Incidental Mutation 'R2152:Myh8'
| ID |
234415 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh8
|
| Ensembl Gene |
ENSMUSG00000055775 |
| Gene Name |
myosin, heavy polypeptide 8, skeletal muscle, perinatal |
| Synonyms |
Myhsp, 4832426G23Rik, MyHC-pn, Myhs-p |
| MMRRC Submission |
040155-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.818)
|
| Stock # |
R2152 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
67277124-67308634 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 67294469 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 849
(E849K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000019625
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019625]
|
| AlphaFold |
P13542 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000019625
AA Change: E849K
PolyPhen 2
Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000019625
Gene: ENSMUSG00000055775
AA Change: E849K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
37 |
76 |
2.1e-13 |
PFAM |
|
MYSc
|
82 |
782 |
N/A |
SMART |
|
IQ
|
783 |
805 |
5.44e-3 |
SMART |
|
Pfam:Myosin_tail_1
|
846 |
1927 |
2.4e-164 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000108686
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139052
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921501E09Rik |
T |
A |
17: 33,066,934 (GRCm38) |
D298V |
probably damaging |
Het |
| Ackr3 |
A |
T |
1: 90,213,843 (GRCm38) |
Y8F |
probably benign |
Het |
| Acy1 |
T |
C |
9: 106,435,617 (GRCm38) |
E175G |
probably damaging |
Het |
| Add2 |
T |
C |
6: 86,098,598 (GRCm38) |
L243P |
probably damaging |
Het |
| Adsl |
A |
G |
15: 80,967,662 (GRCm38) |
D407G |
probably damaging |
Het |
| Afg3l1 |
T |
G |
8: 123,494,836 (GRCm38) |
I478S |
probably damaging |
Het |
| Arfrp1 |
T |
C |
2: 181,359,694 (GRCm38) |
T108A |
probably benign |
Het |
| Art5 |
A |
G |
7: 102,098,200 (GRCm38) |
L124P |
possibly damaging |
Het |
| Asap2 |
A |
T |
12: 21,112,083 (GRCm38) |
T14S |
probably damaging |
Het |
| Atp2c2 |
A |
G |
8: 119,756,102 (GRCm38) |
N901S |
probably benign |
Het |
| Bbs12 |
G |
T |
3: 37,321,160 (GRCm38) |
E586* |
probably null |
Het |
| Bicd2 |
G |
T |
13: 49,379,576 (GRCm38) |
C546F |
probably damaging |
Het |
| Bid |
A |
T |
6: 120,900,254 (GRCm38) |
L42Q |
probably damaging |
Het |
| Bpifb9a |
A |
G |
2: 154,260,135 (GRCm38) |
K51E |
probably benign |
Het |
| Calcr |
G |
T |
6: 3,687,615 (GRCm38) |
T424K |
probably benign |
Het |
| Cd46 |
A |
G |
1: 195,062,413 (GRCm38) |
I339T |
probably benign |
Het |
| Chek1 |
C |
A |
9: 36,723,983 (GRCm38) |
V35F |
probably damaging |
Het |
| Cntn3 |
A |
G |
6: 102,206,537 (GRCm38) |
I719T |
probably damaging |
Het |
| Cyb5r1 |
T |
C |
1: 134,409,625 (GRCm38) |
I163T |
possibly damaging |
Het |
| Cyp2d26 |
A |
T |
15: 82,792,706 (GRCm38) |
|
probably null |
Het |
| Dclk1 |
A |
G |
3: 55,247,212 (GRCm38) |
Y21C |
probably damaging |
Het |
| Dgcr2 |
G |
A |
16: 17,891,487 (GRCm38) |
|
probably null |
Het |
| Dhx38 |
T |
C |
8: 109,560,674 (GRCm38) |
S221G |
probably benign |
Het |
| Dis3l |
T |
A |
9: 64,307,263 (GRCm38) |
N981I |
probably benign |
Het |
| Dnah3 |
C |
T |
7: 119,952,013 (GRCm38) |
V3028I |
probably benign |
Het |
| Dnah6 |
T |
C |
6: 73,049,166 (GRCm38) |
Y3448C |
probably benign |
Het |
| Dok5 |
G |
A |
2: 170,800,896 (GRCm38) |
G38D |
probably damaging |
Het |
| Doxl2 |
T |
A |
6: 48,976,539 (GRCm38) |
I466N |
probably damaging |
Het |
| Epb41l1 |
A |
G |
2: 156,514,128 (GRCm38) |
D528G |
probably damaging |
Het |
| Fat4 |
A |
T |
3: 38,983,395 (GRCm38) |
Y3732F |
probably damaging |
Het |
| Fgfr4 |
A |
T |
13: 55,166,964 (GRCm38) |
Y640F |
