Incidental Mutation 'R2173:Or8b3b'
ID 237626
Institutional Source Beutler Lab
Gene Symbol Or8b3b
Ensembl Gene ENSMUSG00000046150
Gene Name olfactory receptor family 8 subfamily B member 3B
Synonyms GA_x6K02T2PVTD-32375756-32374818, MOR164-3, Olfr918
MMRRC Submission 040175-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.259) question?
Stock # R2173 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 38583800-38584777 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38584240 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 180 (I180V)
Ref Sequence ENSEMBL: ENSMUSP00000057210 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055099] [ENSMUST00000215461]
AlphaFold E9PVZ7
Predicted Effect probably benign
Transcript: ENSMUST00000055099
AA Change: I180V

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000057210
Gene: ENSMUSG00000046150
AA Change: I180V

DomainStartEndE-ValueType
transmembrane domain 9 31 N/A INTRINSIC
Pfam:7tm_4 44 319 6.5e-48 PFAM
Pfam:7tm_1 54 301 3.9e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213750
Predicted Effect probably benign
Transcript: ENSMUST00000215461
AA Change: I167V

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216579
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency 97% (66/68)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk1 T A 3: 127,477,239 (GRCm39) H273L probably damaging Het
Alpk3 A G 7: 80,726,648 (GRCm39) Y111C probably damaging Het
Anapc2 T G 2: 25,163,288 (GRCm39) V175G probably benign Het
Arhgap30 T C 1: 171,235,335 (GRCm39) S570P probably damaging Het
AU040320 T C 4: 126,686,069 (GRCm39) L215P probably benign Het
Ccdc59 A T 10: 105,677,388 (GRCm39) K9M possibly damaging Het
Ccdc65 A G 15: 98,618,914 (GRCm39) N298D probably benign Het
Cfap70 T A 14: 20,458,630 (GRCm39) N727Y probably benign Het
Clcn7 A G 17: 25,364,583 (GRCm39) H63R probably benign Het
Corin A T 5: 72,661,422 (GRCm39) C24S probably benign Het
Cyp1a2 A G 9: 57,584,798 (GRCm39) W419R probably damaging Het
Dlgap4 C A 2: 156,604,732 (GRCm39) A256D probably damaging Het
Eif4enif1 A G 11: 3,192,367 (GRCm39) probably null Het
Eri2 A G 7: 119,385,766 (GRCm39) V245A possibly damaging Het
Erich6b T C 14: 75,896,332 (GRCm39) F73L probably benign Het
Fam110a A G 2: 151,812,429 (GRCm39) C114R probably damaging Het
Fam149a T C 8: 45,806,991 (GRCm39) D288G probably damaging Het
Fam171a1 T A 2: 3,226,656 (GRCm39) Y596* probably null Het
Fsd1 A G 17: 56,298,223 (GRCm39) T183A possibly damaging Het
Fut10 T A 8: 31,726,159 (GRCm39) Y305N probably damaging Het
Ganab A T 19: 8,879,624 (GRCm39) probably benign Het
Gm9922 G T 14: 101,967,012 (GRCm39) probably benign Het
Gp9 A G 6: 87,756,035 (GRCm39) T17A probably benign Het
Gxylt2 T C 6: 100,775,115 (GRCm39) Y345H probably damaging Het
Herc2 A G 7: 55,835,699 (GRCm39) H3269R probably benign Het
Hpx A T 7: 105,241,290 (GRCm39) S374T probably benign Het
Hspa5 T C 2: 34,664,674 (GRCm39) V376A probably damaging Het
Hyi T C 4: 118,219,381 (GRCm39) probably benign Het
Impdh2 G A 9: 108,442,593 (GRCm39) probably null Het
Kremen2 A C 17: 23,961,770 (GRCm39) W246G probably damaging Het
Krt87 A G 15: 101,385,818 (GRCm39) V259A probably damaging Het
L3mbtl4 A T 17: 68,894,188 (GRCm39) H398L probably damaging Het
Lama5 C A 2: 179,838,035 (GRCm39) V894L probably benign Het
Maml2 A G 9: 13,532,912 (GRCm39) probably benign Het
Nup153 A T 13: 46,855,076 (GRCm39) probably benign Het
Or10g6 T G 9: 39,934,550 (GRCm39) I287S probably damaging Het
Or2y15 G T 11: 49,350,967 (GRCm39) V154L probably benign Het
Or5k14 A G 16: 58,692,982 (GRCm39) F177S probably damaging Het
Or9r7 G A 10: 129,962,372 (GRCm39) P185S probably benign Het
Otof C T 5: 30,543,718 (GRCm39) R582H probably damaging Het
Otud4 T C 8: 80,395,093 (GRCm39) S543P probably damaging Het
Pde6a A G 18: 61,387,453 (GRCm39) D448G probably damaging Het
Phgdh A G 3: 98,222,427 (GRCm39) V388A probably benign Het
