Incidental Mutation 'R2142:Ipo9'
ID 236321
Institutional Source Beutler Lab
Gene Symbol Ipo9
Ensembl Gene ENSMUSG00000041879
Gene Name importin 9
Synonyms 0710008K06Rik, Imp9
MMRRC Submission 040145-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2142 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 135310050-135358237 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 135329988 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 484 (V484A)
Ref Sequence ENSEMBL: ENSMUSP00000124779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041023] [ENSMUST00000161032] [ENSMUST00000161189] [ENSMUST00000161838]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000041023
AA Change: V484A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000036093
Gene: ENSMUSG00000041879
AA Change: V484A

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
IBN_N 43 119 3.83e-7 SMART
low complexity region 911 922 N/A INTRINSIC
low complexity region 978 990 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159017
Predicted Effect probably benign
Transcript: ENSMUST00000161032
AA Change: V484A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000124779
Gene: ENSMUSG00000041879
AA Change: V484A

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
IBN_N 43 119 3.83e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161135
Predicted Effect probably benign
Transcript: ENSMUST00000161189
SMART Domains Protein: ENSMUSP00000124492
Gene: ENSMUSG00000041879

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
SCOP:d1i6la_ 21 52 4e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161258
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161704
Predicted Effect probably benign
Transcript: ENSMUST00000161838
SMART Domains Protein: ENSMUSP00000125646
Gene: ENSMUSG00000041879

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
SCOP:d1i6la_ 21 52 4e-3 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 105 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aagab T A 9: 63,523,957 (GRCm39) probably null Het
Adgrb3 G T 1: 25,107,290 (GRCm39) P640T probably damaging Het
Adgrf4 C T 17: 42,977,789 (GRCm39) R518Q possibly damaging Het
Afdn A G 17: 14,030,695 (GRCm39) E202G probably damaging Het
Alkbh2 C T 5: 114,263,777 (GRCm39) V77I probably benign Het
Angpt2 T C 8: 18,764,156 (GRCm39) T129A probably benign Het
Atp6v0a4 T A 6: 38,059,871 (GRCm39) K236* probably null Het
Baz1b G A 5: 135,246,129 (GRCm39) R526H probably damaging Het
Bltp3b A G 10: 89,647,910 (GRCm39) D207G probably damaging Het
Bscl2 T C 19: 8,822,684 (GRCm39) probably null Het
Btnl9 G T 11: 49,061,453 (GRCm39) probably null Het
Cd55 C T 1: 130,377,160 (GRCm39) V333I probably benign Het
Cdh8 C A 8: 99,838,325 (GRCm39) C505F probably damaging Het
Cep112 A G 11: 108,497,151 (GRCm39) E697G probably damaging Het
Ces1c T A 8: 93,857,468 (GRCm39) I38F probably benign Het
Cfhr2 T G 1: 139,758,893 (GRCm39) R52S probably benign Het
Clcn6 A G 4: 148,108,594 (GRCm39) F145S possibly damaging Het
Cnksr1 A G 4: 133,956,939 (GRCm39) Y488H probably damaging Het
Cntrl CAGAG CAG 2: 35,012,818 (GRCm39) probably null Het
Col25a1 A G 3: 130,363,965 (GRCm39) H546R probably damaging Het
Crot A T 5: 9,037,780 (GRCm39) Y179N possibly damaging Het
Dck T C 5: 88,920,582 (GRCm39) C101R probably damaging Het
Ddb1 T C 19: 10,596,490 (GRCm39) probably null Het
Dnah7b T A 1: 46,307,830 (GRCm39) M3048K probably damaging Het
Dsel T C 1: 111,787,187 (GRCm39) N1116S probably benign Het
Efnb1 A G X: 98,191,123 (GRCm39) Y343C probably damaging Het
Elf2 A G 3: 51,163,861 (GRCm39) V496A probably damaging Het
Esco1 A G 18: 10,574,873 (GRCm39) probably null Het
Fbn1 T G 2: 125,254,628 (GRCm39) T212P possibly damaging Het
Fuca2 A G 10: 13,381,609 (GRCm39) Y174C probably damaging Het
