Incidental Mutation 'R2153:Greb1'
| ID |
234541 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Greb1
|
| Ensembl Gene |
ENSMUSG00000036523 |
| Gene Name |
gene regulated by estrogen in breast cancer protein |
| Synonyms |
5730583K22Rik |
| MMRRC Submission |
040156-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2153 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
16720616-16850887 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 16749533 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 1098
(S1098G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124348
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048064]
[ENSMUST00000159120]
[ENSMUST00000162112]
|
| AlphaFold |
Q3UHK3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000048064
AA Change: S1098G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000044454
Gene: ENSMUSG00000036523
AA Change: S1098G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GREB1
|
1 |
1954 |
N/A |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159120
AA Change: S1070G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000125339
Gene: ENSMUSG00000036523
AA Change: S1070G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
52 |
71 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
437 |
453 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
1100 |
1118 |
N/A |
INTRINSIC |
|
low complexity region
|
1196 |
1207 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1265 |
N/A |
INTRINSIC |
|
low complexity region
|
1596 |
1607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160575
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161036
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162112
AA Change: S1098G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124348
Gene: ENSMUSG00000036523
AA Change: S1098G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
52 |
71 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
437 |
453 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1146 |
N/A |
INTRINSIC |
|
low complexity region
|
1224 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1293 |
N/A |
INTRINSIC |
|
low complexity region
|
1624 |
1635 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030K09Rik |
A |
G |
8: 73,208,959 (GRCm39) |
E363G |
probably benign |
Het |
| Abcg2 |
T |
A |
6: 58,661,307 (GRCm39) |
|
probably null |
Het |
| Adgrg7 |
T |
G |
16: 56,572,791 (GRCm39) |
I342L |
possibly damaging |
Het |
| Akap6 |
A |
C |
12: 53,188,187 (GRCm39) |
D1867A |
probably benign |
Het |
| Ankrd17 |
A |
T |
5: 90,381,918 (GRCm39) |
V2416D |
probably damaging |
Het |
| Apaf1 |
A |
G |
10: 90,883,952 (GRCm39) |
V670A |
probably damaging |
Het |
| Art5 |
A |
G |
7: 101,747,407 (GRCm39) |
L124P |
possibly damaging |
Het |
| Atad5 |
T |
A |
11: 79,997,203 (GRCm39) |
D842E |
probably benign |
Het |
| Brd10 |
T |
C |
19: 29,694,229 (GRCm39) |
M1755V |
probably benign |
Het |
| Capns1 |
A |
G |
7: 29,891,765 (GRCm39) |
L124P |
probably damaging |
Het |
| Carmil1 |
A |
G |
13: 24,325,656 (GRCm39) |
S225P |
probably damaging |
Het |
| Cars2 |
C |
T |
8: 11,580,299 (GRCm39) |
A247T |
possibly damaging |
Het |
| Cd46 |
A |
G |
1: 194,744,721 (GRCm39) |
I339T |
probably benign |
Het |
| Ceacam14 |
C |
A |
7: 17,548,153 (GRCm39) |
T81N |
probably benign |
Het |
| Ceacam16 |
G |
A |
7: 19,595,066 (GRCm39) |
P4L |
probably benign |
Het |
| Chek1 |
C |
A |
9: 36,635,279 (GRCm39) |
V35F |
probably damaging |
Het |
| Cntnap5c |
A |
T |
17: 58,362,666 (GRCm39) |
I340L |
possibly damaging |
Het |
| Col2a1 |
C |
A |
15: 97,885,461 (GRCm39) |
A461S |
unknown |
Het |
| Comtd1 |
