Incidental Mutation 'R2208:Wdr90'
ID 236800
Institutional Source Beutler Lab
Gene Symbol Wdr90
Ensembl Gene ENSMUSG00000073434
Gene Name WD repeat domain 90
Synonyms 3230401M21Rik
MMRRC Submission 040210-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R2208 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 25844771-25861501 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 25860388 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 257 (D257E)
Ref Sequence ENSEMBL: ENSMUSP00000078426 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026828] [ENSMUST00000079461] [ENSMUST00000176923]
AlphaFold Q6ZPG2
Predicted Effect probably benign
Transcript: ENSMUST00000026828
SMART Domains Protein: ENSMUSP00000026828
Gene: ENSMUSG00000025732

DomainStartEndE-ValueType
Pfam:FAM195 59 158 8.3e-33 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000079461
AA Change: D257E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078426
Gene: ENSMUSG00000073434
AA Change: D257E

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 183 5e-26 PFAM
Pfam:DUF667 210 271 3.7e-9 PFAM
low complexity region 381 396 N/A INTRINSIC
WD40 478 519 5.94e0 SMART
WD40 522 565 3.2e0 SMART
WD40 572 612 3.3e1 SMART
WD40 687 725 1.15e1 SMART
WD40 728 766 5.75e-1 SMART
WD40 768 808 9.24e-4 SMART
WD40 811 850 4.13e0 SMART
WD40 853 892 4.62e-1 SMART
WD40 950 993 1.07e1 SMART
WD40 996 1035 5.75e-1 SMART
WD40 1040 1077 1.58e-2 SMART
WD40 1290 1334 5.23e-3 SMART
WD40 1337 1378 1.27e-1 SMART
WD40 1384 1419 1.83e2 SMART
WD40 1422 1469 3.08e0 SMART
WD40 1472 1509 9.9e0 SMART
WD40 1568 1607 9.02e-7 SMART
WD40 1610 1655 5.75e-1 SMART
WD40 1659 1697 2.98e-1 SMART
WD40 1700 1749 6.14e1 SMART
WD40 1850 1888 1.92e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176575
Predicted Effect probably benign
Transcript: ENSMUST00000176678
Predicted Effect probably damaging
Transcript: ENSMUST00000176923
AA Change: D239E

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000135420
Gene: ENSMUSG00000073434
AA Change: D239E

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 252 5.1e-14 PFAM
low complexity region 363 378 N/A INTRINSIC
WD40 460 501 5.94e0 SMART
WD40 504 547 3.2e0 SMART
WD40 554 594 3.3e1 SMART
WD40 669 707 1.15e1 SMART
WD40 710 748 5.75e-1 SMART
WD40 750 790 9.24e-4 SMART
WD40 793 832 4.13e0 SMART
WD40 835 874 4.62e-1 SMART
WD40 932 975 1.07e1 SMART
WD40 978 1017 5.75e-1 SMART
WD40 1022 1059 1.58e-2 SMART
WD40 1272 1316 5.23e-3 SMART
WD40 1319 1360 1.27e-1 SMART
WD40 1366 1401 1.83e2 SMART
WD40 1404 1451 3.08e0 SMART
WD40 1454 1491 9.9e0 SMART
WD40 1550 1589 9.02e-7 SMART
WD40 1592 1637 5.75e-1 SMART
WD40 1641 1679 2.98e-1 SMART
WD40 1682 1731 6.14e1 SMART
WD40 1832 1870 1.92e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177031
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177170
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180868
