Mutagenetix > Incidental Mutation

Incidental Mutation 'R2208:Vmn2r15'

236772

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r15

Ensembl Gene

ENSMUSG00000091375

Gene Name

vomeronasal 2, receptor 15

Synonyms

EG211223

MMRRC Submission

040210-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.135) question?

Stock #

R2208 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

109286269-109297556 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 109297443 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 38 (N38K)

Ref Sequence

ENSEMBL: ENSMUSP00000128333 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167133]

AlphaFold

L7N2A0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000167133
AA Change: N38K

PolyPhen 2 Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000128333
Gene: ENSMUSG00000091375
AA Change: N38K

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	75	472	1e-29	PFAM
Pfam:NCD3G	514	568	5.8e-18	PFAM
Pfam:7tm_3	601	836	9.1e-55	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.6%
20x: 96.0%

Validation Efficiency

98% (51/52)

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410089E03Rik	T	A	15: 8,194,403	N883K	probably benign	Het
Ahnak	T	C	19: 9,017,732	V5460A	probably benign	Het
Bco2	A	G	9: 50,533,455	V517A	probably damaging	Het
Brca2	T	A	5: 150,532,344	D183E	probably damaging	Het
Ccdc142	T	C	6: 83,107,960		probably null	Het
Ccdc39	A	G	3: 33,841,178	L34P	probably damaging	Het
Cdc42bpb	T	A	12: 111,336,029	H198L	probably damaging	Het
Cdc73	T	A	1: 143,609,382	E516V	probably damaging	Het
Cep170b	T	A	12: 112,738,985	L1059Q	probably benign	Het
Chrm1	T	C	19: 8,678,099	L56P	probably damaging	Het
Clec4d	T	A	6: 123,265,355	V22D	probably damaging	Het
Cyp2c39	T	C	19: 39,560,961	Y308H	possibly damaging	Het
Cyp2d12	T	C	15: 82,556,936	L141P	probably damaging	Het
Cyp4x1	G	T	4: 115,126,594	Q85K	probably benign	Het
Dpysl5	G	A	5: 30,791,597	D399N	probably damaging	Het
Enpp7	T	C	11: 118,988,762		probably benign	Het
Fabp3	C	T	4: 130,312,387	T57I	probably benign	Het
Fitm2	T	A	2: 163,472,684		probably benign	Het
Gm14139	T	A	2: 150,193,145	V462E	probably benign	Het
Gng10	T	A	4: 59,035,314	I26N	possibly damaging	Het
Gpr33	C	T	12: 52,023,453	V268I	probably benign	Het
Hmcn2	G	A	2: 31,380,297	C1182Y	probably damaging	Het
Kcnh8	GAGACCAACGAGCAGCTGATGCTTCAGA	GAGA	17: 52,725,906	74	probably benign	Het
Krt36	C	T	11: 100,102,939	V358M	probably damaging	Het
Lmod3	T	C	6: 97,247,877	I328V	probably benign	Het
Lrp8	T	C	4: 107,855,790	V580A	probably damaging	Het
Masp2	T	C	4: 148,614,415	I651T	probably damaging	Het
Mnd1	C	A	3: 84,134,109	C62F	probably benign	Het
Msi2	A	T	11: 88,590,108	S118T	probably damaging	Het
Muc19	T	C	15: 91,871,549		noncoding transcript	Het
Nabp1	G	A	1: 51,477,614	R32*	probably null	Het
Nfix	CAAAAA	CAAAA	8: 84,716,247		probably null	Het
Nup88	T	C	11: 70,965,719	D196G	probably damaging	Het
Olfr747	T	C	14: 50,681,563	I24V	probably benign	Het
Pax1	T	A	2: 147,365,802	I198N	probably damaging	Het
Pde3a	A	G	6: 141,250,347	E253G	probably damaging	Het
Phldb1	C	T	9: 44,696,131	R1192Q	probably damaging	Het
Pianp	C	A	6: 124,999,639	P137Q	probably damaging	Het
Prdm15	A	C	16: 97,799,264		probably null	Het
Ptprf	A	T	4: 118,269,172		probably benign	Het
Rfx7	A	G	9: 72,617,964	D812G	probably benign	Het
Rgs22	T	C	15: 36,050,232	T691A	probably benign	Het
Rundc3a	A	T	11: 102,402,088	S436C	probably damaging	Het
Sntb1	T	C	15: 55,906,318	T92A	possibly damaging	Het
Tarsl2	T	C	7: 65,682,848	S566P	probably damaging	Het
Tbc1d32	A	T	10: 56,150,792		probably null	Het
Tep1	T	C	14: 50,866,864	Q191R	probably benign	Het
Tmc2	C	A	2: 130,214,563		probably null	Het
Tns1	A	C	1: 74,079,240	I77S	probably damaging	Het
Trpd52l3	T	C	19: 30,004,246	W134R	probably damaging	Het
Wdr90	A	T	17: 25,860,388	D257E	probably damaging	Het
Zbtb9	T	C	17: 26,974,124	C168R	possibly damaging	Het

