Incidental Mutation 'R2140:Plxnb2'
| ID |
236167 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxnb2
|
| Ensembl Gene |
ENSMUSG00000036606 |
| Gene Name |
plexin B2 |
| Synonyms |
Debt, 1110007H23Rik |
| MMRRC Submission |
040143-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.954)
|
| Stock # |
R2140 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
89155549-89180788 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 89156562 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 1787
(D1787G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104955
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060808]
[ENSMUST00000109331]
|
| AlphaFold |
B2RXS4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000060808
AA Change: D1787G
PolyPhen 2
Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000051731
Gene: ENSMUSG00000036606
AA Change: D1787G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1275 |
1809 |
1.6e-225 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109331
AA Change: D1787G
PolyPhen 2
Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000104955
Gene: ENSMUSG00000036606
AA Change: D1787G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1274 |
1809 |
4.4e-251 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139372
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143014
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151418
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229966
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000230393
|
| Meta Mutation Damage Score |
0.1227 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.5%
|
| Validation Efficiency |
100% (96/96) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygotes for a targeted mutation of this gene die perinatally of exencephaly or survive and seem normal despite severe abnormalities in cerebellar layering and foliation; the external granule cell layer is disorganized due to continued proliferation and migration of differentiated granule cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610042L04Rik |
T |
C |
14: 4,348,902 (GRCm38) |
I21T |
probably damaging |
Het |
| 9230110C19Rik |
T |
C |
9: 8,022,477 (GRCm38) |
D248G |
probably damaging |
Het |
| Adgrf1 |
A |
C |
17: 43,300,802 (GRCm38) |
E186D |
probably damaging |
Het |
| Adgrf4 |
C |
T |
17: 42,666,898 (GRCm38) |
R518Q |
possibly damaging |
Het |
| Afdn |
A |
G |
17: 13,810,433 (GRCm38) |
E202G |
probably damaging |
Het |
| Agfg2 |
T |
A |
5: 137,667,116 (GRCm38) |
R126W |
probably damaging |
Het |
| Alkbh2 |
C |
T |
5: 114,125,716 (GRCm38) |
V77I |
probably benign |
Het |
| Alppl2 |
A |
G |
1: 87,087,697 (GRCm38) |
S381P |
probably benign |
Het |
| Aqp2 |
A |
G |
15: 99,579,366 (GRCm38) |
T72A |
probably damaging |
Het |
| Atp9b |
A |
G |
18: 80,736,087 (GRCm38) |
C1123R |
probably damaging |
Het |
| AU016765 |
T |
A |
17: 64,520,000 (GRCm38) |
|
noncoding transcript |
Het |
| Bscl2 |
T |
C |
19: 8,845,320 (GRCm38) |
|
probably null |
Het |
| Ccdc80 |
A |
T |
16: 45,127,446 (GRCm38) |
Y929F |
probably damaging |
Het |
| Cenpj |
T |
C |
14: 56,526,932 (GRCm38) |
D1341G |
probably damaging |
Het |
| Cir1 |
A |
T |
2: 73,312,437 (GRCm38) |
S18T |
probably damaging |
Het |
| Clcn6 |
A |
G |
4: 148,024,137 (GRCm38) |
F145S |
possibly damaging |
Het |
| Cnksr1 |
A |
G |
4: 134,229,628 (GRCm38) |
Y488H |
probably damaging |
Het |
| Cntrl |
CAGAG |
