|Institutional Source||Beutler Lab|
|Gene Name||golgi autoantigen, golgin subfamily a, 3|
|Synonyms||repro27, G1-499-14, Mea-2, 5430416E01Rik, Mea2|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R2153 (G1)|
|Chromosomal Location||110176701-110226470 bp(+) (GRCm38)|
|Type of Mutation||splice site (3 bp from exon)|
|DNA Base Change (assembly)||A to G at 110187990 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000108131 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031477] [ENSMUST00000112512] [ENSMUST00000139611]|
|AlphaFold||no structure available at present|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]
PHENOTYPE: Males homozygous for a hypomorphic transgenic insertional mutation exhibit impaired spermatogenesis involving loss of pachytene spermatocytes and are usually sterile. Male mice homozygous for an ENU-induced mutation exhibit infertility with low sperm concentration, poor motility and abnormal shape. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Golga3||
(F):5'- CATGCCAGGAACAGCTTACATG -3'
(R):5'- CTCCTACAGAAGAGCATGCTC -3'
(F):5'- AACAGCTTACATGGTTGATGGCC -3'
(R):5'- TCTTAAGAGATAGGGCTACACTGC -3'