Incidental Mutation 'R2182:Zfp839'
ID 237253
Institutional Source Beutler Lab
Gene Symbol Zfp839
Ensembl Gene ENSMUSG00000021271
Gene Name zinc finger protein 839
Synonyms 2810455K09Rik
MMRRC Submission 040184-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R2182 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 110816687-110836430 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 110834772 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 676 (L676F)
Ref Sequence ENSEMBL: ENSMUSP00000131841 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043716] [ENSMUST00000170060] [ENSMUST00000220607] [ENSMUST00000222460]
AlphaFold E9PUU5
Predicted Effect probably benign
Transcript: ENSMUST00000043716
SMART Domains Protein: ENSMUSP00000035245
Gene: ENSMUSG00000021276

DomainStartEndE-ValueType
low complexity region 54 78 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000170060
AA Change: L676F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131841
Gene: ENSMUSG00000021271
AA Change: L676F

DomainStartEndE-ValueType
low complexity region 271 278 N/A INTRINSIC
ZnF_C2H2 295 320 3.02e0 SMART
low complexity region 377 388 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000220607
Predicted Effect probably damaging
Transcript: ENSMUST00000222460
AA Change: L600F

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930550C14Rik A G 9: 53,334,243 (GRCm39) H17R probably damaging Het
Abca15 G A 7: 119,939,450 (GRCm39) W281* probably null Het
Aloxe3 G A 11: 69,020,426 (GRCm39) V157M possibly damaging Het
Arhgap26 G T 18: 39,490,862 (GRCm39) probably benign Het
Atp7b T C 8: 22,504,563 (GRCm39) N698S probably damaging Het
Clec4a4 A G 6: 122,990,716 (GRCm39) probably null Het
Clgn C T 8: 84,137,039 (GRCm39) T252I possibly damaging Het
Cyp2a12 A T 7: 26,730,571 (GRCm39) N179Y probably damaging Het
D630045J12Rik C T 6: 38,151,082 (GRCm39) probably null Het
Dennd5a G T 7: 109,533,201 (GRCm39) R190S probably benign Het
Dtx4 C A 19: 12,460,471 (GRCm39) G384V probably null Het
Dxo T C 17: 35,057,868 (GRCm39) V191A probably benign Het
Eprs1 G A 1: 185,111,939 (GRCm39) probably null Het
Fntb A G 12: 76,909,309 (GRCm39) N99S probably benign Het
Gm5773 T A 3: 93,680,820 (GRCm39) I164K probably benign Het
Golm2 A G 2: 121,697,909 (GRCm39) D75G probably damaging Het
Hyal5 T C 6: 24,877,879 (GRCm39) I325T probably damaging Het
Igsf8 G A 1: 172,118,295 (GRCm39) probably null Het
Lamc2 A G 1: 153,002,612 (GRCm39) V17A possibly damaging Het
Lpxn T C 19: 12,810,122 (GRCm39) probably null Het
Macf1 A G 4: 123,386,464 (GRCm39) V1296A probably damaging Het
Mpdz A T 4: 81,266,959 (GRCm39) L318Q probably damaging Het
Mpl T A 4: 118,314,610 (GRCm39) Q13L probably benign Het
Mpnd A G 17: 56,322,964 (GRCm39) S399G probably benign Het
Mrps5 T C 2: 127,444,407 (GRCm39) L347P probably damaging Het
Naip1 T A 13: 100,550,188 (GRCm39) Q1217H probably benign Het
Nav2 G A 7: 49,247,002 (GRCm39) V2176I probably benign Het
Obi1 A G 14: 104,743,612 (GRCm39) S156P possibly damaging Het
Or13p3 T C 4: 118,567,542 (GRCm39) *313R probably null Het
Or7g33 T C 9: 19,448,638 (GRCm39) N196S probably benign Het
Or8b43 A G 9: 38,360,420 (GRCm39) N84S probably benign Het
Or8g36 A T 9: 39,422,722 (GRCm39) M98K probably damaging Het
Pbx2 C A 17: 34,814,640 (GRCm39) Y324* probably null Het
Pcsk7 T A 9: 45,839,917 (GRCm39) C702S probably benign Het
Pramel11 T A 4: 143,623,760 (GRCm39) H138L possibly damaging Het