CAG |
2: 35,122,806 (GRCm38) |
|
probably null |
Het |
| Crb1 |
T |
C |
1: 139,237,012 (GRCm38) |
I1125V |
probably benign |
Het |
| Cyp3a13 |
A |
T |
5: 137,921,454 (GRCm38) |
V20D |
possibly damaging |
Het |
| Dars |
T |
A |
1: 128,372,162 (GRCm38) |
M362L |
probably benign |
Het |
| Dck |
T |
C |
5: 88,772,723 (GRCm38) |
C101R |
probably damaging |
Het |
| Dnah11 |
T |
C |
12: 118,008,810 (GRCm38) |
T2880A |
probably benign |
Het |
| Dnah7b |
T |
A |
1: 46,268,670 (GRCm38) |
M3048K |
probably damaging |
Het |
| Eef1a2 |
C |
T |
2: 181,148,742 (GRCm38) |
E374K |
probably benign |
Het |
| Eif3a |
A |
T |
19: 60,775,394 (GRCm38) |
|
probably benign |
Het |
| Esco1 |
A |
G |
18: 10,574,873 (GRCm38) |
|
probably null |
Het |
| Exoc8 |
C |
T |
8: 124,897,415 (GRCm38) |
R71Q |
possibly damaging |
Het |
| Fam208a |
C |
T |
14: 27,480,035 (GRCm38) |
T1462I |
probably damaging |
Het |
| Far1 |
G |
A |
7: 113,566,460 (GRCm38) |
V445M |
possibly damaging |
Het |
| Fbn1 |
C |
A |
2: 125,343,810 (GRCm38) |
C1648F |
probably damaging |
Het |
| Fmn1 |
A |
G |
2: 113,595,048 (GRCm38) |
K1189R |
probably benign |
Het |
| Foxl2 |
C |
A |
9: 98,956,487 (GRCm38) |
P276H |
unknown |
Het |
| Fpr3 |
T |
A |
17: 17,970,617 (GRCm38) |
V50E |
probably damaging |
Het |
| Garem1 |
T |
A |
18: 21,129,374 (GRCm38) |
R794S |
probably damaging |
Het |
| Gemin4 |
G |
C |
11: 76,211,050 (GRCm38) |
P962A |
probably damaging |
Het |
| Glyatl3 |
T |
C |
17: 40,911,084 (GRCm38) |
D93G |
probably benign |
Het |
| Gm14124 |
A |
T |
2: 150,269,361 (GRCm38) |
H657L |
probably benign |
Het |
| Gm4787 |
A |
G |
12: 81,378,562 (GRCm38) |
I274T |
probably benign |
Het |
| Gucy1a1 |
C |
T |
3: 82,118,886 (GRCm38) |
|
probably null |
Het |
| Hook1 |
GATGAATGA |
GATGA |
4: 96,013,312 (GRCm38) |
503 |
probably null |
Het |
| Ift20 |
G |
A |
11: 78,540,034 (GRCm38) |
E68K |
probably damaging |
Het |
| Ints13 |
A |
G |
6: 146,576,431 (GRCm38) |
S7P |
probably damaging |
Het |
| Kat5 |
T |
A |
19: 5,605,685 (GRCm38) |
|
probably null |
Het |
| Kcnma1 |
A |
C |
14: 23,314,220 (GRCm38) |
L988R |
probably damaging |
Het |
| Kcnq3 |
C |
A |
15: 66,005,978 (GRCm38) |
|
probably benign |
Het |
| Kctd16 |
A |
G |
18: 40,259,178 (GRCm38) |
E273G |
possibly damaging |
Het |
| Krt82 |
T |
A |
15: 101,545,156 (GRCm38) |
Q265L |
probably damaging |
Het |
| Lama2 |
A |
T |
10: 27,054,694 (GRCm38) |
|
probably null |
Het |
| Laptm4b |
G |
T |
15: 34,238,332 (GRCm38) |
M3I |
probably benign |
Het |
| Lmtk2 |
A |
G |
5: 144,147,615 (GRCm38) |
Y156C |
probably damaging |
Het |
| Lrrc58 |
G |
A |
16: 37,881,409 (GRCm38) |
E350K |
probably damaging |
Het |
| Lrrk1 |
A |
T |
7: 66,330,750 (GRCm38) |
D227E |
probably damaging |
Het |
| Macf1 |
C |
T |
4: 123,355,102 (GRCm38) |
C7210Y |
probably damaging |
Het |
| Madd |
A |
G |
2: 91,152,509 (GRCm38) |
I1363T |
possibly damaging |
Het |
| Mcm3 |
A |
G |
1: 20,813,110 (GRCm38) |
V295A |
probably benign |
Het |
| Mki67 |
A |
G |
7: 135,695,592 (GRCm38) |
I2571T |
possibly damaging |
Het |
| Mtrr |
C |
T |
13: 68,568,940 (GRCm38) |
A385T |
possibly damaging |
Het |
| Myh7b |
A |
G |
2: 155,620,123 (GRCm38) |
Y313C |
probably damaging |
Het |
| Myot |
A |
T |
18: 44,354,125 (GRCm38) |
H343L |
possibly damaging |
Het |
| Myt1 |
C |
A |
2: 181,825,979 (GRCm38) |
Q1069K |
probably damaging |
Het |
| Nid1 |
T |
A |
13: 13,499,668 (GRCm38) |
D877E |
probably damaging |
