Incidental Mutation 'R0201:Adamts16'
| ID |
23667 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adamts16
|
| Ensembl Gene |
ENSMUSG00000049538 |
| Gene Name |
ADAM metallopeptidase with thrombospondin type 1 motif 16 |
| Synonyms |
|
| MMRRC Submission |
038458-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0201 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
70875921-70989930 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 70927763 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Leucine
at position 492
(Q492L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105316
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080145]
[ENSMUST00000109694]
[ENSMUST00000123552]
|
| AlphaFold |
Q69Z28 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000080145
AA Change: Q492L
PolyPhen 2
Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000079041
Gene: ENSMUSG00000049538
AA Change: Q492L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
57 |
203 |
7.8e-34 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
2.9e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
1.2e-8 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
5.4e-32 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
3.7e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
6.4e-11 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
TSP1
|
872 |
926 |
3.48e0 |
SMART |
|
TSP1
|
928 |
985 |
4.84e-3 |
SMART |
|
TSP1
|
987 |
1046 |
1.49e-3 |
SMART |
|
TSP1
|
1052 |
1113 |
3.19e-2 |
SMART |
|
TSP1
|
1127 |
1179 |
7.68e-6 |
SMART |
|
Pfam:PLAC
|
1188 |
1218 |
2.9e-13 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109694
AA Change: Q492L
PolyPhen 2
Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000105316
Gene: ENSMUSG00000049538
AA Change: Q492L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
56 |
203 |
2.2e-32 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
1.8e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
7.3e-9 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
4.6e-33 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
4.1e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
3.3e-10 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000123552
AA Change: Q492L
PolyPhen 2
Score 0.479 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000122031
Gene: ENSMUSG00000049538
AA Change: Q492L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
56 |
203 |
5.9e-33 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
5.1e-14 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
2.2e-9 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
1.2e-33 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
1.2e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
9.7e-11 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
| Meta Mutation Damage Score |
0.3966 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 94.2%
|
| Validation Efficiency |
97% (91/94) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is co-expressed with the Wilms tumor protein, Wt1, in the developing glomeruli of embryonic kidneys. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme. [provided by RefSeq, Jul 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamdec1 |
A |
G |
14: 68,819,406 (GRCm39) |
|
probably null |
Het |
| Aplnr |
A |
G |
2: 84,967,521 (GRCm39) |
D182G |
probably damaging |
Het |
| Arnt2 |
G |
T |
7: 84,010,867 (GRCm39) |
S3* |
probably null |
Het |
| Asxl3 |
T |
C |
18: 22,656,211 (GRCm39) |
V1407A |
probably benign |
Het |
| Atg13 |
A |
T |
2: 91,515,107 (GRCm39) |
|
probably null |
Het |
| Atm |
A |
T |
9: 53,365,579 (GRCm39) |
|
probably benign |
Het |
| Birc6 |
T |
G |
17: 74,916,322 (GRCm39) |
V1746G |
possibly damaging |
Het |
| Cbln1 |
G |
T |
8: 88,198,741 (GRCm39) |
T43K |
probably benign |
Het |
| Cbx5 |
T |
C |
15: 103,108,127 (GRCm39) |
T173A |
probably damaging |
Het |
| Cc2d2a |
A |
G |
5: 43,894,854 (GRCm39) |
Y1437C |
probably damaging |
Het |
| Ccdc78 |
C |
A |
17: 26,008,210 (GRCm39) |
|
probably benign |
Het |
| Cd2bp2 |
A |
G |
7: 126,793,000 (GRCm39) |
Y341H |
probably damaging |
Het |
| Cdhr5 |
T |
A |
7: 140,856,291 (GRCm39) |
D88V |
probably damaging |
Het |
| Ces1f |
T |
A |
8: 93,993,957 (GRCm39) |
T275S |
probably null |
Het |
| Cimip4 |
T |
A |
15: 78,263,028 (GRCm39) |
M209L |
probably damaging |
Het |
| Clca4a |
T |
C |
3: 144,666,478 (GRCm39) |
N458S |
probably benign |
Het |
| Cog5 |
A |
G |
12: 31,889,840 (GRCm39) |
K521R |
probably damaging |
