|Institutional Source||Beutler Lab|
|Gene Name||cytochrome P450, family 2, subfamily b, polypeptide 10|
|Synonyms||phenobarbitol inducible, type b, p16, Cyp2b20, Cyp2b|
|Is this an essential gene?||Probably non essential (E-score: 0.098)|
|Stock #||R2163 (G1)|
|Chromosomal Location||25897620-25926624 bp(+) (GRCm38)|
|Type of Mutation||intron|
|DNA Base Change (assembly)||A to T at 25925385 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000072264 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000005477] [ENSMUST00000072438]|
|AlphaFold||no structure available at present|
AA Change: D436V
AA Change: D436V
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||97% (76/78)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cyp2b10||
(F):5'- CAAGGGTCCTGGTTAGTTGACT -3'
(R):5'- ACTGTGGGAGAGGGCATGTG -3'
(F):5'- GGGGCCCTCAATTCTTCCATAAGAG -3'
(R):5'- TAATGGGAGGTCAGGATCAGGTG -3'