T |
C |
14: 21,898,340 (GRCm39) |
E27G |
possibly damaging |
Het |
| Cyp2a12 |
A |
G |
7: 26,732,042 (GRCm39) |
N261S |
probably benign |
Het |
| Dclk1 |
A |
G |
3: 55,154,633 (GRCm39) |
Y21C |
probably damaging |
Het |
| Dis3l |
T |
A |
9: 64,214,545 (GRCm39) |
N981I |
probably benign |
Het |
| Dlg5 |
A |
T |
14: 24,187,225 (GRCm39) |
I1819N |
probably damaging |
Het |
| Elp1 |
T |
A |
4: 56,779,636 (GRCm39) |
|
probably null |
Het |
| Enpep |
T |
C |
3: 129,074,231 (GRCm39) |
N772S |
probably damaging |
Het |
| Erich1 |
T |
C |
8: 14,128,773 (GRCm39) |
T56A |
probably benign |
Het |
| Ermp1 |
T |
C |
19: 29,614,798 (GRCm39) |
|
probably null |
Het |
| Etl4 |
A |
G |
2: 20,803,545 (GRCm39) |
E807G |
probably benign |
Het |
| Fat4 |
A |
T |
3: 39,037,544 (GRCm39) |
Y3732F |
probably damaging |
Het |
| Fbxw18 |
T |
G |
9: 109,522,438 (GRCm39) |
T144P |
probably damaging |
Het |
| Flywch1 |
A |
T |
17: 23,974,624 (GRCm39) |
I672K |
probably benign |
Het |
| Foxk2 |
C |
A |
11: 121,151,213 (GRCm39) |
A86E |
probably benign |
Het |
| Garem2 |
T |
C |
5: 30,313,297 (GRCm39) |
S54P |
probably damaging |
Het |
| Gda |
A |
G |
19: 21,374,869 (GRCm39) |
|
probably null |
Het |
| Gna15 |
T |
C |
10: 81,338,738 (GRCm39) |
Y367C |
probably damaging |
Het |
| Golga3 |
A |
G |
5: 110,335,856 (GRCm39) |
|
probably null |
Het |
| Hook3 |
C |
A |
8: 26,560,225 (GRCm39) |
L333F |
probably damaging |
Het |
| Il6 |
C |
T |
5: 30,218,502 (GRCm39) |
Q33* |
probably null |
Het |
| Iqgap1 |
T |
C |
7: 80,401,701 (GRCm39) |
E468G |
probably benign |
Het |
| Iqgap1 |
A |
G |
7: 80,409,651 (GRCm39) |
I228T |
possibly damaging |
Het |
| Kat6b |
A |
T |
14: 21,718,735 (GRCm39) |
H1138L |
probably benign |
Het |
| Kcnab1 |
A |
T |
3: 65,278,861 (GRCm39) |
I371F |
probably damaging |
Het |
| Kcnj10 |
A |
T |
1: 172,197,455 (GRCm39) |
Y323F |
possibly damaging |
Het |
| Klk1b5 |
T |
C |
7: 43,869,322 (GRCm39) |
|
probably null |
Het |
| Lmo7 |
A |
G |
14: 102,157,951 (GRCm39) |
|
probably benign |
Het |
| Loxhd1 |
A |
T |
18: 77,443,862 (GRCm39) |
T277S |
possibly damaging |
Het |
| Lrp5 |
A |
T |
19: 3,664,339 (GRCm39) |
M796K |
probably benign |
Het |
| Med15 |
A |
T |
16: 17,503,315 (GRCm39) |
|
probably null |
Het |
| Mfn1 |
T |
A |
3: 32,596,975 (GRCm39) |
H144Q |
probably damaging |
Het |
| Mmp25 |
T |
A |
17: 23,850,048 (GRCm39) |
Y504F |
probably damaging |
Het |
| Nmi |
T |
C |
2: 51,842,555 (GRCm39) |
E179G |
probably damaging |
Het |
| Nrxn2 |
T |
C |
19: 6,554,944 (GRCm39) |
I1141T |
probably damaging |
Het |
| Olah |
T |
C |
2: 3,366,306 (GRCm39) |
S9G |
probably benign |
Het |
| Or1m1 |
T |
C |
9: 18,666,391 (GRCm39) |
D180G |
probably damaging |
Het |
| Or4c106 |
C |
A |
2: 88,683,128 (GRCm39) |
P278H |
probably damaging |
Het |
| Or5b120 |
T |
G |
19: 13,479,852 (GRCm39) |
I48M |
probably damaging |
Het |
| Or8b49 |
G |
T |
9: 38,505,707 (GRCm39) |
L63F |
probably damaging |
Het |
| Or8k22 |
A |
C |
2: 86,162,872 (GRCm39) |
F276C |
probably damaging |
Het |
| Otog |
T |
A |
7: 45,952,328 (GRCm39) |
C2591S |
probably damaging |
Het |
| Pdgfrb |
G |
T |
18: 61,205,828 (GRCm39) |
V605F |
probably damaging |
Het |
| Pik3cb |
T |
A |
9: 98,983,297 (GRCm39) |
K104* |
probably null |
Het |
| Plb1 |
T |
A |
5: 32,471,433 (GRCm39) |
I580N |
probably damaging |
Het |
| Plekha2 |
T |
C |
8: 25,578,413 (GRCm39) |
Y29C |
probably damaging |
Het |
| Plekha7 |
T |
A |
7: 115,775,002 (GRCm39) |
Y213F |
probably damaging |
Het |
| Plin5 |
T |
C |
17: 56,423,836 (GRCm39) |
D33G |
probably benign |
Het |
| Pnpla2 |
C |
A |
7: 141,039,132 (GRCm39) |
Q371K |
probably damaging |
Het |
