Incidental Mutation 'R2144:Skint6'
| ID |
236593 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Skint6
|
| Ensembl Gene |
ENSMUSG00000087194 |
| Gene Name |
selection and upkeep of intraepithelial T cells 6 |
| Synonyms |
OTTMUSG00000008519 |
| MMRRC Submission |
040147-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.051)
|
| Stock # |
R2144 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
112804616-113286973 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 113236260 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 229
(S229G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132312
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000138966]
[ENSMUST00000171224]
|
| AlphaFold |
A7XUZ6 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000138966
AA Change: S229G
PolyPhen 2
Score 0.841 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000121870
Gene: ENSMUSG00000087194
AA Change: S229G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
IGv
|
44 |
125 |
2.32e-8 |
SMART |
|
internal_repeat_1
|
219 |
594 |
1.11e-41 |
PROSPERO |
|
low complexity region
|
601 |
610 |
N/A |
INTRINSIC |
|
low complexity region
|
678 |
690 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
701 |
1076 |
1.11e-41 |
PROSPERO |
|
transmembrane domain
|
1087 |
1104 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1164 |
1186 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1206 |
1228 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000171224
AA Change: S229G
PolyPhen 2
Score 0.841 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000132312
Gene: ENSMUSG00000087194
AA Change: S229G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
IGv
|
44 |
125 |
2.32e-8 |
SMART |
|
internal_repeat_1
|
219 |
594 |
1.11e-41 |
PROSPERO |
|
low complexity region
|
601 |
610 |
N/A |
INTRINSIC |
|
low complexity region
|
678 |
690 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
701 |
1076 |
1.11e-41 |
PROSPERO |
|
transmembrane domain
|
1087 |
1104 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1164 |
1186 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1206 |
1228 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 117 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930553M12Rik |
G |
A |
4: 88,868,174 (GRCm38) |
T69I |
unknown |
Het |
| 4930553M12Rik |
T |
A |
4: 88,868,175 (GRCm38) |
T69S |
unknown |
Het |
| Acsl6 |
A |
T |
11: 54,341,778 (GRCm38) |
Q485L |
probably damaging |
Het |
| Adam5 |
C |
A |
8: 24,815,480 (GRCm38) |
V81F |
probably benign |
Het |
| Aoc1l1 |
A |
G |
6: 48,975,291 (GRCm38) |
H50R |
probably benign |
Het |
| Bag2 |
A |
G |
1: 33,746,831 (GRCm38) |
S137P |
possibly damaging |
Het |
| Birc6 |
A |
T |
17: 74,660,413 (GRCm38) |
Q4103L |
possibly damaging |
Het |
| Camta2 |
A |
G |
11: 70,671,575 (GRCm38) |
F999L |
probably benign |
Het |
| Cap2 |
A |
T |
13: 46,560,502 (GRCm38) |
|
probably null |
Het |
| Ccnk |
T |
A |
12: 108,189,090 (GRCm38) |
L102Q |
probably null |
Het |
| Cd52 |
T |
C |
4: 134,093,737 (GRCm38) |
|
probably benign |
Het |
| Cdc123 |
A |
T |
2: 5,810,806 (GRCm38) |
I160K |
probably benign |
Het |
| Cep85l |
T |
C |