Gabarap C T 11: 69,882,515 (GRCm39) probably benign Het
Gdf2 A G 14: 33,667,198 (GRCm39) T307A probably benign Het
Gemin4 G C 11: 76,101,876 (GRCm39) P962A probably damaging Het
Glyatl3 T C 17: 41,221,975 (GRCm39) D93G probably benign Het
Gm266 C T 12: 111,451,615 (GRCm39) R197K possibly damaging Het
Gns G A 10: 121,228,683 (GRCm39) R498H probably damaging Het
Gprasp1 G A X: 134,702,791 (GRCm39) E995K possibly damaging Het
Grk6 T C 13: 55,602,177 (GRCm39) W335R probably damaging Het
Helz2 T C 2: 180,873,173 (GRCm39) E2379G probably benign Het
Hmx2 A T 7: 131,157,588 (GRCm39) D234V probably damaging Het
Ift20 G A 11: 78,430,860 (GRCm39) E68K probably damaging Het
Itpkc A G 7: 26,919,075 (GRCm39) V397A possibly damaging Het
Jarid2 T A 13: 45,059,752 (GRCm39) N661K probably damaging Het
Kat5 T A 19: 5,655,713 (GRCm39) probably null Het
Kctd16 A G 18: 40,392,231 (GRCm39) E273G possibly damaging Het
Kdr T C 5: 76,129,083 (GRCm39) T188A possibly damaging Het
Kif18a T A 2: 109,163,848 (GRCm39) N732K probably benign Het
Laptm4b G T 15: 34,238,478 (GRCm39) M3I probably benign Het
Macf1 C T 4: 123,248,895 (GRCm39) C7210Y probably damaging Het
Man1a T C 10: 53,811,094 (GRCm39) N338S probably damaging Het
Mical3 A T 6: 121,008,095 (GRCm39) probably null Het
Micall1 T C 15: 79,014,995 (GRCm39) Y751H probably damaging Het
Mki67 A G 7: 135,297,321 (GRCm39) I2571T possibly damaging Het
Mx2 G A 16: 97,339,903 (GRCm39) E20K probably benign Het
Myh2 A G 11: 67,080,158 (GRCm39) E1124G probably damaging Het
Myo10 A G 15: 25,714,194 (GRCm39) E87G probably benign Het
Nat10 T C 2: 103,561,648 (GRCm39) probably null Het
Nipa1 C A 7: 55,647,259 (GRCm39) probably null Het
Nrbp1 A G 5: 31,405,273 (GRCm39) E287G possibly damaging Het
Nup188 T A 2: 30,226,718 (GRCm39) I1165N possibly damaging Het
Obsl1 G A 1: 75,486,756 (GRCm38) T1764M probably benign Het
Optc A T 1: 133,831,534 (GRCm39) probably null Het
Or14j4 T G 17: 37,921,362 (GRCm39) E93D probably benign Het
Or2y13 A G 11: 49,414,666 (GRCm39) I39V probably benign Het
Or4a68 C T 2: 89,269,927 (GRCm39) R232H probably benign Het
Or4k48 C A 2: 111,475,566 (GRCm39) V259L probably benign Het
Or51a10 C T 7: 103,699,507 (GRCm39) G18D probably damaging Het
Or6c1b A G 10: 129,273,616 (GRCm39) K312E probably benign Het
Or9g3 C T 2: 85,590,021 (GRCm39) R233H probably benign Het
Panx3 G C 9: 37,577,969 (GRCm39) S87W probably damaging Het
Parp8 T A 13: 117,031,422 (GRCm39) D430V probably benign Het
Pcdhb11 A G 18: 37,555,176 (GRCm39) N169D probably benign Het
Pdzd2 C A 15: 12,406,645 (GRCm39) G605V probably damaging Het
Phkg2 G A 7: 127,181,386 (GRCm39) probably null Het
Pkhd1 T A 1: 20,594,119 (GRCm39) K1331N probably benign Het
Plcb4 G A 2: 135,818,019 (GRCm39) V762M probably damaging Het
Plec T C 15: 76,067,374 (GRCm39) T1331A probably benign Het
Pot1a T C 6: 25,750,043 (GRCm39) probably null Het
Prb1a T A 6: 132,184,166 (GRCm39) Q489L unknown Het
Prelp C T 1: 133,842,869 (GRCm39) R92K probably benign Het
Psme4 A G 11: 30,770,998 (GRCm39) Y782C possibly damaging Het
Rab11fip5 T C 6: 85,314,210 (GRCm39) probably null Het
Ren1 C G 1: 133,278,516 (GRCm39) probably null Het
Rit2 A G 18: 31,286,766 (GRCm39) F140L probably benign Het
Ro60 T C 1: 143,635,772 (GRCm39) D458G probably benign Het
Rorc G A 3: 94,296,833 (GRCm39) R271Q probably benign Het
Sall3 A T 18: 81,013,046 (GRCm39) M1130K probably damaging Het
Sart3 T C 5: 113,902,154 (GRCm39) E141G probably damaging Het
Serpina9 T C 12: 103,974,568 (GRCm39) D195G probably benign Het
Slitrk6 T G 14: 110,988,226 (GRCm39) T494P probably benign Het
Tars3 A T 7: 65,308,645 (GRCm39) I272L probably benign Het
Tas2r115 T C 6: 132,714,321 (GRCm39) K210R probably benign Het
Tdpoz3 C T 3: 93,734,206 (GRCm39) H294Y probably benign Het
