Incidental Mutation 'R0200:Cecr2'
ID 23563
Institutional Source Beutler Lab
Gene Symbol Cecr2
Ensembl Gene ENSMUSG00000071226
Gene Name CECR2, histone acetyl-lysine reader
Synonyms cat eye syndrome chromosome region, candidate 2, Gtl4, 2610101O16Rik, 2810409N01Rik
MMRRC Submission 038457-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0200 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 120643330-120748151 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 120738758 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Valine at position 1162 (F1162V)
Ref Sequence ENSEMBL: ENSMUSP00000098556 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100993] [ENSMUST00000112686]
AlphaFold E9Q2Z1
Predicted Effect probably damaging
Transcript: ENSMUST00000100993
AA Change: F1162V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000098556
Gene: ENSMUSG00000071226
AA Change: F1162V

DomainStartEndE-ValueType
low complexity region 4 14 N/A INTRINSIC
low complexity region 194 209 N/A INTRINSIC
low complexity region 211 222 N/A INTRINSIC
Pfam:WHIM3 244 284 5.2e-11 PFAM
coiled coil region 322 382 N/A INTRINSIC
BROMO 416 520 5.09e-32 SMART
low complexity region 536 551 N/A INTRINSIC
low complexity region 781 796 N/A INTRINSIC
low complexity region 839 855 N/A INTRINSIC
low complexity region 890 907 N/A INTRINSIC
low complexity region 1173 1187 N/A INTRINSIC
low complexity region 1202 1223 N/A INTRINSIC
low complexity region 1355 1366 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000112686
AA Change: F1134V

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000108306
Gene: ENSMUSG00000071226
AA Change: F1134V

DomainStartEndE-ValueType
low complexity region 4 14 N/A INTRINSIC
low complexity region 194 209 N/A INTRINSIC
low complexity region 211 222 N/A INTRINSIC
coiled coil region 322 382 N/A INTRINSIC
BROMO 416 520 5.09e-32 SMART
low complexity region 536 551 N/A INTRINSIC
low complexity region 753 768 N/A INTRINSIC
low complexity region 811 827 N/A INTRINSIC
low complexity region 862 879 N/A INTRINSIC
low complexity region 1145 1159 N/A INTRINSIC
low complexity region 1174 1195 N/A INTRINSIC
low complexity region 1327 1338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000143563
SMART Domains Protein: ENSMUSP00000116993
Gene: ENSMUSG00000071226

DomainStartEndE-ValueType
low complexity region 5 20 N/A INTRINSIC
low complexity region 63 79 N/A INTRINSIC
low complexity region 114 131 N/A INTRINSIC
low complexity region 155 174 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.8%
  • 10x: 94.7%
  • 20x: 86.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a bromodomain-containing protein that is involved in chromatin remodeling, and may additionally play a role in DNA damage response. The encoded protein functions as part of an ATP-dependent complex that is involved in neurulation. This gene is a candidate gene for Cat Eye Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
PHENOTYPE: Homozygous mutant mice display varied penetrance of exencephaly depending on genetic background. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatf T C 11: 84,336,502 (GRCm39) K466E probably damaging Het
Abcc3 T C 11: 94,245,900 (GRCm39) D1245G probably damaging Het
Adam12 T C 7: 133,576,145 (GRCm39) probably null Het
Akap11 A G 14: 78,748,193 (GRCm39) V1398A probably benign Het