Het |
| Nle1 |
A |
G |
11: 82,905,568 (GRCm38) |
V159A |
probably damaging |
Het |
| Nmbr |
C |
A |
10: 14,770,442 (GRCm38) |
Y353* |
probably null |
Het |
| Nos1ap |
T |
A |
1: 170,329,166 (GRCm38) |
D241V |
probably damaging |
Het |
| Nostrin |
A |
C |
2: 69,166,003 (GRCm38) |
Y209S |
probably damaging |
Het |
| Olfr1099 |
A |
T |
2: 86,959,281 (GRCm38) |
M59K |
probably damaging |
Het |
| Olfr115 |
T |
G |
17: 37,610,471 (GRCm38) |
E93D |
probably benign |
Het |
| Olfr1168 |
A |
T |
2: 88,185,095 (GRCm38) |
S73C |
probably benign |
Het |
| Olfr1240 |
C |
T |
2: 89,439,583 (GRCm38) |
R232H |
probably benign |
Het |
| Olfr283 |
G |
A |
15: 98,378,396 (GRCm38) |
T238I |
possibly damaging |
Het |
| Olfr378 |
A |
T |
11: 73,425,881 (GRCm38) |
M34K |
probably damaging |
Het |
| Pcdh7 |
T |
A |
5: 58,128,996 (GRCm38) |
V1138E |
probably damaging |
Het |
| Pglyrp3 |
T |
G |
3: 92,026,567 (GRCm38) |
V173G |
probably benign |
Het |
| Plec |
T |
C |
15: 76,183,174 (GRCm38) |
T1331A |
probably benign |
Het |
| Pms1 |
T |
A |
1: 53,281,988 (GRCm38) |
I29F |
probably damaging |
Het |
| Ptprt |
G |
A |
2: 161,811,988 (GRCm38) |
T574I |
probably damaging |
Het |
| R3hdm1 |
A |
G |
1: 128,190,693 (GRCm38) |
Y561C |
probably damaging |
Het |
| Rab17 |
A |
G |
1: 90,960,078 (GRCm38) |
F120S |
probably benign |
Het |
| Rab7b |
T |
A |
1: 131,698,419 (GRCm38) |
W62R |
probably damaging |
Het |
| Ryr2 |
C |
T |
13: 11,560,607 (GRCm38) |
G4835E |
probably damaging |
Het |
| Ryr3 |
A |
G |
2: 112,875,148 (GRCm38) |
V807A |
probably benign |
Het |
| Sept4 |
A |
T |
11: 87,583,436 (GRCm38) |
Q60L |
probably benign |
Het |
| Slc23a1 |
C |
T |
18: 35,626,434 (GRCm38) |
R26Q |
unknown |
Het |
| Slc7a4 |
C |
A |
16: 17,574,544 (GRCm38) |
R342L |
possibly damaging |
Het |
| Slfn9 |
C |
T |
11: 82,984,655 (GRCm38) |
C367Y |
possibly damaging |
Het |
| Slitrk6 |
T |
G |
14: 110,750,794 (GRCm38) |
T494P |
probably benign |
Het |
| Tiam1 |
A |
G |
16: 89,849,645 (GRCm38) |
|
probably benign |
Het |
| Tiparp |
C |
A |
3: 65,529,252 (GRCm38) |
|
probably benign |
Het |
| Tmem39b |
T |
C |
4: 129,678,688 (GRCm38) |
T374A |
probably benign |
Het |
| Trim5 |
G |
A |
7: 104,276,791 (GRCm38) |
R188* |
probably null |
Het |
| Ttn |
C |
T |
2: 76,813,339 (GRCm38) |
G11436R |
probably damaging |
Het |
| Ubr4 |
C |
T |
4: 139,477,207 (GRCm38) |
T4810M |
probably damaging |
Het |
| Vmn2r26 |
A |
T |
6: 124,061,237 (GRCm38) |
E590D |
probably benign |
Het |
| Wwc1 |
A |
G |
11: 35,870,528 (GRCm38) |
F650S |
probably benign |
Het |
| Xrcc6 |
T |
A |
15: 82,022,977 (GRCm38) |
F167I |
probably damaging |
Het |
|
| Other mutations in Plxnb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00546:Plxnb2
|
APN |
15 |
89,162,366 (GRCm38) |
splice site |
probably benign |
|
|
IGL01574:Plxnb2
|
APN |
15 |
89,162,683 (GRCm38) |
splice site |
probably null |
|
|
IGL01695:Plxnb2
|
APN |
15 |
89,157,214 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
IGL01763:Plxnb2
|
APN |
15 |
89,161,981 (GRCm38) |
splice site |
probably null |
|
|
IGL01921:Plxnb2
|
APN |
15 |
89,164,271 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL02129:Plxnb2
|
APN |
15 |
89,160,410 (GRCm38) |
missense |
probably benign |
0.04 |
|
IGL02153:Plxnb2
|
APN |
15 |
89,165,813 (GRCm38) |
nonsense |
probably null |
|
|
IGL02637:Plxnb2
|
APN |
15 |
89,164,057 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL02892:Plxnb2