Tesl1 T A X: 23,773,549 (GRCm39) V350E probably benign Het
Tigd4 A G 3: 84,501,670 (GRCm39) T196A possibly damaging Het
Treh G A 9: 44,592,438 (GRCm39) M54I probably damaging Het
Ttn C T 2: 76,643,683 (GRCm39) G11436R probably damaging Het
Ubap1 C T 4: 41,379,257 (GRCm39) A157V probably damaging Het
Ubr4 C T 4: 139,204,518 (GRCm39) T4810M probably damaging Het
Xrcc6 T A 15: 81,907,178 (GRCm39) F167I probably damaging Het
Zfp281 GCGGCAGCTCCGGCAGC GCGGCAGCTCCGGCAGCTCCGGCAGC 1: 136,553,091 (GRCm39) probably benign Het
Zfp473 T C 7: 44,382,501 (GRCm39) T610A possibly damaging Het
Zfp606 T C 7: 12,213,653 (GRCm39) I4T probably damaging Het
Zfp638 T A 6: 83,963,578 (GRCm39) N1918K probably damaging Het
Zfp65 G T 13: 67,856,311 (GRCm39) H333N probably damaging Het
Other mutations in Ipo9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Ipo9 APN 1 135,327,797 (GRCm39) missense probably damaging 1.00
IGL01611:Ipo9 APN 1 135,314,431 (GRCm39) missense possibly damaging 0.76
IGL01941:Ipo9 APN 1 135,335,811 (GRCm39) missense possibly damaging 0.95
IGL01944:Ipo9 APN 1 135,333,624 (GRCm39) missense probably damaging 0.98
IGL01959:Ipo9 APN 1 135,348,093 (GRCm39) critical splice acceptor site probably null
IGL02649:Ipo9 APN 1 135,313,672 (GRCm39) missense possibly damaging 0.92
IGL02697:Ipo9 APN 1 135,318,314 (GRCm39) missense probably benign 0.00
IGL03286:Ipo9 APN 1 135,334,816 (GRCm39) intron probably benign
FR4304:Ipo9 UTSW 1 135,314,017 (GRCm39) nonsense probably null
FR4304:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
FR4340:Ipo9 UTSW 1 135,314,009 (GRCm39) small insertion probably benign
FR4340:Ipo9 UTSW 1 135,314,007 (GRCm39) small insertion probably benign
FR4548:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
FR4589:Ipo9 UTSW 1 135,314,019 (GRCm39) small insertion probably benign
FR4589:Ipo9 UTSW 1 135,314,004 (GRCm39) small insertion probably benign
FR4976:Ipo9 UTSW 1 135,314,019 (GRCm39) small insertion probably benign
R0111:Ipo9 UTSW 1 135,333,662 (GRCm39) missense probably damaging 0.97
R0238:Ipo9 UTSW 1 135,332,074 (GRCm39) splice site probably benign
R0239:Ipo9 UTSW 1 135,332,074 (GRCm39) splice site probably benign
R0279:Ipo9 UTSW 1 135,348,101 (GRCm39) intron probably benign
R0704:Ipo9 UTSW 1 135,314,006 (GRCm39) small deletion probably benign
R1070:Ipo9 UTSW 1 135,334,281 (GRCm39) missense possibly damaging 0.89
R1282:Ipo9 UTSW 1 135,330,030 (GRCm39) missense possibly damaging 0.48
R1467:Ipo9 UTSW 1 135,334,281 (GRCm39) missense possibly damaging 0.89
R1467:Ipo9 UTSW 1 135,334,281 (GRCm39) missense possibly damaging 0.89
R1728:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1728:Ipo9 UTSW 1 135,314,009 (GRCm39) small insertion probably benign
R1728:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1729:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1729:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1730:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1730:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1739:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1739:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1762:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1762:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1783:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1783:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1784:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1784:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1785:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1785:Ipo9 UTSW 1 135,314,019 (GRCm39) small insertion probably benign
R1785:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1899:Ipo9 UTSW 1 135,327,884 (GRCm39) missense probably damaging 0.99
