Incidental Mutation 'R2136:Vmn2r65'
| ID |
235816 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r65
|
| Ensembl Gene |
ENSMUSG00000066372 |
| Gene Name |
vomeronasal 2, receptor 65 |
| Synonyms |
ENSMUSG00000070600 |
| MMRRC Submission |
040139-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
R2136 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
84589377-84613217 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 84592781 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Histidine
at position 475
(Q475H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000036551
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044583]
|
| AlphaFold |
G3X931 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000044583
AA Change: Q475H
PolyPhen 2
Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000036551
Gene: ENSMUSG00000066372
AA Change: Q475H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
435 |
5.6e-41 |
PFAM |
|
Pfam:NCD3G
|
501 |
553 |
1.3e-21 |
PFAM |
|
Pfam:7tm_3
|
584 |
821 |
2.3e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.6%
- 20x: 95.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A930003A15Rik |
T |
G |
16: 19,702,530 (GRCm39) |
|
noncoding transcript |
Het |
| Abca5 |
T |
C |
11: 110,210,658 (GRCm39) |
T174A |
probably benign |
Het |
| Abcg3 |
G |
A |
5: 105,114,680 (GRCm39) |
S279L |
probably benign |
Het |
| Acap3 |
T |
C |
4: 155,981,369 (GRCm39) |
L85P |
probably damaging |
Het |
| Adgrl3 |
A |
G |
5: 81,660,101 (GRCm39) |
K290R |
probably damaging |
Het |
| Ankhd1 |
A |
G |
18: 36,780,674 (GRCm39) |
T1909A |
probably benign |
Het |
| Asap1 |
T |
C |
15: 63,982,808 (GRCm39) |
D832G |
probably damaging |
Het |
| Atp6v0a2 |
T |
A |
5: 124,795,552 (GRCm39) |
L702Q |
possibly damaging |
Het |
| Bsn |
A |
G |
9: 107,990,430 (GRCm39) |
V1774A |
probably damaging |
Het |
| Cd209e |
T |
C |
8: 3,903,248 (GRCm39) |
E48G |
probably benign |
Het |
| Cdadc1 |
T |
C |
14: 59,805,493 (GRCm39) |
|
probably null |
Het |
| Cfap65 |
C |
CA |
1: 74,956,432 (GRCm39) |
|
probably null |
Het |
| Cln3 |
A |
C |
7: 126,181,971 (GRCm39) |
S30R |
probably benign |
Het |
| Cluap1 |
C |
T |
16: 3,751,636 (GRCm39) |
R332W |
probably damaging |
Het |
| Crb1 |
A |
T |
1: 139,265,163 (GRCm39) |
V85E |
probably benign |
Het |
| Crocc |
G |
A |
4: 140,760,265 (GRCm39) |
R789W |
probably damaging |
Het |
| Cwh43 |
A |
G |
5: 73,572,397 (GRCm39) |
I212V |
probably benign |
Het |
| Cyp2t4 |
C |
A |
7: 26,857,585 (GRCm39) |
F391L |
probably benign |
Het |
| Dhx35 |
G |
T |
2: 158,673,781 (GRCm39) |
R404L |
probably damaging |
Het |
| Disp1 |
A |
G |
1: 182,869,942 (GRCm39) |
L826S |
probably damaging |
Het |
| Dync2h1 |
T |
A |
9: 7,122,772 (GRCm39) |
E2061D |
probably damaging |
Het |
| Ep300 |
T |
A |
15: 81,524,648 (GRCm39) |
Y1393N |
unknown |
Het |
| Fap |
C |
T |
2: 62,354,551 (GRCm39) |
G446D |
possibly damaging |
Het |
| Fat3 |
A |
G |
9: 16,288,347 (GRCm39) |
I392T |
probably benign |
Het |
| Fpr-rs4 |
CAGGAA |
CA |
17: 18,242,596 (GRCm39) |
|
probably null |
Het |
| Glipr1l1 |
T |
C |
10: 111,896,381 (GRCm39) |
V56A |
probably damaging |
Het |
| Grsf1 |
A |
G |
5: 88,820,517 (GRCm39) |
V7A |
probably benign |
Het |
| Hmcn1 |
G |
A |
1: 150,509,410 (GRCm39) |
A3646V |
probably damaging |
Het |
| Ipo9 |
A |
T |
1: 135,322,023 (GRCm39) |
I569N |
probably damaging |
