCm38)	missense	probably benign	0.01
R1463:Itpr3	UTSW	17	27,117,154 (GRCm38)	splice site	probably benign
R1472:Itpr3	UTSW	17	27,114,225 (GRCm38)	missense	probably benign	0.09
R1529:Itpr3	UTSW	17	27,105,485 (GRCm38)	splice site	probably null
R1533:Itpr3	UTSW	17	27,095,560 (GRCm38)	missense	possibly damaging	0.71
R1537:Itpr3	UTSW	17	27,114,147 (GRCm38)	missense	possibly damaging	0.96
R1618:Itpr3	UTSW	17	27,116,607 (GRCm38)	critical splice acceptor site	probably null
R1672:Itpr3	UTSW	17	27,089,013 (GRCm38)	missense	probably benign
R1726:Itpr3	UTSW	17	27,111,690 (GRCm38)	missense	probably damaging	0.96
R1865:Itpr3	UTSW	17	27,120,023 (GRCm38)	missense	probably benign	0.01
R1940:Itpr3	UTSW	17	27,111,217 (GRCm38)	missense	probably damaging	1.00
R2023:Itpr3	UTSW	17	27,102,811 (GRCm38)	missense	possibly damaging	0.76
R2063:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2064:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2065:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2067:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2068:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2219:Itpr3	UTSW	17	27,115,053 (GRCm38)	missense	probably benign
R2248:Itpr3	UTSW	17	27,115,059 (GRCm38)	missense	probably damaging	1.00
R2291:Itpr3	UTSW	17	27,113,579 (GRCm38)	missense	possibly damaging	0.92
R2320:Itpr3	UTSW	17	27,095,915 (GRCm38)	missense	probably benign
R2864:Itpr3	UTSW	17	27,091,551 (GRCm38)	missense	probably benign	0.01
R2865:Itpr3	UTSW	17	27,091,551 (GRCm38)	missense	probably benign	0.01
R3778:Itpr3	UTSW	17	27,095,472 (GRCm38)	missense	possibly damaging	0.57
R3881:Itpr3	UTSW	17	27,113,840 (GRCm38)	missense	probably benign	0.01
R3979:Itpr3	UTSW	17	27,091,572 (GRCm38)	missense	probably damaging	1.00
R3979:Itpr3	UTSW	17	27,085,131 (GRCm38)	missense	probably benign	0.23
R4224:Itpr3	UTSW	17	27,107,258 (GRCm38)	missense	probably damaging	1.00
R4259:Itpr3	UTSW	17	27,106,324 (GRCm38)	missense	probably damaging	1.00
R4321:Itpr3	UTSW	17	27,111,974 (GRCm38)	missense	probably benign	0.00
R4466:Itpr3	UTSW	17	27,106,342 (GRCm38)	missense	probably damaging	1.00
R4493:Itpr3	UTSW	17	27,104,612 (GRCm38)	missense	probably damaging	1.00
R4597:Itpr3	UTSW	17	27,093,283 (GRCm38)	missense	probably damaging	1.00
R4823:Itpr3	UTSW	17	27,085,147 (GRCm38)	missense	probably benign	0.30
R4921:Itpr3	UTSW	17	27,098,005 (GRCm38)	missense	probably damaging	1.00
R4974:Itpr3	UTSW	17	27,083,608 (GRCm38)	missense	probably damaging	0.96
R5063:Itpr3	UTSW	17	27,089,911 (GRCm38)	missense	possibly damaging	0.94
R5079:Itpr3	UTSW	17	27,098,423 (GRCm38)	missense	probably damaging	1.00
R5303:Itpr3	UTSW	17	27,116,689 (GRCm38)	missense	probably benign	0.38
R5518:Itpr3	UTSW	17	27,087,592 (GRCm38)	missense	probably damaging	1.00
R5521:Itpr3	UTSW	17	27,107,334 (GRCm38)	missense	probably benign	0.09
R5566:Itpr3	UTSW	17	27,115,952 (GRCm38)	missense	possibly damaging	0.71
R5567:Itpr3	UTSW	17	27,103,906 (GRCm38)	missense	possibly damaging	0.66
R5579:Itpr3	UTSW	17	27,113,519 (GRCm38)	missense	probably damaging	1.00
R5610:Itpr3	UTSW	17	27,118,566 (GRCm38)	missense	probably benign	0.42
R5658:Itpr3	UTSW	17	27,107,878 (GRCm38)	missense	possibly damaging	0.74
R5856:Itpr3	UTSW	17	27,106,405 (GRCm38)	missense	probably damaging	1.00
R5872:Itpr3	UTSW	17	27,086,976 (GRCm38)	missense	probably benign	0.02
R5878:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R5889:Itpr3	UTSW	17	27,115,065 (GRCm38)	missense	probably damaging	0.99
R5907:Itpr3	UTSW	17	27,117,893 (GRCm38)	missense	probably damaging	1.00
R5930:Itpr3	UTSW	17	27,110,921 (GRCm38)	missense	possibly damaging	0.49
R5987:Itpr3	UTSW	17	27,104,601 (GRCm38)	missense	probably damaging	1.00
R6029:Itpr3	UTSW	17	27,098,171 (GRCm38)	missense	probably damaging	1.00
R6195:Itpr3	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R6213:Itpr3	UTSW	17	27,111,200 (GRCm38)	missense	probably benign	0.03
R6233:Itpr3	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R6376:Itpr3	UTSW	17	27,095,475 (GRCm38)	missense	possibly damaging	0.94
R6514:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6515:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6516:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6955:Itpr3	UTSW	17	27,121,467 (GRCm38)	missense	probably damaging	1.00
R7002:Itpr3	UTSW	17	27,110,580 (GRCm38)	missense	probably benign	0.00
R7064:Itpr3	UTSW	17	27,089,295 (GRCm38)	missense	probably damaging	1.00
R7257:Itpr3	UTSW	17	27,118,561 (GRCm38)	missense	probably benign	0.00