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency 98% (51/52)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik T A 15: 8,194,403 (GRCm38) N883K probably benign Het
Ahnak T C 19: 9,017,732 (GRCm38) V5460A probably benign Het
Bco2 A G 9: 50,533,455 (GRCm38) V517A probably damaging Het
Brca2 T A 5: 150,532,344 (GRCm38) D183E probably damaging Het
Ccdc142 T C 6: 83,107,960 (GRCm38) probably null Het
Ccdc39 A G 3: 33,841,178 (GRCm38) L34P probably damaging Het
Cdc42bpb T A 12: 111,336,029 (GRCm38) H198L probably damaging Het
Cdc73 T A 1: 143,609,382 (GRCm38) E516V probably damaging Het
Cep170b T A 12: 112,738,985 (GRCm38) L1059Q probably benign Het
Chrm1 T C 19: 8,678,099 (GRCm38) L56P probably damaging Het
Clec4d T A 6: 123,265,355 (GRCm38) V22D probably damaging Het
Cyp2c39 T C 19: 39,560,961 (GRCm38) Y308H possibly damaging Het
Cyp2d12 T C 15: 82,556,936 (GRCm38) L141P probably damaging Het
Cyp4x1 G T 4: 115,126,594 (GRCm38) Q85K probably benign Het
Dpysl5 G A 5: 30,791,597 (GRCm38) D399N probably damaging Het
Enpp7 T C 11: 118,988,762 (GRCm38) probably benign Het
Fabp3 C T 4: 130,312,387 (GRCm38) T57I probably benign Het
Fitm2 T A 2: 163,472,684 (GRCm38) probably benign Het
Gm14139 T A 2: 150,193,145 (GRCm38) V462E probably benign Het
Gng10 T A 4: 59,035,314 (GRCm38) I26N possibly damaging Het
Gpr33 C T 12: 52,023,453 (GRCm38) V268I probably benign Het
Hmcn2 G A 2: 31,380,297 (GRCm38) C1182Y probably damaging Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 52,725,906 (GRCm38) 74 probably benign Het
Krt36 C T 11: 100,102,939 (GRCm38) V358M probably damaging Het
Lmod3 T C 6: 97,247,877 (GRCm38) I328V probably benign Het
Lrp8 T C 4: 107,855,790 (GRCm38) V580A probably damaging Het
Masp2 T C 4: 148,614,415 (GRCm38) I651T probably damaging Het
Mnd1 C A 3: 84,134,109 (GRCm38) C62F probably benign Het
Msi2 A T 11: 88,590,108 (GRCm38) S118T probably damaging Het
Muc19 T C 15: 91,871,549 (GRCm38) noncoding transcript Het
Nabp1 G A 1: 51,477,614 (GRCm38) R32* probably null Het
Nfix CAAAAA CAAAA 8: 84,716,247 (GRCm38) probably null Het
Nup88 T C 11: 70,965,719 (GRCm38) D196G probably damaging Het
Olfr747 T C 14: 50,681,563 (GRCm38) I24V probably benign Het
Pax1 T A 2: 147,365,802 (GRCm38) I198N probably damaging Het
Pde3a A G 6: 141,250,347 (GRCm38) E253G probably damaging Het
Phldb1 C T 9: 44,696,131 (GRCm38) R1192Q probably damaging Het
Pianp C A 6: 124,999,639 (GRCm38) P137Q probably damaging Het
Prdm15 A C 16: 97,799,264 (GRCm38) probably null Het
Ptprf A T 4: 118,269,172 (GRCm38) probably benign Het
Rfx7 A G 9: 72,617,964 (GRCm38) D812G probably benign Het
Rgs22 T C 15: 36,050,232 (GRCm38) T691A probably benign Het
Rundc3a A T 11: 102,402,088 (GRCm38) S436C probably damaging Het
Sntb1 T C 15: 55,906,318 (GRCm38) T92A possibly damaging Het
Tarsl2 T C 7: 65,682,848 (GRCm38) S566P probably damaging Het
Tbc1d32 A T 10: 56,150,792 (GRCm38) probably null Het
Tep1 T C 14: 50,866,864 (GRCm38) Q191R probably benign Het
Tmc2 C A 2: 130,214,563 (GRCm38) probably null Het