Ank1 T G 8: 23,586,828 (GRCm39) L461R probably damaging Het
Ankfn1 T C 11: 89,332,792 (GRCm39) S402G possibly damaging Het
Arhgef40 A C 14: 52,234,431 (GRCm39) E911D probably damaging Het
Atp2b1 C T 10: 98,815,676 (GRCm39) Q107* probably null Het
Cacng3 T A 7: 122,271,008 (GRCm39) C4* probably null Het
Cds1 G A 5: 101,962,299 (GRCm39) V305M probably damaging Het
Cfap70 A T 14: 20,498,631 (GRCm39) Y19N probably damaging Het
Chrm5 A G 2: 112,311,065 (GRCm39) V17A probably benign Het
Col20a1 T C 2: 180,642,231 (GRCm39) I714T probably damaging Het
Cpeb2 T A 5: 43,419,119 (GRCm39) M156K possibly damaging Het
Cstdc6 T C 16: 36,143,386 (GRCm39) probably null Het
Defb25 C A 2: 152,464,332 (GRCm39) V71L probably benign Het
Dhx35 A T 2: 158,671,543 (GRCm39) M325L probably benign Het
Dhx57 A T 17: 80,558,902 (GRCm39) L1019H probably damaging Het
Dnah6 T A 6: 73,046,403 (GRCm39) D3195V probably damaging Het
Dph5 A G 3: 115,722,352 (GRCm39) S277G probably benign Het
Dpm1 C A 2: 168,065,075 (GRCm39) probably null Het
Dsg1a A T 18: 20,473,995 (GRCm39) M1023L probably benign Het
Egf A G 3: 129,499,882 (GRCm39) Y252H probably benign Het
Egf A G 3: 129,531,198 (GRCm39) S126P probably damaging Het
Enam T C 5: 88,640,886 (GRCm39) W183R possibly damaging Het
Foxn1 T C 11: 78,251,866 (GRCm39) Y455C probably damaging Het
Iars1 A T 13: 49,879,678 (GRCm39) D983V possibly damaging Het
Ikzf4 C A 10: 128,470,545 (GRCm39) G325V probably damaging Het
Il1rl1 T A 1: 40,480,463 (GRCm39) W31R possibly damaging Het
Ip6k3 C T 17: 27,363,999 (GRCm39) D350N probably damaging Het
Irgc T C 7: 24,131,431 (GRCm39) D462G probably benign Het
Itprid1 T C 6: 55,874,941 (GRCm39) L297P probably benign Het
Jph3 A G 8: 122,511,572 (GRCm39) E520G probably benign Het
Kcna2 T A 3: 107,012,476 (GRCm39) D352E probably benign Het
Klk4 T A 7: 43,534,785 (GRCm39) I248N probably damaging Het
Krtap16-1 T C 11: 99,876,123 (GRCm39) Y427C probably damaging Het
Lgr4 A G 2: 109,801,035 (GRCm39) probably null Het
Lhpp C T 7: 132,212,406 (GRCm39) probably benign Het
Lypd3 T A 7: 24,339,656 (GRCm39) V241D probably damaging Het
Lyz2 T A 10: 117,116,678 (GRCm39) N57Y possibly damaging Het
Man1a A G 10: 53,950,594 (GRCm39) V176A probably damaging Het
Mcm4 G A 16: 15,447,503 (GRCm39) T487I probably benign Het
Mettl21c T A 1: 44,052,814 (GRCm39) I68F probably damaging Het
Miip T A 4: 147,946,720 (GRCm39) T313S probably damaging Het
Minar2 A G 18: 59,195,531 (GRCm39) probably null Het
Mog A T 17: 37,323,311 (GRCm39) I209K probably damaging Het
Myo1c C A 11: 75,563,008 (GRCm39) D997E probably benign Het
Npc1 T C 18: 12,352,261 (GRCm39) Y146C probably damaging Het
Nploc4 A G 11: 120,304,507 (GRCm39) L238P probably damaging Het
Opa1 A G 16: 29,432,947 (GRCm39) N544S probably benign Het
Or2j6 T C 7: 139,980,788 (GRCm39) Y57C probably damaging Het
Or2v1 T A 11: 49,025,874 (GRCm39) M285K probably damaging Het
Or6k6 T C 1: 173,945,078 (GRCm39) H168R probably benign Het
Pam C T 1: 97,822,126 (GRCm39) probably null Het
Pdgfra T C 5: 75,324,438 (GRCm39) Y98H probably damaging Het
Plcz1 C T 6: 139,936,459 (GRCm39) R590H probably damaging Het
Plxdc1 T C 11: 97,824,838 (GRCm39) Y339C probably damaging Het
Plxna1 T C 6: 89,300,575 (GRCm39) N1583S probably damaging Het
Plxna4 C T 6: 32,174,023 (GRCm39) V1191M probably damaging Het
Polk T A 13: 96,633,330 (GRCm39) N238Y probably benign Het
