Mutagenetix > Incidental Mutation

Incidental Mutation 'R2177:Vmn2r79'

236942

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r79

Ensembl Gene

ENSMUSG00000090362

Gene Name

vomeronasal 2, receptor 79

Synonyms

EG621430

MMRRC Submission

040179-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R2177 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

86645673-86687176 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 86645839 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 56 (N56S)

Ref Sequence

ENSEMBL: ENSMUSP00000132478 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164462]

AlphaFold

E9Q067

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164462
AA Change: N56S

PolyPhen 2 Score 0.935 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: N56S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	1.9e-31	PFAM
Pfam:NCD3G	506	559	3.1e-21	PFAM
Pfam:7tm_3	592	827	2.8e-53	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.5%
20x: 95.7%

Validation Efficiency

97% (60/62)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310003L06Rik	T	A	5: 88,120,312 (GRCm39)	N356K	probably damaging	Het
Acap2	C	T	16: 30,952,346 (GRCm39)		probably null	Het
Adamts19	T	C	18: 59,087,626 (GRCm39)	L552P	possibly damaging	Het
Adamts2	T	A	11: 50,668,055 (GRCm39)	M539K	probably damaging	Het
Aplp1	A	T	7: 30,141,946 (GRCm39)	C210*	probably null	Het
Apoa1	A	T	9: 46,141,371 (GRCm39)	K156*	probably null	Het
AW551984	G	A	9: 39,511,111 (GRCm39)	R159C	probably benign	Het
Bok	C	T	1: 93,622,787 (GRCm39)	Q112*	probably null	Het
Cemip2	T	C	19: 21,789,149 (GRCm39)	S528P	possibly damaging	Het
Cfap57	T	G	4: 118,463,885 (GRCm39)	I323L	probably benign	Het
Cfap69	T	A	5: 5,675,803 (GRCm39)	E270D	probably damaging	Het
Ch25h	G	T	19: 34,452,097 (GRCm39)	L144M	probably damaging	Het
Clcn6	T	A	4: 148,099,057 (GRCm39)	I429F	possibly damaging	Het
Cpb1	T	A	3: 20,320,611 (GRCm39)	T115S	probably benign	Het
Csf1r	T	A	18: 61,248,015 (GRCm39)		probably benign	Het
Ddx6	A	G	9: 44,539,028 (GRCm39)	T279A	probably damaging	Het
Dnah8	A	G	17: 30,872,367 (GRCm39)	H452R	probably benign	Het
Dscam	T	A	16: 96,411,524 (GRCm39)	D1784V	probably damaging	Het
Exo1	T	A	1: 175,710,456 (GRCm39)		probably null	Het
Fcho1	A	G	8: 72,164,905 (GRCm39)	S459P	probably damaging	Het
Fxyd4	C	T	6: 117,911,393 (GRCm39)	A56T	probably damaging	Het
Gbf1	T	C	19: 46,254,109 (GRCm39)	S599P	probably benign	Het
Iqce	T	C	5: 140,677,348 (GRCm39)		probably benign	Het
Kat2a	A	G	11: 100,601,648 (GRCm39)	F256L	probably damaging	Het
Klk1b1	G	T	7: 43,618,695 (GRCm39)	R24L	possibly damaging	Het
Krtap16-1	A	G	11: 99,877,275 (GRCm39)	V43A	probably damaging	Het
Maea	C	G	5: 33,529,034 (GRCm39)	Q326E	probably benign	Het
Man1a2	A	T	3: 100,539,847 (GRCm39)	I308N	probably damaging	Het
Marf1	G	T	16: 13,970,471 (GRCm39)	R83S	probably benign	Het
Me3	A	C	7: 89,282,278 (GRCm39)	T54P	probably benign	Het
Mme	A	T	3: 63,208,426 (GRCm39)	I63L	probably benign	Het
Mmel1	A	G	4: 154,978,560 (GRCm39)	N664S	probably damaging	Het
Mrgprb2	A	G	7: 48,202,128 (GRCm39)	V199A	probably benign	Het
Mrpl36	T	A	13: 73,479,588 (GRCm39)	F33I	probably benign	Het
Nlrp4e	A	T	7: 23,054,686 (GRCm39)	T947S	probably benign	Het
Or14c45	G	A	7: 86,176,870 (GRCm39)	V302I	probably benign	Het
Or4b1d	T	A	2: 89,968,808 (GRCm39)	H225L	possibly damaging	Het
Or8b55	A	T	9: 38,727,482 (GRCm39)	I228F	possibly damaging	Het
Parp4	A	T	14: 56,896,746 (GRCm39)	R1923S	unknown	Het
Pcm1	T	C	8: 41,729,002 (GRCm39)	V658A	probably benign	Het
Pkhd1l1	A	G	15: 44,322,791 (GRCm39)	S26G	probably benign	Het
Prom1	A	T	5: 44,184,081 (GRCm39)	H433Q	possibly damaging	Het
Rab7	T	C	6: 87,982,063 (GRCm39)	D104G	probably damaging	Het
Rabgap1l	A	G	1: 160,551,632 (GRCm39)	V282A	possibly damaging	Het
Rdh13	T	C	7: 4,430,666 (GRCm39)	E264G	possibly damaging	Het
Rock1	C	G	18: 10,070,263 (GRCm39)	R1270T	probably benign	Het
Sdhaf4	C	T	1: 24,035,370 (GRCm39)	G93R	probably damaging	Het
Sec24a	T	C	11: 51,595,228 (GRCm39)	T910A	probably benign	Het
Sesn1	A	G	10: 41,779,778 (GRCm39)	H345R	possibly damaging	Het
Snx4	T	A	16: 33,106,428 (GRCm39)		probably null	Het
Tchh	A	G	3: 93,351,439 (GRCm39)	E293G	unknown	Het
Ulk2	T	A	11: 61,682,335 (GRCm39)	T727S	probably benign	Het
Usp53	T	C	3: 122,729,706 (GRCm39)	E756G	probably damaging	Het
Vmn2r68	G	A	7: 84,871,123 (GRCm39)	A720V	probably benign	Het
Washc5	A	T	15: 59,235,118 (GRCm39)	Y263*	probably null	Het
Zfp119b	A	T	17: 56,245,639 (GRCm39)	C516S	probably damaging	Het