Plin3 G T 17: 56,586,891 (GRCm39) D385E possibly damaging Het
Polg G T 7: 79,105,341 (GRCm39) D734E probably damaging Het
Pomt1 T C 2: 32,140,912 (GRCm39) Y515H probably damaging Het
Prr35 A C 17: 26,167,461 (GRCm39) H25Q probably damaging Het
Pwwp2a G A 11: 43,573,313 (GRCm39) A132T probably benign Het
Rbm6 A T 9: 107,729,390 (GRCm39) F419L possibly damaging Het
Rfx5 A G 3: 94,864,027 (GRCm39) probably null Het
Rnf135 G A 11: 80,080,066 (GRCm39) S119N probably benign Het
Scfd1 T A 12: 51,433,862 (GRCm39) D51E probably benign Het
Smox A T 2: 131,353,944 (GRCm39) E5D possibly damaging Het
Srpk2 T C 5: 23,723,613 (GRCm39) probably null Het
Syne2 T A 12: 76,147,763 (GRCm39) probably benign Het
Tcf20 A G 15: 82,738,893 (GRCm39) S853P possibly damaging Het
Tmem131l A G 3: 83,833,452 (GRCm39) F804L probably damaging Het
Ttll8 A G 15: 88,798,800 (GRCm39) L645P probably damaging Het
Ubr3 T A 2: 69,727,743 (GRCm39) H35Q probably benign Het
Uck1 GCCAACACC GCC 2: 32,146,088 (GRCm39) probably benign Het
Vmn2r70 A T 7: 85,214,290 (GRCm39) H287Q probably benign Het
Vps26a A T 10: 62,304,171 (GRCm39) I150N probably damaging Het
Zfp605 G A 5: 110,275,323 (GRCm39) R147H probably benign Het
Zfyve16 A G 13: 92,631,596 (GRCm39) M1333T probably damaging Het
Other mutations in Or8b3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Or8b3b APN 9 38,584,320 (GRCm39) missense probably benign 0.01
IGL01388:Or8b3b APN 9 38,584,379 (GRCm39) nonsense probably null
IGL01516:Or8b3b APN 9 38,584,159 (GRCm39) missense probably benign 0.09
IGL02121:Or8b3b APN 9 38,584,711 (GRCm39) missense probably damaging 0.98
IGL02209:Or8b3b APN 9 38,584,342 (GRCm39) missense possibly damaging 0.84
IGL02256:Or8b3b APN 9 38,584,776 (GRCm39) start codon destroyed probably null
IGL02517:Or8b3b APN 9 38,584,209 (GRCm39) missense probably damaging 1.00
IGL02648:Or8b3b APN 9 38,584,312 (GRCm39) missense probably benign
IGL02747:Or8b3b APN 9 38,584,380 (GRCm39) missense probably benign 0.11
IGL02971:Or8b3b APN 9 38,584,564 (GRCm39) missense probably damaging 0.96
E0370:Or8b3b UTSW 9 38,583,857 (GRCm39) missense probably damaging 0.99
R0616:Or8b3b UTSW 9 38,584,776 (GRCm39) start codon destroyed probably null
R2989:Or8b3b UTSW 9 38,583,831 (GRCm39) missense probably benign
R3430:Or8b3b UTSW 9 38,584,435 (GRCm39) missense probably damaging 1.00
R3809:Or8b3b UTSW 9 38,584,159 (GRCm39) missense probably benign 0.09
R4688:Or8b3b UTSW 9 38,584,659 (GRCm39) missense probably damaging 1.00
R4702:Or8b3b UTSW 9 38,584,776 (GRCm39) start codon destroyed probably null
R5548:Or8b3b UTSW 9 38,584,600 (GRCm39) missense probably benign 0.00
R5590:Or8b3b UTSW 9 38,584,261 (GRCm39) missense probably damaging 1.00
R6082:Or8b3b UTSW 9 38,583,866 (GRCm39) missense probably damaging 1.00
R6214:Or8b3b UTSW 9 38,584,510 (GRCm39) missense probably benign 0.13
R6215:Or8b3b UTSW 9 38,584,510 (GRCm39) missense probably benign 0.13
R6893:Or8b3b UTSW 9 38,584,355 (GRCm39) missense possibly damaging 0.95
R7215:Or8b3b UTSW 9 38,584,743 (GRCm39) missense probably benign 0.05
R7624:Or8b3b UTSW 9 38,583,919 (GRCm39) missense probably benign 0.18
R7862:Or8b3b UTSW 9 38,584,624 (GRCm39) missense probably benign 0.01
R8116:Or8b3b UTSW 9 38,584,464 (GRCm39) missense possibly damaging 0.93
R8897:Or8b3b UTSW 9 38,584,147 (GRCm39) missense probably damaging 1.00
R8899:Or8b3b UTSW 9 38,584,147 (GRCm39) missense probably damaging 1.00
R9114:Or8b3b UTSW 9 38,583,892 (GRCm39) missense probably benign
R9293:Or8b3b UTSW 9 38,584,414 (GRCm39) missense probably damaging 1.00
R9311:Or8b3b UTSW 9 38,583,925 (GRCm39) missense probably damaging 1.00
R9690:Or8b3b UTSW 9 38,584,477 (GRCm39) nonsense probably null
R9734:Or8b3b UTSW 9 38,584,239 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AATGTGAGAGCTGCAGGTGC -3'
(R):5'- TCTGAATGCTACATGTTGACCTC -3'

Sequencing Primer
(F):5'- GCTGAAGGCTTTTGATCTTCC -3'
(R):5'- CAATGGCCTATGATCGCTATGTAGC -3'
Posted On 2014-10-02