Tns1 A C 1: 74,079,240 (GRCm38) I77S probably damaging Het
Trpd52l3 T C 19: 30,004,246 (GRCm38) W134R probably damaging Het
Vmn2r15 A C 5: 109,297,443 (GRCm38) N38K possibly damaging Het
Zbtb9 T C 17: 26,974,124 (GRCm38) C168R possibly damaging Het
Other mutations in Wdr90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Wdr90 APN 17 25,849,364 (GRCm38) missense probably damaging 1.00
IGL01118:Wdr90 APN 17 25,854,687 (GRCm38) missense probably damaging 1.00
IGL01964:Wdr90 APN 17 25,848,409 (GRCm38) missense probably benign
IGL02116:Wdr90 APN 17 25,859,492 (GRCm38) missense probably benign 0.12
IGL02172:Wdr90 APN 17 25,850,434 (GRCm38) missense probably benign 0.22
IGL02716:Wdr90 APN 17 25,857,220 (GRCm38) missense probably damaging 0.96
IGL02961:Wdr90 APN 17 25,848,675 (GRCm38) nonsense probably null
IGL03229:Wdr90 APN 17 25,845,463 (GRCm38) splice site probably benign
IGL03367:Wdr90 APN 17 25,847,791 (GRCm38) splice site probably benign
IGL03098:Wdr90 UTSW 17 25,859,987 (GRCm38) intron probably benign
R0111:Wdr90 UTSW 17 25,848,444 (GRCm38) splice site probably benign
R0454:Wdr90 UTSW 17 25,860,049 (GRCm38) missense probably damaging 0.96
R0457:Wdr90 UTSW 17 25,860,485 (GRCm38) missense probably benign 0.00
R0488:Wdr90 UTSW 17 25,848,617 (GRCm38) missense probably damaging 1.00
R0622:Wdr90 UTSW 17 25,855,658 (GRCm38) missense probably damaging 1.00
R0671:Wdr90 UTSW 17 25,846,393 (GRCm38) missense probably benign 0.04
R0799:Wdr90 UTSW 17 25,860,130 (GRCm38) missense probably benign 0.38
R1177:Wdr90 UTSW 17 25,846,054 (GRCm38) missense possibly damaging 0.85
R1460:Wdr90 UTSW 17 25,860,448 (GRCm38) missense possibly damaging 0.82
R1468:Wdr90 UTSW 17 25,854,053 (GRCm38) missense probably damaging 1.00
R1468:Wdr90 UTSW 17 25,854,053 (GRCm38) missense probably damaging 1.00
R1544:Wdr90 UTSW 17 25,849,310 (GRCm38) missense possibly damaging 0.69
R2057:Wdr90 UTSW 17 25,855,199 (GRCm38) missense probably benign 0.05
R2087:Wdr90 UTSW 17 25,846,603 (GRCm38) missense probably damaging 1.00
R2159:Wdr90 UTSW 17 25,851,741 (GRCm38) missense probably benign
R2345:Wdr90 UTSW 17 25,859,162 (GRCm38) missense probably benign 0.05
R2391:Wdr90 UTSW 17 25,851,455 (GRCm38) missense probably damaging 1.00
R2394:Wdr90 UTSW 17 25,851,455 (GRCm38) missense probably damaging 1.00
R2520:Wdr90 UTSW 17 25,855,352 (GRCm38) missense probably damaging 1.00
R3798:Wdr90 UTSW 17 25,850,498 (GRCm38) missense probably benign 0.01
R3979:Wdr90 UTSW 17 25,859,278 (GRCm38) missense probably benign 0.00
R4111:Wdr90 UTSW 17 25,849,368 (GRCm38) missense possibly damaging 0.94
R4326:Wdr90 UTSW 17 25,853,731 (GRCm38) missense probably benign 0.25
R4459:Wdr90 UTSW 17 25,861,002 (GRCm38) missense possibly damaging 0.95
R4697:Wdr90 UTSW 17 25,855,363 (GRCm38) missense probably benign 0.03
R4735:Wdr90 UTSW 17 25,859,450 (GRCm38) missense probably benign
R4907:Wdr90 UTSW 17 25,860,650 (GRCm38) intron probably benign
