Incidental Mutation 'R2187:Cant1'
ID 237885
Institutional Source Beutler Lab
Gene Symbol Cant1
Ensembl Gene ENSMUSG00000025575
Gene Name calcium activated nucleotidase 1
Synonyms SCAN-1, D11Bwg0554e, Shapy, 5830420C20Rik, Apy1h
MMRRC Submission 040189-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R2187 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 118297115-118309912 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 118299667 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 227 (Y227*)
Ref Sequence ENSEMBL: ENSMUSP00000126919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017620] [ENSMUST00000092378] [ENSMUST00000106287] [ENSMUST00000106288] [ENSMUST00000106289] [ENSMUST00000164927]
AlphaFold Q8VCF1
Predicted Effect probably null
Transcript: ENSMUST00000017620
AA Change: Y227*
SMART Domains Protein: ENSMUSP00000017620
Gene: ENSMUSG00000025575
AA Change: Y227*

DomainStartEndE-ValueType
Pfam:Apyrase 115 403 7e-140 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000092378
AA Change: Y227*
SMART Domains Protein: ENSMUSP00000090032
Gene: ENSMUSG00000025575
AA Change: Y227*

DomainStartEndE-ValueType
Pfam:Apyrase 115 403 7e-140 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000106287
AA Change: Y227*
SMART Domains Protein: ENSMUSP00000101894
Gene: ENSMUSG00000025575
AA Change: Y227*

DomainStartEndE-ValueType
Pfam:Apyrase 115 403 7e-140 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000106288
AA Change: Y227*
SMART Domains Protein: ENSMUSP00000101895
Gene: ENSMUSG00000025575
AA Change: Y227*

DomainStartEndE-ValueType
Pfam:Apyrase 115 403 7e-140 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000106289
AA Change: Y264*
SMART Domains Protein: ENSMUSP00000101896
Gene: ENSMUSG00000025575
AA Change: Y264*

DomainStartEndE-ValueType
Pfam:Apyrase 115 216 6.3e-39 PFAM
Pfam:Apyrase 244 440 3.4e-92 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000164927
AA Change: Y227*
SMART Domains Protein: ENSMUSP00000126919
Gene: ENSMUSG00000025575
AA Change: Y227*