| Ppm1n |
A |
G |
7: 19,012,110 (GRCm39) |
Y348H |
probably damaging |
Het |
| Ppp2r1b |
T |
A |
9: 50,777,854 (GRCm39) |
D266E |
probably damaging |
Het |
| Prss23 |
A |
G |
7: 89,159,119 (GRCm39) |
S317P |
probably damaging |
Het |
| Prss33 |
C |
T |
17: 24,053,817 (GRCm39) |
V87M |
probably damaging |
Het |
| Ptpn12 |
C |
A |
5: 21,207,466 (GRCm39) |
Q297H |
probably damaging |
Het |
| Pum1 |
G |
T |
4: 130,478,802 (GRCm39) |
A571S |
probably damaging |
Het |
| Rexo1 |
G |
T |
10: 80,379,943 (GRCm39) |
C13* |
probably null |
Het |
| Rhpn1 |
A |
T |
15: 75,576,243 (GRCm39) |
M1L |
probably null |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,000,336 (GRCm39) |
|
probably benign |
Het |
| Ripk2 |
A |
G |
4: 16,132,775 (GRCm39) |
|
probably null |
Het |
| Rps6kc1 |
T |
C |
1: 190,530,920 (GRCm39) |
Y937C |
probably damaging |
Het |
| Rrbp1 |
A |
G |
2: 143,796,118 (GRCm39) |
L1200P |
possibly damaging |
Het |
| Ryr2 |
A |
G |
13: 11,592,759 (GRCm39) |
I4665T |
possibly damaging |
Het |
| Sbno1 |
C |
A |
5: 124,516,606 (GRCm39) |
V1256F |
probably benign |
Het |
| Senp5 |
T |
C |
16: 31,787,692 (GRCm39) |
I644V |
probably damaging |
Het |
| Serpinb9e |
T |
A |
13: 33,436,961 (GRCm39) |
F94I |
probably damaging |
Het |
| Sidt2 |
T |
C |
9: 45,856,638 (GRCm39) |
D477G |
probably damaging |
Het |
| Slc30a5 |
A |
T |
13: 100,940,457 (GRCm39) |
H619Q |
probably damaging |
Het |
| Slmap |
A |
G |
14: 26,139,402 (GRCm39) |
Y771H |
probably damaging |
Het |
| Sned1 |
T |
A |
1: 93,202,379 (GRCm39) |
D674E |
probably benign |
Het |
| Sorl1 |
T |
C |
9: 41,895,788 (GRCm39) |
H1789R |
probably benign |
Het |
| Sp2 |
T |
C |
11: 96,852,834 (GRCm39) |
D30G |
possibly damaging |
Het |
| Stk33 |
T |
A |
7: 108,940,527 (GRCm39) |
N61I |
probably benign |
Het |
| Stxbp1 |
T |
A |
2: 32,692,868 (GRCm39) |
I383F |
probably damaging |
Het |
| Tbcd |
A |
G |
11: 121,494,457 (GRCm39) |
Q1006R |
possibly damaging |
Het |
| Tln2 |
T |
C |
9: 67,209,842 (GRCm39) |
T432A |
probably damaging |
Het |
| Tnfrsf21 |
A |
G |
17: 43,398,763 (GRCm39) |
D623G |
probably damaging |
Het |
| Trib2 |
A |
G |
12: 15,843,830 (GRCm39) |
F271L |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,810,477 (GRCm39) |
V17A |
probably benign |
Het |
| Ubqlnl |
A |
T |
7: 103,797,890 (GRCm39) |
C536S |
probably benign |
Het |
| Vmn1r230 |
T |
A |
17: 21,067,063 (GRCm39) |
M84K |
probably damaging |
Het |
| Vmn2r97 |
A |
T |
17: 19,167,584 (GRCm39) |
R613* |
probably null |
Het |
| Yeats2 |
T |
A |
16: 19,972,916 (GRCm39) |
D23E |
probably damaging |
Het |
| Zan |
T |
A |
5: 137,434,662 (GRCm39) |
I2214F |
unknown |
Het |
| Zbtb40 |
T |
C |
4: 136,718,946 (GRCm39) |
D917G |
probably damaging |
Het |
| Zcchc2 |
C |
A |
1: 105,949,453 (GRCm39) |
|
probably null |
Het |
| Zdhhc23 |
G |
T |
16: 43,794,282 (GRCm39) |
Q131K |
probably benign |
Het |
| Zfp345 |
T |
C |
2: 150,314,578 (GRCm39) |
T320A |
probably benign |
Het |
| Zfp532 |
A |
G |
18: 65,757,998 (GRCm39) |
T644A |
possibly damaging |
Het |
|
| Other mutations in Greb1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00155:Greb1
|
APN |
12 |
16,761,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01316:Greb1
|
APN |
12 |
16,748,587 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01464:Greb1
|
APN |
12 |
16,764,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01474:Greb1
|
APN |
12 |
16,734,502 (GRCm39) |
missense |
probably benign |
|
|
IGL01522:Greb1
|
APN |
12 |
16,751,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01824:Greb1
|
APN |
12 |
16,761,717 (GRCm39) |
nonsense |
probably null |
|
|
IGL01837:Greb1
|
