Incidental Mutation 'R2173:Srpk2'
ID 237610
Institutional Source Beutler Lab
Gene Symbol Srpk2
Ensembl Gene ENSMUSG00000062604
Gene Name serine/arginine-rich protein specific kinase 2
Synonyms WBP6, mSRPK2
MMRRC Submission 040175-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2173 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 23708262-23889615 bp(-) (GRCm39)
Type of Mutation splice site (4 bp from exon)
DNA Base Change (assembly) T to C at 23723613 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000085734 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088392] [ENSMUST00000088392] [ENSMUST00000196929]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000088392
SMART Domains Protein: ENSMUSP00000085734
Gene: ENSMUSG00000062604

DomainStartEndE-ValueType
low complexity region 5 46 N/A INTRINSIC
Pfam:Pkinase 79 228 1.3e-22 PFAM
Pfam:Pkinase_Tyr 79 228 1e-9 PFAM
coiled coil region 263 314 N/A INTRINSIC
coiled coil region 339 373 N/A INTRINSIC
low complexity region 393 406 N/A INTRINSIC
Pfam:Pkinase 506 680 1.9e-18 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000088392
SMART Domains Protein: ENSMUSP00000085734
Gene: ENSMUSG00000062604

DomainStartEndE-ValueType
low complexity region 5 46 N/A INTRINSIC
Pfam:Pkinase 79 228 1.3e-22 PFAM
Pfam:Pkinase_Tyr 79 228 1e-9 PFAM
coiled coil region 263 314 N/A INTRINSIC
coiled coil region 339 373 N/A INTRINSIC
low complexity region 393 406 N/A INTRINSIC
Pfam:Pkinase 506 680 1.9e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000196929
SMART Domains Protein: ENSMUSP00000143216
Gene: ENSMUSG00000062604

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 1 131 2.6e-8 PFAM
Pfam:Pkinase 2 130 2.3e-18 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency 97% (66/68)
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted allele exhibit normal phenotype. [provided by MGI curators]
Allele List at MGI

All alleles(39) : Targeted(3) Gene trapped(36)

Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk1 T A 3: 127,477,239 (GRCm39) H273L probably damaging Het
Alpk3 A G 7: 80,726,648 (GRCm39) Y111C probably damaging Het
Anapc2 T G 2: 25,163,288 (GRCm39) V175G probably benign Het
Arhgap30 T C 1: 171,235,335 (GRCm39) S570P probably damaging Het
AU040320 T C 4: 126,686,069 (GRCm39) L215P probably benign Het
Ccdc59 A T 10: 105,677,388 (GRCm39) K9M possibly damaging Het
Ccdc65 A G 15: 98,618,914 (GRCm39) N298D probably benign Het
Cfap70 T A 14: 20,458,630 (GRCm39) N727Y probably benign Het
Clcn7 A G 17: 25,364,583 (GRCm39) H63R probably benign Het
Corin A T 5: 72,661,422 (GRCm39) C24S probably benign Het
Cyp1a2 A G 9: 57,584,798 (GRCm39) W419R probably damaging Het
Dlgap4 C A 2: 156,604,732 (GRCm39) A256D probably damaging Het
Eif4enif1 A G 11: 3,192,367 (GRCm39) probably null Het
Eri2 A G 7: 119,385,766 (GRCm39) V245A possibly damaging Het
Erich6b T C 14: 75,896,332 (GRCm39) F73L probably benign Het
Fam110a A G 2: 151,812,429 (GRCm39) C114R probably damaging Het
Fam149a T C 8: 45,806,991 (GRCm39) D288G probably damaging Het
Fam171a1 T A 2: 3,226,656 (GRCm39) Y596* probably null Het
Fsd1 A G 17: 56,298,223 (GRCm39) T183A possibly damaging Het
Fut10 T A 8: 31,726,159 (GRCm39) Y305N probably damaging Het
Ganab A T 19: 8,879,624 (GRCm39) probably benign Het
Gm9922 G T 14: 101,967,012 (GRCm39) probably benign Het
Gp9 A G 6: 87,756,035 (GRCm39) T17A probably benign Het
Gxylt2 T C 6: 100,775,115 (GRCm39) Y345H probably damaging Het
Herc2 A G 7: 55,835,699 (GRCm39) H3269R probably benign Het
Hpx A T 7: 105,241,290 (GRCm39) S374T probably benign Het
Hspa5 T C 2: 34,664,674 (GRCm39) V376A probably damaging Het
Hyi T C 4: 118,219,381 (GRCm39) probably benign Het
Impdh2 G A 9: 108,442,593 (GRCm39) probably null Het
Kremen2 A C 17: 23,961,770 (GRCm39) W246G probably damaging Het
Krt87 A G 15: 101,385,818 (GRCm39) V259A probably damaging Het
L3mbtl4 A T 17: 68,894,188 (GRCm39) H398L probably damaging Het
Lama5 C A 2: 179,838,035 (GRCm39) V894L probably benign Het
Maml2 A G 9: 13,532,912 (GRCm39) probably benign Het
Nup153 A T 13: 46,855,076 (GRCm39) probably benign Het
Or10g6 T G 9: 39,934,550 (GRCm39) I287S probably damaging Het
Or2y15 G T 11: 49,350,967 (GRCm39) V154L probably benign Het
Or5k14 A G 16: 58,692,982 (GRCm39) F177S probably damaging Het
Or8b3b T C 9: 38,584,240 (GRCm39) I180V probably benign Het
Or9r7 G A 10: 129,962,372 (GRCm39) P185S probably benign Het
Otof C T 5: 30,543,718 (GRCm39) R582H probably damaging Het
Otud4 T C 8: 80,395,093 (GRCm39) S543P probably damaging Het
Pde6a A G 18: 61,387,453 (GRCm39) D448G probably damaging Het
Phgdh A G 3: 98,222,427 (GRCm39) V388A probably benign Het
Plin3 G T 17: 56,586,891 (GRCm39) D385E possibly damaging Het
Polg G T 7: 79,105,341 (GRCm39) D734E probably damaging Het
Pomt1 T C 2: 32,140,912 (GRCm39) Y515H probably damaging Het
Prr35 A C 17: 26,167,461 (GRCm39) H25Q probably damaging Het
Pwwp2a G A 11: 43,573,313 (GRCm39) A132T probably benign Het
Rbm6 A T 9: 107,729,390 (GRCm39) F419L possibly damaging Het
Rfx5 A G 3: 94,864,027 (GRCm39) probably null Het
Rnf135 G A 11: 80,080,066 (GRCm39) S119N probably benign Het
Scfd1 T A 12: 51,433,862 (GRCm39) D51E probably benign Het
Smox A T 2: 131,353,944 (GRCm39) E5D possibly damaging Het
