Incidental Mutation 'R2180:Gpr149'
ID 237103
Institutional Source Beutler Lab
Gene Symbol Gpr149
Ensembl Gene ENSMUSG00000043441
Gene Name G protein-coupled receptor 149
Synonyms PGR10, 9630018L10Rik, R35, Ieda
MMRRC Submission 040182-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R2180 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 62436851-62512861 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 62511489 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 170 (L170P)
Ref Sequence ENSEMBL: ENSMUSP00000060893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058535]
AlphaFold Q3UVY1
Predicted Effect probably damaging
Transcript: ENSMUST00000058535
AA Change: L170P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000060893
Gene: ENSMUSG00000043441
AA Change: L170P

DomainStartEndE-ValueType
Pfam:7tm_1 52 363 7.2e-7 PFAM
coiled coil region 694 730 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149007
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Female mice homozygous for a knock-out allele exhibit increased fertility with increased litter size and frequency. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts5 T C 16: 85,684,812 (GRCm39) D377G probably damaging Het
Adgrl4 A T 3: 151,205,779 (GRCm39) I164F probably damaging Het
Anxa9 T C 3: 95,213,735 (GRCm39) probably null Het
Aox4 A T 1: 58,252,226 (GRCm39) T34S probably benign Het
Asic1 G T 15: 99,569,846 (GRCm39) V56F probably benign Het
Atpaf1 T C 4: 115,645,557 (GRCm39) M1T probably null Het
Axin1 A G 17: 26,362,309 (GRCm39) T218A probably benign Het
Bdp1 ATTCTTCTTCTTCTTCTTC ATTCTTCTTCTTCTTCTTCTTC 13: 100,197,913 (GRCm39) probably benign Het
Birc6 T C 17: 74,919,146 (GRCm39) I1988T probably benign Het
Btbd7 A T 12: 102,752,156 (GRCm39) D869E probably damaging Het
Caln1 T C 5: 130,868,249 (GRCm39) *220Q probably null Het
Ccdc150 G A 1: 54,311,706 (GRCm39) probably null Het
Ccnt1 A T 15: 98,441,481 (GRCm39) S596T possibly damaging Het
Cd44 C T 2: 102,658,955 (GRCm39) G640E possibly damaging Het
Cep192 A G 18: 67,957,813 (GRCm39) E582G possibly damaging Het
Clcnkb G T 4: 141,136,819 (GRCm39) probably null Het
Dhx29 T C 13: 113,099,406 (GRCm39) probably null Het
Dnah8 T C 17: 31,059,621 (GRCm39) F4407S probably benign Het
Enah A T 1: 181,746,024 (GRCm39) M419K probably damaging Het
Fancd2 A T 6: 113,551,598 (GRCm39) T1055S probably benign Het
Gigyf2 G A 1: 87,344,642 (GRCm39) G525D probably damaging Het
Gm5800 T A 14: 51,953,451 (GRCm39) K55* probably null Het
Grik4 A T 9: 42,453,301 (GRCm39) Y695N probably benign Het
Gsg1 A T 6: 135,217,143 (GRCm39) V228D probably damaging Het
Helb G A 10: 119,941,353 (GRCm39) T445M probably benign Het
Helz2 A T 2: 180,875,525 (GRCm39) D1656E probably damaging Het
Hyou1 A T 9: 44,299,316 (GRCm39) K669M probably benign Het
Itga2 T C 13: 114,985,917 (GRCm39) N953D possibly damaging Het
Ldhd T C 8: 112,356,018 (GRCm39) I122V probably benign Het
Lrrtm1 A G 6: 77,221,329 (GRCm39) D262G probably damaging Het
Mapkapk5 T C 5: 121,673,927 (GRCm39) probably null Het
Msantd5l C A 11: 51,145,437 (GRCm39) W50L probably damaging Het
Niban1 A T 1: 151,593,829 (GRCm39) H838L probably benign Het
Numa1 T C 7: 101,649,197 (GRCm39) I976T probably benign Het
Or10x1 A G 1: 174,196,967 (GRCm39) I161M probably damaging Het
Or2a12 C T 6: 42,904,459 (GRCm39) T98I probably benign Het
Or4f14b A G 2: 111,775,348 (GRCm39) V151A probably benign Het
Or52e4 T C 7: 104,706,092 (GRCm39) I213T probably benign Het
Patj G A 4: 98,411,739 (GRCm39) probably null Het
Pfas T C 11: 68,883,013 (GRCm39) D757G possibly damaging Het
Pom121l2 A G 13: 22,166,145 (GRCm39) N139D probably benign Het
Ppp2r3d A T 9: 101,004,214 (GRCm39) Y994* probably null Het
Ppp6c T C 2: 39,087,525 (GRCm39) D227G probably benign Het
Ptpn13 T G 5: 103,717,424 (GRCm39) H1855Q probably damaging Het
Ptprh T A 7: 4,604,867 (GRCm39) Q59L probably benign Het
Rap1gap2 T C 11: 74,283,972 (GRCm39) K669E probably benign Het
Rbl2 T C 8: 91,816,683 (GRCm39) S348P possibly damaging Het
