Incidental Mutation 'R2173:Vmn2r70'
ID 237619
Institutional Source Beutler Lab
Gene Symbol Vmn2r70
Ensembl Gene ENSMUSG00000090806
Gene Name vomeronasal 2, receptor 70
Synonyms EG620835
MMRRC Submission 040175-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.130) question?
Stock # R2173 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 85207911-85218296 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 85214290 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 287 (H287Q)
Ref Sequence ENSEMBL: ENSMUSP00000129703 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168230]
AlphaFold K7N702
Predicted Effect probably benign
Transcript: ENSMUST00000168230
AA Change: H287Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000129703
Gene: ENSMUSG00000090806
AA Change: H287Q

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:ANF_receptor 77 468 2.5e-28 PFAM
Pfam:NCD3G 510 562 1.5e-19 PFAM
Pfam:7tm_3 592 830 1.2e-52 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency 97% (66/68)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk1 T A 3: 127,477,239 (GRCm39) H273L probably damaging Het
Alpk3 A G 7: 80,726,648 (GRCm39) Y111C probably damaging Het
Anapc2 T G 2: 25,163,288 (GRCm39) V175G probably benign Het
Arhgap30 T C 1: 171,235,335 (GRCm39) S570P probably damaging Het
AU040320 T C 4: 126,686,069 (GRCm39) L215P probably benign Het
Ccdc59 A T 10: 105,677,388 (GRCm39) K9M possibly damaging Het
Ccdc65 A G 15: 98,618,914 (GRCm39) N298D probably benign Het
Cfap70 T A 14: 20,458,630 (GRCm39) N727Y probably benign Het
Clcn7 A G 17: 25,364,583 (GRCm39) H63R probably benign Het
Corin A T 5: 72,661,422 (GRCm39) C24S probably benign Het
Cyp1a2 A G 9: 57,584,798 (GRCm39) W419R probably damaging Het
Dlgap4 C A 2: 156,604,732 (GRCm39) A256D probably damaging Het
Eif4enif1 A G 11: 3,192,367 (GRCm39) probably null Het
Eri2 A G 7: 119,385,766 (GRCm39) V245A possibly damaging Het
Erich6b T C 14: 75,896,332 (GRCm39) F73L probably benign Het
Fam110a A G 2: 151,812,429 (GRCm39) C114R probably damaging Het
Fam149a T C 8: 45,806,991 (GRCm39) D288G probably damaging Het
Fam171a1 T A 2: 3,226,656 (GRCm39) Y596* probably null Het
Fsd1 A G 17: 56,298,223 (GRCm39) T183A possibly damaging Het
Fut10 T A 8: 31,726,159 (GRCm39) Y305N probably damaging Het
Ganab A T 19: 8,879,624 (GRCm39) probably benign Het
Gm9922 G T 14: 101,967,012 (GRCm39) probably benign Het
Gp9 A G 6: 87,756,035 (GRCm39) T17A probably benign Het
Gxylt2 T C 6: 100,775,115 (GRCm39) Y345H probably damaging Het
Herc2 A G 7: 55,835,699 (GRCm39) H3269R probably benign Het
Hpx A T 7: 105,241,290 (GRCm39) S374T probably benign Het
Hspa5 T C 2: 34,664,674 (GRCm39) V376A probably damaging Het
Hyi T C 4: 118,219,381 (GRCm39) probably benign Het
Impdh2 G A 9: 108,442,593 (GRCm39) probably null Het
Kremen2 A C 17: 23,961,770 (GRCm39) W246G probably damaging Het
Krt87 A G 15: 101,385,818 (GRCm39) V259A probably damaging Het
L3mbtl4 A T 17: 68,894,188 (GRCm39) H398L probably damaging Het
Lama5 C A 2: 179,838,035 (GRCm39) V894L probably benign Het
Maml2 A G 9: 13,532,912 (GRCm39) probably benign Het
Nup153 A T 13: 46,855,076 (GRCm39) probably benign Het
