Incidental Mutation 'R2144:Skint6'
| ID |
236593 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Skint6
|
| Ensembl Gene |
ENSMUSG00000087194 |
| Gene Name |
selection and upkeep of intraepithelial T cells 6 |
| Synonyms |
OTTMUSG00000008519 |
| MMRRC Submission |
040147-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.063)
|
| Stock # |
R2144 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
112661813-113144170 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 113093457 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 229
(S229G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132312
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000138966]
[ENSMUST00000171224]
|
| AlphaFold |
A7XUZ6 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000138966
AA Change: S229G
PolyPhen 2
Score 0.841 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000121870
Gene: ENSMUSG00000087194
AA Change: S229G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
IGv
|
44 |
125 |
2.32e-8 |
SMART |
|
internal_repeat_1
|
219 |
594 |
1.11e-41 |
PROSPERO |
|
low complexity region
|
601 |
610 |
N/A |
INTRINSIC |
|
low complexity region
|
678 |
690 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
701 |
1076 |
1.11e-41 |
PROSPERO |
|
transmembrane domain
|
1087 |
1104 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1164 |
1186 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1206 |
1228 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000171224
AA Change: S229G
PolyPhen 2
Score 0.841 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000132312
Gene: ENSMUSG00000087194
AA Change: S229G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
IGv
|
44 |
125 |
2.32e-8 |
SMART |
|
internal_repeat_1
|
219 |
594 |
1.11e-41 |
PROSPERO |
|
low complexity region
|
601 |
610 |
N/A |
INTRINSIC |
|
low complexity region
|
678 |
690 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
701 |
1076 |
1.11e-41 |
PROSPERO |
|
transmembrane domain
|
1087 |
1104 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1164 |
1186 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1206 |
1228 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 117 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930553M12Rik |
T |
A |
4: 88,786,412 (GRCm39) |
T69S |
unknown |
Het |
| 4930553M12Rik |
G |
A |
4: 88,786,411 (GRCm39) |
T69I |
unknown |
Het |
| Acsl6 |
A |
T |
11: 54,232,604 (GRCm39) |
Q485L |
probably damaging |
Het |
| Adam5 |
C |
A |
8: 25,305,496 (GRCm39) |
V81F |
probably benign |
Het |
| Aoc1l1 |
A |
G |
6: 48,952,225 (GRCm39) |
H50R |
probably benign |
Het |
| Bag2 |
A |
G |
1: 33,785,912 (GRCm39) |
S137P |
possibly damaging |
Het |
| Birc6 |
A |
T |
17: 74,967,408 (GRCm39) |
Q4103L |
possibly damaging |
Het |
| Camta2 |
A |
G |
11: 70,562,401 (GRCm39) |
F999L |
probably benign |
Het |
| Cap2 |
A |
T |
13: 46,713,978 (GRCm39) |
|
probably null |
Het |
| Ccnk |
T |
A |
12: 108,155,349 (GRCm39) |
L102Q |
probably null |
Het |
| Cd52 |
T |
C |
4: 133,821,048 (GRCm39) |
|
probably benign |
Het |
| Cdc123 |
A |
T |
2: 5,815,617 (GRCm39) |
I160K |
probably benign |
Het |
| Cep85l |
T |
C |
10: 53,234,222 (GRCm39) |
N52S |
probably benign |
Het |
| Cntnap5a |
C |
T |
1: 116,029,440 (GRCm39) |
T298I |
probably benign |
Het |
| Cpsf4 |
G |
T |
5: 145,115,572 (GRCm39) |
S192I |
probably benign |
Het |
| Cpxm1 |
A |
G |
2: 130,239,330 (GRCm39) |
S33P |
probably benign |
Het |
| Cyp2a12 |
A |
T |
7: 26,734,194 (GRCm39) |
T376S |
possibly damaging |
Het |
| Cyp3a16 |
A |
G |
5: 145,392,894 (GRCm39) |
F137S |
probably damaging |
Het |
| Des |
A |
G |
1: 75,343,448 (GRCm39) |
T444A |
probably benign |
Het |