probably damaging |
Het |
| Foxo6 |
T |
A |
4: 120,268,614 (GRCm38) |
D328V |
probably benign |
Het |
| Foxp1 |
A |
G |
6: 99,016,541 (GRCm38) |
L134P |
probably damaging |
Het |
| Frem2 |
G |
A |
3: 53,517,029 (GRCm38) |
R2996* |
probably null |
Het |
| Fuk |
T |
A |
8: 110,889,072 (GRCm38) |
T542S |
probably benign |
Het |
| Garem2 |
T |
C |
5: 30,108,299 (GRCm38) |
S54P |
probably damaging |
Het |
| Gcn1l1 |
T |
A |
5: 115,609,829 (GRCm38) |
I1765N |
probably benign |
Het |
| Gm4787 |
T |
A |
12: 81,377,219 (GRCm38) |
I722F |
probably benign |
Het |
| Gpc6 |
G |
T |
14: 116,926,092 (GRCm38) |
A53S |
probably benign |
Het |
| Gtpbp8 |
A |
G |
16: 44,740,027 (GRCm38) |
|
probably null |
Het |
| H2-Q2 |
T |
C |
17: 35,345,276 (GRCm38) |
|
probably null |
Het |
| Hapln2 |
C |
A |
3: 88,023,613 (GRCm38) |
R157L |
probably benign |
Het |
| Hemgn |
C |
A |
4: 46,396,607 (GRCm38) |
E210* |
probably null |
Het |
| Hpse |
T |
A |
5: 100,691,403 (GRCm38) |
K360* |
probably null |
Het |
| Iqcj |
A |
T |
3: 68,055,310 (GRCm38) |
E68V |
probably damaging |
Het |
| Kat2a |
T |
C |
11: 100,712,346 (GRCm38) |
|
probably benign |
Het |
| Kat6b |
A |
T |
14: 21,668,667 (GRCm38) |
H1138L |
probably benign |
Het |
| Kcnab1 |
A |
T |
3: 65,371,440 (GRCm38) |
I371F |
probably damaging |
Het |
| Klhl30 |
C |
A |
1: 91,357,824 (GRCm38) |
A356D |
probably benign |
Het |
| Klra3 |
G |
C |
6: 130,333,144 (GRCm38) |
R138G |
probably benign |
Het |
| Mgea5 |
A |
T |
19: 45,758,022 (GRCm38) |
Y779* |
probably null |
Het |
| Micu1 |
G |
T |
10: 59,863,288 (GRCm38) |
M468I |
probably benign |
Het |
| Mrc1 |
A |
G |
2: 14,327,864 (GRCm38) |
T1292A |
probably damaging |
Het |
| Myom3 |
G |
T |
4: 135,803,233 (GRCm38) |
R1152L |
probably benign |
Het |
| Nedd4l |
T |
A |
18: 65,210,330 (GRCm38) |
H820Q |
probably damaging |
Het |
| Nlrp4g |
T |
A |
9: 124,353,339 (GRCm38) |
|
noncoding transcript |
Het |
| Olfr1339 |
C |
T |
4: 118,735,249 (GRCm38) |
A240V |
possibly damaging |
Het |
| Olfr1413 |
T |
C |
1: 92,573,908 (GRCm38) |
S246P |
probably damaging |
Het |
| Olfr24 |
T |
C |
9: 18,755,095 (GRCm38) |
D180G |
probably damaging |
Het |
| Olfr33 |
G |
T |
7: 102,713,581 (GRCm38) |
H277Q |
probably benign |
Het |
| Olfr435 |
A |
G |
6: 43,202,069 (GRCm38) |
I142V |
probably benign |
Het |
| Olfr592 |
A |
T |
7: 103,186,640 (GRCm38) |
D13V |
probably benign |
Het |
| Olfr913 |
G |
T |
9: 38,594,411 (GRCm38) |
L63F |
probably damaging |
Het |
| Olfr969 |
A |
T |
9: 39,795,647 (GRCm38) |
I91F |
probably benign |
Het |
| Otop1 |
T |
A |
5: 38,302,851 (GRCm38) |
M587K |
probably damaging |
Het |
| Pgm5 |
T |
A |
19: 24,834,815 (GRCm38) |
I118F |
probably damaging |
Het |
| Phc2 |
A |
G |
4: 128,745,066 (GRCm38) |
*41W |
probably null |
Het |
| Piezo2 |
A |
T |
18: 63,114,041 (GRCm38) |
M532K |
probably damaging |
Het |
| Pjvk |
A |
T |
2: 76,658,369 (GRCm38) |
I295F |
probably benign |
Het |
| Popdc2 |
A |
G |
16: 38,363,120 (GRCm38) |
N155S |
possibly damaging |
Het |
| Ppp4r3a |
G |
T |
12: 101,042,567 (GRCm38) |
N684K |
probably damaging |
Het |
| Prpf4b |
T |
A |
13: 34,900,419 (GRCm38) |
M930K |
probably benign |
Het |
| Ptpn12 |
C |
A |
5: 21,002,468 (GRCm38) |
Q297H |
probably damaging |
Het |
| Ptprz1 |
C |
A |
6: 23,030,671 (GRCm38) |
L1010I |
probably damaging |
Het |
| Rabepk |
A |
T |
2: 34,784,550 (GRCm38) |
D232E |
possibly damaging |
Het |
| Rad51ap2 |
A |
G |
12: 11,457,985 (GRCm38) |
H636R |
probably benign |
Het |
| Rb1 |
T |
C |
14: 73,288,725 (GRCm38) |
T169A |
probably benign |
Het |
| Rcc2 |
T |
C |
4: 140,717,117 (GRCm38) |
L373P |
probably damaging |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,110,324 (GRCm38) |
