Mutagenetix > Incidental Mutation

Incidental Mutation 'R0973:Ptpro'

236729

Institutional Source

Beutler Lab

Gene Symbol

Ptpro

Ensembl Gene

ENSMUSG00000030223

Gene Name

protein tyrosine phosphatase, receptor type, O

Synonyms

Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi, D28, PTPROt

MMRRC Submission

039102-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0973 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

137252319-137463233 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 137443594 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 1007 (V1007D)

Ref Sequence

ENSEMBL: ENSMUSP00000127112 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077115] [ENSMUST00000167002] [ENSMUST00000167679] [ENSMUST00000203914]

AlphaFold

E9Q612

Predicted Effect

probably damaging
Transcript: ENSMUST00000077115
AA Change: V1035D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000076364
Gene: ENSMUSG00000030223
AA Change: V1035D

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
transmembrane domain	890	912	N/A	INTRINSIC
PTPc	947	1207	1.43e-127	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000167002
AA Change: V214D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131764
Gene: ENSMUSG00000030223
AA Change: V214D

Domain	Start	End	E-Value	Type
transmembrane domain	10	32	N/A	INTRINSIC
transmembrane domain	69	91	N/A	INTRINSIC
PTPc	126	386	1.43e-127	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000167679
AA Change: V1007D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000127112
Gene: ENSMUSG00000030223
AA Change: V1007D

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
PTPc	919	1179	1.43e-127	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000203914
AA Change: V186D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000144870
Gene: ENSMUSG00000030223
AA Change: V186D

Domain	Start	End	E-Value	Type
signal peptide	1	33	N/A	INTRINSIC
PTPc	98	358	6.1e-130	SMART