| Dgcr8 |
C |
T |
16: 18,102,120 (GRCm39) |
G54D |
probably damaging |
Het |
| Dmac2l |
A |
G |
12: 69,787,828 (GRCm39) |
Q88R |
probably damaging |
Het |
| Dsc3 |
A |
G |
18: 20,113,743 (GRCm39) |
F393S |
possibly damaging |
Het |
| Dstyk |
T |
A |
1: 132,391,113 (GRCm39) |
M838K |
probably damaging |
Het |
| Dvl1 |
G |
A |
4: 155,932,273 (GRCm39) |
V28I |
possibly damaging |
Het |
| Eml5 |
A |
C |
12: 98,776,864 (GRCm39) |
F1417C |
probably damaging |
Het |
| Ep400 |
A |
T |
5: 110,851,384 (GRCm39) |
M1366K |
unknown |
Het |
| Epg5 |
G |
T |
18: 77,997,412 (GRCm39) |
C425F |
possibly damaging |
Het |
| Epha3 |
C |
G |
16: 63,593,680 (GRCm39) |
R136P |
possibly damaging |
Het |
| Extl1 |
C |
A |
4: 134,098,355 (GRCm39) |
E225D |
probably benign |
Het |
| Fam186b |
A |
G |
15: 99,178,538 (GRCm39) |
Y263H |
probably benign |
Het |
| Fbn2 |
A |
G |
18: 58,186,065 (GRCm39) |
V1761A |
possibly damaging |
Het |
| Fer1l6 |
T |
A |
15: 58,499,383 (GRCm39) |
M1251K |
probably benign |
Het |
| Gart |
A |
T |
16: 91,426,969 (GRCm39) |
I555N |
probably damaging |
Het |
| Gm11596 |
A |
T |
11: 99,683,789 (GRCm39) |
C110* |
probably null |
Het |
| Gnptab |
C |
T |
10: 88,264,368 (GRCm39) |
S262L |
possibly damaging |
Het |
| Gpr21 |
T |
C |
2: 37,408,243 (GRCm39) |
V263A |
probably benign |
Het |
| Gxylt1 |
T |
C |
15: 93,152,361 (GRCm39) |
I224V |
probably benign |
Het |
| H2-Aa |
A |
G |
17: 34,502,801 (GRCm39) |
S122P |
probably damaging |
Het |
| Hsph1 |
A |
C |
5: 149,553,802 (GRCm39) |
|
probably null |
Het |
| Hunk |
G |
A |
16: 90,229,420 (GRCm39) |
D94N |
probably damaging |
Het |
| Ikbke |
C |
A |
1: 131,201,211 (GRCm39) |
V176L |
probably damaging |
Het |
| Inpp5k |
A |
T |
11: 75,538,017 (GRCm39) |
|
probably null |
Het |
| Ints10 |
A |
G |
8: 69,249,457 (GRCm39) |
T96A |
probably damaging |
Het |
| Kansl2 |
A |
T |
15: 98,424,512 (GRCm39) |
V306E |
probably benign |
Het |
| Kif20a |
A |
G |
18: 34,758,657 (GRCm39) |
D42G |
possibly damaging |
Het |
| Klhl7 |
A |
T |
5: 24,305,861 (GRCm39) |
M37L |
probably benign |
Het |
| Krtap1-5 |
T |
C |
11: 99,471,644 (GRCm39) |
I50V |
probably benign |
Het |
| Ktn1 |
A |
G |
14: 47,952,109 (GRCm39) |
E983G |
probably damaging |
Het |
| Lrrk1 |
G |
A |
7: 65,945,911 (GRCm39) |
S566L |
probably damaging |
Het |
| M6pr |
A |
G |
6: 122,292,326 (GRCm39) |
M174V |
probably benign |
Het |
| Man2a2 |
A |
G |
7: 80,013,264 (GRCm39) |
S510P |
probably damaging |
Het |
| Mmrn1 |
G |
A |
6: 60,922,059 (GRCm39) |
S172N |
possibly damaging |
Het |
| Mpv17 |
A |
G |
5: 31,311,533 (GRCm39) |
|
probably null |
Het |
| Mrgpra9 |
T |
C |
7: 46,885,211 (GRCm39) |
E152G |
probably benign |
Het |
| Mst1r |
T |
C |
9: 107,790,367 (GRCm39) |
V660A |
probably benign |
Het |
| Myof |
A |
G |
19: 37,969,669 (GRCm39) |
|
probably null |
Het |
| Myrf |
G |
A |
19: 10,206,038 (GRCm39) |
P126L |
probably benign |
Het |
| Nckap1l |
C |
T |
15: 103,384,103 (GRCm39) |
A567V |
probably damaging |
Het |
| Nphs1 |
A |
G |
7: 30,160,395 (GRCm39) |
E169G |
probably benign |
Het |
| Npy1r |
T |
A |
8: 67,157,836 (GRCm39) |
V382D |
probably benign |
Het |
| Nrl |
A |
T |
14: 55,758,307 (GRCm39) |
M140K |
possibly damaging |
Het |
| Odad2 |
C |
T |
18: 7,127,229 (GRCm39) |
E995K |
probably damaging |
Het |
| Or14c39 |
T |
A |
7: 86,344,488 (GRCm39) |
F275I |
probably damaging |
Het |
| Or2ag1b |
A |
T |
7: 106,288,164 (GRCm39) |
M258K |
probably damaging |
Het |
| Or4f56 |
A |
G |
2: 111,703,768 (GRCm39) |
I144T |
probably damaging |
Het |
| Or5ac17 |
C |
T |
16: 59,036,389 (GRCm39) |
V196M |
probably benign |
Het |
| Or8d2 |
C |
T |
9: 38,759,635 (GRCm39) |
T75I |
probably damaging |
Het |