APN |
12 |
16,734,452 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01991:Greb1
|
APN |
12 |
16,749,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01996:Greb1
|
APN |
12 |
16,740,846 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02213:Greb1
|
APN |
12 |
16,756,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02267:Greb1
|
APN |
12 |
16,767,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02512:Greb1
|
APN |
12 |
16,742,713 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02583:Greb1
|
APN |
12 |
16,756,296 (GRCm39) |
splice site |
probably benign |
|
|
IGL02613:Greb1
|
APN |
12 |
16,789,889 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02648:Greb1
|
APN |
12 |
16,758,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02679:Greb1
|
APN |
12 |
16,758,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
begraben
|
UTSW |
12 |
16,734,374 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
Eared
|
UTSW |
12 |
16,723,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Humpback
|
UTSW |
12 |
16,751,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
pied_billed
|
UTSW |
12 |
16,774,858 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
rednecked
|
UTSW |
12 |
16,732,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
G1patch:Greb1
|
UTSW |
12 |
16,738,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03048:Greb1
|
UTSW |
12 |
16,783,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0083:Greb1
|
UTSW |
12 |
16,746,452 (GRCm39) |
missense |
probably benign |
|
|
R0100:Greb1
|
UTSW |
12 |
16,730,225 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0100:Greb1
|
UTSW |
12 |
16,730,225 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0220:Greb1
|
UTSW |
12 |
16,732,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0245:Greb1
|
UTSW |
12 |
16,746,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0540:Greb1
|
UTSW |
12 |
16,732,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0547:Greb1
|
UTSW |
12 |
16,773,412 (GRCm39) |
missense |
probably benign |
|
|
R0563:Greb1
|
UTSW |
12 |
16,730,268 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0607:Greb1
|
UTSW |
12 |
16,732,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0610:Greb1
|
UTSW |
12 |
16,746,443 (GRCm39) |
missense |
probably benign |
|
|
R0652:Greb1
|
UTSW |
12 |
16,746,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0659:Greb1
|
UTSW |
12 |
16,730,213 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0945:Greb1
|
UTSW |
12 |
16,723,803 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1055:Greb1
|
UTSW |
12 |
16,732,252 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1445:Greb1
|
UTSW |
12 |
16,757,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Greb1
|
UTSW |
12 |
16,761,775 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1503:Greb1
|
UTSW |
12 |
16,774,820 (GRCm39) |
nonsense |
probably null |
|
|
R1566:Greb1
|
UTSW |
12 |
16,761,829 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1614:Greb1
|
UTSW |
12 |
16,751,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1623:Greb1
|
UTSW |
12 |
16,724,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Greb1
|
UTSW |
12 |
16,773,439 (GRCm39) |
splice site |
probably benign |
|
|
R1778:Greb1
|
UTSW |
12 |
16,740,895 (GRCm39) |
missense |
probably benign |
|
|
R1842:Greb1
|
UTSW |
12 |
16,746,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2040:Greb1
|
UTSW |
12 |
16,752,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2178:Greb1
|
UTSW |
12 |
16,746,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2194:Greb1
|
UTSW |
12 |