Other mutations in Vmn2r15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01335:Vmn2r15	APN	5	109286736	missense	possibly damaging	0.70
IGL01367:Vmn2r15	APN	5	109293209	missense	probably damaging	0.99
IGL01844:Vmn2r15	APN	5	109286269	makesense	probably null
IGL02190:Vmn2r15	APN	5	109293374	missense	probably damaging	1.00
IGL02754:Vmn2r15	APN	5	109293268	nonsense	probably null
IGL02797:Vmn2r15	APN	5	109297384	missense	probably benign	0.18
IGL03301:Vmn2r15	APN	5	109297355	critical splice donor site	probably null
IGL03407:Vmn2r15	APN	5	109286319	nonsense	probably null
BB001:Vmn2r15	UTSW	5	109286388	missense	probably damaging	1.00
BB011:Vmn2r15	UTSW	5	109286388	missense	probably damaging	1.00
PIT4445001:Vmn2r15	UTSW	5	109287142	missense	probably damaging	0.99
PIT4520001:Vmn2r15	UTSW	5	109287005	missense	probably damaging	1.00
R0038:Vmn2r15	UTSW	5	109293144	missense	possibly damaging	0.46
R0111:Vmn2r15	UTSW	5	109287156	missense	possibly damaging	0.56
R0379:Vmn2r15	UTSW	5	109286478	missense	probably damaging	1.00
R0427:Vmn2r15	UTSW	5	109287087	missense	probably damaging	1.00
R0639:Vmn2r15	UTSW	5	109293015	missense	probably benign	0.22
R0964:Vmn2r15	UTSW	5	109297535	missense	probably benign	0.34
R1147:Vmn2r15	UTSW	5	109293206	missense	probably damaging	1.00
R1147:Vmn2r15	UTSW	5	109293206	missense	probably damaging	1.00
R1232:Vmn2r15	UTSW	5	109293302	missense	probably benign	0.39
R1241:Vmn2r15	UTSW	5	109292904	missense	probably damaging	1.00
R1244:Vmn2r15	UTSW	5	109293226	nonsense	probably null
R1394:Vmn2r15	UTSW	5	109294148	missense	probably benign	0.44
R1395:Vmn2r15	UTSW	5	109294148	missense	probably benign	0.44
R1423:Vmn2r15	UTSW	5	109293227	missense	probably damaging	1.00
R1439:Vmn2r15	UTSW	5	109294087	missense	probably damaging	1.00
R1513:Vmn2r15	UTSW	5	109293329	missense	probably damaging	1.00
R1777:Vmn2r15	UTSW	5	109294270	missense	possibly damaging	0.79
R1844:Vmn2r15	UTSW	5	109286994	nonsense	probably null
R2072:Vmn2r15	UTSW	5	109286753	missense	possibly damaging	0.65
R2074:Vmn2r15	UTSW	5	109286753	missense	possibly damaging	0.65
R2122:Vmn2r15	UTSW	5	109286456	missense	probably damaging	1.00
R2268:Vmn2r15	UTSW	5	109293207	missense	probably benign	0.31
R2831:Vmn2r15	UTSW	5	109286592	missense	probably damaging	1.00
R3848:Vmn2r15	UTSW	5	109297446	missense	probably benign	0.00
R4058:Vmn2r15	UTSW	5	109293446	missense	probably damaging	0.99
R4615:Vmn2r15	UTSW	5	109293482	missense	possibly damaging	0.91
R4663:Vmn2r15	UTSW	5	109294074	missense	probably benign
R4681:Vmn2r15	UTSW	5	109286622	missense	probably damaging	0.97
