Incidental Mutation 'R2187:Nutm2'
ID 237894
Institutional Source Beutler Lab
Gene Symbol Nutm2
Ensembl Gene ENSMUSG00000071909
Gene Name NUT family member 2
Synonyms LOC328250, Gm806
MMRRC Submission 040189-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2187 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 50621343-50629391 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 50621453 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 6 (Q6L)
Ref Sequence ENSEMBL: ENSMUSP00000094390 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096633]
AlphaFold Q3V0C3
Predicted Effect probably benign
Transcript: ENSMUST00000096633
AA Change: Q6L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000094390
Gene: ENSMUSG00000071909
AA Change: Q6L

DomainStartEndE-ValueType
Pfam:NUT 27 733 9e-277 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185962
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg1 T A 17: 31,324,491 (GRCm39) S245R probably damaging Het
AI597479 T A 1: 43,139,983 (GRCm39) W70R probably damaging Het
Ankrd55 A G 13: 112,520,039 (GRCm39) S575G probably benign Het
Bfsp2 T A 9: 103,303,976 (GRCm39) K343* probably null Het
Cant1 A T 11: 118,299,667 (GRCm39) Y227* probably null Het
Cd2bp2 T C 7: 126,793,963 (GRCm39) N109D probably benign Het
Chmp6 A G 11: 119,807,562 (GRCm39) E135G possibly damaging Het
Dsp T G 13: 38,360,383 (GRCm39) S329R probably damaging Het
Epha5 A T 5: 84,234,223 (GRCm39) F767L probably damaging Het
Epha7 A T 4: 28,942,648 (GRCm39) T566S possibly damaging Het
Erap1 A T 13: 74,810,524 (GRCm39) I288F probably damaging Het
Erich6 A G 3: 58,537,266 (GRCm39) probably null Het
Fbxo10 A G 4: 45,058,531 (GRCm39) V402A probably benign Het
Fndc1 T A 17: 7,960,604 (GRCm39) I1604F probably damaging Het
Foxd4 T G 19: 24,877,219 (GRCm39) Q327P probably damaging Het
Fxn T A 19: 24,257,853 (GRCm39) N26I probably benign Het
Hsf5 G T 11: 87,529,010 (GRCm39) G582C possibly damaging Het
Itga8 A G 2: 12,199,231 (GRCm39) V522A possibly damaging Het
Kplce A G 3: 92,775,922 (GRCm39) S254P probably damaging Het
Lyst C T 13: 13,883,926 (GRCm39) T2938I possibly damaging Het
Mib2 T C 4: 155,739,390 (GRCm39) E863G possibly damaging Het
Mrgpra9 A G 7: 46,884,797 (GRCm39) F290S probably damaging Het
Mst1 T C 9: 107,961,539 (GRCm39) Y599H possibly damaging Het
Mylk4 T C 13: 32,905,996 (GRCm39) I165V probably damaging Het
Nipsnap2 T C 5: 129,823,537 (GRCm39) probably null Het
Nol8 T C 13: 49,815,475 (GRCm39) Y528H probably benign Het
Nup93 T A 8: 95,027,478 (GRCm39) S295R probably damaging Het
Or2b6 A T 13: 21,823,555 (GRCm39) I46N probably damaging Het
Or5ak20 T G 2: 85,184,259 (GRCm39) S4R probably benign Het
Or5b12b T A 19: 12,861,619 (GRCm39) C125S probably damaging Het
Or6c33 A G 10: 129,853,557 (GRCm39) E109G probably damaging Het
Pip5k1a A T 3: 94,979,229 (GRCm39) L189Q probably damaging Het
Plekha4 C T 7: 45,198,698 (GRCm39) R574C probably damaging Het
Ppp2cb A G 8: 34,100,705 (GRCm39) E42G possibly damaging Het
Prkd3 T A 17: 79,282,983 (GRCm39) Q244L probably benign Het
Ptpn14 C T 1: 189,595,425 (GRCm39) R1023* probably null Het
Ptpra A G 2: 130,346,219 (GRCm39) T127A probably benign Het
Rad54l2 ACCTCCTCCTCCTCCTCCTCCTCCTC ACCTCCTCCTCCTCCTCCTCCTC 9: 106,631,191 (GRCm39) probably benign Het
Rasgrf1 T C 9: 89,876,888 (GRCm39) I751T possibly damaging Het
Rbm27 A G 18: 42,459,022 (GRCm39) K697R probably damaging Het
Rhoa C T 9: 108,212,352 (GRCm39) T127M probably benign Het
Rnpepl1 A G 1: 92,844,617 (GRCm39) S370G probably null Het
Sdk1 C T 5: 142,100,329 (GRCm39) T1453I probably damaging Het
Sel1l2 A G 2: 140,072,793 (GRCm39) L614S probably damaging Het
Slc6a20b T A 9: 123,427,653 (GRCm39) I419F probably damaging Het