Meta Mutation Damage Score

0.9197

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.6%
20x: 96.0%

Validation Efficiency

93% (38/41)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
PHENOTYPE: Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700056E22Rik	C	T	1: 184,033,505 (GRCm38)	S119N	probably benign	Het
4930503L19Rik	T	A	18: 70,467,926 (GRCm38)		probably null	Het
5430419D17Rik	T	C	7: 131,238,182 (GRCm38)	L611P	probably damaging	Het
Adam18	T	C	8: 24,647,853 (GRCm38)	T324A	probably benign	Het
Adamts20	T	A	15: 94,286,371 (GRCm38)	Q1517L	probably benign	Het
AI429214	A	G	8: 36,994,319 (GRCm38)	Q207R	probably benign	Het
Arhgef7	A	G	8: 11,819,659 (GRCm38)	T432A	possibly damaging	Het
Atad2b	A	G	12: 5,031,784 (GRCm38)	N1231S	probably benign	Het
Atp13a1	T	C	8: 69,802,144 (GRCm38)		probably null	Het
Atp6v0a1	T	A	11: 101,055,491 (GRCm38)	L770*	probably null	Het
Atp8b3	T	C	10: 80,534,198 (GRCm38)	N127S	probably damaging	Het
B3gnt5	T	A	16: 19,770,010 (GRCm38)	D326E	probably damaging	Het
Birc6	T	A	17: 74,565,861 (GRCm38)	S372T	probably damaging	Het
Btbd9	T	A	17: 30,299,633 (GRCm38)	D451V	probably damaging	Het
Cd46	T	C	1: 195,041,992 (GRCm38)	*366W	probably null	Het
Cdh18	T	A	15: 23,473,995 (GRCm38)	D650E	probably damaging	Het
Cenpc1	A	T	5: 86,037,908 (GRCm38)	V248E	probably damaging	Het
Cep152	A	G	2: 125,594,899 (GRCm38)	S574P	probably benign	Het
Chd2	A	G	7: 73,478,664 (GRCm38)	S858P	probably damaging	Het
Cib4	T	C	5: 30,488,594 (GRCm38)	D110G	probably damaging	Het
Col9a2	T	A	4: 121,039,788 (GRCm38)		probably null	Het
Csmd2	A	T	4: 128,496,188 (GRCm38)	I2239F	possibly damaging	Het
Csmd3	C	A	15: 47,659,089 (GRCm38)	G2728V	probably damaging	Het
Cxcl1	A	T	5: 90,891,767 (GRCm38)	K85*	probably null	Het
Cyp2d11	A	G	15: 82,389,529 (GRCm38)	L416P	possibly damaging	Het
Daam1	A	C	12: 71,915,784 (GRCm38)	K90T	unknown	Het
Depdc5	T	A	5: 32,986,966 (GRCm38)	M1435K	possibly damaging	Het
Diexf	A	T	1: 193,114,703 (GRCm38)	N573K	probably damaging	Het
Dip2c	G	A	13: 9,576,908 (GRCm38)	A632T	probably damaging	Het
Dld	A	T	12: 31,334,054 (GRCm38)	I350N	probably damaging	Het
Dmtf1	T	A	5: 9,127,987 (GRCm38)	I391F	possibly damaging	Het
Dnah14	T	C	1: 181,752,145 (GRCm38)	V3081A	probably damaging	Het
Efemp1	A	G	11: 28,854,538 (GRCm38)	E22G	probably damaging	Het
Ephb6	A	G	6: 41,614,104 (GRCm38)	D65G	probably damaging	Het
Fsip2	A	T	2: 82,977,092 (GRCm38)	T1252S	probably benign	Het
Gm13084	T	C	4: 143,811,858 (GRCm38)	Y181C	probably damaging	Het
Gm4847	A	G	1: 166,630,255 (GRCm38)	S510P	probably benign	Het
Golga4	T	C	9: 118,537,273 (GRCm38)	I365T	probably damaging	Het
Gp2	A	T	7: 119,454,543 (GRCm38)	L65Q	probably damaging	Het
Ibtk	T	C	9: 85,743,577 (GRCm38)	Y40C	probably damaging	Het
Ice1	C	A	13: 70,602,427 (GRCm38)	V1847L	probably benign	Het
Ift172	C	T	5: 31,265,355 (GRCm38)	R917H	probably benign	Het
Itgae	C	T	11: 73,138,509 (GRCm38)	Q1037*	probably null	Het
Kbtbd7	A	G	14: 79,427,430 (GRCm38)	E234G	possibly damaging	Het
Khsrp	T	C	17: 57,025,576 (GRCm38)	T235A	probably benign	Het