10: 53,358,126 (GRCm38) |
N52S |
probably benign |
Het |
| Cntnap5a |
C |
T |
1: 116,101,710 (GRCm38) |
T298I |
probably benign |
Het |
| Cpsf4 |
G |
T |
5: 145,178,762 (GRCm38) |
S192I |
probably benign |
Het |
| Cpxm1 |
A |
G |
2: 130,397,410 (GRCm38) |
S33P |
probably benign |
Het |
| Cyp2a12 |
A |
T |
7: 27,034,769 (GRCm38) |
T376S |
possibly damaging |
Het |
| Cyp3a16 |
A |
G |
5: 145,456,084 (GRCm38) |
F137S |
probably damaging |
Het |
| Des |
A |
G |
1: 75,366,804 (GRCm38) |
T444A |
probably benign |
Het |
| Dgcr8 |
C |
T |
16: 18,284,256 (GRCm38) |
G54D |
probably damaging |
Het |
| Dmac2l |
A |
G |
12: 69,741,054 (GRCm38) |
Q88R |
probably damaging |
Het |
| Dsc3 |
A |
G |
18: 19,980,686 (GRCm38) |
F393S |
possibly damaging |
Het |
| Dstyk |
T |
A |
1: 132,463,375 (GRCm38) |
M838K |
probably damaging |
Het |
| Dvl1 |
G |
A |
4: 155,847,816 (GRCm38) |
V28I |
possibly damaging |
Het |
| Eml5 |
A |
C |
12: 98,810,605 (GRCm38) |
F1417C |
probably damaging |
Het |
| Ep400 |
A |
T |
5: 110,703,518 (GRCm38) |
M1366K |
unknown |
Het |
| Epg5 |
G |
T |
18: 77,954,197 (GRCm38) |
C425F |
possibly damaging |
Het |
| Epha3 |
C |
G |
16: 63,773,317 (GRCm38) |
R136P |
possibly damaging |
Het |
| Extl1 |
C |
A |
4: 134,371,044 (GRCm38) |
E225D |
probably benign |
Het |
| Fam186b |
A |
G |
15: 99,280,657 (GRCm38) |
Y263H |
probably benign |
Het |
| Fbn2 |
A |
G |
18: 58,052,993 (GRCm38) |
V1761A |
possibly damaging |
Het |
| Fer1l6 |
T |
A |
15: 58,627,534 (GRCm38) |
M1251K |
probably benign |
Het |
| Gart |
A |
T |
16: 91,630,081 (GRCm38) |
I555N |
probably damaging |
Het |
| Gm11596 |
A |
T |
11: 99,792,963 (GRCm38) |
C110* |
probably null |
Het |
| Gnptab |
C |
T |
10: 88,428,506 (GRCm38) |
S262L |
possibly damaging |
Het |
| Gpr21 |
T |
C |
2: 37,518,231 (GRCm38) |
V263A |
probably benign |
Het |
| Gxylt1 |
T |
C |
15: 93,254,480 (GRCm38) |
I224V |
probably benign |
Het |
| H2-Aa |
A |
G |
17: 34,283,827 (GRCm38) |
S122P |
probably damaging |
Het |
| Hsph1 |
A |
C |
5: 149,630,337 (GRCm38) |
|
probably null |
Het |
| Hunk |
G |
A |
16: 90,432,532 (GRCm38) |
D94N |
probably damaging |
Het |
| Ikbke |
C |
A |
1: 131,273,474 (GRCm38) |
V176L |
probably damaging |
Het |
| Inpp5k |
A |
T |
11: 75,647,191 (GRCm38) |
|
probably null |
Het |
| Ints10 |
A |
G |
8: 68,796,805 (GRCm38) |
T96A |
probably damaging |
Het |
| Kansl2 |
A |
T |
15: 98,526,631 (GRCm38) |
V306E |
probably benign |
Het |
| Kif20a |
A |
G |
18: 34,625,604 (GRCm38) |
D42G |
possibly damaging |
Het |
| Klhl7 |
A |
T |
5: 24,100,863 (GRCm38) |
M37L |
probably benign |
Het |
| Krtap1-5 |
T |
C |
11: 99,580,818 (GRCm38) |
I50V |
probably benign |
Het |
| Ktn1 |
A |
G |
14: 47,714,652 (GRCm38) |
E983G |
probably damaging |
Het |
| Lrrk1 |
G |
A |
7: 66,296,163 (GRCm38) |
S566L |
probably damaging |
Het |
| M6pr |
A |
G |
6: 122,315,367 (GRCm38) |
M174V |
probably benign |
Het |
| Man2a2 |
A |
G |
7: 80,363,516 (GRCm38) |
S510P |
probably damaging |
Het |
| Mmrn1 |
G |
A |
6: 60,945,075 (GRCm38) |
S172N |
possibly damaging |
Het |
| Mpv17 |
A |
G |
5: 31,154,189 (GRCm38) |
|
probably null |
Het |
| Mrgpra9 |
T |
C |
7: 47,235,463 (GRCm38) |
E152G |
