Incidental Mutation 'R2137:Nudt4'
ID 235900
Institutional Source Beutler Lab
Gene Symbol Nudt4
Ensembl Gene ENSMUSG00000020029
Gene Name nudix hydrolase 4
Synonyms DIPP2, DIPP2beta, DIPP2alpha, HDCMB47P, 4933436C10Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 4
MMRRC Submission 040140-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.925) question?
Stock # R2137 (G1)
Quality Score 92
Status Validated
Chromosome 10
Chromosomal Location 95382869-95400008 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 95399600 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 7 (Q7R)
Ref Sequence ENSEMBL: ENSMUSP00000020217 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020217]
AlphaFold Q8R2U6
PDB Structure Crystal structure of MS0616 [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000020217
AA Change: Q7R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000020217
Gene: ENSMUSG00000020029
AA Change: Q7R

DomainStartEndE-ValueType
Pfam:NUDIX 17 141 1.3e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175126
Meta Mutation Damage Score 0.2344 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 97% (60/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd24 C T 10: 81,482,143 (GRCm39) T88I probably damaging Het
Atm A T 9: 53,364,675 (GRCm39) V49D probably damaging Het
Bub1b G T 2: 118,467,199 (GRCm39) E841* probably null Het
Cdh20 A T 1: 110,027,836 (GRCm39) N527I probably damaging Het
Cdh22 G A 2: 164,958,314 (GRCm39) probably benign Het
Cog1 T C 11: 113,550,127 (GRCm39) L262P probably damaging Het
Col22a1 T C 15: 71,878,797 (GRCm39) H120R possibly damaging Het
Col4a2 T C 8: 11,483,749 (GRCm39) S890P probably benign Het
Cubn T C 2: 13,340,978 (GRCm39) I2248V probably benign Het
Evpl T C 11: 116,112,665 (GRCm39) E1675G probably damaging Het
Faiml G A 9: 99,114,545 (GRCm39) P115S probably benign Het
Fgg A T 3: 82,915,745 (GRCm39) D62V possibly damaging Het
Gak C T 5: 108,754,743 (GRCm39) probably null Het
Galntl6 C T 8: 58,988,939 (GRCm39) probably null Het
Glyr1 T C 16: 4,836,346 (GRCm39) Y501C probably benign Het
Gm9847 G T 12: 14,545,082 (GRCm39) noncoding transcript Het
Gria4 T G 9: 4,427,026 (GRCm39) probably benign Het
Il36b A G 2: 24,044,672 (GRCm39) N24S probably benign Het
Il6st C A 13: 112,639,392 (GRCm39) H606N possibly damaging Het
Itprid1 A G 6: 55,866,174 (GRCm39) Q189R probably damaging Het
Kctd10 A G 5: 114,505,389 (GRCm39) F202L probably damaging Het
Kif17 T A 4: 137,989,978 (GRCm39) D55E probably damaging Het
Klf1 C T 8: 85,629,775 (GRCm39) A200V possibly damaging Het
Klhl32 A T 4: 24,629,275 (GRCm39) Y497* probably null Het
Kng2 G T 16: 22,816,076 (GRCm39) probably benign Het
Lats1 T C 10: 7,577,611 (GRCm39) V245A possibly damaging Het
Mbd3l2 A T 9: 18,356,254 (GRCm39) D193V probably damaging Het
Ms4a18 A T 19: 10,974,695 (GRCm39) V332D possibly damaging Het
Mss51 T C 14: 20,537,591 (GRCm39) I47V probably benign Het
Myoz2 G A 3: 122,827,861 (GRCm39) T19M probably benign Het
Nampt T A 12: 32,880,309 (GRCm39) N67K probably benign Het
Ncor2 A T 5: 125,107,776 (GRCm39) I1607K probably damaging Het
Or5b119 A G 19: 13,457,173 (GRCm39) Y130H probably damaging Het
Or5b121 T A 19: 13,507,802 (GRCm39) I255N probably damaging Het
Or8b12i T A 9: 20,082,463 (GRCm39) I135F probably damaging Het
Pgm2 A T 5: 64,273,709 (GRCm39) M565L probably benign Het
Phactr1 T G 13: 43,288,651 (GRCm39) F639V possibly damaging Het
Plod3 C A 5: 137,017,571 (GRCm39) R165S probably damaging Het
Polr2b T A 5: 77,468,193 (GRCm39) N164K probably benign Het
Rcbtb2 G A 14: 73,399,491 (GRCm39) G52S probably damaging Het
Rfc1 A G 5: 65,468,382 (GRCm39) probably null Het
Rheb A G 5: 25,012,601 (GRCm39) probably null Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Ripor2 G A 13: 24,905,817 (GRCm39) probably null Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Scg3 A T 9: 75,584,092 (GRCm39) D136E probably damaging Het
Slc10a4 C T 5: 73,164,923 (GRCm39) L172F probably damaging Het
Slc35c2 A G 2: 165,123,299 (GRCm39) Y113H probably damaging Het
Slc47a1 T A 11: 61,235,318 (GRCm39) D505V probably benign Het
Snap29 C A 16: 17,246,113 (GRCm39) D244E possibly damaging Het
Taar1 T C 10: 23,797,168 (GRCm39) F289L probably benign Het
Thbs2 T A 17: 14,893,568 (GRCm39) N871Y probably damaging Het
Tmem108 T A 9: 103,377,162 (GRCm39) T96S possibly damaging Het
Tnk2 G T 16: 32,489,620 (GRCm39) probably null Het
Trak1 T A 9: 121,302,028 (GRCm39) M928K possibly damaging Het
Tuba3b A G 6: 145,564,559 (GRCm39) I110V probably benign Het
Tyk2 A G 9: 21,022,281 (GRCm39) probably benign Het
Ugt1a9 T A 1: 87,998,759 (GRCm39) C70S probably benign Het
Vmn2r10 A T 5: 109,151,410 (GRCm39) I68K possibly damaging Het
Wfs1 T C 5: 37,124,845 (GRCm39) E682G probably damaging Het
Zfp213 T C 17: 23,778,481 (GRCm39) probably null Het
Zfp809 T C 9: 22,146,434 (GRCm39) V41A probably benign Het
Zfp831 A G 2: 174,547,539 (GRCm39) K1574R possibly damaging Het
Other mutations in Nudt4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02425:Nudt4 APN 10 95,385,245 (GRCm39) missense probably benign
R2905:Nudt4 UTSW 10 95,399,571 (GRCm39) missense probably benign 0.00
R3722:Nudt4 UTSW 10 95,385,367 (GRCm39) splice site probably null
R6082:Nudt4 UTSW 10 95,387,318 (GRCm39) missense probably benign 0.01
RF003:Nudt4 UTSW 10 95,385,236 (GRCm39) missense possibly damaging 0.72
RF018:Nudt4 UTSW 10 95,385,675 (GRCm39) splice site probably null
Z1088:Nudt4 UTSW 10 95,388,377 (GRCm39) missense probably benign 0.14
Predicted Primers PCR Primer
(F):5'- GCTTGCGACCTAATGGGAG -3'
(R):5'- GCACCGTCGCTTCCAACTG -3'

Sequencing Primer
(F):5'- TCTAAAAGGCAGGCTGGC -3'
(R):5'- TCCAACTGTCTCCGCGTGG -3'
Posted On 2014-10-01