Klk13	T	C	7: 43,721,158 (GRCm38)		probably null	Het
Lrfn5	G	A	12: 61,843,437 (GRCm38)	G504D	probably damaging	Het
Macf1	A	G	4: 123,476,000 (GRCm38)	V91A	possibly damaging	Het
Map6	G	A	7: 99,336,743 (GRCm38)	G821D	possibly damaging	Het
Mark1	A	C	1: 184,921,604 (GRCm38)	V167G	probably damaging	Het
Mrgprf	T	A	7: 145,308,256 (GRCm38)	L185Q	probably damaging	Het
Mtor	T	A	4: 148,550,188 (GRCm38)	V2422D	probably damaging	Het
Myh13	T	A	11: 67,332,520 (GRCm38)	I222N	probably damaging	Het
Myh7b	G	A	2: 155,620,427 (GRCm38)	C350Y	probably benign	Het
Nfix	G	A	8: 84,726,526 (GRCm38)	R300C	probably damaging	Het
Olfm3	C	A	3: 115,101,986 (GRCm38)	S172R	probably benign	Het
Olfr1168	A	T	2: 88,184,978 (GRCm38)	T34S	probably benign	Het
Olfr1231	A	T	2: 89,303,184 (GRCm38)	I136N	probably damaging	Het
Olfr342	A	G	2: 36,528,008 (GRCm38)	I199V	probably benign	Het
Olfr70	A	G	4: 43,696,706 (GRCm38)	S156P	probably damaging	Het
Olfr912	T	A	9: 38,581,283 (GRCm38)	V2D	possibly damaging	Het
Pacs1	A	T	19: 5,143,829 (GRCm38)	D557E	probably damaging	Het
Pde1c	A	G	6: 56,361,815 (GRCm38)	F11L	probably benign	Het
Phactr2	T	C	10: 13,247,139 (GRCm38)	D343G	possibly damaging	Het
Piezo2	T	C	18: 63,015,802 (GRCm38)	Y2659C	probably damaging	Het
Pkd2l2	A	G	18: 34,428,252 (GRCm38)	T438A	probably damaging	Het
Pld2	T	C	11: 70,557,081 (GRCm38)	W857R	probably damaging	Het
Plxnb1	T	C	9: 109,102,142 (GRCm38)	V410A	possibly damaging	Het
Ptger2	A	G	14: 44,989,500 (GRCm38)	Y179C	probably damaging	Het
Rcan1	A	T	16: 92,393,520 (GRCm38)	M177K	probably benign	Het
Rilpl1	A	G	5: 124,501,888 (GRCm38)	I122T	possibly damaging	Het
Rilpl1	A	G	5: 124,501,871 (GRCm38)	S156P	probably benign	Het
Rims4	C	T	2: 163,863,929 (GRCm38)	V262M	possibly damaging	Het
Rpa1	C	T	11: 75,312,973 (GRCm38)		probably null	Het
Saxo2	A	G	7: 82,634,870 (GRCm38)	V260A	probably benign	Het
Sel1l	T	C	12: 91,824,860 (GRCm38)	Y309C	probably damaging	Het
Setd1b	GCCCCCCC	GCCCCCCCCCCCCC	5: 123,160,703 (GRCm38)		probably benign	Het
Slc33a1	A	G	3: 63,943,304 (GRCm38)	F533S	probably benign	Het
Slc38a4	C	T	15: 97,005,858 (GRCm38)	V421M	probably benign	Het
Snx14	A	G	9: 88,400,721 (GRCm38)		probably null	Het
Spef2	A	G	15: 9,716,396 (GRCm38)	F368S	probably damaging	Het
Sri	A	T	5: 8,059,381 (GRCm38)	Q55L	probably damaging	Het
Stat4	A	G	1: 52,096,820 (GRCm38)	I429M	probably damaging	Het
Stkld1	A	T	2: 26,951,450 (GRCm38)	Q469L	probably benign	Het
Tm9sf1	T	C	14: 55,642,935 (GRCm38)	T2A	possibly damaging	Het
Tmco5	A	G	2: 116,883,218 (GRCm38)	T122A	probably benign	Het
Tmem59l	G	A	8: 70,486,060 (GRCm38)	P124S	possibly damaging	Het
Tmem81	G	A	1: 132,507,924 (GRCm38)	R156Q	probably damaging	Het
Trpv6	T	A	6: 41,625,188 (GRCm38)	T396S	probably benign	Het
Usp24	T	A	4: 106,371,079 (GRCm38)	Y780*	probably null	Het
Vmn1r120	A	G	7: 21,053,016 (GRCm38)	C257R	probably damaging	Het
Vmn2r53	A	G	7: 12,601,392 (GRCm38)	F114L	probably damaging	Het
Vwf	A	G	6: 125,643,006 (GRCm38)	E1549G	probably damaging	Het
Zfp626	G	A	7: 27,818,482 (GRCm38)	R296H	probably damaging	Het