Het |
| Csf2ra |
T |
A |
19: 61,214,006 (GRCm39) |
T305S |
probably benign |
Het |
| Csmd3 |
T |
A |
15: 47,483,125 (GRCm39) |
|
probably benign |
Het |
| Cts6 |
T |
A |
13: 61,349,313 (GRCm39) |
R132* |
probably null |
Het |
| D5Ertd579e |
G |
T |
5: 36,773,809 (GRCm39) |
N195K |
probably damaging |
Het |
| Ddx1 |
A |
G |
12: 13,273,809 (GRCm39) |
V606A |
probably damaging |
Het |
| Dip2b |
G |
A |
15: 100,084,028 (GRCm39) |
D884N |
probably damaging |
Het |
| Ehhadh |
A |
G |
16: 21,592,243 (GRCm39) |
|
probably null |
Het |
| Enpp1 |
T |
A |
10: 24,529,815 (GRCm39) |
T608S |
probably benign |
Het |
| Fancm |
T |
C |
12: 65,148,406 (GRCm39) |
Y674H |
probably damaging |
Het |
| Fat4 |
T |
A |
3: 38,945,745 (GRCm39) |
V1546D |
probably damaging |
Het |
| Fsd1 |
G |
A |
17: 56,297,522 (GRCm39) |
A158T |
probably benign |
Het |
| Fzd2 |
T |
A |
11: 102,496,948 (GRCm39) |
M464K |
probably damaging |
Het |
| Gjc2 |
A |
G |
11: 59,068,416 (GRCm39) |
F22S |
possibly damaging |
Het |
| Gria2 |
T |
C |
3: 80,615,145 (GRCm39) |
Y445C |
probably damaging |
Het |
| Hsdl1 |
T |
A |
8: 120,292,995 (GRCm39) |
I147F |
possibly damaging |
Het |
| Ifi44 |
T |
C |
3: 151,451,273 (GRCm39) |
Y226C |
probably damaging |
Het |
| Il16 |
A |
G |
7: 83,371,516 (GRCm39) |
C97R |
probably damaging |
Het |
| Impg1 |
A |
T |
9: 80,252,843 (GRCm39) |
S369T |
probably damaging |
Het |
| Jmjd1c |
A |
G |
10: 67,054,888 (GRCm39) |
T390A |
unknown |
Het |
| Lgi1 |
A |
G |
19: 38,289,741 (GRCm39) |
E269G |
possibly damaging |
Het |
| Lrp6 |
G |
T |
6: 134,427,860 (GRCm39) |
Y1577* |
probably null |
Het |
| Lrrc74a |
G |
T |
12: 86,808,547 (GRCm39) |
|
probably benign |
Het |
| Man1c1 |
A |
T |
4: 134,367,709 (GRCm39) |
|
probably null |
Het |
| Map1lc3b |
A |
C |
8: 122,317,289 (GRCm39) |
Q9P |
possibly damaging |
Het |
| Mboat1 |
G |
A |
13: 30,386,358 (GRCm39) |
R124H |
probably benign |
Het |
| Mcu |
A |
G |
10: 59,292,499 (GRCm39) |
L60P |
probably damaging |
Het |
| Mrs2 |
G |
T |
13: 25,202,517 (GRCm39) |
Q75K |
probably benign |
Het |
| Muc2 |
CGTG |
CGTGTG |
7: 141,699,185 (GRCm38) |
|
probably null |
Het |
| Neb |
G |
A |
2: 52,096,890 (GRCm39) |
|
probably benign |
Het |
| Nlrp2 |
C |
T |
7: 5,331,328 (GRCm39) |
G356D |
probably benign |
Het |
| Notch3 |
A |
G |
17: 32,375,122 (GRCm39) |
|
probably benign |
Het |
| Npr2 |
A |
C |
4: 43,641,617 (GRCm39) |
S474R |
probably damaging |
Het |
| Nup58 |
A |
G |
14: 60,482,065 (GRCm39) |
F100L |
probably benign |
Het |
| Osbpl6 |
A |
C |
2: 76,376,386 (GRCm39) |
D87A |
possibly damaging |
Het |
| Pabpc2 |
A |
T |
18: 39,908,360 (GRCm39) |
M542L |
probably benign |
Het |
| Papln |
A |
G |
12: 83,829,801 (GRCm39) |
|
probably benign |
Het |
| Parpbp |
T |
C |
10: 87,928,758 (GRCm39) |
I561V |
possibly damaging |
Het |
| Pcdhb13 |
C |
T |
18: 37,575,634 (GRCm39) |
A4V |
probably benign |
Het |
| Pelp1 |
T |
C |
11: 70,286,530 (GRCm39) |
T533A |
possibly damaging |
Het |
| Poldip3 |
T |
A |
15: 83,019,497 (GRCm39) |
M182L |
probably benign |
Het |
| Por |
T |
C |
5: 135,760,032 (GRCm39) |
S240P |
possibly damaging |
Het |
| Pramel15 |
A |
T |
4: 144,103,843 (GRCm39) |
|
probably benign |
Het |
| Pramel28 |
T |
C |
4: 143,691,460 (GRCm39) |
E421G |
probably damaging |
Het |
| Prss22 |
A |
T |
17: 24,215,275 (GRCm39) |
V167D |
probably damaging |
Het |
| Prss37 |
A |
C |
6: 40,493,283 (GRCm39) |
L61R |
probably damaging |
Het |
| Psmd1 |
C |
T |
1: 86,046,338 (GRCm39) |
T702M |
probably benign |
Het |
| Pxdn |
G |
T |
12: 30,052,430 (GRCm39) |
G869V |
possibly damaging |
Het |
| Rabgap1l |
A |
G |
1: 160,281,315 (GRCm39) |
|
probably benign |
Het |
| Rapgef6 |
T |
C |
11: 54,510,767 (GRCm39) |
V228A |
probably damaging |
Het |
| Rnf169 |
T |
C |
7: 99,575,210 (GRCm39) |
R462G |
possibly damaging |
Het |
| Rnft2 |
A |
G |
5: 118,332,745 (GRCm39) |
|
probably benign |
Het |
| Sgo2b |
T |
C |
8: 64,379,670 (GRCm39) |
D1054G |
probably benign |
Het |
| Sh3bgr |
T |
C |
16: 96,029,717 (GRCm39) |
|
probably benign |
Het |
| Slc12a4 |
A |
G |
8: 106,671,982 (GRCm39) |
V910A |
possibly damaging |
Het |
| Slc6a12 |
A |
T |
6: 121,332,331 (GRCm39) |
I222F |
probably benign |
Het |
| Spty2d1 |
G |
A |
7: 46,647,649 (GRCm39) |
R427* |
probably null |
Het |
| Ssc5d |
A |
G |
7: 4,947,662 (GRCm39) |
T1339A |
probably benign |
Het |
| Sspo |
A |
C |
6: 48,432,686 (GRCm39) |
E854A |
possibly damaging |
Het |
| Stx7 |
A |
G |
10: 24,060,977 (GRCm39) |
|
probably benign |
Het |
| Styk1 |
A |
T |