Other mutations in Vmn2r79

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01401:Vmn2r79	APN	7	86,686,481 (GRCm39)	missense	probably benign	0.01
IGL01675:Vmn2r79	APN	7	86,645,856 (GRCm39)	missense	probably benign	0.01
IGL01760:Vmn2r79	APN	7	86,651,366 (GRCm39)	missense	probably benign
IGL01834:Vmn2r79	APN	7	86,686,354 (GRCm39)	missense	probably benign	0.01
IGL01843:Vmn2r79	APN	7	86,686,485 (GRCm39)	missense	probably damaging	1.00
IGL01914:Vmn2r79	APN	7	86,686,571 (GRCm39)	missense	probably benign	0.14
IGL01980:Vmn2r79	APN	7	86,686,290 (GRCm39)	missense	possibly damaging	0.49
IGL02438:Vmn2r79	APN	7	86,651,744 (GRCm39)	missense	probably damaging	0.98
IGL02740:Vmn2r79	APN	7	86,653,366 (GRCm39)	missense	probably benign	0.00
IGL03052:Vmn2r79	UTSW	7	86,652,799 (GRCm39)	missense	probably benign	0.00
PIT4445001:Vmn2r79	UTSW	7	86,651,408 (GRCm39)	missense	possibly damaging	0.46
R0096:Vmn2r79	UTSW	7	86,686,527 (GRCm39)	missense	probably damaging	1.00
R0096:Vmn2r79	UTSW	7	86,686,527 (GRCm39)	missense	probably damaging	1.00
R0270:Vmn2r79	UTSW	7	86,652,594 (GRCm39)	missense	probably benign	0.00
R0336:Vmn2r79	UTSW	7	86,651,287 (GRCm39)	missense	probably benign	0.15
R0418:Vmn2r79	UTSW	7	86,651,611 (GRCm39)	missense	probably benign	0.18
R1070:Vmn2r79	UTSW	7	86,652,681 (GRCm39)	missense	probably damaging	1.00
R1234:Vmn2r79	UTSW	7	86,653,307 (GRCm39)	missense	possibly damaging	0.71
R1459:Vmn2r79	UTSW	7	86,687,002 (GRCm39)	missense	probably benign	0.01
R1513:Vmn2r79	UTSW	7	86,686,652 (GRCm39)	missense	probably benign	0.01
R1624:Vmn2r79	UTSW	7	86,653,247 (GRCm39)	critical splice acceptor site	probably null
R1633:Vmn2r79	UTSW	7	86,687,042 (GRCm39)	missense	possibly damaging	0.52
R1676:Vmn2r79	UTSW	7	86,651,839 (GRCm39)	missense	probably benign
R1781:Vmn2r79	UTSW	7	86,651,555 (GRCm39)	missense	probably benign	0.00
R1794:Vmn2r79	UTSW	7	86,650,621 (GRCm39)	missense	probably benign	0.37
R1823:Vmn2r79	UTSW	7	86,687,080 (GRCm39)	missense	probably damaging	1.00
R2013:Vmn2r79	UTSW	7	86,653,289 (GRCm39)	missense	possibly damaging	0.50
R2018:Vmn2r79	UTSW	7	86,651,634 (GRCm39)	missense	probably benign	0.07
R2019:Vmn2r79	UTSW	7	86,651,634 (GRCm39)	missense	probably benign	0.07
R2984:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R3719:Vmn2r79	UTSW	7	86,651,245 (GRCm39)	missense	probably benign	0.05
R3798:Vmn2r79	UTSW	7	86,651,402 (GRCm39)	missense	possibly damaging	0.88
R3969:Vmn2r79	UTSW	7	86,652,801 (GRCm39)	missense	probably damaging	1.00
R4182:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4183:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4245:Vmn2r79	UTSW	7	86,651,624 (GRCm39)	missense	possibly damaging	0.73
R4301:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4391:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4393:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4394:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4396:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4397:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4592:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R4697:Vmn2r79	UTSW	7	86,687,168 (GRCm39)	missense	probably damaging	0.98