Het |
| Irs1 |
G |
T |
1: 82,267,763 (GRCm39) |
P151Q |
probably damaging |
Het |
| Kalrn |
T |
C |
16: 34,128,094 (GRCm39) |
D491G |
possibly damaging |
Het |
| Kctd7 |
T |
C |
5: 130,181,207 (GRCm39) |
L210P |
probably damaging |
Het |
| Lifr |
C |
A |
15: 7,211,338 (GRCm39) |
D625E |
possibly damaging |
Het |
| Lrguk |
T |
C |
6: 34,020,454 (GRCm39) |
V201A |
probably benign |
Het |
| Mark1 |
A |
G |
1: 184,651,770 (GRCm39) |
V135A |
probably damaging |
Het |
| Mical2 |
T |
A |
7: 111,870,722 (GRCm39) |
D70E |
possibly damaging |
Het |
| Mrc1 |
T |
C |
2: 14,275,000 (GRCm39) |
Y434H |
probably damaging |
Het |
| Myh10 |
C |
A |
11: 68,695,540 (GRCm39) |
Q1556K |
probably damaging |
Het |
| Nav1 |
G |
A |
1: 135,382,174 (GRCm39) |
T1400I |
probably null |
Het |
| Or1j11 |
A |
G |
2: 36,311,950 (GRCm39) |
D180G |
probably damaging |
Het |
| Or2a7 |
A |
G |
6: 43,151,435 (GRCm39) |
K172E |
probably benign |
Het |
| Or4b13 |
A |
C |
2: 90,082,597 (GRCm39) |
V245G |
probably damaging |
Het |
| Or4f4b |
T |
C |
2: 111,313,961 (GRCm39) |
V62A |
probably damaging |
Het |
| Or4p7 |
T |
A |
2: 88,221,663 (GRCm39) |
I24N |
probably benign |
Het |
| Or5d43 |
T |
C |
2: 88,104,584 (GRCm39) |
K270E |
probably damaging |
Het |
| Or5e1 |
G |
A |
7: 108,354,430 (GRCm39) |
M122I |
possibly damaging |
Het |
| Osmr |
T |
A |
15: 6,881,943 (GRCm39) |
Q67L |
probably damaging |
Het |
| Pan2 |
T |
G |
10: 128,149,506 (GRCm39) |
V522G |
possibly damaging |
Het |
| Pard3 |
T |
G |
8: 128,103,366 (GRCm39) |
|
probably null |
Het |
| Pcdhgc5 |
G |
T |
18: 37,953,166 (GRCm39) |
A147S |
possibly damaging |
Het |
| Pcsk9 |
T |
C |
4: 106,303,967 (GRCm39) |
I506V |
probably benign |
Het |
| Polr3d |
GCCCCC |
GCCCC |
14: 70,680,487 (GRCm39) |
|
probably null |
Het |
| Prdm4 |
G |
A |
10: 85,729,215 (GRCm39) |
R731* |
probably null |
Het |
| Prdx6b |
T |
A |
2: 80,123,507 (GRCm39) |
D105E |
probably damaging |
Het |
| Prss3b |
A |
G |
6: 41,012,396 (GRCm39) |
F6S |
probably benign |
Het |
| Rab42 |
A |
G |
4: 132,029,790 (GRCm39) |
L144P |
probably damaging |
Het |
| Ralbp1 |
T |
A |
17: 66,171,661 (GRCm39) |
K104M |
probably damaging |
Het |
| Resf1 |
T |
A |
6: 149,230,320 (GRCm39) |
I1122K |
probably benign |
Het |
| Rrp12 |
A |
G |
19: 41,881,038 (GRCm39) |
V131A |
probably damaging |
Het |
| Sbno1 |
C |
T |
5: 124,525,597 (GRCm39) |
|
probably null |
Het |
| Sbno2 |
A |
T |
10: 79,898,527 (GRCm39) |
I645N |
probably damaging |
Het |
| Scfd2 |
T |
C |
5: 74,367,028 (GRCm39) |
K624R |
probably benign |
Het |
| Sgk2 |
C |
A |
2: 162,841,099 (GRCm39) |
|
probably null |
Het |
| Sirt4 |
A |
G |
5: 115,617,760 (GRCm39) |
S299P |
probably benign |
Het |
| Skic3 |
T |
C |
13: 76,321,473 (GRCm39) |
S1322P |
possibly damaging |
Het |
| Slit2 |
C |
T |
5: 48,461,567 (GRCm39) |
A1521V |
probably benign |
Het |
| Socs7 |
T |
G |
11: 97,263,933 (GRCm39) |
V275G |
possibly damaging |
Het |
| Spink11 |
G |
A |
18: 44,323,554 (GRCm39) |
P102S |
probably benign |
Het |
| Tacc3 |
A |
G |
5: 33,828,748 (GRCm39) |
N534D |
probably damaging |
Het |
| Tas2r115 |
T |
C |
6: 132,714,309 (GRCm39) |
Y214C |
probably damaging |
Het |
| Tcaf1 |
A |
T |
6: 42,650,454 (GRCm39) |
M875K |
probably benign |
Het |
| Ttc22 |
T |
A |
4: 106,479,869 (GRCm39) |
L41Q |
possibly damaging |
Het |
| Vasn |
T |
A |
16: 4,467,659 (GRCm39) |
C535* |