R5070:Wdr90 UTSW 17 25,846,333 (GRCm38) missense probably damaging 1.00
R5230:Wdr90 UTSW 17 25,855,303 (GRCm38) missense probably benign 0.01
R5268:Wdr90 UTSW 17 25,850,845 (GRCm38) missense probably damaging 1.00
R5287:Wdr90 UTSW 17 25,861,467 (GRCm38) utr 5 prime probably benign
R5382:Wdr90 UTSW 17 25,845,598 (GRCm38) missense probably damaging 1.00
R5511:Wdr90 UTSW 17 25,845,021 (GRCm38) unclassified probably benign
R5545:Wdr90 UTSW 17 25,845,856 (GRCm38) missense probably damaging 1.00
R5707:Wdr90 UTSW 17 25,857,192 (GRCm38) missense probably benign 0.00
R5973:Wdr90 UTSW 17 25,846,407 (GRCm38) missense probably damaging 1.00
R5973:Wdr90 UTSW 17 25,845,133 (GRCm38) missense probably damaging 0.99
R6385:Wdr90 UTSW 17 25,848,530 (GRCm38) missense probably damaging 1.00
R6481:Wdr90 UTSW 17 25,845,911 (GRCm38) missense probably damaging 0.99
R7078:Wdr90 UTSW 17 25,849,649 (GRCm38) missense probably damaging 1.00
R7214:Wdr90 UTSW 17 25,845,393 (GRCm38) missense probably benign 0.00
R7288:Wdr90 UTSW 17 25,846,312 (GRCm38) missense probably benign 0.03
R7304:Wdr90 UTSW 17 25,851,506 (GRCm38) missense probably benign 0.10
R7309:Wdr90 UTSW 17 25,860,702 (GRCm38) missense probably benign 0.02
R7391:Wdr90 UTSW 17 25,846,528 (GRCm38) missense probably benign 0.08
R7622:Wdr90 UTSW 17 25,854,109 (GRCm38) missense probably benign 0.00
R7646:Wdr90 UTSW 17 25,860,130 (GRCm38) missense probably benign 0.38
R7772:Wdr90 UTSW 17 25,861,491 (GRCm38) start gained probably benign
R7779:Wdr90 UTSW 17 25,846,326 (GRCm38) missense probably damaging 1.00
R7780:Wdr90 UTSW 17 25,846,326 (GRCm38) missense probably damaging 1.00
R7781:Wdr90 UTSW 17 25,846,326 (GRCm38) missense probably damaging 1.00
R7782:Wdr90 UTSW 17 25,846,326 (GRCm38) missense probably damaging 1.00
R7812:Wdr90 UTSW 17 25,852,558 (GRCm38) missense probably damaging 1.00
R7870:Wdr90 UTSW 17 25,860,539 (GRCm38) missense probably damaging 0.96
R7911:Wdr90 UTSW 17 25,850,749 (GRCm38) missense probably benign 0.00
R8126:Wdr90 UTSW 17 25,848,977 (GRCm38) missense possibly damaging 0.48
R8260:Wdr90 UTSW 17 25,845,167 (GRCm38) missense probably damaging 1.00
R8315:Wdr90 UTSW 17 25,845,425 (GRCm38) missense probably benign 0.21
R8919:Wdr90 UTSW 17 25,857,172 (GRCm38) missense
R8938:Wdr90 UTSW 17 25,857,172 (GRCm38) missense
R8940:Wdr90 UTSW 17 25,857,172 (GRCm38) missense
R9038:Wdr90 UTSW 17 25,857,226 (GRCm38) missense
R9079:Wdr90 UTSW 17 25,857,429 (GRCm38) missense
R9401:Wdr90 UTSW 17 25,845,776 (GRCm38) small insertion probably benign
R9471:Wdr90 UTSW 17 25,861,041 (GRCm38) missense possibly damaging 0.72
R9642:Wdr90 UTSW 17 25,853,720 (GRCm38) critical splice donor site probably null
X0064:Wdr90 UTSW 17 25,848,563 (GRCm38) missense probably damaging 1.00
Z1176:Wdr90 UTSW 17 25,860,496 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATTACCAAGTATCTGCCACTCC -3'
(R):5'- CAACTGGGCATGTGCTTCTG -3'

Sequencing Primer
(F):5'- GTATCTGCCACTCCACCAAC -3'
(R):5'- TGGCCCTGAGGATAGCTAG -3'
Posted On 2014-10-02