Or10g6 T G 9: 39,934,550 (GRCm39) I287S probably damaging Het
Or2y15 G T 11: 49,350,967 (GRCm39) V154L probably benign Het
Or5k14 A G 16: 58,692,982 (GRCm39) F177S probably damaging Het
Or8b3b T C 9: 38,584,240 (GRCm39) I180V probably benign Het
Or9r7 G A 10: 129,962,372 (GRCm39) P185S probably benign Het
Otof C T 5: 30,543,718 (GRCm39) R582H probably damaging Het
Otud4 T C 8: 80,395,093 (GRCm39) S543P probably damaging Het
Pde6a A G 18: 61,387,453 (GRCm39) D448G probably damaging Het
Phgdh A G 3: 98,222,427 (GRCm39) V388A probably benign Het
Plin3 G T 17: 56,586,891 (GRCm39) D385E possibly damaging Het
Polg G T 7: 79,105,341 (GRCm39) D734E probably damaging Het
Pomt1 T C 2: 32,140,912 (GRCm39) Y515H probably damaging Het
Prr35 A C 17: 26,167,461 (GRCm39) H25Q probably damaging Het
Pwwp2a G A 11: 43,573,313 (GRCm39) A132T probably benign Het
Rbm6 A T 9: 107,729,390 (GRCm39) F419L possibly damaging Het
Rfx5 A G 3: 94,864,027 (GRCm39) probably null Het
Rnf135 G A 11: 80,080,066 (GRCm39) S119N probably benign Het
Scfd1 T A 12: 51,433,862 (GRCm39) D51E probably benign Het
Smox A T 2: 131,353,944 (GRCm39) E5D possibly damaging Het
Srpk2 T C 5: 23,723,613 (GRCm39) probably null Het
Syne2 T A 12: 76,147,763 (GRCm39) probably benign Het
Tcf20 A G 15: 82,738,893 (GRCm39) S853P possibly damaging Het
Tmem131l A G 3: 83,833,452 (GRCm39) F804L probably damaging Het
Ttll8 A G 15: 88,798,800 (GRCm39) L645P probably damaging Het
Ubr3 T A 2: 69,727,743 (GRCm39) H35Q probably benign Het
Uck1 GCCAACACC GCC 2: 32,146,088 (GRCm39) probably benign Het
Vps26a A T 10: 62,304,171 (GRCm39) I150N probably damaging Het
Zfp605 G A 5: 110,275,323 (GRCm39) R147H probably benign Het
Zfyve16 A G 13: 92,631,596 (GRCm39) M1333T probably damaging Het
Other mutations in Vmn2r70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00978:Vmn2r70 APN 7 85,213,007 (GRCm39) missense probably benign 0.00
IGL01140:Vmn2r70 APN 7 85,214,379 (GRCm39) nonsense probably null
IGL01287:Vmn2r70 APN 7 85,218,227 (GRCm39) nonsense probably null
IGL01581:Vmn2r70 APN 7 85,213,122 (GRCm39) splice site probably null
IGL01632:Vmn2r70 APN 7 85,215,280 (GRCm39) missense probably benign 0.00
IGL01725:Vmn2r70 APN 7 85,208,594 (GRCm39) missense probably damaging 1.00
IGL02244:Vmn2r70 APN 7 85,214,211 (GRCm39) missense probably benign
IGL02288:Vmn2r70 APN 7 85,214,342 (GRCm39) missense probably benign 0.31
IGL02313:Vmn2r70 APN 7 85,214,376 (GRCm39) missense probably damaging 0.99
IGL02591:Vmn2r70 APN 7 85,214,153 (GRCm39) missense probably damaging 0.96
IGL02725:Vmn2r70 APN 7 85,214,553 (GRCm39) missense possibly damaging 0.46
IGL02797:Vmn2r70 APN 7 85,208,295 (GRCm39) missense probably benign 0.00
R0045:Vmn2r70 UTSW 7 85,215,252 (GRCm39) missense probably damaging 1.00
R0729:Vmn2r70 UTSW 7 85,215,112 (GRCm39) missense probably benign 0.00
R0967:Vmn2r70 UTSW 7 85,208,827 (GRCm39) missense probably damaging 0.99
R1217:Vmn2r70 UTSW 7 85,208,269 (GRCm39) missense probably damaging 1.00
R1351:Vmn2r70 UTSW 7 85,214,262 (GRCm39) missense probably damaging 1.00
R1387:Vmn2r70 UTSW 7 85,207,969 (GRCm39) missense probably benign 0.12
R1483:Vmn2r70 UTSW 7 85,208,375 (GRCm39) missense probably benign 0.04