probably null |
Het |
| Vcan |
T |
A |
13: 89,837,856 (GRCm39) |
I2563F |
probably damaging |
Het |
| Vmn2r63 |
T |
G |
7: 42,576,297 (GRCm39) |
Q505H |
probably damaging |
Het |
| Zbtb43 |
T |
C |
2: 33,344,532 (GRCm39) |
Y231C |
probably damaging |
Het |
| Zfp292 |
A |
G |
4: 34,810,266 (GRCm39) |
V931A |
probably benign |
Het |
|
| Other mutations in Vmn2r65 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00942:Vmn2r65
|
APN |
7 |
84,592,761 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01104:Vmn2r65
|
APN |
7 |
84,589,996 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01154:Vmn2r65
|
APN |
7 |
84,592,729 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01453:Vmn2r65
|
APN |
7 |
84,589,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Vmn2r65
|
APN |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01748:Vmn2r65
|
APN |
7 |
84,589,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01997:Vmn2r65
|
APN |
7 |
84,589,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02527:Vmn2r65
|
APN |
7 |
84,595,724 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02617:Vmn2r65
|
APN |
7 |
84,589,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02676:Vmn2r65
|
APN |
7 |
84,589,381 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL03084:Vmn2r65
|
APN |
7 |
84,592,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
A4554:Vmn2r65
|
UTSW |
7 |
84,595,791 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4651001:Vmn2r65
|
UTSW |
7 |
84,595,461 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0322:Vmn2r65
|
UTSW |
7 |
84,595,756 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0453:Vmn2r65
|
UTSW |
7 |
84,595,442 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0862:Vmn2r65
|
UTSW |
7 |
84,592,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1508:Vmn2r65
|
UTSW |
7 |
84,589,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1687:Vmn2r65
|
UTSW |
7 |
84,590,026 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1876:Vmn2r65
|
UTSW |
7 |
84,595,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2259:Vmn2r65
|
UTSW |
7 |
84,590,119 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2338:Vmn2r65
|
UTSW |
7 |
84,590,051 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2880:Vmn2r65
|
UTSW |
7 |
84,613,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3410:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3411:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3770:Vmn2r65
|
UTSW |
7 |
84,589,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3800:Vmn2r65
|
UTSW |
7 |
84,589,738 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3850:Vmn2r65
|
UTSW |
7 |
84,595,859 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4105:Vmn2r65
|
UTSW |
7 |
84,595,691 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4568:Vmn2r65
|
UTSW |
7 |
84,596,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4677:Vmn2r65
|
UTSW |
7 |
84,613,082 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4768:Vmn2r65
|
UTSW |
7 |
84,596,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4778:Vmn2r65
|
UTSW |
7 |
84,592,801 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5057:Vmn2r65
|
UTSW |
7 |
84,589,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5279:Vmn2r65
|
UTSW |
7 |
84,589,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r65