Slc8a1 C T 17: 81,955,982 (GRCm39) S352N possibly damaging Het
Spta1 A G 1: 174,020,532 (GRCm39) D547G probably damaging Het
Tc2n G A 12: 101,672,803 (GRCm39) T46I probably damaging Het
Terb1 T A 8: 105,199,516 (GRCm39) Y476F probably benign Het
Trim12a T A 7: 103,953,399 (GRCm39) E237D probably damaging Het
Usp47 T C 7: 111,666,398 (GRCm39) L309P probably damaging Het
Other mutations in Nutm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00885:Nutm2 APN 13 50,628,896 (GRCm39) missense probably benign 0.18
IGL01087:Nutm2 APN 13 50,623,665 (GRCm39) missense probably damaging 1.00
IGL01707:Nutm2 APN 13 50,623,753 (GRCm39) missense probably damaging 0.96
IGL02085:Nutm2 APN 13 50,627,829 (GRCm39) splice site probably null
IGL02238:Nutm2 APN 13 50,625,075 (GRCm39) missense probably damaging 1.00
IGL02369:Nutm2 APN 13 50,623,944 (GRCm39) missense probably benign 0.16
IGL02429:Nutm2 APN 13 50,623,516 (GRCm39) missense probably benign 0.44
IGL03083:Nutm2 APN 13 50,621,480 (GRCm39) missense probably damaging 0.98
R0233:Nutm2 UTSW 13 50,621,441 (GRCm39) missense probably benign 0.41
R0233:Nutm2 UTSW 13 50,621,441 (GRCm39) missense probably benign 0.41
R0321:Nutm2 UTSW 13 50,626,991 (GRCm39) missense probably damaging 0.98
R1481:Nutm2 UTSW 13 50,623,517 (GRCm39) missense probably damaging 0.99
R1605:Nutm2 UTSW 13 50,623,955 (GRCm39) missense possibly damaging 0.68
R1679:Nutm2 UTSW 13 50,623,422 (GRCm39) missense probably benign 0.17
R1744:Nutm2 UTSW 13 50,623,390 (GRCm39) missense probably benign 0.03
R1768:Nutm2 UTSW 13 50,627,152 (GRCm39) missense probably damaging 1.00
R1969:Nutm2 UTSW 13 50,627,878 (GRCm39) missense probably damaging 1.00
R2026:Nutm2 UTSW 13 50,628,856 (GRCm39) missense probably benign 0.00
R3912:Nutm2 UTSW 13 50,626,976 (GRCm39) missense possibly damaging 0.92
R4025:Nutm2 UTSW 13 50,623,389 (GRCm39) missense probably benign
R4367:Nutm2 UTSW 13 50,623,920 (GRCm39) missense probably benign 0.01
R4668:Nutm2 UTSW 13 50,627,033 (GRCm39) missense probably benign 0.18
R4940:Nutm2 UTSW 13 50,628,909 (GRCm39) missense possibly damaging 0.58
R4987:Nutm2 UTSW 13 50,626,379 (GRCm39) missense possibly damaging 0.93
R4988:Nutm2 UTSW 13 50,626,379 (GRCm39) missense possibly damaging 0.93
R5821:Nutm2 UTSW 13 50,623,891 (GRCm39) missense probably benign 0.01
R5986:Nutm2 UTSW 13 50,628,496 (GRCm39) missense probably damaging 1.00
R6189:Nutm2 UTSW 13 50,623,774 (GRCm39) missense possibly damaging 0.91
R7101:Nutm2 UTSW 13 50,626,934 (GRCm39) missense probably benign 0.00
R7192:Nutm2 UTSW 13 50,627,105 (GRCm39) missense probably damaging 1.00
R7394:Nutm2 UTSW 13 50,624,043 (GRCm39) missense probably damaging 1.00
R7591:Nutm2 UTSW 13 50,627,903 (GRCm39) missense probably damaging 0.98
R8217:Nutm2 UTSW 13 50,623,759 (GRCm39) missense probably benign 0.16
R8347:Nutm2 UTSW 13 50,626,373 (GRCm39) missense probably benign 0.05
R8811:Nutm2 UTSW 13 50,623,989 (GRCm39) missense probably benign 0.02
R9093:Nutm2 UTSW 13 50,628,964 (GRCm39) missense probably damaging 1.00
R9420:Nutm2 UTSW 13 50,626,964 (GRCm39) missense probably damaging 1.00
R9507:Nutm2 UTSW 13 50,621,455 (GRCm39) missense probably benign
R9532:Nutm2 UTSW 13 50,628,475 (GRCm39) missense probably benign 0.00
R9632:Nutm2 UTSW 13 50,628,901 (GRCm39) missense probably benign 0.10
R9650:Nutm2 UTSW 13 50,623,755 (GRCm39) missense probably benign 0.25
R9683:Nutm2 UTSW 13 50,629,017 (GRCm39) missense possibly damaging 0.92
X0028:Nutm2 UTSW 13 50,626,990 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GCCAAGGTTCTTATGCACCTG -3'
(R):5'- CTTCACAGTGGGATGTCCTTG -3'

Sequencing Primer
(F):5'- GGAATGTTCCCCCAGTCCTG -3'
(R):5'- ATGTCCTTGCAGAAGTCCAG -3'
Posted On 2014-10-02