Mutagenetix > Incidental Mutations

Incidental Mutation 'R2185:Tas2r107'

237818

Institutional Source

Beutler Lab

Gene Symbol

Tas2r107

Ensembl Gene

ENSMUSG00000053389

Gene Name

taste receptor, type 2, member 107

Synonyms

T2R4, Tas2r7, mGR06, STC 5-1, mt2r43, T2R07

MMRRC Submission

040187-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R2185 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

131659118-131660149 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 131659603 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 161 (N161S)

Ref Sequence

ENSEMBL: ENSMUSP00000067082 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065781]

AlphaFold

Q7M725

Predicted Effect

probably damaging
Transcript: ENSMUST00000065781
AA Change: N161S

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000067082
Gene: ENSMUSG00000053389
AA Change: N161S

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	297	4e-106	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.6%
20x: 96.0%

Validation Efficiency

100% (48/48)

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700123K08Rik	T	C	5: 138,563,567	D119G	probably damaging	Het
Abca1	A	G	4: 53,089,830	M427T	probably benign	Het
Ankra2	T	C	13: 98,266,404	F53S	probably damaging	Het
Ano3	T	C	2: 110,775,045	E272G	probably benign	Het
Aqr	C	T	2: 114,130,534		probably null	Het
Clca4b	T	C	3: 144,928,556	Y92C	probably damaging	Het
Crebbp	A	T	16: 4,084,138	N2374K	probably damaging	Het
Cspg4	A	T	9: 56,886,972	I664L	probably benign	Het
Ctnnd1	A	T	2: 84,612,548	D626E	probably damaging	Het
Eml2	A	G	7: 19,194,028	Y254C	probably damaging	Het
Fam92a	A	T	4: 12,169,041		probably benign	Het
Gabrr3	T	C	16: 59,434,668	S239P	probably damaging	Het
Gen1	T	C	12: 11,261,040	T64A	probably null	Het
Gm14399	C	A	2: 175,131,395	C189F	probably damaging	Het
Gm8251	G	A	1: 44,061,381	H186Y	probably benign	Het
Gm9476	T	G	10: 100,307,178		noncoding transcript	Het
Kcnh5	A	T	12: 75,130,931	F134I	possibly damaging	Het
Kdm4b	G	C	17: 56,393,750	A474P	probably benign	Het
Kif2b	TTCTCTCTCT	TTCTCTCT	11: 91,576,971		probably null	Het
Klk14	G	A	7: 43,692,077	C51Y	probably damaging	Het
Lrrc28	C	T	7: 67,545,453	R203Q	possibly damaging	Het
Lrrc8e	G	T	8: 4,234,986	E404*	probably null	Het
Macf1	A	T	4: 123,475,556	M239K	probably damaging	Het
Mamdc4	A	G	2: 25,569,692		probably null	Het
Matr3	A	G	18: 35,581,225	Y75C	probably damaging	Het
Myo19	T	C	11: 84,892,221	V187A	probably benign	Het
Ncbp2	A	G	16: 31,956,377	D116G	probably damaging	Het
Olfr1012	T	C	2: 85,760,019	Y119C	probably damaging	Het
Olfr1208	A	C	2: 88,896,703	V298G	probably damaging	Het
Olfr412	A	T	11: 74,364,746	I26F	probably benign	Het
Olfr679	T	A	7: 105,086,302	D195E	possibly damaging	Het
Pkd1l3	T	A	8: 109,633,195	M894K	possibly damaging	Het
Prpf8	C	T	11: 75,487,113	R8*	probably null	Het
Prss12	T	A	3: 123,487,144	S493T	probably benign	Het
Ptov1	T	G	7: 44,867,283		probably benign	Het
Rfpl4	A	T	7: 5,115,500	L24M	probably damaging	Het
Rundc1	C	A	11: 101,425,331	D76E	probably benign	Het
Slc5a11	G	T	7: 123,273,198	A673S	probably damaging	Het
Smg5	T	C	3: 88,351,561	M613T	probably benign	Het
Swt1	T	A	1: 151,384,468	H677L	probably damaging	Het
Trp73	A	T	4: 154,104,817		probably null	Het
Tsr1	A	G	11: 74,902,080	I405V	probably damaging	Het
Ttll4	A	G	1: 74,679,829	T280A	possibly damaging	Het
Ube2q2	A	G	9: 55,195,082		probably null	Het
Usp5	T	C	6: 124,817,410	E769G	probably damaging	Het
Vmn2r68	T	A	7: 85,233,693	K284*	probably null	Het
Wdr63	A	G	3: 146,066,864	S476P	possibly damaging	Het
Zfp963	C	A	8: 69,742,911	K297N	probably benign	Het
Zfp975	C	A	7: 42,661,681	A503S	possibly damaging	Het

Other mutations in Tas2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02749:Tas2r107	APN	6	131659954	missense	probably damaging	1.00
IGL02751:Tas2r107	APN	6	131659484	missense	probably damaging	1.00
IGL02868:Tas2r107	APN	6	131659286	missense	probably benign	0.11
IGL02943:Tas2r107	APN	6	131659406	missense	probably damaging	0.99
R1564:Tas2r107	UTSW	6	131659822	missense	probably damaging	0.96
R1905:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R1906:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R1907:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R3014:Tas2r107	UTSW	6	131660009	missense	probably benign	0.30
R3824:Tas2r107	UTSW	6	131659330	missense	probably benign	0.00
R4465:Tas2r107	UTSW	6	131660009	missense	probably benign	0.30
R5058:Tas2r107	UTSW	6	131659742	missense	probably damaging	1.00
R5646:Tas2r107	UTSW	6	131659708	missense	probably benign	0.02
R5975:Tas2r107	UTSW	6	131659780	missense	probably benign	0.02
R6008:Tas2r107	UTSW	6	131659912	missense	possibly damaging	0.82
R6144:Tas2r107	UTSW	6	131660003	missense	possibly damaging	0.87
R6451:Tas2r107	UTSW	6	131660014	missense	possibly damaging	0.81
R6662:Tas2r107	UTSW	6	131659489	missense	possibly damaging	0.82
R6702:Tas2r107	UTSW	6	131659384	missense	probably benign	0.12
R7032:Tas2r107	UTSW	6	131659190	missense	possibly damaging	0.62
R7635:Tas2r107	UTSW	6	131659600	missense	possibly damaging	0.92
R8303:Tas2r107	UTSW	6	131659622	missense	probably benign	0.00
R9156:Tas2r107	UTSW	6	131659459	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- TGGTCTCTGAATCCTGAAACATC -3'
(R):5'- CCACACATGCTTACCTCTGG -3'

Sequencing Primer
(F):5'- CTCTGAATCCTGAAACATCTGAATGC -3'
(R):5'- GCTTACCTCTGGAAACATAACTG -3'

Posted On

2014-10-02