Syne2 T A 12: 76,147,763 (GRCm39) probably benign Het
Tcf20 A G 15: 82,738,893 (GRCm39) S853P possibly damaging Het
Tmem131l A G 3: 83,833,452 (GRCm39) F804L probably damaging Het
Ttll8 A G 15: 88,798,800 (GRCm39) L645P probably damaging Het
Ubr3 T A 2: 69,727,743 (GRCm39) H35Q probably benign Het
Uck1 GCCAACACC GCC 2: 32,146,088 (GRCm39) probably benign Het
Vmn2r70 A T 7: 85,214,290 (GRCm39) H287Q probably benign Het
Vps26a A T 10: 62,304,171 (GRCm39) I150N probably damaging Het
Zfp605 G A 5: 110,275,323 (GRCm39) R147H probably benign Het
Zfyve16 A G 13: 92,631,596 (GRCm39) M1333T probably damaging Het
Other mutations in Srpk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00697:Srpk2 APN 5 23,745,377 (GRCm39) missense probably benign 0.10
IGL02057:Srpk2 APN 5 23,723,705 (GRCm39) missense probably damaging 0.99
IGL02217:Srpk2 APN 5 23,750,568 (GRCm39) missense probably damaging 1.00
IGL03115:Srpk2 APN 5 23,729,616 (GRCm39) splice site probably null
FR4737:Srpk2 UTSW 5 23,750,194 (GRCm39) splice site probably null
P0008:Srpk2 UTSW 5 23,718,976 (GRCm39) missense probably damaging 1.00
R0142:Srpk2 UTSW 5 23,732,928 (GRCm39) missense probably damaging 0.97
R0462:Srpk2 UTSW 5 23,723,424 (GRCm39) missense probably damaging 1.00
R0992:Srpk2 UTSW 5 23,750,541 (GRCm39) missense probably damaging 0.99
R1569:Srpk2 UTSW 5 23,719,024 (GRCm39) missense probably damaging 1.00
R1677:Srpk2 UTSW 5 23,730,748 (GRCm39) splice site probably null
R1696:Srpk2 UTSW 5 23,753,492 (GRCm39) nonsense probably null
R1752:Srpk2 UTSW 5 23,733,017 (GRCm39) missense probably damaging 1.00
R1862:Srpk2 UTSW 5 23,729,148 (GRCm39) missense probably benign 0.32
R1989:Srpk2 UTSW 5 23,723,421 (GRCm39) missense probably damaging 1.00
R4096:Srpk2 UTSW 5 23,745,500 (GRCm39) intron probably benign
R4271:Srpk2 UTSW 5 23,753,513 (GRCm39) missense possibly damaging 0.95
R4894:Srpk2 UTSW 5 23,750,527 (GRCm39) missense probably damaging 1.00
R5043:Srpk2 UTSW 5 23,729,515 (GRCm39) missense probably benign
R5044:Srpk2 UTSW 5 23,729,390 (GRCm39) missense possibly damaging 0.91
R5309:Srpk2 UTSW 5 23,730,716 (GRCm39) missense probably damaging 0.97
R5478:Srpk2 UTSW 5 23,729,181 (GRCm39) missense possibly damaging 0.71
R5568:Srpk2 UTSW 5 23,730,697 (GRCm39) missense possibly damaging 0.73
R5665:Srpk2 UTSW 5 23,723,475 (GRCm39) missense probably damaging 0.99
R5678:Srpk2 UTSW 5 23,729,604 (GRCm39) frame shift probably null
R6364:Srpk2 UTSW 5 23,745,465 (GRCm39) missense probably damaging 1.00
R7201:Srpk2 UTSW 5 23,712,626 (GRCm39) missense possibly damaging 0.64
R7597:Srpk2 UTSW 5 23,753,517 (GRCm39) missense possibly damaging 0.96
R8251:Srpk2 UTSW 5 23,729,266 (GRCm39) missense probably benign
R8477:Srpk2 UTSW 5 23,718,986 (GRCm39) missense probably benign 0.03
R9348:Srpk2 UTSW 5 23,719,671 (GRCm39) missense probably damaging 0.98
R9606:Srpk2 UTSW 5 23,729,604 (GRCm39) missense probably benign
R9745:Srpk2 UTSW 5 23,880,874 (GRCm39) intron probably benign
RF035:Srpk2 UTSW 5 23,730,573 (GRCm39) utr 3 prime probably benign
RF042:Srpk2 UTSW 5 23,730,573 (GRCm39) utr 3 prime probably benign
Predicted Primers PCR Primer
(F):5'- GCCGTTCTTACCATGCAAGC -3'
(R):5'- AATCATTCTACCTGGCAAGCATTG -3'

Sequencing Primer
(F):5'- ACTCCAAATGTCTGCAGGTG -3'
(R):5'- GTGCTCACACATGCAAACCTC -3'
Posted On 2014-10-02