|
probably benign |
Het |
| Rrbp1 |
A |
G |
2: 143,954,198 (GRCm38) |
L1200P |
possibly damaging |
Het |
| Sdk1 |
A |
G |
5: 141,792,944 (GRCm38) |
N226D |
probably damaging |
Het |
| Selenbp1 |
G |
A |
3: 94,944,130 (GRCm38) |
R398H |
probably damaging |
Het |
| Selenoo |
A |
G |
15: 89,099,282 (GRCm38) |
M509V |
probably benign |
Het |
| Sidt2 |
T |
C |
9: 45,945,340 (GRCm38) |
D477G |
probably damaging |
Het |
| Slc2a5 |
T |
G |
4: 150,125,638 (GRCm38) |
S27A |
probably damaging |
Het |
| Slc30a5 |
A |
T |
13: 100,803,949 (GRCm38) |
H619Q |
probably damaging |
Het |
| Slc5a9 |
A |
G |
4: 111,893,223 (GRCm38) |
I146T |
possibly damaging |
Het |
| Slc6a1 |
G |
T |
6: 114,307,770 (GRCm38) |
G263V |
probably damaging |
Het |
| Slmap |
A |
G |
14: 26,418,247 (GRCm38) |
Y771H |
probably damaging |
Het |
| Snx29 |
A |
G |
16: 11,400,843 (GRCm38) |
D181G |
possibly damaging |
Het |
| Spata31d1c |
G |
A |
13: 65,033,965 (GRCm38) |
|
probably null |
Het |
| Stat5a |
C |
A |
11: 100,874,090 (GRCm38) |
T213N |
probably benign |
Het |
| Stt3a |
A |
T |
9: 36,747,996 (GRCm38) |
V349D |
probably damaging |
Het |
| Tcf20 |
A |
T |
15: 82,855,602 (GRCm38) |
D549E |
probably damaging |
Het |
| Thbs2 |
T |
A |
17: 14,673,209 (GRCm38) |
D903V |
probably damaging |
Het |
| Tln2 |
T |
C |
9: 67,302,560 (GRCm38) |
T432A |
probably damaging |
Het |
| Tmc1 |
A |
T |
19: 20,856,675 (GRCm38) |
N241K |
probably benign |
Het |
| Tmem260 |
G |
T |
14: 48,477,609 (GRCm38) |
R240L |
possibly damaging |
Het |
| Tnfaip6 |
A |
T |
2: 52,043,730 (GRCm38) |
E32D |
probably damaging |
Het |
| Trpa1 |
A |
T |
1: 14,899,401 (GRCm38) |
H381Q |
probably damaging |
Het |
| Tsen2 |
T |
C |
6: 115,547,975 (GRCm38) |
I45T |
possibly damaging |
Het |
| Ttc6 |
G |
A |
12: 57,705,552 (GRCm38) |
V1415I |
probably damaging |
Het |
| Ttll7 |
G |
T |
3: 146,930,189 (GRCm38) |
R426L |
probably damaging |
Het |
| Ttn |
A |
C |
2: 76,740,138 (GRCm38) |
S26804A |
probably damaging |
Het |
| Ubqlnl |
A |
T |
7: 104,148,683 (GRCm38) |
C536S |
probably benign |
Het |
| Vmn2r73 |
A |
G |
7: 85,857,728 (GRCm38) |
V792A |
probably benign |
Het |
| Zfp345 |
T |
C |
2: 150,472,658 (GRCm38) |
T320A |
probably benign |
Het |
| Zfp407 |
T |
C |
18: 84,209,649 (GRCm38) |
D1945G |
possibly damaging |
Het |
|
| Other mutations in Myh8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00236:Myh8
|
APN |
11 |
67,283,818 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL01020:Myh8
|
APN |
11 |
67,283,403 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01348:Myh8
|
APN |
11 |
67,297,780 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01382:Myh8
|
APN |
11 |
67,301,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01454:Myh8
|
APN |
11 |
67,283,596 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01457:Myh8
|
APN |
11 |
67,292,679 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01472:Myh8
|
APN |
11 |
67,288,379 (GRCm38) |
splice site |
probably benign |
|
|
IGL01473:Myh8
|
APN |
11 |
67,301,825 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01613:Myh8
|
APN |
11 |
67,301,710 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL01763:Myh8
|
APN |
11 |
67,286,419 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01828:Myh8
|
APN |
11 |
67,303,826 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
IGL01862:Myh8
|
APN |
11 |
67,289,694 (GRCm38) |
nonsense |
probably null |
|
|
IGL01905:Myh8
|
APN |
11 |
67,284,651 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
IGL02280:Myh8
|
APN |
11 |
67,283,372 (GRCm38) |
unclassified |
probably benign |
|
|
IGL02386:Myh8