probably benign |
Het |
| Mst1r |
T |
C |
9: 107,913,168 (GRCm38) |
V660A |
probably benign |
Het |
| Myof |
A |
G |
19: 37,981,221 (GRCm38) |
|
probably null |
Het |
| Myrf |
G |
A |
19: 10,228,674 (GRCm38) |
P126L |
probably benign |
Het |
| Nckap1l |
C |
T |
15: 103,475,676 (GRCm38) |
A567V |
probably damaging |
Het |
| Nphs1 |
A |
G |
7: 30,460,970 (GRCm38) |
E169G |
probably benign |
Het |
| Npy1r |
T |
A |
8: 66,705,184 (GRCm38) |
V382D |
probably benign |
Het |
| Nrl |
A |
T |
14: 55,520,850 (GRCm38) |
M140K |
possibly damaging |
Het |
| Odad2 |
C |
T |
18: 7,127,229 (GRCm38) |
E995K |
probably damaging |
Het |
| Or14c39 |
T |
A |
7: 86,695,280 (GRCm38) |
F275I |
probably damaging |
Het |
| Or2ag1b |
A |
T |
7: 106,688,957 (GRCm38) |
M258K |
probably damaging |
Het |
| Or4f56 |
A |
G |
2: 111,873,423 (GRCm38) |
I144T |
probably damaging |
Het |
| Or5ac17 |
C |
T |
16: 59,216,026 (GRCm38) |
V196M |
probably benign |
Het |
| Or8d2 |
C |
T |
9: 38,848,339 (GRCm38) |
T75I |
probably damaging |
Het |
| Orc5 |
T |
A |
5: 22,547,927 (GRCm38) |
L36F |
possibly damaging |
Het |
| Osbpl1a |
A |
T |
18: 12,871,173 (GRCm38) |
S396T |
probably benign |
Het |
| Pappa |
T |
A |
4: 65,180,949 (GRCm38) |
Y568* |
probably null |
Het |
| Pask |
C |
T |
1: 93,321,297 (GRCm38) |
A794T |
probably benign |
Het |
| Pclo |
C |
T |
5: 14,858,752 (GRCm38) |
L5025F |
unknown |
Het |
| Pde3a |
T |
C |
6: 141,490,111 (GRCm38) |
V924A |
probably benign |
Het |
| Pdpr |
A |
G |
8: 111,118,036 (GRCm38) |
N355S |
probably damaging |
Het |
| Pepd |
A |
T |
7: 34,921,418 (GRCm38) |
K36M |
probably benign |
Het |
| Pet100 |
T |
G |
8: 3,622,355 (GRCm38) |
L14R |
probably damaging |
Het |
| Pfkfb2 |
T |
C |
1: 130,698,723 (GRCm38) |
T438A |
probably benign |
Het |
| Pik3r6 |
T |
A |
11: 68,543,611 (GRCm38) |
L546* |
probably null |
Het |
| Pira2 |
A |
T |
7: 3,844,345 (GRCm38) |
L115Q |
probably damaging |
Het |
| Plxdc1 |
T |
C |
11: 97,934,012 (GRCm38) |
Y339C |
probably damaging |
Het |
| Primpol |
A |
T |
8: 46,586,343 (GRCm38) |
M414K |
probably damaging |
Het |
| Prol1 |
A |
T |
5: 88,328,395 (GRCm38) |
T215S |
unknown |
Het |
| Prss22 |
A |
G |
17: 23,994,682 (GRCm38) |
Y212H |
probably damaging |
Het |
| Ralgapa2 |
C |
A |
2: 146,388,604 (GRCm38) |
V1014L |
probably damaging |
Het |
| Rap1gap2 |
G |
A |
11: 74,425,976 (GRCm38) |
T245M |
probably damaging |
Het |
| Rbm26 |
T |
A |
14: 105,115,202 (GRCm38) |
R1009* |
probably null |
Het |
| Rbm42 |
A |
G |
7: 30,641,110 (GRCm38) |
*450Q |
probably null |
Het |
| Rere |
T |
C |
4: 150,616,931 (GRCm38) |
V1256A |
probably damaging |
Het |
| Rmi1 |
G |
T |
13: 58,407,983 (GRCm38) |
L15F |
probably damaging |
Het |
| Rnf213 |
T |
C |
11: 119,443,690 (GRCm38) |
S3242P |
probably damaging |
Het |
| Rtel1 |
T |
A |
2: 181,323,706 (GRCm38) |
V167E |
probably damaging |
Het |
| Scgb1b2 |
G |
T |
7: 31,291,763 (GRCm38) |
|
probably benign |
Het |
| Sin3b |
T |
C |
8: 72,731,265 (GRCm38) |
L203P |
probably damaging |
Het |
| Slco1a4 |
T |
C |
6: 141,809,378 (GRCm38) |
Y566C |
probably damaging |
Het |
| Smgc |
T |
G |
15: 91,844,421 (GRCm38) |
D121E |
possibly damaging |