R4751:Vmn2r15	UTSW	5	109286754	missense	probably benign	0.01
R5095:Vmn2r15	UTSW	5	109288451	critical splice acceptor site	probably null
R5300:Vmn2r15	UTSW	5	109294108	missense	probably damaging	0.99
R5309:Vmn2r15	UTSW	5	109293090	missense	probably damaging	0.99
R5335:Vmn2r15	UTSW	5	109286807	missense	probably damaging	0.99
R5421:Vmn2r15	UTSW	5	109286535	missense	probably damaging	1.00
R5805:Vmn2r15	UTSW	5	109286940	missense	possibly damaging	0.88
R6280:Vmn2r15	UTSW	5	109293425	missense	possibly damaging	0.65
R6324:Vmn2r15	UTSW	5	109286271	makesense	probably null
R6383:Vmn2r15	UTSW	5	109293226	nonsense	probably null
R6772:Vmn2r15	UTSW	5	109286372	missense	probably damaging	0.99
R6991:Vmn2r15	UTSW	5	109293314	missense	probably damaging	1.00
R7194:Vmn2r15	UTSW	5	109292783	missense	probably damaging	1.00
R7365:Vmn2r15	UTSW	5	109293239	missense	probably benign	0.19
R7365:Vmn2r15	UTSW	5	109297522	missense	probably benign	0.15
R7423:Vmn2r15	UTSW	5	109297528	missense	probably benign	0.00
R7552:Vmn2r15	UTSW	5	109292908	nonsense	probably null
R7619:Vmn2r15	UTSW	5	109288324	critical splice donor site	probably null
R7892:Vmn2r15	UTSW	5	109286351	missense	probably damaging	1.00
R7924:Vmn2r15	UTSW	5	109286388	missense	probably damaging	1.00
R8058:Vmn2r15	UTSW	5	109293090	missense	probably damaging	0.99
R8099:Vmn2r15	UTSW	5	109293319	missense	possibly damaging	0.58
R8189:Vmn2r15	UTSW	5	109286847	missense	probably benign	0.02
R8275:Vmn2r15	UTSW	5	109286284	missense	probably benign	0.08
R8277:Vmn2r15	UTSW	5	109293104	missense	probably benign	0.00
R8277:Vmn2r15	UTSW	5	109293444	missense	probably damaging	1.00
R8465:Vmn2r15	UTSW	5	109297436	missense	probably damaging	1.00
R8679:Vmn2r15	UTSW	5	109286913	missense	probably benign	0.31
R8682:Vmn2r15	UTSW	5	109294072	missense	probably damaging	0.98
R8809:Vmn2r15	UTSW	5	109287008	missense	probably benign	0.22
R9016:Vmn2r15	UTSW	5	109294243	missense	probably benign	0.01
R9372:Vmn2r15	UTSW	5	109294087	missense	possibly damaging	0.60
R9596:Vmn2r15	UTSW	5	109292925	missense	probably benign	0.01
R9619:Vmn2r15	UTSW	5	109292756	missense	possibly damaging	0.58
R9685:Vmn2r15	UTSW	5	109292732	missense	probably benign	0.05
R9716:Vmn2r15	UTSW	5	109297358	missense	possibly damaging	0.88
R9772:Vmn2r15	UTSW	5	109287057	missense	probably damaging	1.00
X0065:Vmn2r15	UTSW	5	109293308	missense	probably damaging	1.00
Z1187:Vmn2r15	UTSW	5	109286663	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGACAAAACCCCACAGTTTG -3'
(R):5'- GTGGATCTTCAGAGAGCAGTAG -3'

Sequencing Primer
(F):5'- CCCCACAGTTTGTGTACACAG -3'
(R):5'- CACACAGGTGTATATATGCATGTGAG -3'

Posted On

2014-10-02