Rictor T C 15: 6,801,685 (GRCm39) S458P probably damaging Het
Scaf4 T C 16: 90,027,028 (GRCm39) M905V probably benign Het
Scarf2 T C 16: 17,620,886 (GRCm39) C185R probably damaging Het
Scd1 T G 19: 44,391,732 (GRCm39) I101L probably benign Het
Slc6a2 A G 8: 93,687,876 (GRCm39) M1V probably null Het
Sost T C 11: 101,854,676 (GRCm39) Y211C probably damaging Het
Sphkap A G 1: 83,254,405 (GRCm39) S828P probably damaging Het
Tnn T C 1: 159,968,170 (GRCm39) probably null Het
Tnrc18 T C 5: 142,745,816 (GRCm39) K1319R unknown Het
Vmn2r60 A G 7: 41,844,931 (GRCm39) T765A probably benign Het
Vmn2r91 C A 17: 18,325,691 (GRCm39) T103K possibly damaging Het
Zbtb44 T C 9: 30,977,972 (GRCm39) C429R possibly damaging Het
Zc3h4 G A 7: 16,156,441 (GRCm39) G327D unknown Het
Zfp292 A G 4: 34,807,417 (GRCm39) C1876R probably damaging Het
Zg16 A G 7: 126,649,544 (GRCm39) L139P probably damaging Het
Zscan12 A G 13: 21,552,961 (GRCm39) I262V probably benign Het
Other mutations in Zfp839
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00821:Zfp839 APN 12 110,831,441 (GRCm39) critical splice donor site probably null
IGL00941:Zfp839 APN 12 110,827,382 (GRCm39) missense probably damaging 1.00
R0013:Zfp839 UTSW 12 110,834,820 (GRCm39) missense possibly damaging 0.66
R0013:Zfp839 UTSW 12 110,834,820 (GRCm39) missense possibly damaging 0.66
R0109:Zfp839 UTSW 12 110,827,308 (GRCm39) missense possibly damaging 0.92
R0116:Zfp839 UTSW 12 110,825,203 (GRCm39) intron probably benign
R1219:Zfp839 UTSW 12 110,834,707 (GRCm39) missense possibly damaging 0.63
R1406:Zfp839 UTSW 12 110,832,744 (GRCm39) missense probably damaging 0.99
R1406:Zfp839 UTSW 12 110,832,744 (GRCm39) missense probably damaging 0.99
R1434:Zfp839 UTSW 12 110,827,333 (GRCm39) missense probably benign 0.08
R1653:Zfp839 UTSW 12 110,821,684 (GRCm39) missense probably benign 0.02
R1754:Zfp839 UTSW 12 110,821,891 (GRCm39) missense probably damaging 0.98
R3765:Zfp839 UTSW 12 110,821,597 (GRCm39) missense probably benign 0.22
R3981:Zfp839 UTSW 12 110,832,765 (GRCm39) missense probably damaging 0.97
R4756:Zfp839 UTSW 12 110,821,635 (GRCm39) missense possibly damaging 0.92
R5088:Zfp839 UTSW 12 110,834,610 (GRCm39) missense probably damaging 0.99
R5394:Zfp839 UTSW 12 110,822,020 (GRCm39) missense probably benign 0.05
R5619:Zfp839 UTSW 12 110,830,470 (GRCm39) missense probably damaging 1.00
R6856:Zfp839 UTSW 12 110,833,195 (GRCm39) nonsense probably null
R7661:Zfp839 UTSW 12 110,835,226 (GRCm39) missense probably benign 0.32
R7860:Zfp839 UTSW 12 110,822,060 (GRCm39) missense probably damaging 1.00
R8022:Zfp839 UTSW 12 110,821,532 (GRCm39) missense probably damaging 1.00
R8855:Zfp839 UTSW 12 110,834,848 (GRCm39) missense probably benign 0.06
R8866:Zfp839 UTSW 12 110,834,848 (GRCm39) missense probably benign 0.06
R8896:Zfp839 UTSW 12 110,835,277 (GRCm39) missense probably damaging 1.00
R9289:Zfp839 UTSW 12 110,834,878 (GRCm39) missense probably benign 0.04
R9606:Zfp839 UTSW 12 110,834,776 (GRCm39) missense probably benign
R9668:Zfp839 UTSW 12 110,822,280 (GRCm39) missense probably damaging 0.98
R9686:Zfp839 UTSW 12 110,821,932 (GRCm39) missense probably damaging 1.00
Z1177:Zfp839 UTSW 12 110,833,218 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GAACTATTCAGGCTCTGACCC -3'
(R):5'- TGATTAGTCTCCCTGAGGGCTC -3'

Sequencing Primer
(F):5'- AGGCTCTGACCCTGCAG -3'
(R):5'- CTGCATTTTCAGACTCTCTAAACAAC -3'
Posted On 2014-10-02