Het |
| Sned1 |
T |
A |
1: 93,271,684 (GRCm38) |
F495L |
probably damaging |
Het |
| St7 |
A |
T |
6: 17,886,007 (GRCm38) |
N52I |
possibly damaging |
Het |
| Sycn |
C |
A |
7: 28,541,069 (GRCm38) |
Q54K |
probably benign |
Het |
| Syngr4 |
A |
G |
7: 45,887,040 (GRCm38) |
V186A |
probably benign |
Het |
| Tars3 |
G |
A |
7: 65,655,791 (GRCm38) |
M254I |
possibly damaging |
Het |
| Tcaf2 |
A |
T |
6: 42,642,804 (GRCm38) |
H96Q |
probably benign |
Het |
| Tcp11l2 |
T |
C |
10: 84,613,499 (GRCm38) |
Y443H |
probably damaging |
Het |
| Tmem200c |
A |
T |
17: 68,842,249 (GRCm38) |
Q609L |
possibly damaging |
Het |
| Tmx3 |
G |
A |
18: 90,517,490 (GRCm38) |
G83R |
probably damaging |
Het |
| Tpgs2 |
A |
C |
18: 25,168,541 (GRCm38) |
V23G |
possibly damaging |
Het |
| Trhr |
T |
C |
15: 44,197,183 (GRCm38) |
V33A |
probably benign |
Het |
| Trim66 |
A |
T |
7: 109,475,113 (GRCm38) |
I647N |
probably damaging |
Het |
| Trnt1 |
A |
G |
6: 106,778,039 (GRCm38) |
K244E |
probably damaging |
Het |
| Tsfm |
G |
A |
10: 127,028,445 (GRCm38) |
Q134* |
probably null |
Het |
| Ttll9 |
A |
G |
2: 153,003,007 (GRCm38) |
T432A |
probably benign |
Het |
| Vmn2r78 |
C |
T |
7: 86,954,482 (GRCm38) |
L623F |
probably damaging |
Het |
| Wdr55 |
A |
G |
18: 36,762,366 (GRCm38) |
N132S |
possibly damaging |
Het |
| Wipf2 |
A |
T |
11: 98,896,214 (GRCm38) |
R356S |
possibly damaging |
Het |
| Wnk1 |
A |
G |
6: 119,948,988 (GRCm38) |
|
probably benign |
Het |
| Zfp260 |
A |
G |
7: 30,105,340 (GRCm38) |
K222E |
probably damaging |
Het |
| Zfp300 |
A |
G |
X: 21,081,951 (GRCm38) |
S525P |
possibly damaging |
Het |
| Zfp592 |
A |
G |
7: 81,038,202 (GRCm38) |
T959A |
probably benign |
Het |
|
| Other mutations in Skint6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01123:Skint6
|
APN |
4 |
112,804,682 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
IGL01296:Skint6
|
APN |
4 |
113,236,440 (GRCm38) |
missense |
probably benign |
0.37 |
|
IGL01343:Skint6
|
APN |
4 |
113,283,626 (GRCm38) |
missense |
probably benign |
0.07 |
|
IGL01543:Skint6
|
APN |
4 |
112,899,963 (GRCm38) |
missense |
probably benign |
0.18 |
|
IGL01633:Skint6
|
APN |
4 |
113,238,049 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01818:Skint6
|
APN |
4 |
112,948,569 (GRCm38) |
missense |
probably benign |
0.18 |
|
IGL02124:Skint6
|
APN |
4 |
113,087,796 (GRCm38) |
missense |
probably benign |
|
|
IGL02517:Skint6
|
APN |
4 |
112,948,540 (GRCm38) |
splice site |
probably benign |
|
|
IGL02647:Skint6
|
APN |
4 |
113,127,891 (GRCm38) |
splice site |
probably benign |
|
|
IGL02887:Skint6
|
APN |
4 |
113,238,184 (GRCm38) |
nonsense |
probably null |
|
|
IGL03026:Skint6
|
APN |
4 |
112,991,244 (GRCm38) |
splice site |
probably null |
|
|
IGL03030:Skint6
|
APN |
4 |
113,012,956 (GRCm38) |
missense |
probably benign |
0.03 |
|
meissner
|
UTSW |
4 |
112,804,694 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
Tegmentum
|
UTSW |
4 |
112,842,822 (GRCm38) |
splice site |
probably null |
|
|
PIT4576001:Skint6
|
UTSW |
4 |
113,053,367 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R0058:Skint6
|
UTSW |
4 |
113,046,815 (GRCm38) |
splice site |