Ptprq T C 10: 107,521,018 (GRCm39) N718S probably benign Het
Rsrc1 A T 3: 67,088,194 (GRCm39) H176L probably damaging Het
Sbno1 T C 5: 124,522,604 (GRCm39) D1072G probably damaging Het
Scmh1 A G 4: 120,341,028 (GRCm39) K238R probably damaging Het
Senp7 A G 16: 55,944,236 (GRCm39) T187A possibly damaging Het
Slc12a4 T C 8: 106,678,249 (GRCm39) R315G probably benign Het
Slc16a10 A G 10: 39,916,612 (GRCm39) V430A probably benign Het
Slc26a7 T C 4: 14,621,317 (GRCm39) D23G probably benign Het
Slc28a2b T A 2: 122,357,928 (GRCm39) *661R probably null Het
Slc7a7 A G 14: 54,615,259 (GRCm39) L246P probably damaging Het
Spata7 T A 12: 98,629,428 (GRCm39) S332T probably benign Het
Spsb1 A G 4: 149,982,673 (GRCm39) *274R probably null Het
Sspo T G 6: 48,463,349 (GRCm39) V3767G probably null Het
Syt10 C A 15: 89,711,144 (GRCm39) A130S probably benign Het
Tgm6 T A 2: 129,994,865 (GRCm39) probably null Het
Them7 A C 2: 105,128,262 (GRCm39) N81T probably damaging Het
Tinag C A 9: 76,859,217 (GRCm39) A464S probably damaging Het
Tmem217 T G 17: 29,745,284 (GRCm39) I149L probably benign Het
Trp53rkb T G 2: 166,637,603 (GRCm39) D186E probably damaging Het
Vmn1r20 T C 6: 57,409,084 (GRCm39) Y137H probably damaging Het
Vmn1r60 T A 7: 5,547,379 (GRCm39) L240F probably benign Het
Vmn1r64 A G 7: 5,886,817 (GRCm39) M242T probably benign Het
Xkr4 T C 1: 3,740,886 (GRCm39) N229S probably benign Het
Zcchc2 T A 1: 105,931,853 (GRCm39) L352M probably damaging Het
Zfp217 C T 2: 169,957,382 (GRCm39) A539T probably benign Het
Zfp638 T C 6: 83,944,336 (GRCm39) L1018P probably damaging Het
Other mutations in Cecr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00435:Cecr2 APN 6 120,733,678 (GRCm39) missense probably damaging 1.00
IGL00782:Cecr2 APN 6 120,738,582 (GRCm39) missense probably benign 0.00
IGL01137:Cecr2 APN 6 120,738,989 (GRCm39) missense probably damaging 1.00
IGL01446:Cecr2 APN 6 120,735,560 (GRCm39) missense probably benign
IGL02108:Cecr2 APN 6 120,739,519 (GRCm39) critical splice donor site probably null
IGL02195:Cecr2 APN 6 120,708,367 (GRCm39) missense probably damaging 1.00
IGL02689:Cecr2 APN 6 120,739,128 (GRCm39) missense probably damaging 1.00
IGL03189:Cecr2 APN 6 120,739,391 (GRCm39) missense probably benign 0.13
PIT1430001:Cecr2 UTSW 6 120,735,440 (GRCm39) missense probably benign 0.01
R0586:Cecr2 UTSW 6 120,734,845 (GRCm39) missense probably damaging 1.00
R0715:Cecr2 UTSW 6 120,735,159 (GRCm39) missense probably benign 0.21
R0784:Cecr2 UTSW 6 120,735,110 (GRCm39) missense possibly damaging 0.74
R1185:Cecr2 UTSW 6 120,735,166 (GRCm39) nonsense probably null
R1185:Cecr2 UTSW 6 120,735,166 (GRCm39) nonsense probably null
R1185:Cecr2 UTSW 6 120,735,166 (GRCm39) nonsense probably null
R1343:Cecr2 UTSW 6 120,731,672 (GRCm39) missense probably damaging 0.99
R1349:Cecr2 UTSW 6 120,734,564 (GRCm39) missense probably damaging 0.99
R1386:Cecr2 UTSW 6 120,739,092 (GRCm39) missense probably damaging 1.00
R1438:Cecr2 UTSW 6 120,738,433 (GRCm39) nonsense probably null
R1602:Cecr2 UTSW 6 120,732,548 (GRCm39) missense possibly damaging 0.52
R1664:Cecr2 UTSW 6 120,738,987 (GRCm39) missense probably damaging 0.96
R1731:Cecr2 UTSW 6 120,735,141 (GRCm39) missense possibly damaging 0.74
R1817:Cecr2 UTSW 6 120,708,228 (GRCm39) missense probably damaging 1.00