Rptor T A 11: 119,615,970 (GRCm39) N161K probably damaging Het
Satb1 C T 17: 52,110,524 (GRCm39) A192T probably damaging Het
Scn5a A G 9: 119,345,117 (GRCm39) V1083A probably benign Het
Sec14l2 C T 11: 4,058,964 (GRCm39) A194T probably damaging Het
Sema4b A G 7: 79,862,583 (GRCm39) N53S probably benign Het
Sin3b T A 8: 73,479,923 (GRCm39) Y876* probably null Het
Smchd1 C A 17: 71,770,794 (GRCm39) M129I probably benign Het
Spmip6 T A 4: 41,507,170 (GRCm39) M209L probably benign Het
Tmc1 T C 19: 20,801,448 (GRCm39) Y484C probably damaging Het
Utp20 A G 10: 88,656,801 (GRCm39) S135P probably damaging Het
Zfp266 A T 9: 20,410,975 (GRCm39) C401S probably damaging Het
Zfp738 G A 13: 67,819,313 (GRCm39) T226I probably damaging Het
Zfp871 G A 17: 32,994,275 (GRCm39) T300M probably damaging Het
Other mutations in Gpr149
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Gpr149 APN 3 62,438,094 (GRCm39) missense probably damaging 1.00
IGL01339:Gpr149 APN 3 62,511,718 (GRCm39) missense probably damaging 1.00
IGL01399:Gpr149 APN 3 62,511,852 (GRCm39) missense probably damaging 1.00
IGL01954:Gpr149 APN 3 62,438,348 (GRCm39) missense probably benign 0.36
IGL02115:Gpr149 APN 3 62,502,336 (GRCm39) missense probably benign 0.02
IGL02218:Gpr149 APN 3 62,437,952 (GRCm39) utr 3 prime probably benign
IGL02592:Gpr149 APN 3 62,511,231 (GRCm39) missense possibly damaging 0.75
IGL03393:Gpr149 APN 3 62,511,366 (GRCm39) missense probably benign 0.15
R0578:Gpr149 UTSW 3 62,510,110 (GRCm39) missense possibly damaging 0.81
R1173:Gpr149 UTSW 3 62,511,888 (GRCm39) missense probably damaging 1.00
R1174:Gpr149 UTSW 3 62,511,888 (GRCm39) missense probably damaging 1.00
R1175:Gpr149 UTSW 3 62,511,888 (GRCm39) missense probably damaging 1.00
R1432:Gpr149 UTSW 3 62,438,439 (GRCm39) missense probably damaging 1.00
R1484:Gpr149 UTSW 3 62,502,592 (GRCm39) missense probably benign 0.00
R1972:Gpr149 UTSW 3 62,438,216 (GRCm39) missense probably benign 0.39
R1973:Gpr149 UTSW 3 62,438,216 (GRCm39) missense probably benign 0.39
R2241:Gpr149 UTSW 3 62,511,474 (GRCm39) missense probably benign 0.00
R3118:Gpr149 UTSW 3 62,502,443 (GRCm39) missense probably benign 0.00
R3547:Gpr149 UTSW 3 62,502,549 (GRCm39) missense probably benign 0.01
R3548:Gpr149 UTSW 3 62,502,549 (GRCm39) missense probably benign 0.01
R4206:Gpr149 UTSW 3 62,511,924 (GRCm39) missense possibly damaging 0.92
R4332:Gpr149 UTSW 3 62,511,794 (GRCm39) missense possibly damaging 0.93
R4531:Gpr149 UTSW 3 62,510,099 (GRCm39) missense probably benign 0.00
R4557:Gpr149 UTSW 3 62,511,918 (GRCm39) missense probably benign 0.02
R4557:Gpr149 UTSW 3 62,438,291 (GRCm39) missense probably damaging 1.00
R4593:Gpr149 UTSW 3 62,510,151 (GRCm39) intron probably benign
R5397:Gpr149 UTSW 3 62,438,226 (GRCm39) missense probably damaging 1.00
R6592:Gpr149 UTSW 3 62,437,961 (GRCm39) missense probably benign 0.02
R6642:Gpr149 UTSW 3 62,437,995 (GRCm39) missense probably damaging 1.00
R6845:Gpr149 UTSW 3 62,511,942 (GRCm39) missense possibly damaging 0.58
R7303:Gpr149 UTSW 3 62,502,491 (GRCm39) missense possibly damaging 0.59
R7659:Gpr149 UTSW 3 62,511,256 (GRCm39) missense probably benign 0.01
R7682:Gpr149 UTSW 3 62,438,160 (GRCm39) missense probably damaging 1.00
R7803:Gpr149 UTSW 3 62,438,136 (GRCm39) missense probably damaging 1.00
R7904:Gpr149 UTSW 3 62,502,356 (GRCm39) missense probably benign 0.00
R7943:Gpr149 UTSW 3 62,438,132 (GRCm39) missense probably damaging 1.00
R8844:Gpr149 UTSW 3 62,502,572 (GRCm39) missense probably benign 0.05
R8919:Gpr149 UTSW 3 62,438,478 (GRCm39) missense probably damaging 1.00
R9043:Gpr149 UTSW 3 62,511,360 (GRCm39) missense probably damaging 1.00
R9209:Gpr149 UTSW 3 62,511,093 (GRCm39) missense probably benign 0.40
Z1177:Gpr149 UTSW 3 62,511,380 (GRCm39) frame shift probably null
Z1190:Gpr149 UTSW 3 62,511,972 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CGAGAAATTTCCTGGTAGTTGGC -3'
(R):5'- ACAGGGCTACTTCCAGTCTC -3'

Sequencing Primer
(F):5'- CATGGAGTCTCAGCGGTTC -3'
(R):5'- GCCCTACTGTATATGTGCCAGG -3'
Posted On 2014-10-02