probably benign |
|
|
R0058:Skint6
|
UTSW |
4 |
113,046,815 (GRCm38) |
splice site |
probably benign |
|
|
R0099:Skint6
|
UTSW |
4 |
112,811,501 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R0158:Skint6
|
UTSW |
4 |
113,184,814 (GRCm38) |
splice site |
probably benign |
|
|
R0164:Skint6
|
UTSW |
4 |
112,991,236 (GRCm38) |
splice site |
probably benign |
|
|
R0312:Skint6
|
UTSW |
4 |
112,809,100 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R0591:Skint6
|
UTSW |
4 |
112,858,169 (GRCm38) |
splice site |
probably benign |
|
|
R0762:Skint6
|
UTSW |
4 |
112,865,651 (GRCm38) |
splice site |
probably benign |
|
|
R0941:Skint6
|
UTSW |
4 |
113,238,358 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1023:Skint6
|
UTSW |
4 |
113,238,103 (GRCm38) |
missense |
probably benign |
0.20 |
|
R1132:Skint6
|
UTSW |
4 |
112,898,099 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1228:Skint6
|
UTSW |
4 |
112,854,452 (GRCm38) |
missense |
probably benign |
|
|
R1338:Skint6
|
UTSW |
4 |
113,012,961 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R1432:Skint6
|
UTSW |
4 |
112,869,524 (GRCm38) |
splice site |
probably benign |
|
|
R1512:Skint6
|
UTSW |
4 |
113,238,132 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1577:Skint6
|
UTSW |
4 |
113,148,523 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R1733:Skint6
|
UTSW |
4 |
113,177,037 (GRCm38) |
splice site |
probably benign |
|
|
R1762:Skint6
|
UTSW |
4 |
113,236,481 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1891:Skint6
|
UTSW |
4 |
112,846,696 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R1908:Skint6
|
UTSW |
4 |
112,891,990 (GRCm38) |
missense |
probably benign |
|
|
R2069:Skint6
|
UTSW |
4 |
113,238,132 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2089:Skint6
|
UTSW |
4 |
112,846,684 (GRCm38) |
missense |
probably benign |
|
|
R2091:Skint6
|
UTSW |
4 |
112,846,684 (GRCm38) |
missense |
probably benign |
|
|
R2091:Skint6
|
UTSW |
4 |
112,846,684 (GRCm38) |
missense |
probably benign |
|
|
R2166:Skint6
|
UTSW |
4 |
112,854,452 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2192:Skint6
|
UTSW |
4 |
112,865,712 (GRCm38) |
nonsense |
probably null |
|
|
R2267:Skint6
|
UTSW |
4 |
112,842,822 (GRCm38) |
splice site |
probably null |
|
|
R2312:Skint6
|
UTSW |
4 |
113,238,142 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2324:Skint6
|
UTSW |
4 |
112,872,457 (GRCm38) |
splice site |
probably null |
|
|
R2342:Skint6
|
UTSW |
4 |
113,176,983 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3028:Skint6
|
UTSW |
4 |
113,236,493 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R3704:Skint6
|
UTSW |
4 |
113,136,472 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R3752:Skint6
|
UTSW |
4 |
112,842,899 (GRCm38) |
splice site |
probably benign |
|
|
R3760:Skint6
|
UTSW |
4 |
112,937,458 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R3827:Skint6
|
UTSW |
4 |
112,937,437 (GRCm38) |
missense |
probably benign |
|
|
R4377:Skint6
|
UTSW |
4 |
113,236,518 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R4406:Skint6
|
UTSW |
4 |
113,156,486 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4611:Skint6