|
UTSW |
7 |
84,595,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5394:Vmn2r65
|
UTSW |
7 |
84,595,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5487:Vmn2r65
|
UTSW |
7 |
84,595,529 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5580:Vmn2r65
|
UTSW |
7 |
84,596,802 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5638:Vmn2r65
|
UTSW |
7 |
84,590,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5673:Vmn2r65
|
UTSW |
7 |
84,596,615 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5688:Vmn2r65
|
UTSW |
7 |
84,589,900 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5935:Vmn2r65
|
UTSW |
7 |
84,592,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6354:Vmn2r65
|
UTSW |
7 |
84,589,574 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6372:Vmn2r65
|
UTSW |
7 |
84,589,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6924:Vmn2r65
|
UTSW |
7 |
84,613,198 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7021:Vmn2r65
|
UTSW |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7195:Vmn2r65
|
UTSW |
7 |
84,592,347 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7422:Vmn2r65
|
UTSW |
7 |
84,595,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7654:Vmn2r65
|
UTSW |
7 |
84,590,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7686:Vmn2r65
|
UTSW |
7 |
84,589,744 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7691:Vmn2r65
|
UTSW |
7 |
84,592,851 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,596,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,595,530 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8103:Vmn2r65
|
UTSW |
7 |
84,595,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8272:Vmn2r65
|
UTSW |
7 |
84,596,817 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8303:Vmn2r65
|
UTSW |
7 |
84,589,391 (GRCm39) |
nonsense |
probably null |
|
|
R8354:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8454:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8489:Vmn2r65
|
UTSW |
7 |
84,589,964 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8554:Vmn2r65
|
UTSW |
7 |
84,595,960 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8680:Vmn2r65
|
UTSW |
7 |
84,589,388 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8731:Vmn2r65
|
UTSW |
7 |
84,589,447 (GRCm39) |
nonsense |
probably null |
|
|
R8839:Vmn2r65
|
UTSW |
7 |
84,595,489 (GRCm39) |
nonsense |
probably null |
|
|
R8847:Vmn2r65
|
UTSW |
7 |
84,590,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8916:Vmn2r65
|
UTSW |
7 |
84,595,665 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9254:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9392:Vmn2r65
|
UTSW |
7 |
84,589,718 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9563:Vmn2r65
|
UTSW |
7 |
84,589,880 (GRCm39) |
nonsense |
probably null |
|
|
R9686:Vmn2r65
|
UTSW |
7 |
84,590,084 (GRCm39) |
missense |
probably benign |
0.45 |
|
X0067:Vmn2r65
|
UTSW |
7 |
84,590,113 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1088:Vmn2r65
|
UTSW |
7 |
84,592,473 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Vmn2r65
|
UTSW |
7 |
84,590,234 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAAGAGTTTGACCCACTTCAC -3'
(R):5'- TATCTACCCTAATGTGCATGCATAG -3'
Sequencing Primer
(F):5'- TGCGATTTGCAGTCTTATT -3'
(R):5'- CCTTTCCTGGAGAACAACA -3'
|
| Posted On |
2014-10-01 |
Incidental Mutation