|
APN |
15 |
89,161,222 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL03108:Plxnb2
|
APN |
15 |
89,158,031 (GRCm38) |
missense |
probably benign |
0.32 |
|
IGL03115:Plxnb2
|
APN |
15 |
89,162,438 (GRCm38) |
splice site |
probably benign |
|
|
P0040:Plxnb2
|
UTSW |
15 |
89,162,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0022:Plxnb2
|
UTSW |
15 |
89,163,276 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0095:Plxnb2
|
UTSW |
15 |
89,165,331 (GRCm38) |
missense |
probably benign |
|
|
R0103:Plxnb2
|
UTSW |
15 |
89,161,769 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R0544:Plxnb2
|
UTSW |
15 |
89,158,613 (GRCm38) |
splice site |
probably benign |
|
|
R0671:Plxnb2
|
UTSW |
15 |
89,157,981 (GRCm38) |
missense |
probably benign |
0.14 |
|
R1279:Plxnb2
|
UTSW |
15 |
89,162,321 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1530:Plxnb2
|
UTSW |
15 |
89,167,192 (GRCm38) |
missense |
probably benign |
|
|
R1542:Plxnb2
|
UTSW |
15 |
89,165,921 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1610:Plxnb2
|
UTSW |
15 |
89,158,493 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1686:Plxnb2
|
UTSW |
15 |
89,162,462 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1702:Plxnb2
|
UTSW |
15 |
89,161,984 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1996:Plxnb2
|
UTSW |
15 |
89,158,768 (GRCm38) |
missense |
probably benign |
0.13 |
|
R1997:Plxnb2
|
UTSW |
15 |
89,158,768 (GRCm38) |
missense |
probably benign |
0.13 |
|
R2031:Plxnb2
|
UTSW |
15 |
89,162,810 (GRCm38) |
nonsense |
probably null |
|
|
R2049:Plxnb2
|
UTSW |
15 |
89,159,002 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2072:Plxnb2
|
UTSW |
15 |
89,158,451 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2076:Plxnb2
|
UTSW |
15 |
89,158,026 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2418:Plxnb2
|
UTSW |
15 |
89,161,069 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R2419:Plxnb2
|
UTSW |
15 |
89,161,069 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R3752:Plxnb2
|
UTSW |
15 |
89,157,255 (GRCm38) |
splice site |
probably benign |
|
|
R3825:Plxnb2
|
UTSW |
15 |
89,166,399 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4154:Plxnb2
|
UTSW |
15 |
89,159,642 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4197:Plxnb2
|
UTSW |
15 |
89,157,018 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4385:Plxnb2
|
UTSW |
15 |
89,160,623 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4434:Plxnb2
|
UTSW |
15 |
89,162,803 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4678:Plxnb2
|
UTSW |
15 |
89,160,928 (GRCm38) |
missense |
probably benign |
0.37 |
|
R4717:Plxnb2
|
UTSW |
15 |
89,157,419 (GRCm38) |
nonsense |
probably null |
|
|
R4773:Plxnb2
|
UTSW |
15 |
89,166,947 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4905:Plxnb2
|
UTSW |
15 |
89,157,411 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5368:Plxnb2
|
UTSW |
15 |
89,159,593 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5418:Plxnb2
|
UTSW |
15 |
89,166,491 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5484:Plxnb2
|
UTSW |
15 |
89,164,209 (GRCm38) |
splice site |
probably null |
|
|
R5520:Plxnb2
|
UTSW |
15 |
89,167,543 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R5566:Plxnb2
|
UTSW |
15 |
89,164,020 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5568:Plxnb2
|
UTSW |
15 |
