|Institutional Source||Beutler Lab|
|Gene Name||interleukin 17B|
|Synonyms||Zcyto7, 1700006N07Rik, 1110006O16Rik|
|Is this an essential gene?||Probably non essential (E-score: 0.164)|
|Stock #||R2157 (G1)|
|Chromosomal Location||61687935-61692537 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to T at 61690368 bp|
|Amino Acid Change||Tryptophan to Leucine at position 91 (W91L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000025471 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000025471]|
|Predicted Effect||probably damaging
AA Change: W91L
PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
AA Change: W91L
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.1518|
|Coding Region Coverage||
|Validation Efficiency||100% (80/80)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased susceptibility to DDS-induced colitis and Citrobacter rodentium infection. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il17b||
(F):5'- CTGGCCTTTGACCAGTAGTC -3'
(R):5'- TGTACTGACAAAGCTTCCATTGG -3'
(F):5'- CATCTTCCTGGCGCCAAG -3'
(R):5'- AAAGCTTCCATTGGCAGCTG -3'