R7349:Itpr3	UTSW	17	27,107,812 (GRCm38)	splice site	probably null
R7469:Itpr3	UTSW	17	27,121,054 (GRCm38)	missense	possibly damaging	0.74
R7493:Itpr3	UTSW	17	27,094,800 (GRCm38)	missense	probably benign	0.09
R7510:Itpr3	UTSW	17	27,089,039 (GRCm38)	missense	probably damaging	0.97
R7565:Itpr3	UTSW	17	27,110,888 (GRCm38)	missense	probably benign	0.01
R7616:Itpr3	UTSW	17	27,088,977 (GRCm38)	missense	probably damaging	1.00
R7728:Itpr3	UTSW	17	27,098,114 (GRCm38)	missense	probably damaging	1.00
R7779:Itpr3	UTSW	17	27,096,063 (GRCm38)	missense	probably damaging	1.00
R7788:Itpr3	UTSW	17	27,118,597 (GRCm38)	nonsense	probably null
R7871:Itpr3	UTSW	17	27,117,179 (GRCm38)	missense	probably damaging	1.00
R7889:Itpr3	UTSW	17	27,116,777 (GRCm38)	missense	probably damaging	1.00
R7966:Itpr3	UTSW	17	27,112,028 (GRCm38)	critical splice donor site	probably null
R8065:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R8067:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R8230:Itpr3	UTSW	17	27,107,737 (GRCm38)	critical splice donor site	probably null
R8263:Itpr3	UTSW	17	27,115,913 (GRCm38)	nonsense	probably null
R8264:Itpr3	UTSW	17	27,104,112 (GRCm38)	synonymous	silent
R8269:Itpr3	UTSW	17	27,093,284 (GRCm38)	missense	possibly damaging	0.60
R8271:Itpr3	UTSW	17	27,087,648 (GRCm38)	missense	probably damaging	1.00
R8316:Itpr3	UTSW	17	27,106,225 (GRCm38)	missense	possibly damaging	0.50
R8354:Itpr3	UTSW	17	27,115,919 (GRCm38)	missense	possibly damaging	0.74
R8413:Itpr3	UTSW	17	27,111,926 (GRCm38)	missense	probably damaging	1.00
R8437:Itpr3	UTSW	17	27,107,303 (GRCm38)	missense	probably damaging	1.00
R8676:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8679:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8846:Itpr3	UTSW	17	27,112,022 (GRCm38)	missense	probably damaging	1.00
R8884:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8885:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8886:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8887:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8888:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8891:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8896:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8975:Itpr3	UTSW	17	27,116,654 (GRCm38)	missense	possibly damaging	0.56
R9025:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9026:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9063:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9087:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9088:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9089:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9090:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9091:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9200:Itpr3	UTSW	17	27,107,662 (GRCm38)	missense	probably damaging	0.99
R9270:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9271:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9294:Itpr3	UTSW	17	27,111,217 (GRCm38)	missense	probably damaging	1.00
R9389:Itpr3	UTSW	17	27,095,925 (GRCm38)	missense	possibly damaging	0.84
R9433:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9434:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9443:Itpr3	UTSW	17	27,105,549 (GRCm38)	missense	probably damaging	1.00
R9472:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9474:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9475:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9476:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9477:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9507:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9508:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9511:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9694:Itpr3	UTSW	17	27,115,953 (GRCm38)	missense	probably damaging	0.99
R9789:Itpr3	UTSW	17	27,089,941 (GRCm38)	missense	probably benign	0.15
V7732:Itpr3	UTSW	17	27,111,026 (GRCm38)	splice site	probably null
V7732:Itpr3	UTSW	17	27,111,024 (GRCm38)	splice site	probably benign
Z1088:Itpr3	UTSW	17	27,113,528 (GRCm38)	missense	possibly damaging	0.50
Z1177:Itpr3	UTSW	17	27,119,987 (GRCm38)	missense	probably damaging	1.00
Z1177:Itpr3	UTSW	17	27,114,929 (GRCm38)	missense	probably damaging	1.00
Z31818:Itpr3	UTSW	17	27,095,478 (GRCm38)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- TGTGAGAACCACAACCGTGACC -3'
(R):5'- ATTGAGGATCAGCGCCGTGATG -3'

Sequencing Primer
(F):5'- AACCGTGACCTGCAAGTG -3'
(R):5'- TCGTGAGTCACAATGCAGGTC -3'

Posted On

2013-04-16