DomainStartEndE-ValueType
Pfam:Apyrase 115 403 7e-140 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: The protein encoded by this gene is a calcium-dependent nucleotidase that preferentially hydrolyzes UDP, GDP, and IDP. The encoded protein has low activity with ADP and ATP and shows no activity with AMP and GMP. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg1 T A 17: 31,324,491 (GRCm39) S245R probably damaging Het
AI597479 T A 1: 43,139,983 (GRCm39) W70R probably damaging Het
Ankrd55 A G 13: 112,520,039 (GRCm39) S575G probably benign Het
Bfsp2 T A 9: 103,303,976 (GRCm39) K343* probably null Het
Cd2bp2 T C 7: 126,793,963 (GRCm39) N109D probably benign Het
Chmp6 A G 11: 119,807,562 (GRCm39) E135G possibly damaging Het
Dsp T G 13: 38,360,383 (GRCm39) S329R probably damaging Het
Epha5 A T 5: 84,234,223 (GRCm39) F767L probably damaging Het
Epha7 A T 4: 28,942,648 (GRCm39) T566S possibly damaging Het
Erap1 A T 13: 74,810,524 (GRCm39) I288F probably damaging Het
Erich6 A G 3: 58,537,266 (GRCm39) probably null Het
Fbxo10 A G 4: 45,058,531 (GRCm39) V402A probably benign Het
Fndc1 T A 17: 7,960,604 (GRCm39) I1604F probably damaging Het
Foxd4 T G 19: 24,877,219 (GRCm39) Q327P probably damaging Het
Fxn T A 19: 24,257,853 (GRCm39) N26I probably benign Het
Hsf5 G T 11: 87,529,010 (GRCm39) G582C possibly damaging Het
Itga8 A G 2: 12,199,231 (GRCm39) V522A possibly damaging Het
Kplce A G 3: 92,775,922 (GRCm39) S254P probably damaging Het
Lyst C T 13: 13,883,926 (GRCm39) T2938I possibly damaging Het
Mib2 T C 4: 155,739,390 (GRCm39) E863G possibly damaging Het
Mrgpra9 A G 7: 46,884,797 (GRCm39) F290S probably damaging Het
Mst1 T C 9: 107,961,539 (GRCm39) Y599H possibly damaging Het
Mylk4 T C 13: 32,905,996 (GRCm39) I165V probably damaging Het
Nipsnap2 T C 5: 129,823,537 (GRCm39) probably null Het
Nol8 T C 13: 49,815,475 (GRCm39) Y528H probably benign Het
Nup93 T A 8: 95,027,478 (GRCm39) S295R probably damaging Het
Nutm2 A T 13: 50,621,453 (GRCm39) Q6L probably benign Het
Or2b6 A T 13: 21,823,555 (GRCm39) I46N probably damaging Het
Or5ak20 T G 2: 85,184,259 (GRCm39) S4R probably benign Het
Or5b12b T A 19: 12,861,619 (GRCm39) C125S probably damaging Het
Or6c33 A G 10: 129,853,557 (GRCm39) E109G probably damaging Het
Pip5k1a A T 3: 94,979,229 (GRCm39) L189Q probably damaging Het
Plekha4 C T 7: 45,198,698 (GRCm39) R574C probably damaging Het
Ppp2cb A G 8: 34,100,705 (GRCm39) E42G possibly damaging Het
Prkd3 T A 17: 79,282,983 (GRCm39) Q244L probably benign Het
Ptpn14 C T 1: 189,595,425 (GRCm39) R1023* probably null Het
Ptpra A G 2: 130,346,219 (GRCm39) T127A probably benign Het
Rad54l2 ACCTCCTCCTCCTCCTCCTCCTCCTC ACCTCCTCCTCCTCCTCCTCCTC 9: 106,631,191 (GRCm39) probably benign Het
Rasgrf1 T C 9: 89,876,888 (GRCm39) I751T possibly damaging Het
Rbm27 A G 18: 42,459,022 (GRCm39) K697R probably damaging Het
Rhoa C T 9: 108,212,352 (GRCm39) T127M probably benign Het
Rnpepl1 A G 1: 92,844,617 (GRCm39) S370G probably null Het
Sdk1 C T 5: 142,100,329 (GRCm39) T1453I probably damaging Het
Sel1l2 A G 2: 140,072,793 (GRCm39) L614S probably damaging Het
Slc6a20b T A 9: 123,427,653 (GRCm39) I419F probably damaging Het
Slc8a1 C T 17: 81,955,982 (GRCm39) S352N possibly damaging Het
Spta1 A G 1: 174,020,532 (GRCm39) D547G probably damaging Het
Tc2n G A 12: 101,672,803 (GRCm39) T46I probably damaging Het
Terb1 T A 8: 105,199,516 (GRCm39) Y476F probably benign Het
Trim12a T A 7: 103,953,399 (GRCm39) E237D probably damaging Het
Usp47 T C 7: 111,666,398 (GRCm39) L309P probably damaging Het
Other mutations in Cant1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02927:Cant1 APN 11 118,301,888 (GRCm39) missense probably benign 0.01
IGL02989:Cant1 APN 11 118,302,038 (GRCm39) missense probably damaging 1.00
R0512:Cant1 UTSW 11 118,302,091 (GRCm39) missense probably benign 0.26
R0535:Cant1 UTSW 11 118,301,969 (GRCm39) missense probably damaging 1.00
R1953:Cant1 UTSW 11 118,299,609 (GRCm39) missense probably damaging 1.00
R2154:Cant1 UTSW 11 118,302,263 (GRCm39) missense probably damaging 1.00
R3916:Cant1 UTSW 11 118,299,572 (GRCm39) missense probably damaging 0.98
R4065:Cant1 UTSW 11 118,298,823 (GRCm39) missense probably benign
R4786:Cant1 UTSW 11 118,299,665 (GRCm39) missense possibly damaging 0.68
R4847:Cant1 UTSW 11 118,300,936 (GRCm39) nonsense probably null
R5093:Cant1 UTSW 11 118,302,038 (GRCm39) missense probably damaging 1.00
R5265:Cant1 UTSW 11 118,298,876 (GRCm39) missense probably damaging 1.00
R5281:Cant1 UTSW 11 118,299,696 (GRCm39) missense probably damaging 0.99
R5506:Cant1 UTSW 11 118,302,268 (GRCm39) missense probably benign 0.10
R5614:Cant1 UTSW 11 118,299,569 (GRCm39) missense probably benign
R6705:Cant1 UTSW 11 118,298,698 (GRCm39) missense probably damaging 1.00
R7538:Cant1 UTSW 11 118,302,291 (GRCm39) missense possibly damaging 0.81
R7707:Cant1 UTSW 11 118,301,724 (GRCm39) missense possibly damaging 0.62
R7982:Cant1 UTSW 11 118,300,968 (GRCm39) missense probably benign
R9034:Cant1 UTSW 11 118,302,128 (GRCm39) missense probably benign
R9463:Cant1 UTSW 11 118,302,281 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- ACGGTGAATCAGCATCTTCAGC -3'
(R):5'- TGTCTCAGCCTCCAGTGAAG -3'

Sequencing Primer
(F):5'- CACGTAGAGAGAATCGTCTTACCTG -3'
(R):5'- GCTCAAGGGTGGTAACTTCTGAAC -3'
Posted On 2014-10-02