89,157,435 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5619:Plxnb2
|
UTSW |
15 |
89,162,809 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R5685:Plxnb2
|
UTSW |
15 |
89,167,032 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5688:Plxnb2
|
UTSW |
15 |
89,158,696 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5809:Plxnb2
|
UTSW |
15 |
89,167,571 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R5813:Plxnb2
|
UTSW |
15 |
89,160,759 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R5866:Plxnb2
|
UTSW |
15 |
89,167,572 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6016:Plxnb2
|
UTSW |
15 |
89,161,022 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R6117:Plxnb2
|
UTSW |
15 |
89,158,000 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6187:Plxnb2
|
UTSW |
15 |
89,167,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6260:Plxnb2
|
UTSW |
15 |
89,165,291 (GRCm38) |
missense |
probably benign |
0.22 |
|
R6263:Plxnb2
|
UTSW |
15 |
89,161,986 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6269:Plxnb2
|
UTSW |
15 |
89,160,713 (GRCm38) |
missense |
probably benign |
0.18 |
|
R6351:Plxnb2
|
UTSW |
15 |
89,157,770 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6522:Plxnb2
|
UTSW |
15 |
89,164,426 (GRCm38) |
missense |
probably benign |
0.18 |
|
R6856:Plxnb2
|
UTSW |
15 |
89,164,320 (GRCm38) |
missense |
probably benign |
0.27 |
|
R6930:Plxnb2
|
UTSW |
15 |
89,160,389 (GRCm38) |
missense |
probably benign |
|
|
R7354:Plxnb2
|
UTSW |
15 |
89,165,725 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R7513:Plxnb2
|
UTSW |
15 |
89,158,322 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7522:Plxnb2
|
UTSW |
15 |
89,161,774 (GRCm38) |
missense |
probably benign |
0.20 |
|
R7730:Plxnb2
|
UTSW |
15 |
89,162,330 (GRCm38) |
missense |
probably benign |
|
|
R7766:Plxnb2
|
UTSW |
15 |
89,161,271 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7781:Plxnb2
|
UTSW |
15 |
89,157,022 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R8126:Plxnb2
|
UTSW |
15 |
89,163,303 (GRCm38) |
missense |
probably benign |
|
|
R8131:Plxnb2
|
UTSW |
15 |
89,158,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8372:Plxnb2
|
UTSW |
15 |
89,158,493 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8736:Plxnb2
|
UTSW |
15 |
89,162,058 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8772:Plxnb2
|
UTSW |
15 |
89,162,746 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9022:Plxnb2
|
UTSW |
15 |
89,164,268 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R9044:Plxnb2
|
UTSW |
15 |
89,160,363 (GRCm38) |
splice site |
probably benign |
|
|
R9253:Plxnb2
|
UTSW |
15 |
89,167,812 (GRCm38) |
missense |
probably benign |
|
|
R9398:Plxnb2
|
UTSW |
15 |
89,160,919 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9562:Plxnb2
|
UTSW |
15 |
89,165,933 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9568:Plxnb2
|
UTSW |
15 |
89,160,957 (GRCm38) |
nonsense |
probably null |
|
|
R9613:Plxnb2
|
UTSW |
15 |
89,164,293 (GRCm38) |
missense |
probably benign |
0.01 |
|
X0027:Plxnb2
|
UTSW |
15 |
89,160,713 (GRCm38) |
missense |
probably benign |
0.18 |
|
Z1177:Plxnb2
|
UTSW |
15 |
89,159,096 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTCCTCCAGAGCATTGATGATC -3'
(R):5'- ACTGAGGTGCTTAGAACCCTG -3'
Sequencing Primer
(F):5'- AGCATTGATGATCTGGTGGG -3'
(R):5'- TGCTTAGAACCCTGGTGCC -3'
|
| Posted On |
2014-10-01 |
Incidental Mutation