Incidental Mutation 'R2180:Zfp871'
ID 237159
Institutional Source Beutler Lab
Gene Symbol Zfp871
Ensembl Gene ENSMUSG00000024298
Gene Name zinc finger protein 871
Synonyms 9030612M13Rik
MMRRC Submission 040182-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2180 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 32984470-33007261 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 32994275 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 300 (T300M)
Ref Sequence ENSEMBL: ENSMUSP00000127178 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057501] [ENSMUST00000159086]
AlphaFold G5E905
Predicted Effect possibly damaging
Transcript: ENSMUST00000057501
AA Change: T281M

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000050501
Gene: ENSMUSG00000024298
AA Change: T281M

DomainStartEndE-ValueType
KRAB 1 42 1.32e0 SMART
ZnF_C2H2 174 196 5.9e-3 SMART
ZnF_C2H2 202 224 6.32e-3 SMART
ZnF_C2H2 230 252 1.47e-3 SMART
ZnF_C2H2 258 280 3.63e-3 SMART
ZnF_C2H2 286 308 1.79e-2 SMART
ZnF_C2H2 314 336 4.79e-3 SMART
ZnF_C2H2 342 364 1.69e-3 SMART
ZnF_C2H2 370 392 2.79e-4 SMART
ZnF_C2H2 398 420 1.23e-5 SMART
ZnF_C2H2 426 448 1.2e-3 SMART
ZnF_C2H2 454 476 5.42e-2 SMART
ZnF_C2H2 482 504 8.6e-5 SMART
ZnF_C2H2 510 532 5.21e-4 SMART
ZnF_C2H2 538 560 3.11e-2 SMART
ZnF_C2H2 566 588 2.86e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000159086
AA Change: T300M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000127178
Gene: ENSMUSG00000024298
AA Change: T300M

DomainStartEndE-ValueType
KRAB 4 61 2.18e-15 SMART
ZnF_C2H2 193 215 5.9e-3 SMART
ZnF_C2H2 221 243 6.32e-3 SMART
ZnF_C2H2 249 271 1.47e-3 SMART
ZnF_C2H2 277 299 3.63e-3 SMART
ZnF_C2H2 305 327 1.79e-2 SMART
ZnF_C2H2 333 355 4.79e-3 SMART
ZnF_C2H2 361 383 1.69e-3 SMART
ZnF_C2H2 389 411 2.79e-4 SMART
ZnF_C2H2 417 439 1.23e-5 SMART
ZnF_C2H2 445 467 1.2e-3 SMART
ZnF_C2H2 473 495 5.42e-2 SMART
ZnF_C2H2 501 523 8.6e-5 SMART
ZnF_C2H2 529 551 5.21e-4 SMART
ZnF_C2H2 557 579 3.11e-2 SMART
ZnF_C2H2 585 607 2.86e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168337
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts5 T C 16: 85,684,812 (GRCm39) D377G probably damaging Het
Adgrl4 A T 3: 151,205,779 (GRCm39) I164F probably damaging Het
Anxa9 T C 3: 95,213,735 (GRCm39) probably null Het
Aox4 A T 1: 58,252,226 (GRCm39) T34S probably benign Het
Asic1 G T 15: 99,569,846 (GRCm39) V56F probably benign Het
Atpaf1 T C 4: 115,645,557 (GRCm39) M1T probably null Het
Axin1 A G 17: 26,362,309 (GRCm39) T218A probably benign Het
Bdp1 ATTCTTCTTCTTCTTCTTC ATTCTTCTTCTTCTTCTTCTTC 13: 100,197,913 (GRCm39) probably benign Het
Birc6 T C 17: 74,919,146 (GRCm39) I1988T probably benign Het
Btbd7 A T 12: 102,752,156 (GRCm39) D869E probably damaging Het
Caln1 T C 5: 130,868,249 (GRCm39) *220Q probably null Het
Ccdc150 G A 1: 54,311,706 (GRCm39) probably null Het
Ccnt1 A T 15: 98,441,481 (GRCm39) S596T possibly damaging Het
Cd44 C T 2: 102,658,955 (GRCm39) G640E possibly damaging Het
Cep192 A G 18: 67,957,813 (GRCm39) E582G possibly damaging Het
Clcnkb G T 4: 141,136,819 (GRCm39) probably null Het
Dhx29 T C 13: 113,099,406 (GRCm39) probably null Het
Dnah8 T C 17: 31,059,621 (GRCm39) F4407S probably benign Het
Enah A T 1: 181,746,024 (GRCm39) M419K probably damaging Het
Fancd2 A T 6: 113,551,598 (GRCm39) T1055S probably benign Het
Gigyf2 G A 1: 87,344,642 (GRCm39) G525D probably damaging Het
Gm5800 T A 14: 51,953,451 (GRCm39) K55* probably null Het
Gpr149 A G 3: 62,511,489 (GRCm39) L170P probably damaging Het
Grik4 A T 9: 42,453,301 (GRCm39) Y695N probably benign Het
Gsg1 A T 6: 135,217,143 (GRCm39) V228D probably damaging Het
Helb G A 10: 119,941,353 (GRCm39) T445M probably benign Het
Helz2 A T 2: 180,875,525 (GRCm39) D1656E probably damaging Het
Hyou1 A T 9: 44,299,316 (GRCm39) K669M probably benign Het
Itga2 T C 13: 114,985,917 (GRCm39) N953D possibly damaging Het
Ldhd T C 8: 112,356,018 (GRCm39) I122V probably benign Het
Lrrtm1 A G 6: 77,221,329 (GRCm39) D262G probably damaging Het
Mapkapk5 T C 5: 121,673,927 (GRCm39) probably null Het
Msantd5l C A 11: 51,145,437 (GRCm39) W50L probably damaging Het
Niban1 A T 1: 151,593,829 (GRCm39) H838L probably benign Het
Numa1 T C 7: 101,649,197 (GRCm39) I976T probably benign Het
Or10x1 A G 1: 174,196,967 (GRCm39) I161M probably damaging Het
Or2a12 C T 6: 42,904,459 (GRCm39) T98I probably benign Het
Or4f14b A G 2: 111,775,348 (GRCm39) V151A probably benign Het
Or52e4 T C 7: 104,706,092 (GRCm39) I213T probably benign Het
Patj G A 4: 98,411,739 (GRCm39) probably null Het
Pfas T C 11: 68,883,013 (GRCm39) D757G possibly damaging Het
Pom121l2 A G 13: 22,166,145 (GRCm39) N139D probably benign Het
Ppp2r3d A T 9: 101,004,214 (GRCm39) Y994* probably null Het
Ppp6c T C 2: 39,087,525 (GRCm39) D227G probably benign Het
Ptpn13 T G 5: 103,717,424 (GRCm39) H1855Q probably damaging Het
Ptprh T A 7: 4,604,867 (GRCm39) Q59L probably benign Het
Rap1gap2 T C 11: 74,283,972 (GRCm39) K669E probably benign Het
Rbl2 T C 8: 91,816,683 (GRCm39) S348P possibly damaging Het
Rptor T A 11: 119,615,970 (GRCm39) N161K probably damaging Het
Satb1 C T 17: 52,110,524 (GRCm39) A192T probably damaging Het
Scn5a A G 9: 119,345,117 (GRCm39) V1083A probably benign Het
Sec14l2 C T 11: 4,058,964 (GRCm39) A194T probably damaging Het
Sema4b A G 7: 79,862,583 (GRCm39) N53S probably benign Het
Sin3b T A 8: 73,479,923 (GRCm39) Y876* probably null Het
Smchd1 C A 17: 71,770,794 (GRCm39) M129I probably benign Het
Spmip6 T A 4: 41,507,170 (GRCm39) M209L probably benign Het
Tmc1 T C 19: 20,801,448 (GRCm39) Y484C probably damaging Het
Utp20 A G 10: 88,656,801 (GRCm39) S135P probably damaging Het
Zfp266 A T 9: 20,410,975 (GRCm39) C401S probably damaging Het
Zfp738 G A 13: 67,819,313 (GRCm39) T226I probably damaging Het
Other mutations in Zfp871
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00849:Zfp871 APN 17 32,994,873 (GRCm39) missense probably benign
IGL00963:Zfp871 APN 17 32,993,726 (GRCm39) missense probably benign 0.25
IGL01687:Zfp871 APN 17 32,994,618 (GRCm39) missense probably benign 0.00
IGL02170:Zfp871 APN 17 32,994,662 (GRCm39) missense possibly damaging 0.72
IGL02399:Zfp871 APN 17 32,993,329 (GRCm39) missense probably benign 0.18
R0304:Zfp871 UTSW 17 32,993,408 (GRCm39) missense probably damaging 0.99
R1215:Zfp871 UTSW 17 32,994,946 (GRCm39) missense possibly damaging 0.70
R1444:Zfp871 UTSW 17 32,993,900 (GRCm39) missense possibly damaging 0.85
R1754:Zfp871 UTSW 17 32,994,308 (GRCm39) missense probably damaging 1.00
R1913:Zfp871 UTSW 17 32,994,891 (GRCm39) missense possibly damaging 0.53
R2018:Zfp871 UTSW 17 32,993,751 (GRCm39) missense probably damaging 1.00
R2881:Zfp871 UTSW 17 32,994,407 (GRCm39) missense probably damaging 1.00
R4422:Zfp871 UTSW 17 32,993,808 (GRCm39) missense probably benign 0.37
R4422:Zfp871 UTSW 17 32,993,807 (GRCm39) missense probably benign 0.39
R4979:Zfp871 UTSW 17 32,994,829 (GRCm39) missense probably damaging 0.99
R5564:Zfp871 UTSW 17 32,994,842 (GRCm39) missense possibly damaging 0.70
R6228:Zfp871 UTSW 17 32,994,858 (GRCm39) missense possibly damaging 0.50
R6232:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R6233:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R6234:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R6474:Zfp871 UTSW 17 32,994,647 (GRCm39) missense possibly damaging 0.85
R7237:Zfp871 UTSW 17 32,994,289 (GRCm39) missense probably damaging 1.00
R7809:Zfp871 UTSW 17 32,993,826 (GRCm39) missense probably damaging 1.00
R8830:Zfp871 UTSW 17 32,993,901 (GRCm39) missense probably benign 0.03
R9219:Zfp871 UTSW 17 32,993,914 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CACCCCACTGTGAATTATTTCATGC -3'
(R):5'- GTGACGAAGACTATAGATATGGCC -3'

Sequencing Primer
(F):5'- TGCTTTCGCAACTGAATCCAACG -3'
(R):5'- CTCCAGGTATTTTCGAAGGCACG -3'
Posted On 2014-10-02