Incidental Mutation 'R2187:Ppp2cb'
ID 237872
Institutional Source Beutler Lab
Gene Symbol Ppp2cb
Ensembl Gene ENSMUSG00000009630
Gene Name protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Synonyms PP2Ac, D8Ertd766e
MMRRC Submission 040189-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2187 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 34089653-34109469 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 34100705 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 42 (E42G)
Ref Sequence ENSEMBL: ENSMUSP00000009774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009774]
AlphaFold P62715
Predicted Effect possibly damaging
Transcript: ENSMUST00000009774
AA Change: E42G

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000009774
Gene: ENSMUSG00000009630
AA Change: E42G

DomainStartEndE-ValueType
PP2Ac 23 293 2.48e-156 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg1 T A 17: 31,324,491 (GRCm39) S245R probably damaging Het
AI597479 T A 1: 43,139,983 (GRCm39) W70R probably damaging Het
Ankrd55 A G 13: 112,520,039 (GRCm39) S575G probably benign Het
Bfsp2 T A 9: 103,303,976 (GRCm39) K343* probably null Het
Cant1 A T 11: 118,299,667 (GRCm39) Y227* probably null Het
Cd2bp2 T C 7: 126,793,963 (GRCm39) N109D probably benign Het
Chmp6 A G 11: 119,807,562 (GRCm39) E135G possibly damaging Het
Dsp T G 13: 38,360,383 (GRCm39) S329R probably damaging Het
Epha5 A T 5: 84,234,223 (GRCm39) F767L probably damaging Het
Epha7 A T 4: 28,942,648 (GRCm39) T566S possibly damaging Het
Erap1 A T 13: 74,810,524 (GRCm39) I288F probably damaging Het
Erich6 A G 3: 58,537,266 (GRCm39) probably null Het
Fbxo10 A G 4: 45,058,531 (GRCm39) V402A probably benign Het
Fndc1 T A 17: 7,960,604 (GRCm39) I1604F probably damaging Het
Foxd4 T G 19: 24,877,219 (GRCm39) Q327P probably damaging Het
Fxn T A 19: 24,257,853 (GRCm39) N26I probably benign Het
Hsf5 G T 11: 87,529,010 (GRCm39) G582C possibly damaging Het
Itga8 A G 2: 12,199,231 (GRCm39) V522A possibly damaging Het
Kplce A G 3: 92,775,922 (GRCm39) S254P probably damaging Het
Lyst C T 13: 13,883,926 (GRCm39) T2938I possibly damaging Het
Mib2 T C 4: 155,739,390 (GRCm39) E863G possibly damaging Het
Mrgpra9 A G 7: 46,884,797 (GRCm39) F290S probably damaging Het
Mst1 T C 9: 107,961,539 (GRCm39) Y599H possibly damaging Het
Mylk4 T C 13: 32,905,996 (GRCm39) I165V probably damaging Het
Nipsnap2 T C 5: 129,823,537 (GRCm39) probably null Het
Nol8 T C 13: 49,815,475 (GRCm39) Y528H probably benign Het
Nup93 T A 8: 95,027,478 (GRCm39) S295R probably damaging Het
Nutm2 A T 13: 50,621,453 (GRCm39) Q6L probably benign Het
Or2b6 A T 13: 21,823,555 (GRCm39) I46N probably damaging Het
Or5ak20 T G 2: 85,184,259 (GRCm39) S4R probably benign Het
Or5b12b T A 19: 12,861,619 (GRCm39) C125S probably damaging Het
Or6c33 A G 10: 129,853,557 (GRCm39) E109G probably damaging Het
Pip5k1a A T 3: 94,979,229 (GRCm39) L189Q probably damaging Het
Plekha4 C T 7: 45,198,698 (GRCm39) R574C probably damaging Het
Prkd3 T A 17: 79,282,983 (GRCm39) Q244L probably benign Het
Ptpn14 C T 1: 189,595,425 (GRCm39) R1023* probably null Het
Ptpra A G 2: 130,346,219 (GRCm39) T127A probably benign Het
Rad54l2 ACCTCCTCCTCCTCCTCCTCCTCCTC ACCTCCTCCTCCTCCTCCTCCTC 9: 106,631,191 (GRCm39) probably benign Het
Rasgrf1 T C 9: 89,876,888 (GRCm39) I751T possibly damaging Het
Rbm27 A G 18: 42,459,022 (GRCm39) K697R probably damaging Het
Rhoa C T 9: 108,212,352 (GRCm39) T127M probably benign Het
Rnpepl1 A G 1: 92,844,617 (GRCm39) S370G probably null Het
Sdk1 C T 5: 142,100,329 (GRCm39) T1453I probably damaging Het
Sel1l2 A G 2: 140,072,793 (GRCm39) L614S probably damaging Het
Slc6a20b T A 9: 123,427,653 (GRCm39) I419F probably damaging Het
Slc8a1 C T 17: 81,955,982 (GRCm39) S352N possibly damaging Het
Spta1 A G 1: 174,020,532 (GRCm39) D547G probably damaging Het
Tc2n G A 12: 101,672,803 (GRCm39) T46I probably damaging Het
Terb1 T A 8: 105,199,516 (GRCm39) Y476F probably benign Het
Trim12a T A 7: 103,953,399 (GRCm39) E237D probably damaging Het
Usp47 T C 7: 111,666,398 (GRCm39) L309P probably damaging Het
Other mutations in Ppp2cb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01566:Ppp2cb APN 8 34,101,791 (GRCm39) missense probably benign 0.38
IGL02985:Ppp2cb APN 8 34,105,474 (GRCm39) unclassified probably benign
IGL03251:Ppp2cb APN 8 34,100,679 (GRCm39) splice site probably benign
Breakthrough UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R0940:Ppp2cb UTSW 8 34,105,689 (GRCm39) splice site probably null
R1688:Ppp2cb UTSW 8 34,105,480 (GRCm39) missense probably benign 0.02
R2350:Ppp2cb UTSW 8 34,101,855 (GRCm39) missense probably null 1.00
R4418:Ppp2cb UTSW 8 34,107,077 (GRCm39) missense probably benign
R4566:Ppp2cb UTSW 8 34,100,723 (GRCm39) missense possibly damaging 0.67
R6187:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R6990:Ppp2cb UTSW 8 34,109,161 (GRCm39) missense probably benign 0.01
R7477:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably benign 0.01
R9018:Ppp2cb UTSW 8 34,105,787 (GRCm39) missense probably benign 0.17
R9301:Ppp2cb UTSW 8 34,090,038 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- CGGCCATGGATAGTTGGAAC -3'
(R):5'- GAAGAGTCACAGTCTCCACAGAG -3'

Sequencing Primer
(F):5'- ATAAGGGCTCCAAGTTCTCTG -3'
(R):5'- AGAGTAGTACCCTCTGTCTACATAG -3'
Posted On 2014-10-02