Other mutations in Ptpro

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Ptpro	APN	6	137,394,909 (GRCm38)	critical splice donor site	probably null
IGL00844:Ptpro	APN	6	137,414,239 (GRCm38)	missense	probably damaging	1.00
IGL00983:Ptpro	APN	6	137,418,248 (GRCm38)	missense	probably benign	0.01
IGL01073:Ptpro	APN	6	137,377,088 (GRCm38)	missense	probably damaging	1.00
IGL01832:Ptpro	APN	6	137,393,668 (GRCm38)	missense	possibly damaging	0.93
IGL02308:Ptpro	APN	6	137,454,700 (GRCm38)	missense	probably benign	0.37
IGL02387:Ptpro	APN	6	137,410,980 (GRCm38)	missense	probably damaging	0.96
IGL02605:Ptpro	APN	6	137,380,318 (GRCm38)	missense	probably benign	0.02
IGL02666:Ptpro	APN	6	137,378,059 (GRCm38)	missense	probably damaging	0.96
IGL03275:Ptpro	APN	6	137,450,006 (GRCm38)	missense	probably damaging	1.00
Brau	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
court	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
Hoff	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
Jester	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
mann	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0020:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0022:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0023:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0024:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0103:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0106:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0316:Ptpro	UTSW	6	137,376,989 (GRCm38)	missense	possibly damaging	0.81
R0427:Ptpro	UTSW	6	137,368,296 (GRCm38)	missense	possibly damaging	0.81
R0456:Ptpro	UTSW	6	137,414,230 (GRCm38)	missense	probably benign	0.04
R0536:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0537:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0552:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0555:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0664:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0708:Ptpro	UTSW	6	137,386,253 (GRCm38)	missense	probably benign	0.26
R0730:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0735:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0738:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0786:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0811:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0812:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0881:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1259:Ptpro	UTSW	6	137,392,741 (GRCm38)	missense	probably damaging	0.98
R1340:Ptpro	UTSW	6	137,441,081 (GRCm38)	missense	possibly damaging	0.95
R1381:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1382:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1385:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1396:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1401:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1416:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1422:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1448:Ptpro	UTSW	6	137,441,116 (GRCm38)	missense	probably damaging	1.00
R1513:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1518:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1526:Ptpro	UTSW	6	137,461,726 (GRCm38)	missense	probably damaging	1.00
R1540:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1571:Ptpro	UTSW	6	137,378,130 (GRCm38)	missense	probably benign
R1573:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1587:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1588:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1649:Ptpro	UTSW	6	137,444,017 (GRCm38)	nonsense	probably null
R1700:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1701:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1745:Ptpro	UTSW	6	137,400,645 (GRCm38)	missense	probably benign	0.03
R1772:Ptpro	UTSW	6	137,430,743 (GRCm38)	missense	probably damaging	1.00
R1911:Ptpro	UTSW	6	137,400,619 (GRCm38)	splice site	probably benign
R1958:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1967:Ptpro	UTSW	6	137,416,865 (GRCm38)	missense	probably benign	0.38
R2025:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2026:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2040:Ptpro	UTSW	6	137,386,164 (GRCm38)	splice site	probably benign
R2115:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2117:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2130:Ptpro	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R2161:Ptpro	UTSW	6	137,449,887 (GRCm38)	missense	probably benign	0.01