| Orc5 |
T |
A |
5: 22,752,925 (GRCm39) |
L36F |
possibly damaging |
Het |
| Osbpl1a |
A |
T |
18: 13,004,230 (GRCm39) |
S396T |
probably benign |
Het |
| Pappa |
T |
A |
4: 65,099,186 (GRCm39) |
Y568* |
probably null |
Het |
| Pask |
C |
T |
1: 93,249,019 (GRCm39) |
A794T |
probably benign |
Het |
| Pclo |
C |
T |
5: 14,908,766 (GRCm39) |
L5025F |
unknown |
Het |
| Pde3a |
T |
C |
6: 141,435,837 (GRCm39) |
V924A |
probably benign |
Het |
| Pdpr |
A |
G |
8: 111,844,668 (GRCm39) |
N355S |
probably damaging |
Het |
| Pepd |
A |
T |
7: 34,620,843 (GRCm39) |
K36M |
probably benign |
Het |
| Pet100 |
T |
G |
8: 3,672,355 (GRCm39) |
L14R |
probably damaging |
Het |
| Pfkfb2 |
T |
C |
1: 130,626,460 (GRCm39) |
T438A |
probably benign |
Het |
| Pik3r6 |
T |
A |
11: 68,434,437 (GRCm39) |
L546* |
probably null |
Het |
| Pira2 |
A |
T |
7: 3,847,344 (GRCm39) |
L115Q |
probably damaging |
Het |
| Plxdc1 |
T |
C |
11: 97,824,838 (GRCm39) |
Y339C |
probably damaging |
Het |
| Primpol |
A |
T |
8: 47,039,378 (GRCm39) |
M414K |
probably damaging |
Het |
| Prol1 |
A |
T |
5: 88,476,254 (GRCm39) |
T215S |
unknown |
Het |
| Prss22 |
A |
G |
17: 24,213,656 (GRCm39) |
Y212H |
probably damaging |
Het |
| Ralgapa2 |
C |
A |
2: 146,230,524 (GRCm39) |
V1014L |
probably damaging |
Het |
| Rap1gap2 |
G |
A |
11: 74,316,802 (GRCm39) |
T245M |
probably damaging |
Het |
| Rbm26 |
T |
A |
14: 105,352,638 (GRCm39) |
R1009* |
probably null |
Het |
| Rbm42 |
A |
G |
7: 30,340,535 (GRCm39) |
*450Q |
probably null |
Het |
| Rere |
T |
C |
4: 150,701,388 (GRCm39) |
V1256A |
probably damaging |
Het |
| Rmi1 |
G |
T |
13: 58,555,797 (GRCm39) |
L15F |
probably damaging |
Het |
| Rnf213 |
T |
C |
11: 119,334,516 (GRCm39) |
S3242P |
probably damaging |
Het |
| Rtel1 |
T |
A |
2: 180,965,499 (GRCm39) |
V167E |
probably damaging |
Het |
| Scgb1b2 |
G |
T |
7: 30,991,188 (GRCm39) |
|
probably benign |
Het |
| Sin3b |
T |
C |
8: 73,457,893 (GRCm39) |
L203P |
probably damaging |
Het |
| Slco1a4 |
T |
C |
6: 141,755,104 (GRCm39) |
Y566C |
probably damaging |
Het |
| Smgc |
T |
G |
15: 91,728,624 (GRCm39) |
D121E |
possibly damaging |
Het |
| Sned1 |
T |
A |
1: 93,199,406 (GRCm39) |
F495L |
probably damaging |
Het |
| St7 |
A |
T |
6: 17,886,006 (GRCm39) |
N52I |
possibly damaging |
Het |
| Sycn |
C |
A |
7: 28,240,494 (GRCm39) |
Q54K |
probably benign |
Het |
| Syngr4 |
A |
G |
7: 45,536,464 (GRCm39) |
V186A |
probably benign |
Het |
| Tars3 |
G |
A |
7: 65,305,539 (GRCm39) |
M254I |
possibly damaging |
Het |
| Tcaf2 |
A |
T |
6: 42,619,738 (GRCm39) |
H96Q |
probably benign |
Het |
| Tcp11l2 |
T |
C |
10: 84,449,363 (GRCm39) |
Y443H |
probably damaging |
Het |
| Tmem200c |
A |
T |
17: 69,149,244 (GRCm39) |
Q609L |
possibly damaging |
Het |
| Tmx3 |
G |
A |
18: 90,535,614 (GRCm39) |
G83R |
probably damaging |
Het |
| Tpgs2 |
A |
C |
18: 25,301,598 (GRCm39) |
V23G |
possibly damaging |
Het |
| Trhr |
T |
C |
15: 44,060,579 (GRCm39) |
V33A |
probably benign |
Het |
| Trim66 |
A |
T |
7: 109,074,320 (GRCm39) |
I647N |
probably damaging |
Het |
| Trnt1 |
A |
G |
6: 106,755,000 (GRCm39) |
K244E |
probably damaging |
Het |
| Tsfm |
G |
A |
10: 126,864,314 (GRCm39) |
Q134* |
probably null |
Het |
| Ttll9 |
A |
G |
2: 152,844,927 (GRCm39) |
T432A |
probably benign |
Het |
| Vmn2r78 |
C |
T |
7: 86,603,690 (GRCm39) |
L623F |
probably damaging |
Het |
| Wdr55 |
A |
G |
18: 36,895,419 (GRCm39) |
N132S |
possibly damaging |
Het |
| Wipf2 |
A |
T |
11: 98,787,040 (GRCm39) |
R356S |
possibly damaging |
Het |
| Wnk1 |
A |
G |
6: 119,925,949 (GRCm39) |
|
probably benign |
Het |
| Zfp260 |
A |
G |
7: 29,804,765 (GRCm39) |
K222E |
probably damaging |
Het |
| Zfp300 |