|
APN |
11 |
67,294,440 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02449:Myh8
|
APN |
11 |
67,294,614 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02500:Myh8
|
APN |
11 |
67,305,710 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02745:Myh8
|
APN |
11 |
67,297,501 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
IGL02799:Myh8
|
APN |
11 |
67,301,592 (GRCm38) |
splice site |
probably benign |
|
|
IGL03063:Myh8
|
APN |
11 |
67,288,205 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03223:Myh8
|
APN |
11 |
67,283,818 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL03336:Myh8
|
APN |
11 |
67,284,702 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03338:Myh8
|
APN |
11 |
67,298,346 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03351:Myh8
|
APN |
11 |
67,303,913 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL03392:Myh8
|
APN |
11 |
67,294,418 (GRCm38) |
missense |
probably damaging |
1.00 |
|
BB003:Myh8
|
UTSW |
11 |
67,278,906 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
BB009:Myh8
|
UTSW |
11 |
67,294,604 (GRCm38) |
missense |
probably benign |
0.00 |
|
BB013:Myh8
|
UTSW |
11 |
67,278,906 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
BB019:Myh8
|
UTSW |
11 |
67,294,604 (GRCm38) |
missense |
probably benign |
0.00 |
|
PIT4354001:Myh8
|
UTSW |
11 |
67,289,630 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0012:Myh8
|
UTSW |
11 |
67,300,021 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0016:Myh8
|
UTSW |
11 |
67,298,525 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0016:Myh8
|
UTSW |
11 |
67,298,525 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0115:Myh8
|
UTSW |
11 |
67,306,264 (GRCm38) |
splice site |
probably benign |
|
|
R0131:Myh8
|
UTSW |
11 |
67,292,188 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0131:Myh8
|
UTSW |
11 |
67,292,188 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0132:Myh8
|
UTSW |
11 |
67,292,188 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0238:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0238:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0239:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0239:Myh8
|
UTSW |
11 |
67,301,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0393:Myh8
|
UTSW |
11 |
67,306,017 (GRCm38) |
splice site |
probably benign |
|
|
R0453:Myh8
|
UTSW |
11 |
67,292,905 (GRCm38) |
missense |
probably benign |
0.03 |
|
R0454:Myh8
|
UTSW |
11 |
67,303,765 (GRCm38) |
nonsense |
probably null |
|
|
R0466:Myh8
|
UTSW |
11 |
67,298,579 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0487:Myh8
|
UTSW |
11 |
67,302,011 (GRCm38) |
missense |
probably benign |
|
|
R0511:Myh8
|
UTSW |
11 |
67,284,507 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0557:Myh8
|
UTSW |
11 |
67,301,798 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0589:Myh8
|
UTSW |
11 |
67,298,627 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0658:Myh8
|
UTSW |
11 |
67,284,532 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0782:Myh8
|
UTSW |
11 |
67,289,754 (GRCm38) |
missense |
probably benign |
0.16 |
|
R0829:Myh8
|
UTSW |
11 |
67,283,500 (GRCm38) |
unclassified |
probably benign |
|
|
R0845:Myh8
|
UTSW |
11 |
67,286,264 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0930:Myh8
|
UTSW |
11 |
67,305,998 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R0972:Myh8
|
UTSW |
11 |
67,297,759 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1132:Myh8
|
UTSW |
11 |
67,297,131 (GRCm38) |
nonsense |
probably null |
|
|
R1417:Myh8
|
UTSW |
11 |
67,306,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1478:Myh8