|
UTSW |
4 |
113,074,076 (GRCm38) |
missense |
probably benign |
|
|
R4780:Skint6
|
UTSW |
4 |
113,236,397 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4788:Skint6
|
UTSW |
4 |
113,238,336 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R4818:Skint6
|
UTSW |
4 |
112,955,392 (GRCm38) |
intron |
probably benign |
|
|
R4900:Skint6
|
UTSW |
4 |
113,067,470 (GRCm38) |
missense |
probably benign |
0.03 |
|
R4972:Skint6
|
UTSW |
4 |
112,835,068 (GRCm38) |
missense |
probably benign |
|
|
R5008:Skint6
|
UTSW |
4 |
112,991,255 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R5016:Skint6
|
UTSW |
4 |
113,171,533 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R5085:Skint6
|
UTSW |
4 |
113,236,268 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5165:Skint6
|
UTSW |
4 |
112,865,668 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R5221:Skint6
|
UTSW |
4 |
112,894,924 (GRCm38) |
splice site |
probably null |
|
|
R5310:Skint6
|
UTSW |
4 |
113,184,768 (GRCm38) |
nonsense |
probably null |
|
|
R5423:Skint6
|
UTSW |
4 |
112,850,740 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R5436:Skint6
|
UTSW |
4 |
113,096,591 (GRCm38) |
missense |
probably benign |
0.08 |
|
R5447:Skint6
|
UTSW |
4 |
113,105,909 (GRCm38) |
missense |
probably benign |
0.34 |
|
R5564:Skint6
|
UTSW |
4 |
112,988,965 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R5629:Skint6
|
UTSW |
4 |
113,012,979 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R5936:Skint6
|
UTSW |
4 |
113,096,593 (GRCm38) |
missense |
probably benign |
0.33 |
|
R5993:Skint6
|
UTSW |
4 |
112,809,079 (GRCm38) |
missense |
probably benign |
0.02 |
|
R6027:Skint6
|
UTSW |
4 |
113,096,564 (GRCm38) |
splice site |
probably null |
|
|
R6174:Skint6
|
UTSW |
4 |
112,839,313 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R6497:Skint6
|
UTSW |
4 |
113,236,398 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6552:Skint6
|
UTSW |
4 |
113,067,490 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R6645:Skint6
|
UTSW |
4 |
112,892,038 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R6810:Skint6
|
UTSW |
4 |
112,948,380 (GRCm38) |
splice site |
probably null |
|
|
R7003:Skint6
|
UTSW |
4 |
113,105,912 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7211:Skint6
|
UTSW |
4 |
113,238,369 (GRCm38) |
missense |
probably benign |
0.09 |
|
R7269:Skint6
|
UTSW |
4 |
112,854,489 (GRCm38) |
splice site |
probably null |
|
|
R7398:Skint6
|
UTSW |
4 |
112,898,138 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7438:Skint6
|
UTSW |
4 |
113,238,228 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7461:Skint6
|
UTSW |
4 |
113,177,046 (GRCm38) |
splice site |
probably null |
|
|
R7536:Skint6
|
UTSW |
4 |
112,811,547 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7613:Skint6
|
UTSW |
4 |
113,177,046 (GRCm38) |
splice site |
probably null |
|
|
R7956:Skint6
|
UTSW |
4 |
112,846,697 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R8118:Skint6
|
UTSW |
4 |
113,156,494 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R8118:Skint6
|
UTSW |
4 |
112,865,675 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R8197:Skint6