A |
G |
X: 20,948,190 (GRCm39) |
S525P |
possibly damaging |
Het |
| Zfp592 |
A |
G |
7: 80,687,950 (GRCm39) |
T959A |
probably benign |
Het |
|
| Other mutations in Skint6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01123:Skint6
|
APN |
4 |
112,661,879 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL01296:Skint6
|
APN |
4 |
113,093,637 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL01343:Skint6
|
APN |
4 |
113,140,823 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL01543:Skint6
|
APN |
4 |
112,757,160 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01633:Skint6
|
APN |
4 |
113,095,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01818:Skint6
|
APN |
4 |
112,805,766 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL02124:Skint6
|
APN |
4 |
112,944,993 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Skint6
|
APN |
4 |
112,805,737 (GRCm39) |
splice site |
probably benign |
|
|
IGL02647:Skint6
|
APN |
4 |
112,985,088 (GRCm39) |
splice site |
probably benign |
|
|
IGL02887:Skint6
|
APN |
4 |
113,095,381 (GRCm39) |
nonsense |
probably null |
|
|
IGL03026:Skint6
|
APN |
4 |
112,848,441 (GRCm39) |
splice site |
probably null |
|
|
IGL03030:Skint6
|
APN |
4 |
112,870,153 (GRCm39) |
missense |
probably benign |
0.03 |
|
meissner
|
UTSW |
4 |
112,661,891 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Tegmentum
|
UTSW |
4 |
112,700,019 (GRCm39) |
splice site |
probably null |
|
|
PIT4576001:Skint6
|
UTSW |
4 |
112,910,564 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0058:Skint6
|
UTSW |
4 |
112,904,012 (GRCm39) |
splice site |
probably benign |
|
|
R0058:Skint6
|
UTSW |
4 |
112,904,012 (GRCm39) |
splice site |
probably benign |
|
|
R0099:Skint6
|
UTSW |
4 |
112,668,698 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0158:Skint6
|
UTSW |
4 |
113,042,011 (GRCm39) |
splice site |
probably benign |
|
|
R0164:Skint6
|
UTSW |
4 |
112,848,433 (GRCm39) |
splice site |
probably benign |
|
|
R0312:Skint6
|
UTSW |
4 |
112,666,297 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0591:Skint6
|
UTSW |
4 |
112,715,366 (GRCm39) |
splice site |
probably benign |
|
|
R0762:Skint6
|
UTSW |
4 |
112,722,848 (GRCm39) |
splice site |
probably benign |
|
|
R0941:Skint6
|
UTSW |
4 |
113,095,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1023:Skint6
|
UTSW |
4 |
113,095,300 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1132:Skint6
|
UTSW |
4 |
112,755,296 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1228:Skint6
|
UTSW |
4 |
112,711,649 (GRCm39) |
missense |
probably benign |
|
|
R1338:Skint6
|
UTSW |
4 |
112,870,158 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1432:Skint6
|
UTSW |
4 |
112,726,721 (GRCm39) |
splice site |
probably benign |
|
|
R1512:Skint6
|
UTSW |
4 |
113,095,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1577:Skint6
|
UTSW |
4 |
113,005,720 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1733:Skint6
|
UTSW |
4 |
113,034,234 (GRCm39) |
splice site |
probably benign |
|
|
R1762:Skint6
|
UTSW |
4 |
113,093,678 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1891:Skint6
|
UTSW |
4 |
112,703,893 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1908:Skint6
|
UTSW |
4 |
112,749,187 (GRCm39) |
missense |
probably benign |
|
|
R2069:Skint6
|
UTSW |
4 |
113,095,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2089:Skint6
|
UTSW |
4 |
112,703,881 (GRCm39) |
missense |
probably benign |
|
|
R2091:Skint6
|
UTSW |
4 |
112,703,881 (GRCm39) |
missense |
probably benign |
|
|
R2091:Skint6
|
UTSW |
4 |
112,703,881 (GRCm39) |
missense |
probably benign |
|
|
R2166:Skint6
|
UTSW |
4 |