R1796:Vmn2r70 UTSW 7 85,213,011 (GRCm39) nonsense probably null
R1809:Vmn2r70 UTSW 7 85,215,130 (GRCm39) missense probably benign 0.23
R2154:Vmn2r70 UTSW 7 85,212,923 (GRCm39) missense possibly damaging 0.67
R2334:Vmn2r70 UTSW 7 85,208,800 (GRCm39) missense probably benign 0.05
R2871:Vmn2r70 UTSW 7 85,208,227 (GRCm39) missense probably damaging 1.00
R2871:Vmn2r70 UTSW 7 85,208,227 (GRCm39) missense probably damaging 1.00
R3975:Vmn2r70 UTSW 7 85,208,540 (GRCm39) missense probably benign 0.00
R4525:Vmn2r70 UTSW 7 85,208,787 (GRCm39) missense probably damaging 1.00
R4527:Vmn2r70 UTSW 7 85,208,787 (GRCm39) missense probably damaging 1.00
R4535:Vmn2r70 UTSW 7 85,214,541 (GRCm39) missense probably damaging 1.00
R5181:Vmn2r70 UTSW 7 85,208,387 (GRCm39) missense probably damaging 0.99
R5600:Vmn2r70 UTSW 7 85,212,935 (GRCm39) missense probably benign 0.07
R5641:Vmn2r70 UTSW 7 85,208,572 (GRCm39) missense probably damaging 0.99
R5726:Vmn2r70 UTSW 7 85,208,315 (GRCm39) missense probably damaging 1.00
R5943:Vmn2r70 UTSW 7 85,215,199 (GRCm39) missense probably benign 0.09
R6166:Vmn2r70 UTSW 7 85,215,189 (GRCm39) missense probably benign 0.25
R6272:Vmn2r70 UTSW 7 85,208,194 (GRCm39) missense probably damaging 1.00
R6324:Vmn2r70 UTSW 7 85,208,087 (GRCm39) missense probably benign 0.01
R6429:Vmn2r70 UTSW 7 85,208,276 (GRCm39) missense probably damaging 1.00
R6449:Vmn2r70 UTSW 7 85,214,157 (GRCm39) missense probably damaging 1.00
R6512:Vmn2r70 UTSW 7 85,215,305 (GRCm39) missense probably benign
R7000:Vmn2r70 UTSW 7 85,208,819 (GRCm39) missense probably damaging 0.99
R7141:Vmn2r70 UTSW 7 85,208,044 (GRCm39) missense probably benign
R7153:Vmn2r70 UTSW 7 85,214,262 (GRCm39) missense probably damaging 1.00
R7424:Vmn2r70 UTSW 7 85,213,076 (GRCm39) missense probably damaging 1.00
R7565:Vmn2r70 UTSW 7 85,214,499 (GRCm39) missense probably benign 0.35
R7567:Vmn2r70 UTSW 7 85,214,243 (GRCm39) missense probably benign 0.41
R7593:Vmn2r70 UTSW 7 85,215,312 (GRCm39) nonsense probably null
R7660:Vmn2r70 UTSW 7 85,218,130 (GRCm39) missense probably damaging 0.99
R7806:Vmn2r70 UTSW 7 85,208,401 (GRCm39) missense probably benign
R7892:Vmn2r70 UTSW 7 85,208,588 (GRCm39) missense possibly damaging 0.58
R7965:Vmn2r70 UTSW 7 85,211,071 (GRCm39) missense probably damaging 0.96
R8052:Vmn2r70 UTSW 7 85,212,923 (GRCm39) missense probably benign
R8251:Vmn2r70 UTSW 7 85,215,186 (GRCm39) nonsense probably null
R8814:Vmn2r70 UTSW 7 85,215,169 (GRCm39) missense probably benign 0.00
R8934:Vmn2r70 UTSW 7 85,211,188 (GRCm39) missense possibly damaging 0.87
R9225:Vmn2r70 UTSW 7 85,208,242 (GRCm39) missense probably damaging 1.00
R9322:Vmn2r70 UTSW 7 85,208,498 (GRCm39) missense possibly damaging 0.92
R9430:Vmn2r70 UTSW 7 85,215,240 (GRCm39) missense probably benign 0.10
R9477:Vmn2r70 UTSW 7 85,218,244 (GRCm39) missense possibly damaging 0.50
Z1088:Vmn2r70 UTSW 7 85,213,968 (GRCm39) missense possibly damaging 0.53
Z1176:Vmn2r70 UTSW 7 85,218,253 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCTTACAATCAGAAGGTGGCAAAG -3'
(R):5'- CCTTTCTGAATTGAGAGGAGAAATG -3'

Sequencing Primer
(F):5'- TGGCAAAGGAAAATTCACTACTG -3'
(R):5'- GAGAAATGCAAAACAACATTGTCTG -3'
Posted On 2014-10-02