|
UTSW |
4 |
112,894,843 (GRCm38) |
splice site |
probably null |
|
|
R8218:Skint6
|
UTSW |
4 |
112,839,274 (GRCm38) |
splice site |
probably null |
|
|
R8344:Skint6
|
UTSW |
4 |
113,236,445 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8518:Skint6
|
UTSW |
4 |
113,238,268 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R8776:Skint6
|
UTSW |
4 |
112,804,688 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R8776-TAIL:Skint6
|
UTSW |
4 |
112,804,688 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R8794:Skint6
|
UTSW |
4 |
113,192,672 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R8796:Skint6
|
UTSW |
4 |
112,804,694 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R8812:Skint6
|
UTSW |
4 |
112,988,952 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8866:Skint6
|
UTSW |
4 |
112,854,453 (GRCm38) |
missense |
probably benign |
|
|
R8881:Skint6
|
UTSW |
4 |
112,815,519 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R8949:Skint6
|
UTSW |
4 |
113,074,099 (GRCm38) |
missense |
probably benign |
0.04 |
|
R8967:Skint6
|
UTSW |
4 |
112,872,504 (GRCm38) |
nonsense |
probably null |
|
|
R9005:Skint6
|
UTSW |
4 |
113,238,150 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9007:Skint6
|
UTSW |
4 |
113,238,150 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9053:Skint6
|
UTSW |
4 |
113,238,150 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9055:Skint6
|
UTSW |
4 |
113,238,150 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9144:Skint6
|
UTSW |
4 |
113,127,905 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R9149:Skint6
|
UTSW |
4 |
113,176,976 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9297:Skint6
|
UTSW |
4 |
112,811,520 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9388:Skint6
|
UTSW |
4 |
113,192,641 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9407:Skint6
|
UTSW |
4 |
113,177,027 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R9475:Skint6
|
UTSW |
4 |
112,806,840 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9515:Skint6
|
UTSW |
4 |
112,858,178 (GRCm38) |
missense |
probably benign |
|
|
R9572:Skint6
|
UTSW |
4 |
113,127,931 (GRCm38) |
missense |
probably benign |
|
|
R9689:Skint6
|
UTSW |
4 |
113,236,349 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9744:Skint6
|
UTSW |
4 |
112,809,163 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9785:Skint6
|
UTSW |
4 |
112,883,687 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
Z1176:Skint6
|
UTSW |
4 |
113,238,294 (GRCm38) |
missense |
probably damaging |
0.96 |
|
Z1176:Skint6
|
UTSW |
4 |
112,892,014 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
Z1176:Skint6
|
UTSW |
4 |
113,238,295 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
Z1177:Skint6
|
UTSW |
4 |
113,105,961 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
Z1177:Skint6
|
UTSW |
4 |
112,806,928 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGTCTTAGAAACTTCAATGTGAA -3'
(R):5'- CAGCCTCACATGGAATGGAGAG -3'
Sequencing Primer
(F):5'- TGGAACTCACTCTGTAGACCAGG -3'
(R):5'- GACAGCAAAGGAGAGTACATTCC -3'
|
| Posted On |
2014-10-01 |
Incidental Mutation