R2049:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2049:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2130:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2130:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2131:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2131:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2133:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2133:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
R2133:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2136:Ipo9 UTSW 1 135,322,023 (GRCm39) missense probably damaging 0.98
R2141:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2141:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2142:Ipo9 UTSW 1 135,314,020 (GRCm39) small insertion probably benign
R2142:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2142:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
R2356:Ipo9 UTSW 1 135,334,555 (GRCm39) missense probably benign 0.00
R2923:Ipo9 UTSW 1 135,327,867 (GRCm39) missense probably benign 0.25
R3161:Ipo9 UTSW 1 135,337,214 (GRCm39) missense probably benign 0.43
R3162:Ipo9 UTSW 1 135,337,214 (GRCm39) missense probably benign 0.43
R3162:Ipo9 UTSW 1 135,337,214 (GRCm39) missense probably benign 0.43
R4086:Ipo9 UTSW 1 135,316,428 (GRCm39) unclassified probably benign
R4679:Ipo9 UTSW 1 135,321,907 (GRCm39) missense probably benign
R4816:Ipo9 UTSW 1 135,334,288 (GRCm39) missense probably benign 0.21
R4956:Ipo9 UTSW 1 135,331,960 (GRCm39) critical splice donor site probably null
R5052:Ipo9 UTSW 1 135,316,349 (GRCm39) splice site probably null
R5055:Ipo9 UTSW 1 135,330,097 (GRCm39) nonsense probably null
R5230:Ipo9 UTSW 1 135,347,808 (GRCm39) missense probably damaging 1.00
R5240:Ipo9 UTSW 1 135,317,344 (GRCm39) unclassified probably benign
R5257:Ipo9 UTSW 1 135,313,173 (GRCm39) missense probably damaging 1.00
R5340:Ipo9 UTSW 1 135,313,170 (GRCm39) missense probably benign 0.00
R5560:Ipo9 UTSW 1 135,329,983 (GRCm39) missense probably damaging 0.99
R5602:Ipo9 UTSW 1 135,329,983 (GRCm39) missense probably damaging 0.99
R5604:Ipo9 UTSW 1 135,329,983 (GRCm39) missense probably damaging 0.99
R5654:Ipo9 UTSW 1 135,313,210 (GRCm39) nonsense probably null
R6018:Ipo9 UTSW 1 135,318,274 (GRCm39) critical splice donor site probably null
R6128:Ipo9 UTSW 1 135,318,311 (GRCm39) missense possibly damaging 0.90
R6841:Ipo9 UTSW 1 135,314,046 (GRCm39) missense probably benign
R7230:Ipo9 UTSW 1 135,334,496 (GRCm39) critical splice donor site probably benign
R7255:Ipo9 UTSW 1 135,313,726 (GRCm39) missense probably benign 0.01
R7383:Ipo9 UTSW 1 135,316,411 (GRCm39) missense probably damaging 1.00
R7844:Ipo9 UTSW 1 135,322,062 (GRCm39) missense probably benign 0.00
R7889:Ipo9 UTSW 1 135,334,591 (GRCm39) missense probably benign 0.22
R8125:Ipo9 UTSW 1 135,331,078 (GRCm39) missense probably benign 0.00
R8823:Ipo9 UTSW 1 135,347,077 (GRCm39) missense probably damaging 0.99
R8889:Ipo9 UTSW 1 135,314,544 (GRCm39) missense possibly damaging 0.50
R8892:Ipo9 UTSW 1 135,314,544 (GRCm39) missense possibly damaging 0.50
R8906:Ipo9 UTSW 1 135,321,951 (GRCm39) missense probably damaging 1.00
R8926:Ipo9 UTSW 1 135,313,952 (GRCm39) splice site probably benign
R9084:Ipo9 UTSW 1 135,334,563 (GRCm39) missense probably benign 0.01
R9215:Ipo9 UTSW 1 135,347,033 (GRCm39) missense probably benign 0.05
R9756:Ipo9 UTSW 1 135,314,057 (GRCm39) missense probably benign 0.00
Y5405:Ipo9 UTSW 1 135,314,022 (GRCm39) small insertion probably benign
Y5405:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
Y5405:Ipo9 UTSW 1 135,314,007 (GRCm39) small insertion probably benign
Predicted Primers PCR Primer
(F):5'- CTCAAAGGACTAGGCAGGGGT -3'
(R):5'- GAAATACTGACAAATGATTTGGGATC -3'

Sequencing Primer
(F):5'- CTAGGCAGGGGTAATATAGGATAC -3'
(R):5'- ACTTTGGAATACTCTGAGGGATC -3'
Posted On 2014-10-01