R4897:Vmn2r79	UTSW	7	86,650,675 (GRCm39)	missense	probably benign
R5016:Vmn2r79	UTSW	7	86,686,548 (GRCm39)	missense	probably benign	0.00
R5058:Vmn2r79	UTSW	7	86,651,423 (GRCm39)	missense	probably damaging	0.98
R5177:Vmn2r79	UTSW	7	86,651,177 (GRCm39)	missense	probably damaging	0.97
R6078:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R6079:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R6138:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R6257:Vmn2r79	UTSW	7	86,651,778 (GRCm39)	missense	probably benign	0.27
R6260:Vmn2r79	UTSW	7	86,686,365 (GRCm39)	missense	probably benign	0.00
R6307:Vmn2r79	UTSW	7	86,686,976 (GRCm39)	missense	probably damaging	1.00
R6323:Vmn2r79	UTSW	7	86,650,522 (GRCm39)	missense	probably benign	0.05
R6374:Vmn2r79	UTSW	7	86,651,498 (GRCm39)	missense	probably benign	0.02
R6530:Vmn2r79	UTSW	7	86,651,252 (GRCm39)	missense	possibly damaging	0.91
R6546:Vmn2r79	UTSW	7	86,652,741 (GRCm39)	missense	probably benign	0.01
R6682:Vmn2r79	UTSW	7	86,653,370 (GRCm39)	missense	possibly damaging	0.69
R6858:Vmn2r79	UTSW	7	86,686,580 (GRCm39)	missense	probably benign
R6965:Vmn2r79	UTSW	7	86,651,100 (GRCm39)	missense	probably benign	0.10
R7130:Vmn2r79	UTSW	7	86,651,474 (GRCm39)	missense	probably damaging	0.99
R7156:Vmn2r79	UTSW	7	86,686,851 (GRCm39)	missense	probably damaging	0.98
R7604:Vmn2r79	UTSW	7	86,652,592 (GRCm39)	critical splice acceptor site	probably null
R7691:Vmn2r79	UTSW	7	86,687,111 (GRCm39)	missense	probably damaging	0.96
R8055:Vmn2r79	UTSW	7	86,686,541 (GRCm39)	missense	possibly damaging	0.94
R8070:Vmn2r79	UTSW	7	86,651,336 (GRCm39)	missense	probably benign
R8073:Vmn2r79	UTSW	7	86,651,462 (GRCm39)	missense	probably benign	0.00
R8145:Vmn2r79	UTSW	7	86,686,862 (GRCm39)	missense	probably benign	0.02
R8263:Vmn2r79	UTSW	7	86,686,726 (GRCm39)	missense	possibly damaging	0.89
R8350:Vmn2r79	UTSW	7	86,686,741 (GRCm39)	nonsense	probably null
R8400:Vmn2r79	UTSW	7	86,651,308 (GRCm39)	missense	probably benign	0.00
R8814:Vmn2r79	UTSW	7	86,651,714 (GRCm39)	missense	probably benign	0.00
R8862:Vmn2r79	UTSW	7	86,645,712 (GRCm39)	missense	probably benign	0.23
R9146:Vmn2r79	UTSW	7	86,650,681 (GRCm39)	nonsense	probably null
R9276:Vmn2r79	UTSW	7	86,687,045 (GRCm39)	missense	probably damaging	1.00
R9361:Vmn2r79	UTSW	7	86,652,822 (GRCm39)	critical splice donor site	probably null
R9676:Vmn2r79	UTSW	7	86,686,452 (GRCm39)	missense	probably damaging	1.00
U15987:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
X0054:Vmn2r79	UTSW	7	86,653,270 (GRCm39)	missense	probably benign	0.01
Z1088:Vmn2r79	UTSW	7	86,651,549 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r79	UTSW	7	86,686,377 (GRCm39)	missense	probably benign
Z1176:Vmn2r79	UTSW	7	86,651,526 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GATGGCACTGCAAAGATGTTCTC -3'
(R):5'- AGGGCATCTCTCTAAGATCAAAGTC -3'

Sequencing Primer
(F):5'- CTTGGTTCTGAAGCTTTCC -3'
(R):5'- TCATTCTACATCTAACTGGATTTGTG -3'

Posted On

2014-10-02