16,740,909 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2248:Greb1
|
UTSW |
12 |
16,730,379 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2474:Greb1
|
UTSW |
12 |
16,764,954 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2509:Greb1
|
UTSW |
12 |
16,774,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2860:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2861:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2862:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2866:Greb1
|
UTSW |
12 |
16,749,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2890:Greb1
|
UTSW |
12 |
16,754,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3056:Greb1
|
UTSW |
12 |
16,738,592 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3863:Greb1
|
UTSW |
12 |
16,752,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3864:Greb1
|
UTSW |
12 |
16,752,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3956:Greb1
|
UTSW |
12 |
16,732,300 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4493:Greb1
|
UTSW |
12 |
16,748,611 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4548:Greb1
|
UTSW |
12 |
16,749,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4683:Greb1
|
UTSW |
12 |
16,761,774 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4739:Greb1
|
UTSW |
12 |
16,746,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4770:Greb1
|
UTSW |
12 |
16,731,357 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4838:Greb1
|
UTSW |
12 |
16,734,361 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4925:Greb1
|
UTSW |
12 |
16,731,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4982:Greb1
|
UTSW |
12 |
16,774,762 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5009:Greb1
|
UTSW |
12 |
16,774,858 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5086:Greb1
|
UTSW |
12 |
16,758,023 (GRCm39) |
intron |
probably benign |
|
|
R5213:Greb1
|
UTSW |
12 |
16,764,791 (GRCm39) |
nonsense |
probably null |
|
|
R5310:Greb1
|
UTSW |
12 |
16,766,760 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5353:Greb1
|
UTSW |
12 |
16,738,567 (GRCm39) |
nonsense |
probably null |
|
|
R5544:Greb1
|
UTSW |
12 |
16,723,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Greb1
|
UTSW |
12 |
16,758,727 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5708:Greb1
|
UTSW |
12 |
16,723,843 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5837:Greb1
|
UTSW |
12 |
16,738,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5890:Greb1
|
UTSW |
12 |
16,783,422 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5938:Greb1
|
UTSW |
12 |
16,767,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6049:Greb1
|
UTSW |
12 |
16,731,395 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6093:Greb1
|
UTSW |
12 |
16,734,487 (GRCm39) |
missense |
probably benign |
|
|
R6120:Greb1
|
UTSW |
12 |
16,758,622 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6175:Greb1
|
UTSW |
12 |
16,724,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6247:Greb1
|
UTSW |
12 |
16,766,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6274:Greb1
|
UTSW |
12 |
16,785,152 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6376:Greb1
|
UTSW |
12 |
16,749,580 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6523:Greb1
|
UTSW |
12 |
16,734,374 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6557:Greb1
|
UTSW |
12 |
16,760,384 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6602:Greb1
|
UTSW |
12 |
16,759,441 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6621:Greb1
|
UTSW |
12 |
16,742,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6645:Greb1
|
UTSW |