|
UTSW |
11 |
67,292,725 (GRCm38) |
missense |
probably benign |
0.23 |
|
R1497:Myh8
|
UTSW |
11 |
67,289,812 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1605:Myh8
|
UTSW |
11 |
67,301,671 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1701:Myh8
|
UTSW |
11 |
67,280,138 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1950:Myh8
|
UTSW |
11 |
67,279,004 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R1989:Myh8
|
UTSW |
11 |
67,292,724 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2010:Myh8
|
UTSW |
11 |
67,297,164 (GRCm38) |
nonsense |
probably null |
|
|
R2095:Myh8
|
UTSW |
11 |
67,286,224 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2132:Myh8
|
UTSW |
11 |
67,292,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2229:Myh8
|
UTSW |
11 |
67,308,348 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2302:Myh8
|
UTSW |
11 |
67,286,239 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2364:Myh8
|
UTSW |
11 |
67,294,518 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2429:Myh8
|
UTSW |
11 |
67,303,897 (GRCm38) |
missense |
probably benign |
0.21 |
|
R2880:Myh8
|
UTSW |
11 |
67,297,264 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3692:Myh8
|
UTSW |
11 |
67,301,918 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3756:Myh8
|
UTSW |
11 |
67,284,617 (GRCm38) |
unclassified |
probably benign |
|
|
R3924:Myh8
|
UTSW |
11 |
67,297,137 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4172:Myh8
|
UTSW |
11 |
67,292,421 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4255:Myh8
|
UTSW |
11 |
67,299,734 (GRCm38) |
missense |
probably benign |
|
|
R4621:Myh8
|
UTSW |
11 |
67,286,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4623:Myh8
|
UTSW |
11 |
67,286,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4790:Myh8
|
UTSW |
11 |
67,279,963 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4914:Myh8
|
UTSW |
11 |
67,292,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5074:Myh8
|
UTSW |
11 |
67,305,916 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R5119:Myh8
|
UTSW |
11 |
67,298,358 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5159:Myh8
|
UTSW |
11 |
67,288,353 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5229:Myh8
|
UTSW |
11 |
67,284,484 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5320:Myh8
|
UTSW |
11 |
67,286,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5455:Myh8
|
UTSW |
11 |
67,301,418 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R5523:Myh8
|
UTSW |
11 |
67,305,962 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5540:Myh8
|
UTSW |
11 |
67,286,440 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5726:Myh8
|
UTSW |
11 |
67,294,566 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R5770:Myh8
|
UTSW |
11 |
67,297,200 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6135:Myh8
|
UTSW |
11 |
67,297,500 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R6253:Myh8
|
UTSW |
11 |
67,301,967 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6318:Myh8
|
UTSW |
11 |
67,299,341 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6432:Myh8
|
UTSW |
11 |
67,298,579 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6452:Myh8
|
UTSW |
11 |
67,305,739 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6452:Myh8
|
UTSW |
11 |
67,292,449 (GRCm38) |
missense |
probably benign |
0.27 |
|
R6512:Myh8
|
UTSW |
11 |
67,289,662 (GRCm38) |
nonsense |
probably null |
|
|
R6714:Myh8
|
UTSW |
11 |
67,306,949 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6842:Myh8
|
UTSW |
11 |
67,284,655 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7007:Myh8