112,711,649 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2192:Skint6
|
UTSW |
4 |
112,722,909 (GRCm39) |
nonsense |
probably null |
|
|
R2267:Skint6
|
UTSW |
4 |
112,700,019 (GRCm39) |
splice site |
probably null |
|
|
R2312:Skint6
|
UTSW |
4 |
113,095,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2324:Skint6
|
UTSW |
4 |
112,729,654 (GRCm39) |
splice site |
probably null |
|
|
R2342:Skint6
|
UTSW |
4 |
113,034,180 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3028:Skint6
|
UTSW |
4 |
113,093,690 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R3704:Skint6
|
UTSW |
4 |
112,993,669 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3752:Skint6
|
UTSW |
4 |
112,700,096 (GRCm39) |
splice site |
probably benign |
|
|
R3760:Skint6
|
UTSW |
4 |
112,794,655 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3827:Skint6
|
UTSW |
4 |
112,794,634 (GRCm39) |
missense |
probably benign |
|
|
R4377:Skint6
|
UTSW |
4 |
113,093,715 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4406:Skint6
|
UTSW |
4 |
113,013,683 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4611:Skint6
|
UTSW |
4 |
112,931,273 (GRCm39) |
missense |
probably benign |
|
|
R4780:Skint6
|
UTSW |
4 |
113,093,594 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4788:Skint6
|
UTSW |
4 |
113,095,533 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R4818:Skint6
|
UTSW |
4 |
112,812,589 (GRCm39) |
intron |
probably benign |
|
|
R4900:Skint6
|
UTSW |
4 |
112,924,667 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4972:Skint6
|
UTSW |
4 |
112,692,265 (GRCm39) |
missense |
probably benign |
|
|
R5008:Skint6
|
UTSW |
4 |
112,848,452 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5016:Skint6
|
UTSW |
4 |
113,028,730 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5085:Skint6
|
UTSW |
4 |
113,093,465 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5165:Skint6
|
UTSW |
4 |
112,722,865 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5221:Skint6
|
UTSW |
4 |
112,752,121 (GRCm39) |
splice site |
probably null |
|
|
R5310:Skint6
|
UTSW |
4 |
113,041,965 (GRCm39) |
nonsense |
probably null |
|
|
R5423:Skint6
|
UTSW |
4 |
112,707,937 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5436:Skint6
|
UTSW |
4 |
112,953,788 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5447:Skint6
|
UTSW |
4 |
112,963,106 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5564:Skint6
|
UTSW |
4 |
112,846,162 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5629:Skint6
|
UTSW |
4 |
112,870,176 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5936:Skint6
|
UTSW |
4 |
112,953,790 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5993:Skint6
|
UTSW |
4 |
112,666,276 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6027:Skint6
|
UTSW |
4 |
112,953,761 (GRCm39) |
splice site |
probably null |
|
|
R6174:Skint6
|
UTSW |
4 |
112,696,510 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6497:Skint6
|
UTSW |
4 |
113,093,595 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6552:Skint6
|
UTSW |
4 |
112,924,687 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6645:Skint6
|
UTSW |
4 |
112,749,235 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6810:Skint6
|
UTSW |
4 |
112,805,577 (GRCm39) |
splice site |
probably null |
|
|
R7003:Skint6
|
UTSW |
4 |
112,963,109 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7211:Skint6
|
UTSW |
4 |
113,095,566 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7269:Skint6
|
UTSW |
4 |
112,711,686 (GRCm39) |
splice site |
probably null |
|
|
R7398:Skint6
|
UTSW |
4 |
112,755,335 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7438:Skint6
|
UTSW |
4 |