R1818:Cecr2 UTSW 6 120,708,228 (GRCm39) missense probably damaging 1.00
R1819:Cecr2 UTSW 6 120,708,228 (GRCm39) missense probably damaging 1.00
R1862:Cecr2 UTSW 6 120,734,902 (GRCm39) missense probably damaging 1.00
R1907:Cecr2 UTSW 6 120,738,121 (GRCm39) missense probably benign 0.03
R1911:Cecr2 UTSW 6 120,739,526 (GRCm39) unclassified probably benign
R2135:Cecr2 UTSW 6 120,697,923 (GRCm39) missense probably damaging 1.00
R2273:Cecr2 UTSW 6 120,733,702 (GRCm39) missense probably benign 0.00
R2275:Cecr2 UTSW 6 120,733,702 (GRCm39) missense probably benign 0.00
R3713:Cecr2 UTSW 6 120,735,221 (GRCm39) missense probably damaging 1.00
R4271:Cecr2 UTSW 6 120,739,436 (GRCm39) missense probably damaging 1.00
R4706:Cecr2 UTSW 6 120,732,539 (GRCm39) missense possibly damaging 0.73
R4873:Cecr2 UTSW 6 120,727,877 (GRCm39) missense probably damaging 0.99
R4875:Cecr2 UTSW 6 120,727,877 (GRCm39) missense probably damaging 0.99
R5137:Cecr2 UTSW 6 120,732,478 (GRCm39) missense probably benign
R5153:Cecr2 UTSW 6 120,711,521 (GRCm39) missense probably benign 0.03
R5377:Cecr2 UTSW 6 120,733,530 (GRCm39) missense possibly damaging 0.87
R5598:Cecr2 UTSW 6 120,708,407 (GRCm39) splice site probably null
R5651:Cecr2 UTSW 6 120,732,521 (GRCm39) missense probably damaging 0.96
R5680:Cecr2 UTSW 6 120,738,387 (GRCm39) missense probably benign
R5813:Cecr2 UTSW 6 120,739,169 (GRCm39) missense probably damaging 0.99
R5970:Cecr2 UTSW 6 120,697,868 (GRCm39) missense probably damaging 0.98
R6255:Cecr2 UTSW 6 120,735,011 (GRCm39) missense probably damaging 1.00
R6266:Cecr2 UTSW 6 120,738,647 (GRCm39) missense probably benign
R6630:Cecr2 UTSW 6 120,739,139 (GRCm39) missense probably damaging 1.00
R6737:Cecr2 UTSW 6 120,714,084 (GRCm39) missense possibly damaging 0.86
R6754:Cecr2 UTSW 6 120,734,539 (GRCm39) missense probably damaging 0.98
R6807:Cecr2 UTSW 6 120,711,503 (GRCm39) splice site probably null
R7187:Cecr2 UTSW 6 120,733,647 (GRCm39) missense probably benign
R7256:Cecr2 UTSW 6 120,739,490 (GRCm39) missense probably benign
R7282:Cecr2 UTSW 6 120,738,582 (GRCm39) missense
R7548:Cecr2 UTSW 6 120,738,675 (GRCm39) missense
R7596:Cecr2 UTSW 6 120,739,167 (GRCm39) missense probably benign
R7802:Cecr2 UTSW 6 120,720,808 (GRCm39) missense probably benign 0.45
R8112:Cecr2 UTSW 6 120,739,175 (GRCm39) missense probably benign 0.00
R8289:Cecr2 UTSW 6 120,735,077 (GRCm39) missense probably benign 0.24
R8294:Cecr2 UTSW 6 120,710,747 (GRCm39) missense probably damaging 0.99
R8470:Cecr2 UTSW 6 120,733,894 (GRCm39) missense probably benign 0.21
R8697:Cecr2 UTSW 6 120,710,779 (GRCm39) missense probably damaging 1.00
R8887:Cecr2 UTSW 6 120,715,162 (GRCm39) missense probably damaging 1.00
R9371:Cecr2 UTSW 6 120,739,229 (GRCm39) missense probably benign 0.01
R9416:Cecr2 UTSW 6 120,735,538 (GRCm39) missense
R9477:Cecr2 UTSW 6 120,720,743 (GRCm39) critical splice acceptor site probably null
R9588:Cecr2 UTSW 6 120,733,770 (GRCm39) missense possibly damaging 0.87
X0012:Cecr2 UTSW 6 120,710,735 (GRCm39) missense probably damaging 0.99
X0063:Cecr2 UTSW 6 120,739,032 (GRCm39) missense probably benign 0.01
Z1177:Cecr2 UTSW 6 120,697,923 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCATGTACAGGACCGAATGCAAC -3'
(R):5'- GGACCAGAATTGTGTCCATCAGGAG -3'

Sequencing Primer
(F):5'- GCACAGATCCCAGTTTGATG -3'
(R):5'- TGCAGACTAGACAGGACATTCTTC -3'
Posted On 2013-04-16