|
UTSW |
11 |
67,288,316 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7025:Myh8
|
UTSW |
11 |
67,297,539 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7086:Myh8
|
UTSW |
11 |
67,292,627 (GRCm38) |
splice site |
probably null |
|
|
R7098:Myh8
|
UTSW |
11 |
67,279,053 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7498:Myh8
|
UTSW |
11 |
67,283,437 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R7716:Myh8
|
UTSW |
11 |
67,298,652 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R7765:Myh8
|
UTSW |
11 |
67,303,655 (GRCm38) |
missense |
probably benign |
0.44 |
|
R7825:Myh8
|
UTSW |
11 |
67,303,712 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7921:Myh8
|
UTSW |
11 |
67,283,818 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7926:Myh8
|
UTSW |
11 |
67,278,906 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7932:Myh8
|
UTSW |
11 |
67,294,604 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8003:Myh8
|
UTSW |
11 |
67,299,760 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8028:Myh8
|
UTSW |
11 |
67,303,676 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R8121:Myh8
|
UTSW |
11 |
67,289,821 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8125:Myh8
|
UTSW |
11 |
67,299,772 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8170:Myh8
|
UTSW |
11 |
67,288,266 (GRCm38) |
missense |
probably benign |
0.30 |
|
R8277:Myh8
|
UTSW |
11 |
67,292,909 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8304:Myh8
|
UTSW |
11 |
67,304,336 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R8431:Myh8
|
UTSW |
11 |
67,283,614 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8535:Myh8
|
UTSW |
11 |
67,278,915 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8795:Myh8
|
UTSW |
11 |
67,283,377 (GRCm38) |
critical splice acceptor site |
probably benign |
|
|
R8858:Myh8
|
UTSW |
11 |
67,301,994 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R8927:Myh8
|
UTSW |
11 |
67,283,255 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8928:Myh8
|
UTSW |
11 |
67,283,255 (GRCm38) |
missense |
probably benign |
0.10 |
|
R9031:Myh8
|
UTSW |
11 |
67,299,315 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R9172:Myh8
|
UTSW |
11 |
67,292,434 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R9252:Myh8
|
UTSW |
11 |
67,286,476 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9365:Myh8
|
UTSW |
11 |
67,283,806 (GRCm38) |
missense |
probably benign |
0.42 |
|
R9468:Myh8
|
UTSW |
11 |
67,306,904 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9564:Myh8
|
UTSW |
11 |
67,286,389 (GRCm38) |
missense |
probably benign |
0.40 |
|
R9565:Myh8
|
UTSW |
11 |
67,286,389 (GRCm38) |
missense |
probably benign |
0.40 |
|
T0722:Myh8
|
UTSW |
11 |
67,304,436 (GRCm38) |
missense |
probably benign |
0.41 |
|
Z1088:Myh8
|
UTSW |
11 |
67,298,592 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh8
|
UTSW |
11 |
67,303,674 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Myh8
|
UTSW |
11 |
67,308,355 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
Z1177:Myh8
|
UTSW |
11 |
67,301,424 (GRCm38) |
missense |
probably damaging |
0.99 |
|
Z1187:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
Z1188:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
Z1190:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
Z1191:Myh8
|
UTSW |
11 |
67,297,486 (GRCm38) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CGATTGTCAGGATGAACACGC -3'
(R):5'- GGTGCTATGACATGGTCAGG -3'
Sequencing Primer
(F):5'- GGAAAACCATGTTGCCTGC -3'
(R):5'- GATAGAGCACTTACAGATTGAACCTG -3'
|
| Posted On |
2014-10-01 |
Incidental Mutation