6: 131,278,693 (GRCm39) |
|
probably benign |
Het |
| Tmem163 |
T |
G |
1: 127,596,374 (GRCm39) |
|
probably benign |
Het |
| Tmppe |
C |
CT |
9: 114,233,707 (GRCm39) |
|
probably null |
Het |
| Tmx2 |
A |
G |
2: 84,503,426 (GRCm39) |
V229A |
probably benign |
Het |
| Top2b |
T |
C |
14: 16,383,174 (GRCm38) |
L54P |
probably damaging |
Het |
| Trim62 |
A |
T |
4: 128,796,343 (GRCm39) |
Y280F |
probably benign |
Het |
| Tssk4 |
A |
T |
14: 55,889,016 (GRCm39) |
K181* |
probably null |
Het |
| Tssk4 |
A |
T |
14: 55,889,017 (GRCm39) |
K181M |
probably damaging |
Het |
| Ubn1 |
A |
G |
16: 4,882,478 (GRCm39) |
D313G |
probably damaging |
Het |
| Ugt1a10 |
C |
T |
1: 88,142,845 (GRCm39) |
P113L |
probably damaging |
Het |
| Ugt1a10 |
C |
T |
1: 88,145,971 (GRCm39) |
P473L |
probably damaging |
Het |
|
| Other mutations in Adamts16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01024:Adamts16
|
APN |
13 |
70,943,603 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01338:Adamts16
|
APN |
13 |
70,984,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01663:Adamts16
|
APN |
13 |
70,941,260 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01804:Adamts16
|
APN |
13 |
70,949,080 (GRCm39) |
nonsense |
probably null |
|
|
IGL01874:Adamts16
|
APN |
13 |
70,916,823 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01984:Adamts16
|
APN |
13 |
70,935,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02305:Adamts16
|
APN |
13 |
70,921,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Adamts16
|
APN |
13 |
70,886,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02357:Adamts16
|
APN |
13 |
70,886,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02429:Adamts16
|
APN |
13 |
70,935,289 (GRCm39) |
splice site |
probably benign |
|
|
IGL02450:Adamts16
|
APN |
13 |
70,984,419 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02807:Adamts16
|
APN |
13 |
70,886,897 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03356:Adamts16
|
APN |
13 |
70,901,410 (GRCm39) |
missense |
probably benign |
0.00 |
|
swap
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
switcheroo
|
UTSW |
13 |
70,949,073 (GRCm39) |
missense |
probably benign |
|
|
R0046:Adamts16
|
UTSW |
13 |
70,911,579 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0046:Adamts16
|
UTSW |
13 |
70,911,579 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0326:Adamts16
|
UTSW |
13 |
70,927,730 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0336:Adamts16
|
UTSW |
13 |
70,939,913 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R0369:Adamts16
|
UTSW |
13 |
70,927,671 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0422:Adamts16
|
UTSW |
13 |
70,887,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0507:Adamts16
|
UTSW |
13 |
70,916,766 (GRCm39) |
missense |
probably benign |
|
|
R0524:Adamts16
|
UTSW |
13 |
70,949,013 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0590:Adamts16
|
UTSW |
13 |
70,949,073 (GRCm39) |
missense |
probably benign |
|
|
R0734:Adamts16
|
UTSW |
13 |
70,886,600 (GRCm39) |
splice site |
probably benign |
|
|
R0787:Adamts16
|
UTSW |
13 |
70,886,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0826:Adamts16
|
UTSW |
13 |
70,916,811 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0920:Adamts16
|
UTSW |
13 |
70,911,680 (GRCm39) |
splice site |
probably benign |
|
|
R1027:Adamts16
|
UTSW |
13 |
70,915,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Adamts16
|
UTSW |
13 |
70,984,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1462:Adamts16
|
UTSW |
13 |
70,984,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1535:Adamts16
|
UTSW |
13 |
70,939,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1617:Adamts16
|
UTSW |
13 |
70,946,154 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1700:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1734:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1736:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1737:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1738:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1746:Adamts16
|
UTSW |
13 |
70,927,717 (GRCm39) |
splice site |
probably null |
|
|
R1869:Adamts16
|
UTSW |
13 |
70,883,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1944:Adamts16
|
UTSW |
13 |
70,940,005 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1997:Adamts16
|
UTSW |
13 |
70,901,386 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2018:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R2135:Adamts16