113,095,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7461:Skint6
|
UTSW |
4 |
113,034,243 (GRCm39) |
splice site |
probably null |
|
|
R7536:Skint6
|
UTSW |
4 |
112,668,744 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7613:Skint6
|
UTSW |
4 |
113,034,243 (GRCm39) |
splice site |
probably null |
|
|
R7956:Skint6
|
UTSW |
4 |
112,703,894 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8118:Skint6
|
UTSW |
4 |
113,013,691 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8118:Skint6
|
UTSW |
4 |
112,722,872 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8197:Skint6
|
UTSW |
4 |
112,752,040 (GRCm39) |
splice site |
probably null |
|
|
R8218:Skint6
|
UTSW |
4 |
112,696,471 (GRCm39) |
splice site |
probably null |
|
|
R8344:Skint6
|
UTSW |
4 |
113,093,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8518:Skint6
|
UTSW |
4 |
113,095,465 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8776:Skint6
|
UTSW |
4 |
112,661,885 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8776-TAIL:Skint6
|
UTSW |
4 |
112,661,885 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8794:Skint6
|
UTSW |
4 |
113,049,869 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8796:Skint6
|
UTSW |
4 |
112,661,891 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8812:Skint6
|
UTSW |
4 |
112,846,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8866:Skint6
|
UTSW |
4 |
112,711,650 (GRCm39) |
missense |
probably benign |
|
|
R8881:Skint6
|
UTSW |
4 |
112,672,716 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8949:Skint6
|
UTSW |
4 |
112,931,296 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8967:Skint6
|
UTSW |
4 |
112,729,701 (GRCm39) |
nonsense |
probably null |
|
|
R9005:Skint6
|
UTSW |
4 |
113,095,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9007:Skint6
|
UTSW |
4 |
113,095,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9053:Skint6
|
UTSW |
4 |
113,095,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9055:Skint6
|
UTSW |
4 |
113,095,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9144:Skint6
|
UTSW |
4 |
112,985,102 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9149:Skint6
|
UTSW |
4 |
113,034,173 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9297:Skint6
|
UTSW |
4 |
112,668,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9388:Skint6
|
UTSW |
4 |
113,049,838 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9407:Skint6
|
UTSW |
4 |
113,034,224 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9475:Skint6
|
UTSW |
4 |
112,664,037 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9515:Skint6
|
UTSW |
4 |
112,715,375 (GRCm39) |
missense |
probably benign |
|
|
R9572:Skint6
|
UTSW |
4 |
112,985,128 (GRCm39) |
missense |
probably benign |
|
|
R9689:Skint6
|
UTSW |
4 |
113,093,546 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9744:Skint6
|
UTSW |
4 |
112,666,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9785:Skint6
|
UTSW |
4 |
112,740,884 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1176:Skint6
|
UTSW |
4 |
113,095,491 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Skint6
|
UTSW |
4 |
112,749,211 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
Z1176:Skint6
|
UTSW |
4 |
113,095,492 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1177:Skint6
|
UTSW |
4 |
112,963,158 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Skint6
|
UTSW |
4 |
112,664,125 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGTCTTAGAAACTTCAATGTGAA -3'
(R):5'- CAGCCTCACATGGAATGGAGAG -3'
Sequencing Primer
(F):5'- TGGAACTCACTCTGTAGACCAGG -3'
(R):5'- GACAGCAAAGGAGAGTACATTCC -3'
|
| Posted On |
2014-10-01 |
Incidental Mutation