12 |
16,748,580 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6725:Greb1
|
UTSW |
12 |
16,738,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6750:Greb1
|
UTSW |
12 |
16,738,584 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6863:Greb1
|
UTSW |
12 |
16,734,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6914:Greb1
|
UTSW |
12 |
16,757,903 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6996:Greb1
|
UTSW |
12 |
16,773,355 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7083:Greb1
|
UTSW |
12 |
16,773,315 (GRCm39) |
missense |
probably benign |
|
|
R7147:Greb1
|
UTSW |
12 |
16,783,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Greb1
|
UTSW |
12 |
16,724,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7290:Greb1
|
UTSW |
12 |
16,761,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7358:Greb1
|
UTSW |
12 |
16,774,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7395:Greb1
|
UTSW |
12 |
16,759,431 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7526:Greb1
|
UTSW |
12 |
16,766,766 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7530:Greb1
|
UTSW |
12 |
16,767,207 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7536:Greb1
|
UTSW |
12 |
16,732,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7643:Greb1
|
UTSW |
12 |
16,761,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7732:Greb1
|
UTSW |
12 |
16,723,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7740:Greb1
|
UTSW |
12 |
16,790,122 (GRCm39) |
start gained |
probably benign |
|
|
R7747:Greb1
|
UTSW |
12 |
16,724,796 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7760:Greb1
|
UTSW |
12 |
16,773,417 (GRCm39) |
missense |
probably benign |
|
|
R7937:Greb1
|
UTSW |
12 |
16,766,670 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8043:Greb1
|
UTSW |
12 |
16,761,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8259:Greb1
|
UTSW |
12 |
16,774,925 (GRCm39) |
nonsense |
probably null |
|
|
R8553:Greb1
|
UTSW |
12 |
16,773,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8559:Greb1
|
UTSW |
12 |
16,746,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8690:Greb1
|
UTSW |
12 |
16,746,548 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8830:Greb1
|
UTSW |
12 |
16,738,520 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8911:Greb1
|
UTSW |
12 |
16,740,903 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8963:Greb1
|
UTSW |
12 |
16,774,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8986:Greb1
|
UTSW |
12 |
16,734,457 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9013:Greb1
|
UTSW |
12 |
16,789,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9279:Greb1
|
UTSW |
12 |
16,732,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9360:Greb1
|
UTSW |
12 |
16,790,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9563:Greb1
|
UTSW |
12 |
16,774,824 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9616:Greb1
|
UTSW |
12 |
16,790,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9627:Greb1
|
UTSW |
12 |
16,756,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9731:Greb1
|
UTSW |
12 |
16,738,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9761:Greb1
|
UTSW |
12 |
16,751,275 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Greb1
|
UTSW |
12 |
16,746,757 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Greb1
|
UTSW |
12 |
16,752,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAGGAATCTACCAGCACTG -3'
(R):5'- GCATGCAATGGATACCTTCTGTC -3'
Sequencing Primer
(F):5'- TGAGCCATAAGAAATGACCACTTTC -3'
(R):5'- CCTCCCCAGGTCTCTGAGGTAC -3'
|
| Posted On |
2014-10-01 |
Incidental Mutation