|
UTSW |
13 |
70,949,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2219:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R2228:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R3410:Adamts16
|
UTSW |
13 |
70,901,345 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3411:Adamts16
|
UTSW |
13 |
70,901,345 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3842:Adamts16
|
UTSW |
13 |
70,887,010 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4117:Adamts16
|
UTSW |
13 |
70,916,111 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4435:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4436:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4526:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4552:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4555:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4556:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4557:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4579:Adamts16
|
UTSW |
13 |
70,927,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4639:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4640:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4641:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4642:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4672:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R5350:Adamts16
|
UTSW |
13 |
70,901,315 (GRCm39) |
nonsense |
probably null |
|
|
R5464:Adamts16
|
UTSW |
13 |
70,909,868 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5613:Adamts16
|
UTSW |
13 |
70,878,253 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5667:Adamts16
|
UTSW |
13 |
70,984,494 (GRCm39) |
nonsense |
probably null |
|
|
R5735:Adamts16
|
UTSW |
13 |
70,984,337 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5762:Adamts16
|
UTSW |
13 |
70,886,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5907:Adamts16
|
UTSW |
13 |
70,877,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Adamts16
|
UTSW |
13 |
70,918,393 (GRCm39) |
nonsense |
probably null |
|
|
R6351:Adamts16
|
UTSW |
13 |
70,984,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6665:Adamts16
|
UTSW |
13 |
70,927,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6913:Adamts16
|
UTSW |
13 |
70,877,017 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6982:Adamts16
|
UTSW |
13 |
70,916,639 (GRCm39) |
splice site |
probably null |
|
|
R6996:Adamts16
|
UTSW |
13 |
70,946,157 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7313:Adamts16
|
UTSW |
13 |
70,921,074 (GRCm39) |
nonsense |
probably null |
|
|
R7356:Adamts16
|
UTSW |
13 |
70,984,399 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7509:Adamts16
|
UTSW |
13 |
70,935,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7595:Adamts16
|
UTSW |
13 |
70,878,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7782:Adamts16
|
UTSW |
13 |
70,984,265 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7968:Adamts16
|
UTSW |
13 |
70,886,701 (GRCm39) |
missense |
probably benign |
|
|
R8231:Adamts16
|
UTSW |
13 |
70,925,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8232:Adamts16
|
UTSW |
13 |
70,941,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8470:Adamts16
|
UTSW |
13 |
70,984,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8485:Adamts16
|
UTSW |
13 |
70,886,794 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8772:Adamts16
|
UTSW |
13 |
70,984,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8916:Adamts16
|
UTSW |
13 |
70,941,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8921:Adamts16
|
UTSW |
13 |
70,939,910 (GRCm39) |
splice site |
probably benign |
|
|
R8973:Adamts16
|
UTSW |
13 |
70,886,959 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9132:Adamts16
|
UTSW |
13 |
70,901,408 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9149:Adamts16
|
UTSW |
13 |
70,883,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9159:Adamts16
|
UTSW |
13 |
70,901,408 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9312:Adamts16
|
UTSW |
13 |
70,949,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9584:Adamts16
|
UTSW |
13 |
70,949,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adamts16
|
UTSW |
13 |
70,909,892 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACTGAGCATGTGGCAGTAACTAACC -3'
(R):5'- GGGGAAACCCTCACGTTAGACATC -3'
Sequencing Primer
(F):5'- GTGGCAGTAACTAACCACTTG -3'
(R):5'- GTCATATATCCCTTGGTAACTCATCC -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation