Incidental Mutation 'R2181:Or2p2'
ID 237200
Institutional Source Beutler Lab
Gene Symbol Or2p2
Ensembl Gene ENSMUSG00000042869
Gene Name olfactory receptor family 2 subfamily P member 2
Synonyms Olfr1370, MOR256-14, GA_x6K02T2QHY8-12181473-12182423
MMRRC Submission 040183-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R2181 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 21256519-21257469 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 21257394 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 26 (P26T)
Ref Sequence ENSEMBL: ENSMUSP00000149341 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058168] [ENSMUST00000215357] [ENSMUST00000215806]
AlphaFold Q8VFG4
Predicted Effect probably damaging
Transcript: ENSMUST00000058168
AA Change: P26T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000054533
Gene: ENSMUSG00000042869
AA Change: P26T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 24 305 1.8e-8 PFAM
Pfam:7tm_4 31 308 3.6e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 306 1.9e-6 PFAM
Pfam:7tm_1 41 290 2e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213848
Predicted Effect probably damaging
Transcript: ENSMUST00000215357
AA Change: P26T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215806
AA Change: P26T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700037C18Rik C T 16: 3,724,950 (GRCm39) S43N possibly damaging Het
Abcb5 T G 12: 118,831,681 (GRCm39) I1224L possibly damaging Het
Adgra2 G A 8: 27,611,701 (GRCm39) G1002S probably damaging Het
Arhgap28 T C 17: 68,203,112 (GRCm39) T114A probably damaging Het
Colec12 T A 18: 9,846,828 (GRCm39) S75T probably damaging Het
Cyp2c67 A G 19: 39,597,541 (GRCm39) C486R possibly damaging Het
Ecm2 T A 13: 49,683,765 (GRCm39) L581Q probably damaging Het
Faxc T A 4: 21,931,591 (GRCm39) S10T probably benign Het
Frem2 A G 3: 53,482,008 (GRCm39) I1893T possibly damaging Het
Gabrr3 T A 16: 59,268,372 (GRCm39) D328E probably damaging Het
Gbp7 A G 3: 142,249,791 (GRCm39) I421V possibly damaging Het
Gorasp1 A G 9: 119,757,422 (GRCm39) S317P probably damaging Het
Htr6 A G 4: 138,801,736 (GRCm39) S113P probably damaging Het
Ift74 A G 4: 94,520,951 (GRCm39) E168G probably damaging Het
Kdm6b A T 11: 69,291,952 (GRCm39) Y1443* probably null Het
Mmp28 A C 11: 83,333,543 (GRCm39) V466G possibly damaging Het
Nbea A T 3: 55,937,360 (GRCm39) S750R possibly damaging Het
Nbeal1 T C 1: 60,317,939 (GRCm39) F1959L probably damaging Het
Nelfa T C 5: 34,057,853 (GRCm39) N314D probably benign Het
Numbl T A 7: 26,968,346 (GRCm39) probably null Het
Or13c25 T A 4: 52,911,524 (GRCm39) K90M probably damaging Het
Or1j17 G A 2: 36,578,346 (GRCm39) D111N probably damaging Het
Or52e5 T C 7: 104,719,418 (GRCm39) V248A possibly damaging Het
Or5b113 G T 19: 13,342,438 (GRCm39) V149F probably benign Het
Penk T C 4: 4,134,041 (GRCm39) probably null Het
Pglyrp2 A G 17: 32,637,936 (GRCm39) S31P probably damaging Het
Pigg T C 5: 108,484,366 (GRCm39) S538P probably damaging Het
Pld2 A G 11: 70,433,815 (GRCm39) T252A possibly damaging Het
Ppp2r5e T C 12: 75,509,098 (GRCm39) I394V probably benign Het
Sh3rf1 G T 8: 61,816,272 (GRCm39) V510F probably damaging Het
Slc4a2 A G 5: 24,640,651 (GRCm39) H677R possibly damaging Het
Stam2 A T 2: 52,593,156 (GRCm39) H345Q probably benign Het
Tmtc3 T C 10: 100,284,835 (GRCm39) N600S probably benign Het
Trappc8 A G 18: 20,952,279 (GRCm39) probably null Het
Vmn1r72 A T 7: 11,403,595 (GRCm39) C284* probably null Het
Vmn2r76 T C 7: 85,874,743 (GRCm39) I745V probably benign Het
Zfhx4 A C 3: 5,468,392 (GRCm39) D2850A probably damaging Het
Zfp764 A G 7: 127,005,671 (GRCm39) W36R probably damaging Het
Zfp804b G A 5: 6,821,674 (GRCm39) T463I probably damaging Het
Zfp811 T G 17: 33,016,695 (GRCm39) K448N probably damaging Het
Other mutations in Or2p2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01655:Or2p2 APN 13 21,257,075 (GRCm39) missense probably damaging 1.00
IGL02658:Or2p2 APN 13 21,256,982 (GRCm39) missense probably damaging 1.00
R0281:Or2p2 UTSW 13 21,256,544 (GRCm39) missense probably benign
R1838:Or2p2 UTSW 13 21,256,595 (GRCm39) nonsense probably null
R1858:Or2p2 UTSW 13 21,256,641 (GRCm39) missense probably damaging 0.98
R4502:Or2p2 UTSW 13 21,256,916 (GRCm39) missense probably damaging 1.00
R4594:Or2p2 UTSW 13 21,256,692 (GRCm39) missense probably benign 0.30
R4757:Or2p2 UTSW 13 21,256,715 (GRCm39) missense probably damaging 1.00
R5222:Or2p2 UTSW 13 21,256,739 (GRCm39) missense probably damaging 1.00
R6245:Or2p2 UTSW 13 21,256,860 (GRCm39) missense possibly damaging 0.69
R6350:Or2p2 UTSW 13 21,256,775 (GRCm39) missense probably benign 0.00
R6360:Or2p2 UTSW 13 21,256,753 (GRCm39) missense probably damaging 1.00
R8539:Or2p2 UTSW 13 21,257,343 (GRCm39) missense probably benign 0.00
R8812:Or2p2 UTSW 13 21,257,220 (GRCm39) missense probably damaging 1.00
R9074:Or2p2 UTSW 13 21,256,784 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- AAGATTCCGAAGCAGCTGAG -3'
(R):5'- TCTTGGAAATGCTGAACGGG -3'

Sequencing Primer
(F):5'- TTCCGAAGCAGCTGAGGGATG -3'
(R):5'- TTGGAAATGCTGAACGGGAATATTTG -3'
Posted On 2014-10-02