R2431:Ptpro	UTSW	6	137,443,585 (GRCm38)	nonsense	probably null
R2915:Ptpro	UTSW	6	137,414,241 (GRCm38)	start gained	probably benign
R2988:Ptpro	UTSW	6	137,443,599 (GRCm38)	nonsense	probably null
R3772:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3773:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3795:Ptpro	UTSW	6	137,380,309 (GRCm38)	missense	probably benign
R3885:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3886:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3887:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3888:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3893:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4032:Ptpro	UTSW	6	137,461,742 (GRCm38)	missense	probably damaging	1.00
R4133:Ptpro	UTSW	6	137,420,372 (GRCm38)	missense	probably damaging	1.00
R4377:Ptpro	UTSW	6	137,380,266 (GRCm38)	missense	probably benign	0.26
R4455:Ptpro	UTSW	6	137,393,659 (GRCm38)	missense	probably damaging	1.00
R4613:Ptpro	UTSW	6	137,416,836 (GRCm38)	nonsense	probably null
R4827:Ptpro	UTSW	6	137,442,710 (GRCm38)	missense	probably damaging	1.00
R4863:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4870:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R4910:Ptpro	UTSW	6	137,368,338 (GRCm38)	missense	probably damaging	0.99
R4932:Ptpro	UTSW	6	137,411,105 (GRCm38)	nonsense	probably null
R4941:Ptpro	UTSW	6	137,392,765 (GRCm38)	missense	probably damaging	1.00
R4989:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5009:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R5032:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5033:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5162:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5393:Ptpro	UTSW	6	137,380,224 (GRCm38)	missense	probably benign	0.04
R5423:Ptpro	UTSW	6	137,442,707 (GRCm38)	missense	probably damaging	1.00
R5782:Ptpro	UTSW	6	137,399,498 (GRCm38)	missense	possibly damaging	0.80
R6103:Ptpro	UTSW	6	137,400,706 (GRCm38)	missense	possibly damaging	0.76
R6239:Ptpro	UTSW	6	137,380,608 (GRCm38)	missense	probably benign	0.28
R6488:Ptpro	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
R6494:Ptpro	UTSW	6	137,382,642 (GRCm38)	missense	probably benign	0.20
R6746:Ptpro	UTSW	6	137,394,823 (GRCm38)	missense	probably damaging	1.00
R6763:Ptpro	UTSW	6	137,418,281 (GRCm38)	splice site	probably null
R6888:Ptpro	UTSW	6	137,380,200 (GRCm38)	missense	probably benign	0.30
R6983:Ptpro	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
R7019:Ptpro	UTSW	6	137,380,478 (GRCm38)	missense	probably benign
R7218:Ptpro	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
R7236:Ptpro	UTSW	6	137,368,337 (GRCm38)	missense	probably damaging	1.00
R7299:Ptpro	UTSW	6	137,441,144 (GRCm38)	critical splice donor site	probably null
R7381:Ptpro	UTSW	6	137,399,561 (GRCm38)	missense	possibly damaging	0.93
R7493:Ptpro	UTSW	6	137,382,649 (GRCm38)	missense	probably benign	0.01
R7733:Ptpro	UTSW	6	137,414,286 (GRCm38)	nonsense	probably null
R7793:Ptpro	UTSW	6	137,416,820 (GRCm38)	missense	probably damaging	0.99
R7804:Ptpro	UTSW	6	137,399,601 (GRCm38)	splice site	probably null
R7833:Ptpro	UTSW	6	137,416,863 (GRCm38)	nonsense	probably null
R7859:Ptpro	UTSW	6	137,392,807 (GRCm38)	critical splice donor site	probably null
R7873:Ptpro	UTSW	6	137,430,739 (GRCm38)	missense	probably benign	0.44
R8042:Ptpro	UTSW	6	137,416,883 (GRCm38)	missense	possibly damaging	0.71
R8859:Ptpro	UTSW	6	137,426,784 (GRCm38)	nonsense	probably null
R8979:Ptpro	UTSW	6	137,368,142 (GRCm38)	missense	probably benign
R9138:Ptpro	UTSW	6	137,411,115 (GRCm38)	critical splice donor site	probably null
R9309:Ptpro	UTSW	6	137,454,658 (GRCm38)	missense	probably damaging	1.00
R9420:Ptpro	UTSW	6	137,443,935 (GRCm38)	missense	probably benign	0.08
R9612:Ptpro	UTSW	6	137,414,320 (GRCm38)	missense	probably benign	0.31
R9625:Ptpro	UTSW	6	137,394,875 (GRCm38)	missense	probably damaging	1.00
R9697:Ptpro	UTSW	6	137,386,290 (GRCm38)	missense	probably damaging	1.00
R9715:Ptpro	UTSW	6	137,368,110 (GRCm38)	missense	probably damaging	0.96
Z1177:Ptpro	UTSW	6	137,378,140 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AAAACGGCAGCTGTCCTCAC -3'
(R):5'- AGTCTGTGCTCATGACAGGG -3'

Sequencing Primer
(F):5'- TGTCCTCACAGGTGTAGAACG -3'
(R):5'- TGATGCAGCCCCATGAAG -3'

Posted On

2014-10-02